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Your grandfather complains of pain in his swollen and inflamed big toe and the doctor indicates that it is caused by gout. (a) How would you explain to him what gout is and its biochemical cause? (b) What can you suggest to him to prevent these gouty attacks?

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(a) When urate anion is present in excess in the blood, it precipitates as sodium urate crystals. Gout is the pain resulting from a cascade of inflammatory responses to the sodium urate crystals in the big toe.

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