Pox Virus

what type of virus is Pox virus?

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what type of virus is Pox virus?

what is the Variola virus?

cause of smallpox

what is the vaccinia virus?

- vaccine used to eradicate smallpox
- virus has been engineered to make vaccine

why was the vaccinia virus successful?

capsid proteins of vaccinia virus and variola virus are HIGHLY CONSERVED

how does the Vaccinia virus work?

- has proteins that shut down innate immunity
- stops recognition of PRRs and PAMPs
- interfering with interferon: captures interferon when it has been released from the cell

how is the Variola virus produced?

- modified in Golgi and transported to cell surface to be released by exocytosis
- virus endorse polymerisation of actin tails to move away from cells

how does the Variola virus spread?

- virus comes out fo first cell and infects second cell
- virions bounce across cell surface of surrounding cells to infect distant cells without needing to replicate (interferons allow surrounding cells to become resistant to the virus)