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What were major problems with Darwin's work?
No system for generating variation - soem variants consistently do better than others, eventually entire population identical to best variant socnothing now for selection to act on
Blending inheritance detroys variation that exists - everything regresses to the mean, getting rid of variation
Darwins theory doesnt work with these theories
How did Mendelian inheritance fix where Darwin went wrong?
Mutations solve the genetic variance problem, variation not lost through Mendelian inheritance
Does Mendelism work well with natural selection?
Yes with variation, no with natural selection
What mutations are usually selected?
Mutations with small effect - slow gradual change
But sometimes macromutation key - endosymbiosis where acheal cell got a bacterial cell in it, becoming eukaryotic and polyploidy events where genomes double
Why are macro mutations important in microbes?
Widespread transfer of genetic material between microbes
Cassettes of genes introduced to improve function - forms resistance
What is altruism?
A behaviour beneficial to other but costly to self
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