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Two pathways, homologous recombination and nonhomologous end joining (NHEJ), can repair double-strand breaks in DNA. If homologous recombination is an errorfree pathway whereas NHEJ is not always error free, why is NHEJ used most of the time in eukaryotes?

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Nonhomologous end joining are used most of the time, especially in higher eukaryotes because the DNA in the cells are in a non-replication state that is either in a resting phase or had stopped completely. In addition, they can function even if there are no sister chromatids or undamaged DNA. Homologous recombination occurs in active dividing cells that require a sister chromatid as template for the repair.

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