P.M., a 24-year-old house painter, has been too ill to work for the past 3 days. When he arrives at your outpatient clinic with his girlfriend, he seems alert but acutely ill, with an average build and a deep tan over the exposed areas of skin. He reports headaches, joint pain, a low-grade fever, cough, anorexia, and nausea and vomiting (N/V), especially after eating any fatty food. P.M. describes vague abdominal pain that started about the same time as the other problems. His past medical history reveals he has no health problems, is a nonsmoker, and drinks a "few" beers each evening to relax. Vital signs (VS) are 128/84,88, 26,100.6∘F(38.1∘C); awake, alert, and oriented ×3; moves all extremities well except for aching pain in his muscles; very slight scleral jaundice present; heart tones clear and without adventitious sounds; bowel sounds clear throughout abdomen and pelvis; and abdomen soft and palpable without distinct masses. You note moderate hepatomegaly measured at the midclavicular line; liver edge is easily palpated and tender to palpation. P.M. mentions that his urine has been getting darker over the past 2 days.
P.M. is manifesting the key signs of hepatitis. Lab work is sent for identification of his precise problem, and results are shown below.
Laboratory Test Results
Sodium Potassium Chloride CO2BUN Creatinine Platelets Indirect bilirubin Total bilirubin Albumin Total protein Alanine aminotransferase (ALT) Aspartate aminotransferase (AST) Lactic dehydrogenase (LDH) Alkaline phosphatase Prothrombin time (PT)/INR Activated partial thromboplastin time (aPTT) Urine urobilinogen Anti-HAV (hepatitis A virus) IgM Hepatitis B surface antigen (HBsAg) 140mEq/L3.9mEq/L102mEq/L26mEq/L10mg/dL1.0mg/dL210,000/mm31.6mg/dL2.3mg/dL3.8 g/dL6.5 g/dL66units/L52units/L245units/L176units/L12sec/1.0632sec1.6IU/L Negative Positive
List three drugs that can cause increased ALT levels.