Question

Malignant tumors are sometimes treated with drugs that halt mitosis, and thus stop the production of new cancer cells. Two such drugs, vincristine sulfate and vinblastine sulfate, interfere with the formation of spindle fibers. How could this action halt mitosis? Antibiotics such as mitomycin C and inorganic compounds such as cis-platinum also can be used to stop the growth of tumors. These drugs interfere with DNA synthesis in treated cells. How could this action halt mitosis?

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By interfering with the formation of spindle fibers\textit{spindle fibers}, the drugs (vincristine sulfate and vinblastine sulfate) disrupt the cell division because spindle fibers are responsible for the separation of the chromatids and their migration to the opposite parts of the cell.

Interfering with DNA synthesis by some drugs (mitomycin C, cis-platinum) stops the tumor growth by stopping the cell division\textit{cell division}.

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