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Study sets matching "alzheimer"

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Study sets matching "alzheimer"

31 terms
ALZHEIMER
Alzheimer Disease (AD)
pathophysiology of Alzheimer
atrophy
FAD (Familial alzheimers Disease)
A progressive deterioration of brain function (memory, thinki…
Changes in acetylcholine, nicotinic, muscarinic and acetylcho…
cellular changes
People in whom got the AD show a clear pattern of the inherit…
Alzheimer Disease (AD)
A progressive deterioration of brain function (memory, thinki…
pathophysiology of Alzheimer
Changes in acetylcholine, nicotinic, muscarinic and acetylcho…
63 terms
Alzheimer
Alzheimer (AD)
How to diagnose Alzheimer
10 warning signs of Alzheimer: 1 to 4
10 warning signs of AD: 5 to 10
Non reversible, progressive dementia, manifested by gradual d…
By exclusion. Must rule out other etiologies of dementia. ... Mu…
1. Memory loss... 2. Difficulty performing familiar everyday tas…
5. Poor, decreased judgement ... 6. Problem with abstract thinki…
Alzheimer (AD)
Non reversible, progressive dementia, manifested by gradual d…
How to diagnose Alzheimer
By exclusion. Must rule out other etiologies of dementia. ... Mu…
238 terms
Alzheimer
die Lebensgestaltung
die Beziehungen
die Voraussetzungen
gelingen
l'existence, l'organisation de la vie
les relations sociales
les conditions, les prérequis
parvenir, réussir
die Lebensgestaltung
l'existence, l'organisation de la vie
die Beziehungen
les relations sociales
62 terms
Alzheimer
Alzheimer (AD)
How to diagnose Alzheimer
10 warning signs of Alzheimer: 1 to 4
10 warning signs of AD: 5 to 10
Non reversible, progressive dementia, manifested by gradual d…
By exclusion. Must rule out other etiologies of dementia. ... Mu…
1. Memory loss... 2. Difficulty performing familiar everyday tas…
5. Poor, decreased judgement ... 6. Problem with abstract thinki…
Alzheimer (AD)
Non reversible, progressive dementia, manifested by gradual d…
How to diagnose Alzheimer
By exclusion. Must rule out other etiologies of dementia. ... Mu…
16 terms
Alzheimer
Alzheimer pathophysiology... and symptoms…
Drugs worsen Dementia
Natural products
Rx for Alhzeimers... can't take Ach... ONLY…
Dec Ach ... neuritic plague in brain... dementia MMSE... personality/b…
Anti-cholinergics (IBS, incontinence, benztropine, DITROPAN X…
Vit E <150 IU... Gingko biloba (modest benefit high bleeding risk)
ACh Enz Inh (inc ACh)... NMDA Inh (block glutamate - too much ce…
Alzheimer pathophysiology... and symptoms…
Dec Ach ... neuritic plague in brain... dementia MMSE... personality/b…
Drugs worsen Dementia
Anti-cholinergics (IBS, incontinence, benztropine, DITROPAN X…
17 terms
alzheimer
nature of delirium
Delirium Medical Conditions
Major Neurocognitive Disorder
Progression of Neuro cognitive disorde…
- Temporary condition of confused, disoriented and out of tou…
- Drug intoxication, poisons, withdrawal from drugs... - Infecti…
( previously labelled as dementia)... - Gradual deterioration of…
- Memory impairment, visuospatial skills deficits... - Agnosia... -…
nature of delirium
- Temporary condition of confused, disoriented and out of tou…
Delirium Medical Conditions
- Drug intoxication, poisons, withdrawal from drugs... - Infecti…
63 terms
Alzheimer
brody
haug
terry
reduction in processing speed
senility is normal
shrinkage artifact
reduction in neuron size & volume of cortex
key mental feature impacted by age
brody
senility is normal
haug
shrinkage artifact
35 terms
alzheimer
neurologo
convegno scientifico
