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Phenylketonuria (PKU) is a recessive genetic disorder. If both parents are carriers, what is the probability of this couple having a child with PKU? What is the chance of this couple having two children with PKU?
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Answered 2 years ago
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1 of 2Since phenyketonuria (PKU) is a recessive genetic disorder, the trait is inherited when the child receives two recessive alleles from the parents.
Given that the parents are carrier (heterozygous dominant), the probability of having a child that develops PKU is 25 or . (Recall that a cross of Aa Aa gives 1AA: 2Aa: 1aa).
Note that the chance of having a second child with PKU is still 25 or . Now, the the chance of this couple having two children with PKU is
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