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Question

If the lac repressor gene were mutated so that the allosteric site on the encoded protein no longer bound allolactose, what would be the effect on transcription of the lac operon? What about a similar mutation in the trp repressor gene?

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When allolactose binds the lac repressor, it cannot bind to the operator and the transcription can happen in order to produce enzymes for lactose. If lac repressor cannot be inhibited with allolactose, this means that it will be on the operator site and the transcription cannot occur. If trp repressor cannot bind trp, this means that, even when there is high concentration of tryptophan in the cell, the cell will continue to produce it nevertheless, because the repressor is not activated by the corepressor.

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