delirio di gelosia
perdita memoria
neurolog
konwencja naukowa
napady zazdrości
utrata pamięci
neurologo
neurolog
convegno scientifico
konwencja naukowa
2 terms
ALZHEIMER
memantina
alzheimer
enlantece el ritmo de deterioro cognitivo y funcional. AGONIS…
ENTRE LOS 40 Y 90 AÑOS CON UNA MAYOR INCIDENCIA DESPUÉS DE LO…
memantina
enlantece el ritmo de deterioro cognitivo y funcional. AGONIS…
alzheimer
ENTRE LOS 40 Y 90 AÑOS CON UNA MAYOR INCIDENCIA DESPUÉS DE LO…
11 terms
Alzheimer
alzheimer's
Environmental Design: 1. Maximizing Aw…
Environmental Design: 2. Ensuring Safe…
Environmental Design: 3. Providing Pri…
causes a steady decline in memory and is the leading cause of…
-keep signs simple... -place signs at eye level (48" to 60" from…
-exits that lead to unprotected areas should be monitored ... +d…
-if private rooms are not possible, try to provide something…
alzheimer's
causes a steady decline in memory and is the leading cause of…
Environmental Design: 1. Maximizing Aw…
-keep signs simple... -place signs at eye level (48" to 60" from…
8 terms
Alzheimer
Alzheimer disease
Risk Factors
Prevention
Clinical Manifestations
most common degenerative neurological disorder
Aging,Gender (Women),Family History, Head Injury
There is no way to prevent Alzheimers, but exercising,eating…
Memory loss that affects job skills... Difficulty performing fam…
Alzheimer disease
most common degenerative neurological disorder
Risk Factors
Aging,Gender (Women),Family History, Head Injury
33 terms
alzheimer
circuitos neuronales implicados
etapas del alzheimer
epidemiología
factores de riesgo y protectores
...
preclínica y clínica
99% edad, 1% genética
...
circuitos neuronales implicados
...
etapas del alzheimer
preclínica y clínica
10 terms
Alzheimer
Hallazgo neuropatalogico post mortem e…
Mayor factor de riesgo para desarrolla…
Estudios bioquimicos en EA
Trastornos Monogenicos de EA
Depositos amiloides en ovillos neurofibrilares y en las placa…
Edad avanzada ( Alrededor de 1.3% en personas con menos de 70…
Depositos amiloides situados en los ovillos nuerofibrilares y…
Existe la hipotesis que la duplicacon del gen APP ubicado en…
Hallazgo neuropatalogico post mortem e…
Depositos amiloides en ovillos neurofibrilares y en las placa…
Mayor factor de riesgo para desarrolla…
Edad avanzada ( Alrededor de 1.3% en personas con menos de 70…
Alzheimer
Etiología de Alzheimer
Placas seniles
APP
PSEN 1 y PSEN 2
Atrofia notable de la corteza cerebral y pérdida de las neuro…
Acumulaciones esféricas de proteína beta amiloide
Proteína beta amiloide
Presenilina 1 y 2
Etiología de Alzheimer
Atrofia notable de la corteza cerebral y pérdida de las neuro…
Placas seniles
Acumulaciones esféricas de proteína beta amiloide
14 terms
Alzheimer
comportarse
envejecimiento
pérdida
padecer
to behave
ageing
loss
to suffer from
comportarse
to behave
envejecimiento
ageing
13 terms
Alzheimer
Mild(MMSE score 18-26)
Moderate (MMSE score 10-17)
Severe (MMSE score 0-9)
Galantamine
difficulty recalling recent events; difficulty managing finan…
disoriented to time; severely impaired recall of recent event…
loss of ability to speak, walk and feed self; incontinent; re…
A selective, competitive reversible acetylcholinesterase inhi…
Mild(MMSE score 18-26)
difficulty recalling recent events; difficulty managing finan…
Moderate (MMSE score 10-17)
disoriented to time; severely impaired recall of recent event…
127 terms
Alzheimer
Classification of neurodegenerative di…
Normal ageing neurological profile
MCI (3)... (Salmon & Bondi, 2009)
MCI: how long before diagnosis?
