Zea mays (maize, or corn) was originally domesticated in central Mexico at least $7000$ years ago from an endemic grass called teosinte. Teosinte is generally unbranched, has male and female flowers on the same branch, and has few kernels per “cob,” each encased in a hard, leaf-like organ called a glume. In contrast, maize is highly branched, with a male inflorescence (tassel) on its central branch and female inflorescences (cobs) on axillary branches. In addition, maize cobs have many rows of kernels and soft glumes. George Beadle crossed cultivated maize and wild teosinte, which resulted in fully fertile F$_{1}$ plants. When the F$_{1}$ plants were self-fertilized, about 1 plant in every $1000$ of the F$_{2}$ progeny resembled either a modern maize plant or a wild teosinte plant. What did Beadle conclude about whether the different architectures of maize and teosinte were caused by changes with a small effect in many genes or changes with a large effect in just a few genes?