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2.2 Coagulation: Platelet and Vascular Disorders [ HARR MLS REVIEWER - HEMATOLOGY]

Terms in this set (23)

Thrombotic thrombocytopenic purpura (TTP) is characterized by:

A. Prolonged PT
B. Increased platelet aggregation
C. Thrombocytosis
D. Prolonged APTT
B. Increased platelet aggregation
Thrombocytopenia may be associated with:

A. Postsplenectomy
B. Hypersplenism
C. Acute blood loss
D. Increased proliferation of pluripotential stem cells
B. Hypersplenism
Aspirin prevents platelet aggregation by inhibiting the action of which enzyme?

A. Phospholipase
B. Cyclo-oxygenase
C. Tromboxane A2 synthetase
D. Prostacyclin synthetase
B. Cyclo-oxygenase
Normal platelet adhesion depends upon:

A. Fibrinogen
B. Glycoprotein Ib
C. Glycoprotein IIb, IIIa complex
D. Calcium
B. Glycoprotein Ib
Which of the following test results is normal in a patient with classic von Willebrand's disease?

A. Bleeding time
B. Activated partial thromboplastin time
C. Platelet count
D. Factor VIII:C and von Willebrand's factor (VWF) levels
C. Platelet count
Bernard-Soulier syndrome is associated with:

A. Decreased bleeding time
B. Decreased factor VIII assay
C. Thrombocytopenia and giant platelets
D. Abnormal platelet aggregation to ADP
C. Thrombocytopenia and giant platelets
When performing platelet aggregation studies, which set of platelet aggregation results would most likely be associated with Bernard-Soulier syndrome?

A. Normal platelet aggregation to collagen, ADP, and ristocetin
B. Normal platelet aggregation to collagen, ADP, and epinephrine; decreased aggregation to ristocetin
C. Normal platelet aggregation to epinephrine and ristocetin; decreased aggregation to collagen and ADP
D. Normal platelet aggregation to epinephrine, ristocetin, and collagen; decreased aggregation to ADP
B. Normal platelet aggregation to collagen, ADP, and epinephrine; decreased aggregation to ristocetin
Which set of platelet responses would be most likely associated with Glanzmann's thrombasthenia?

A. Normal platelet aggregation to ADP and ristocetin; decreased aggregation to collagen
B. Normal platelet aggregation to collagen; decreased aggregation to ADP and ristocetin
C. Normal platelet aggregation to ristocetin; decreased aggregation to collagen, ADP, and epinephrine
D. Normal platelet aggregation to ADP; decreased aggregation to collagen and ristocetin
C. Normal platelet aggregation to ristocetin; decreased aggregation to collagen, ADP, and epinephrine
Which of the following is a characteristic of acute immune thrombocytopenic purpura?

A. Spontaneous remission within a few weeks
B. Predominantly seen in adults
C. Nonimmune platelet destruction
D. Insidious onset
A. Spontaneous remission within a few weeks
TTP differs from DIC in that:

A. APTT is normal in TTP but prolonged in DIC
B. Schistocytes are not present in TTP but are present in DIC
C. Platelet count is decreased in TTP but normal in DIC
D. PT is prolonged in TTP but decreased in DIC
A. APTT is normal in TTP but prolonged in DIC
Several hours after birth, a baby boy develops petechiae and purpura and a hemorrhagic diathesis. The platelet count is 18 × 109/L. What is the most likely explanation for the low platelet count?

A. Drug-induced thrombocytopenia
B. Secondary thrombocytopenia
C. Neonatal alloimmune thrombocytopenia
D. Neonatal DIC
C. Neonatal alloimmune thrombocytopenia
Which of the following is associated with post-transfusion purpura (PTP)?

A. Nonimmune thrombocytopenia/ alloantibodies
B. Immune-mediated thrombocytopenia/ alloantibodies
C. Immune-mediated thrombocytopenia/ autoantibodies
D. Nonimmune-mediated thrombocytopenia/ autoantibodies
B. Immune-mediated thrombocytopenia/ alloantibodies
Hemolytic uremic syndrome (HUS) is associated with:

A. Fever, thrombocytosis, anemia, and renal failure
B. Fever, granulocytosis, and thrombocytosis
C. Escherichia coli 0157:H7
D. Leukocytosis and thrombocytosis
C. Escherichia coli 0157:H7
Storage pool deficiencies are defects of:

A. Platelet adhesion
B. Platelet aggregation
C. Platelet granules
D. Platelet production
C. Platelet granules
Lumi-aggregation measures:

A. Platelet aggregation only
B. Platelet aggregation and ATP release
C. Platelet adhesion
D. Platelet glycoprotein Ib
B. Platelet aggregation and ATP release
Neurological findings may be commonly associated with which of the following disorders?

A. HUS
B. TTP
C. ITP
D. PTP
B. TTP
Which of the following is correct regarding acquired thrombotic thrombocytopenic purpura?

A. Autoimmune disease
B. Decreased VWF
C. Decreased platelet aggregation
D. Decreased platelet adhesion
A. Autoimmune disease
Hereditary hemorrhagic telangiectasia is a disorder of:

A. Platelets
B. Clotting proteins
C. Fibrinolysis
D. Connective tissue
D. Connective tissue
Which of the following prevents platelet aggregation?

A. Tromboxane A2
B. Tromboxane B2
C. Prostacyclin
D. Antithrombin
C. Prostacyclin.
Which defect characterizes Gray's syndrome?

A. Platelet adhesion defect
B. Dense granule defect
C. Alpha granule defect
D. Coagulation defect
C. Alpha granule defect
The P2Y12 ADP receptor agonist assay may be used to monitor platelet aggregation inhibition to which of the following drugs?

A. Warfarin
B. Heparin
C. LMWH
D. Clopidogrel (Plavix)
D. Clopidogrel (Plavix)
Which of the following instruments can be used to evaluate platelet function?

A. Platelet aggregometer
B. VerifyNow
C. PFA-100
D. All of the above
Platelet aggregometer, VerifyNow, PFA-100
D. All of the above
Which of the following platelet aggregating agents demonstrates a monophasic aggregation curve when used in optimal concentration?

A. Trombin
B. Collagen
C. Adenosine diphosphate (ADP)
D. Epinephrine
B. Collagen
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