Topographical emphasis of pathological change
Senile plaques & Tangles in frontal & temporal cortex
1. Cognitive complaint & deficit in tests,... 2. Impairment stab…
2-3 years (Salmon & Bondi, 2009)
Classification of neurodegenerative di…
Topographical emphasis of pathological change
Normal ageing neurological profile
Senile plaques & Tangles in frontal & temporal cortex
34 terms
alzheimer
multiple sclerosis
complaints
significant
particularly
stwardnienie rozsiane
uskarzanie sie
znaczacy
szczególnie
multiple sclerosis
stwardnienie rozsiane
complaints
uskarzanie sie
31 terms
ALZHEIMER
Alzheimer Disease (AD)
pathophysiology of Alzheimer
atrophy
FAD (Familial alzheimers Disease)
A progressive deterioration of brain function (memory, thinki…
Changes in acetylcholine, nicotinic, muscarinic and acetylcho…
cellular changes
People in whom got the AD show a clear pattern of the inherit…
Alzheimer Disease (AD)
A progressive deterioration of brain function (memory, thinki…
pathophysiology of Alzheimer
Changes in acetylcholine, nicotinic, muscarinic and acetylcho…
13 terms
ALZHEIMER
Alzheimer
Etiology
Risk factors
Incidence
Progressive degenerative brain disease characterized by plaqu…
The cause of AD is unknown.Those with family history have hig…
Age... Female gender after 80... Family history... Genetics... Hypertensi…
25 million people worldwide 5 million of which live in the US…
Alzheimer
Progressive degenerative brain disease characterized by plaqu…
Etiology
The cause of AD is unknown.Those with family history have hig…
31 terms
ALZHEIMER
Alzheimer Disease (AD)
pathophysiology of Alzheimer
atrophy
FAD (Familial alzheimers Disease)
A progressive deterioration of brain function (memory, thinki…
Changes in acetylcholine, nicotinic, muscarinic and acetylcho…
cellular changes
People in whom got the AD show a clear pattern of the inherit…
Alzheimer Disease (AD)
A progressive deterioration of brain function (memory, thinki…
pathophysiology of Alzheimer
Changes in acetylcholine, nicotinic, muscarinic and acetylcho…
22 terms
Alzheimer
Alzheimer is a neurodegenerative brain…
What are the 3 consistent neuropatholo…
The 3 consistent neuropathological hal…
What is Amyloid cascade hypothesis
a progressive loss of memory and cognitive function
Amyloid-rich senile plaques... Neurofibrillary tangles... Neuronal…
only measurable post-mortem
Amyloid - peptides that aggregate to form beta-sheet structur…
Alzheimer is a neurodegenerative brain…
a progressive loss of memory and cognitive function
What are the 3 consistent neuropatholo…
Amyloid-rich senile plaques... Neurofibrillary tangles... Neuronal…
24 terms
Alzheimer
How many people have this desease in t…
What is a complete workup?
Hallmark of the disease found in a bra…
Three stages of the disease.
4,000,000
Psysical, mri, psycological exam.
Protein deposit, tangles , plaque
Early , mid , late.
How many people have this desease in t…
4,000,000
What is a complete workup?
Psysical, mri, psycological exam.
39 terms
Alzheimer
which NT play a role in causing alzhei…
How does the disease progress?
How do we test neuropsychological test…
What is the cons of MMSE?
decrease in ACh activity
start with memo loss -> then have diffi carrying convo, formi…
MMSE ... If MMSE < 24 -> we say that pt is having Alzheimer ... Dur…
Intelligent ppl can get high score in this test although they…
which NT play a role in causing alzhei…
decrease in ACh activity
How does the disease progress?
start with memo loss -> then have diffi carrying convo, formi…
Alzheimer
Wozu dient der Hippocampus?
wann entdeckte Alois Alzheimer die Kra…
Wie heissen die für Alzheimer typische…
Wo befindet sich der Hippocampus?
speichert persönliche, autobiographische Erinnerungen
1905
amyloide Plaques
im Grosshirn, tief im Bereich der beiden Schläfen
Wozu dient der Hippocampus?
speichert persönliche, autobiographische Erinnerungen
wann entdeckte Alois Alzheimer die Kra…
1905
46 terms
Alzheimer
Basic Facts
Late onset AD - Basic Facts
Early Onset AD - Basic Facts
What is the trend with occurrences at…
-Most common type of dementia... -Accounts for 60-80% of all dem…
-Symptoms do not appear until after age 65... -Used to be called…
-Symptoms appear in the 30s, 40s, or 50s... -Rare - accounts for…
Double, double, double, double, triple.
