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Drugs acting on enzyme-linked receptors
Terms in this set (14)
Which signal transduction pathway is most important in cell division, growth and differentiation?
Ras/Raf/MAP kinase pathway.
Receptors for insulin...
contain tyrosine kinase in their intracellular domain.
The insulin receptor is a...
tyrosine protein kinase receptor.
The Jak/Stat pathway of signal transduction responds to activation by...
Which of the following statements is true of the mechanism of action of insulin?
Binding of insulin to its receptor causes autophosphorylation of the receptor.
What is true about human interferon alpha?
It is used to treat hepatitis B virus infection.
Endogenous and exogenous compounds-induced autophosphorylation, internalisation and down-regulation is a distinctive feature of...
tyrosine protein kinase receptors.
Which of the following statements is true of the adverse effects of insulin?
The principal unwanted effect is hypoglycaemia.
A cytoplasmic kinase (Bcr/Abl) involved in the pathogenesis of chronic myeloid leukemia is inhibited by...
The treatment of chronic myeloid leukemia with imatinib results from the ability of the drug to inhibit a specific...
In growth factor kinase cascade, MAP (Mitogen-Activated Protein) kinase acts to phosphorylate...
Which of the following statements about the treatment of diabetes mellitus is true?
Type 1, insulin-dependent, diabetes mellitus (IDDM) requires treatment with insulin.
The mechanism of action of imatinib is...
to inhibit a specific intracellular tyrosine kinase.
Tick the drug which belongs to endogenous proteins:
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