What is the biochemical rationale for ATP serving as a positive regulator of ATCase?


Answered 1 year ago
Answered 1 year ago

ATP is a positive allosteric regulator of aspartate transcarbamoylase, therefore, it activates the enzyme to produce more of its product which is N-carbamoyl aspartate.

This step is also the committed step of the biosynthesis so the amounts of N-carbamoyl aspartate will determine the amounts of the final product, which is the pyrimidine nucleotide cytidine triphosphate (CTP).

Also, high amounts of ATP in the cell signal the enzyme that there is enough energy present to synthesize other nucleotides, in this case, CTP. That is why it’s biochemically rational that ATP serves as a positive regulator.

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