Basic Facts
-Most common type of dementia... -Accounts for 60-80% of all dem…
Late onset AD - Basic Facts
-Symptoms do not appear until after age 65... -Used to be called…
20 terms
Alzheimer
Qu'est ce qu'une démence?
Qu'est ce que la maladie d'Alzheimer?
Qui est le plus touché par la maladie…
Quelles sont les 3 anomalies structure…
trouble et maladie cérébrales qui détruise lentement les fonc…
maladie neurodégénérative qui affecte le système cholinergiqu…
les femmes
- dégénérescence neurofibrillaires (intracellulaire) ... - dével…
Qu'est ce qu'une démence?
trouble et maladie cérébrales qui détruise lentement les fonc…
Qu'est ce que la maladie d'Alzheimer?
maladie neurodégénérative qui affecte le système cholinergiqu…
39 terms
Alzheimers
language disturbance
impaired motor activity ability
failure to recognize objects
planning, organizing, sequencing, abst…
Aphasia
Apraxia
Agnosia
Disturbance in execute functions
language disturbance
Aphasia
impaired motor activity ability
Apraxia
14 terms
el Alzheimer
illness
to behave
ageing
loss
enfermedad
comportarse
envejecimiento
pérdida
illness
enfermedad
to behave
comportarse
5 terms
alzheimers
amnesia
aphasia
agnosia
apraxia
a partial or total loss of memory.
loss of ability to understand or express speech, caused by br…
inability to interpret sensations and hence to recognize thin…
inability to perform particular purpose actions, as a result…
amnesia
a partial or total loss of memory.
aphasia
loss of ability to understand or express speech, caused by br…
12 terms
Alzheimers
Donepezil
Rivastigmine
Galantamine
Memantine
MOA: antagonist of acetylcholine esterase (AChE) (100x more s…
MOA: antagonist of acetylcholine esterase (AChE) & BuCHe... pseu…
MOA: antagonist of acetylcholine esterase (AChE), also binds…
MOA: NMDA antagonist (non competitive)... block excess excitatio…
Donepezil
MOA: antagonist of acetylcholine esterase (AChE) (100x more s…
Rivastigmine
MOA: antagonist of acetylcholine esterase (AChE) & BuCHe... pseu…
60 terms
Alzheimers
Pediatrician
gerontologist
Hospitalist
Internist
a medical practitioner specializing in children and their dis…
Gerontologists are health care professionals who specialize i…
a dedicated in-patient physician who works exclusively in a h…
a specialist in internal medicine.
