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Eukaryotic transcriptional control
Terms in this set (53)
What is BRE?
TFIIB recognition element
What histones have only N-terminal tails?
H2A and H2B
What is the oestrogen receptor?
Is inactive in the cytosol in resting cells
What does H3K27me3 mean?
Trimethylation of lysine 27 on Histone 3
What are the members of the steroid receptor or nuclear receptor superfamily?
Zinc Finger proteins - C4
What histone modification typically associates with euchromatin?
How would you identify genomic sequences modulating transcriptional activity?
By recombinant DNA technologies and reporter gene assays
How does epigentic repression of gene transcription occur?
Through histone methylation
What is the word for changes in phenotype that can be inherited irrespective of genotype?
What do acetylated histone tails lead to?
Euchromatic - the active form of DNA
What is the enzyme that methylates histones?
What interactions regulate DNA condensation?
Electrostatic attractions between negative DNA and positive histones, the degree of this determines the level of attachment
What is the movement of components between the cytosol and nucleus called?
What is the protein that retains heterodimeric nuclear reporters in an inactive state?
What are the proteins that make up nuclesomes and attach to DNA?
H3, H4, H2B, H2A, H1
What removes acetyl groups from histones?
What wraps 147bp of DNA?
What is the domain that allows multimerisation of HP-1 and DNA silencing?
What domains interact with acetylated histones?
What are the two most commonly modified amino acids in histones?
Lysine and arginine
What is transcriptionally inactive DNA?
What is the structure of the central core of histones?
A globular structure
What is a complex of DNA and proteins called?
Chromatin - this constitutes chromosomes
What are protein modifications that occur after peptide chain synthesis called?
What is the technique to study interactions between two proteins?
What is the molecular bridge that coordinates transcription factor activation?
What is the hormone that binds homodimeric cytosolic nuclear receptors?
Which modification retains the positive charge of amino acids
What is the hormone that binds nuclear heterodimeric reporters?
What is the property of the highly conserved domain in the nuclear reporter superfamily?
What is the protein group that drives gene expression?
What is the DNA sequence box that drives expression of strong genes?
What is the type of RNA produced by 2 different RNA polymerases?
What is the structural arrangement of domains in transcription factors?
What is the genetic element on the transcription start site?
What is the DNA sequence that that impacts transcription from 3000bp upstream?
The enhancer zone
What is formed on the transcription start site?
What is the name for the cooperative interaction of multiple transcription factors?
What are the transcription factors which bind Zn ions via 4 cysteine residues?
What is the activity that separates the double helix of DNA?
What is the most basic DNA binding domain?
What is the DNA sequence recognised by an RNA pol called?
The promotor region
What is located within the first 200bp of the transcription start site?
The proximal end
What are the promotors of genes expressed constantly called?
What is the name for genes whose expression is low but constant
House keeping genes
Genetic elements that affect transcription and are present in the genome are..
What phosphorylates the C-terminal domain of the RNA pol II?
What is the mist common DNA binding domain?
The zinc finger
What is needed for RNA pol II?
The CTF and CPG
What is the technique used to identify genetic elements that contribute to transcription?
Reporter Gene Assay
Actin is an essential cytoskeleton protein that determines the shape of cells. How do you think it is transcribed?
By RNA pol II and a weak broad promoter (CpG island).
18S is an essential RNA constituent of ribosomes. How do you think it is transcribed?
By RNA pol I and a weak dispersed promoter (CpG island).
Tumour necrosis factor (TNF) is a potent cytokine that induces inflammatory responses during pathogen infection. How do you think it is transcribed?
By RNA pol II and a strong sharp promoter (TATA box).
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