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John and Martha are contemplating having children, but John’s brother has galactosemia (an autosomal recessive disease) and Martha’s great-grandmother also had galactosemia. Martha has a sister who has three children, none of whom have galactosemia. What is the probability that John and Martha’s first child will have galactosemia? 1. Can the problem be restated as a pedigree? If so, write one. 2. Can parts of the problem be restated by using Punnett squares? 3. Can parts of the problem be restated by using branch diagrams? 4. In the pedigree, identify a mating that illustrates Mendel’s first law. 5. Define all the scientific terms in the problem, and look up any other terms about which you are uncertain. 6. What assumptions need to be made in answering this problem? 7. Which unmentioned family members must be considered? Why? 8. What statistical rules might be relevant, and in what situations can they be applied? Do such situations exist in this problem? 9. What are two generalities about autosomal recessive diseases in human populations? 10. What is the relevance of the rareness of the phenotype under study in pedigree analysis generally, and what can be inferred in this problem? 11. In this family, whose genotypes are certain and whose are uncertain? 12. In what way is John’s side of the pedigree different from Martha’s side? How does this difference affect your calculations? 13. Is there any irrelevant information in the problem as stated? 14. In what way is solving this kind of problem similar to solving problems that you have already successfully solved? In what way is it different? 15. Can you make up a short story based on the human dilemma in this problem?


Refer to the 10-K reports of Under Armour, Inc., and Columbia Sportswear that are available for download from the companion website at


Comment on Under Armour’s and Columbia’s debt management.


Answered 11 months ago
Answered 11 months ago
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This exercise will evaluate Under Armour Inc.'s and Columbia Sportswear's ratios.

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