Mutations are normal part of replication. They can arise in somatic and germline cells. The difference is that mutation that occurs in somatic cells are only passed to the daughter cells of that particular cell – this means that all subsequent cells carry that mutation – dark patches of skin or synthesis of a defective enzyme etc. Germline mutations are more dangerous. Germline cells make gametes – so any mutation that arises in these cells is being passed down after sexual reproduction (fertilization).
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