Pediatrician
a medical practitioner specializing in children and their dis…
gerontologist
Gerontologists are health care professionals who specialize i…
7 terms
Alzheimers
NT involved with Alzheimers
Part of the brain affect by Alzheimers
Amyloid Plaques & Neurofibrillary tang…
Drugs used to treat Alzheimers
Acetylchlone (Ach)
Hippocampus
Alzheimers
AchE inhibitors
NT involved with Alzheimers
Acetylchlone (Ach)
Part of the brain affect by Alzheimers
Hippocampus
11 terms
Alzheimers
donepezil (tablet strength)
donepezil (ODT strength)
galantamine tablet
Razadyne ER
(Cholinesterase Inhibitors) Aricept: 5,10,23mg (recommend pat…
(Cholinesterase Inhibitors) Aricept ODT: 5,10mg
(Cholinesterase Inhibitors) Razadyne
(Cholinesterase Inhibitors) galantamine ER caps
donepezil (tablet strength)
(Cholinesterase Inhibitors) Aricept: 5,10,23mg (recommend pat…
donepezil (ODT strength)
(Cholinesterase Inhibitors) Aricept ODT: 5,10mg
20 terms
Alzheimers
Noncognitive symptoms of dementia
Cognition
The four A's of dementia
Loss of memory (working memory)
delusions, suspicions, hallucinations, agitation, depression
- Impairment in memory & cognition... -decreased ability to rela…
-Amnesia... -Agnosia... -Apraxia... -Aphasia
Amnesia
Noncognitive symptoms of dementia
delusions, suspicions, hallucinations, agitation, depression
Cognition
- Impairment in memory & cognition... -decreased ability to rela…
17 terms
Alzheimers
Early onset familiar includes what thr…
Late onset familial may be associated…
Late onset nonhereditary (sporadic) is
Greatest risk factors for developing A…
Amyloid precursor protein gene on chromo 21, preesnilin1 on c…
chromo 19 and the apolipoprotein E gene- allele 4 (apoE4). ap…
most common, no specific genetic association. Cllular and pat…
age and family history. Other factors may be diabetes, midlif…
Early onset familiar includes what thr…
Amyloid precursor protein gene on chromo 21, preesnilin1 on c…
Late onset familial may be associated…
chromo 19 and the apolipoprotein E gene- allele 4 (apoE4). ap…
19 terms
Alzheimers
Risk Factors that contribute to AD
Early Symptoms
dementia
Diagnostic criteria for dementia
-Age... -Family history of AD or dementia (ApoE4)... -exposures to…
problems with... -Short term memory... -Navigation ... -Word finding…
cognitive disfunction that impacts daily functions
Cognitive impairment severe enough to cause social or occupat…
Risk Factors that contribute to AD
-Age... -Family history of AD or dementia (ApoE4)... -exposures to…
Early Symptoms
problems with... -Short term memory... -Navigation ... -Word finding…
Alzheimers
What are the physical changes in the b…
What are the goals of treatment for al…
What is the primary drug for treating…
How long can pts delay alzheimers with…
Cortical shrinkage... Enlarged Ventricles... Hippocampal shrinkage
stop cognitive decline... lengthen period of self sufficiency... re…
acetylcholinesterase inhibitors
6 months to a year
What are the physical changes in the b…
Cortical shrinkage... Enlarged Ventricles... Hippocampal shrinkage
What are the goals of treatment for al…
stop cognitive decline... lengthen period of self sufficiency... re…
33 terms
Alzheimers
Alzheimer's disease
Risk factors
Health promotion and maintenance
History Assessment
-A complex disease that damages the brain long before symptom…
1. *Age*... →Generally affects 65 y/o and older, but can affect…
-There is no proven way to prevent this disease... -Encourage di…
1. Obtain information from pt family or spouse bc the pt may…
Alzheimer's disease
-A complex disease that damages the brain long before symptom…
Risk factors
1. *Age*... →Generally affects 65 y/o and older, but can affect…
47 terms
Alzheimers
AZD brain: ... ____, ____ get smaller, __…
Two hallmarks AZD?
1. Amyloid plaque formation - extracel…
APP stands for_____? It's _____
1. Hipocampus, cortex... 2. Ventricles.
1. Amyloid plaque formation - extracellular ... 2. Neurofibrilla…
...
1. Amyloid... Precursor Protein... 2. membrane anchored proteins
AZD brain: ... ____, ____ get smaller, __…
1. Hipocampus, cortex... 2. Ventricles.
Two hallmarks AZD?
1. Amyloid plaque formation - extracellular ... 2. Neurofibrilla…
14 terms
Alzheimers
Cingulate Gyrus
Name 3 components of limbic system(bor…
What's another term for hippocampus?
How many items can hippocampus hold in…
Mood, empathy, reward, anticipation... Located right below cereb…
Cingulate gyrus, hippocampus, amygdala
Seahorse
7 items +/- 2
Cingulate Gyrus
Mood, empathy, reward, anticipation... Located right below cereb…
Name 3 components of limbic system(bor…
Cingulate gyrus, hippocampus, amygdala
18 terms
Alzheimers
Explain the Pathophysiology of AD
Which of these show non-cognitive symp…
What should you rule out before diagno…
A medication review for a patient rece…
https://youtu.be/dj3GGDuu15I
a.
e. Cobalamin deficiency may cause cognitive deficits and even…
d.
