Like Hurler syndrome, Fabry disease involves an abnormal accumulation of substances within lysosomes. However, the lysosomes of individuals with Fabry disease show an abnormal accumulation of lipids. The defective enzyme is $\alpha$-galactosidase $A$, which is a lysosomal enzyme that functions in lipid metabolism. This defect causes cell damage, especially to the kidneys, heart, and eyes. The gene that encodes a-galactosidase $\mathrm{A}$ is found on the $\mathrm{X}$ chromosome. Let's suppose a phenotypically unaffected couple produces two sons with Fabry disease and one phenotypically unaffected daughter. What is the probability that the daughter will have an affected son?

Prions are pathogens that are responsible for (a) AIDS. (b) Ebola hemorrhagic fever. (c) mad cow disease. (d) bird flu. (e) SARS.

Janet and David Scott bought 1,500 shares of Metro Health Care REIT (MHC) at $84.92 per share. The broker's commission was$14.95 for fewer than 1,000 shares or $0.015 per share for 1,000 shares or more. (a) What was the cost of the stock? (b) What was the total paid?

Distinguish between acute and chronic, mortality and morbidity, prevalence and incidence, and epidemic and pandemic, as these terms relate to infectious disease. (Section 28.1)

The Occupational Safety and Health Administration (OSHA) requires food service kitchens to follow safety rules to prevent accidents. Interview your school’s food service director to learn about OSHA rules. Find out how the school reaches its kitchen safety goals.

If you knew that a devastating late-onset inherited disease runs in your family (in other words, a disease that does not appear until later in life) and you could be tested for it at the age of 20, would you want to know whether you are a carrier? Would your answer be likely to change when you reach age 40?

Will the passage of a law be sped up or slowed down by an attempt to IMPEDE it?

Make an informational poster listing ways to protect yourself from infectious disease. Post copies of the poster in your home and school.

Explain Ohm’s law in your own words, including references.

Considering the following table shows the results of mammogram screenings for 64,810 women.

a. According to these data, what is the incidence rate of breast cancer among the women who had mammograms? b. What percentage of women who tested positive had cancer? c. What percentage of women who tested negative had cancer? d. The sensitivity of a screening test is the accuracy of the test among people with the disease. In this case, what percentage of women with the disease tested positive? e. The specificity of a screening test is the accuracy of the test among people without the disease. In this case, what percentage of women without the disease tested negative?

List the advantages of using two chemotherapeutic agents simultaneously to treat a disease. What problem can be encountered using two drugs?

a. Why do peripheral pulses become feeble when the iliac artery is blocked? b. Why should patients with arterial peripheral vascular disease carefully examine their feet every day? c. Why may healing after amputation cure gangrene be reduced in cases of arterial peripheral vascular disease, and how does gangrene occur in such cases?

Compare and contrast the use of SNP genotyping: (a) in the positional cloning of Mendelian disease genes, (b) in direct QTL mapping, and (c) in GWAS.

Barb suffers from Crohn's disease, a regional inflammation of the intestine that is thought to have some genetic basis, although the actual cause remains unknown. When the disease flares up, she experiences abdominal pain, weight loss, and anemia. Which part(s) of the intestine is (are) probably involved, and what might be the causes of her signs and symptoms?