Explain the Pathophysiology of AD
https://youtu.be/dj3GGDuu15I
Which of these show non-cognitive symp…
a.
17 terms
Alzheimers
Early Onset
Sporadic
Affected areas in AD patients
AB42
-caused by autosomal dominant ... -5-10%... -caused by mutations in…
-caused by age ... -90-95%
-cortex shrivels up damaging thinking and remembering ... -hippo…
-peptides aggregate into smaller oligomers know as ADDLs or 2…
Early Onset
-caused by autosomal dominant ... -5-10%... -caused by mutations in…
Sporadic
-caused by age ... -90-95%
23 terms
Alzheimers
donepezil
Aricept
Aricept (donepezil) category
Aricept donepezil form, strengths (3)
Aricept
donepezil
cholinesterase inhibitor
tab, 5, 10, 23 mg
donepezil
Aricept
Aricept
donepezil
29 terms
Alzheimers
Alzheimers vs. dementia... Dementia is th…
Progressive dementias: (6)
Reversible dementia: (4)
Stage 1: __ impairment. No memory prob…
umbrella, dementia
Lewy body dementia... TBI... Vascular brain lesion... Frontotemporal d…
Infections... Metabolic disorders... Nutritional deficiencies... poise…
no
Alzheimers vs. dementia... Dementia is th…
umbrella, dementia
Progressive dementias: (6)
Lewy body dementia... TBI... Vascular brain lesion... Frontotemporal d…
23 terms
ALZHEIMERS
definition
age affected
characterized by
pathophysiology
neurodegenerative disorder of uncertain etiology
over 60
memory problems and dementia
senile or neurofibrillary tangles with amyloid core... neurofibr…
definition
neurodegenerative disorder of uncertain etiology
age affected
over 60
5 terms
Alzheimers
Tacrine (Cognex)
Donepezil (Aricept)
Rivastigmine (Exelon)
Galantamine (Razadyne)
AChE inhibitor ... Inhibits AChE and BuChE ... Mild to moderate Alz…
AChE inhibitor ... Inhibits AChE ... Mild to moderate Alzheimers; s…
AChE inhibitor ... Inhibits AChE and BuChE ... Mild to moderate Alz…
AChE inhibitor ... Inhibits AChE; allosteric modulator of nicoti…
Tacrine (Cognex)
AChE inhibitor ... Inhibits AChE and BuChE ... Mild to moderate Alz…
Donepezil (Aricept)
AChE inhibitor ... Inhibits AChE ... Mild to moderate Alzheimers; s…
22 terms
Alzheimers
4-5 million
5 years after 65
women
Age
Affects how many in the US?
Risk of AD doubles every ___ years after ___
Higher risk of AD in this group of people
Biggest risk factor for AD
4-5 million
Affects how many in the US?
5 years after 65
Risk of AD doubles every ___ years after ___
7 terms
Alzheimers
Cholinesterase Inhibitors
Donepezil (Aricept) ... Mild to moderate…
Rivastigmine (Exelon)... Mild to moderat…
Aripiprazole (Abilify)... Dangerous
Reversal of blockade by neuromuscular blockers
dizzines, insomnia, ↓HR, seizures, g.i. bleed
.tremors, confusion, insomnia, AV block, g.i. bleed
Treats schizophrenia... Typical Antipsychotics... are more likely…
Cholinesterase Inhibitors
Reversal of blockade by neuromuscular blockers
Donepezil (Aricept) ... Mild to moderate…
dizzines, insomnia, ↓HR, seizures, g.i. bleed
49 terms
alzheimers
alzheimer is the most common form of w…
alzheimers is the __th leading cause o…
causes and risk factors
autosomal dominant familial AD can be…
dementia 50-80% of cases
6th
- age... -family history ... -risk genes... -deterministic genes
1) APP amyloid precurso protein... 2)PSEN1 presenilin1... 2) PSEN2…
alzheimer is the most common form of w…
dementia 50-80% of cases
alzheimers is the __th leading cause o…
6th
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