Study sets matching "antibiotics"

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Study sets matching "antibiotics"

96 terms
Antibiotics
What are the patient factors to consid…
What the antibiotic factors to conside…
What is MIC?
What are the pharmaco-dynamic determin…
Site and source of infection... Likely cause of infection at sit…
Spectrum of activity... Method of administration... Penetration to…
Minimum Inhibitory Capacity - the concentration under standar…
Different parameters predict response to therapy for differen…
What are the patient factors to consid…
Site and source of infection... Likely cause of infection at sit…
What the antibiotic factors to conside…
Spectrum of activity... Method of administration... Penetration to…
96 terms
Antibiotics
What are the patient factors to consid…
What the antibiotic factors to conside…
What is MIC?
What are the pharmaco-dynamic determin…
Site and source of infection... Likely cause of infection at sit…
Spectrum of activity... Method of administration... Penetration to…
Minimum Inhibitory Capacity - the concentration under standar…
Different parameters predict response to therapy for differen…
What are the patient factors to consid…
Site and source of infection... Likely cause of infection at sit…
What the antibiotic factors to conside…
Spectrum of activity... Method of administration... Penetration to…
83 terms
Antibiotics
Gram stain
Gram stain coccobacilli
Coagulase test
Hemolysis test
Blood agar
Gram stain
Gram stain coccobacilli
Antibiotics
Aminoglycosides MOA
AMG - Concentration or Time
Aminoglycosides
When are aminoglycosides used?
bind to 30S and 50S part of ribosome (inhibition of protein s…
Concentration
-mycins, streptomycin, gentamicin, neomycin, tobramycin, rela…
Useful as adjunct treatment for serious infections (coverage…
Aminoglycosides MOA
bind to 30S and 50S part of ribosome (inhibition of protein s…
AMG - Concentration or Time
Concentration
19 terms
Antibiotics
Antibiotics exert their effects via 5…
Aminoglycans
Bacitracin... (Carbapenems)
Carbapenems
(1) Inhibition of cell wall synthesis (cephalosporins, penici…
-inhibits protein synthesis... -from Streptomyces and Micromnosp…
-from Bacillus, ... -highly toxic, ... -only used topically.
-broad spectrum w/ two-part structure. ... -Primaxin and cilasta…
Antibiotics exert their effects via 5…
(1) Inhibition of cell wall synthesis (cephalosporins, penici…
Aminoglycans
-inhibits protein synthesis... -from Streptomyces and Micromnosp…
126 terms
Antibiotics
If you have a Cardiothoracic surgery w…
If you have a Cardiothoracic surgery w…
If you have a Colorectal surgery what…
If you have a Colorectal surgery what…
Routine: Cefazolin... if MRSA: Cefazolin +vancomycin
Vancomycin + aztreonam ( routine & MRSA)
Ampicillin/sulbactam
Ciprofloxacin + metronidazole or... ciprofloxacin + clindamycin
If you have a Cardiothoracic surgery w…
Routine: Cefazolin... if MRSA: Cefazolin +vancomycin
If you have a Cardiothoracic surgery w…
Vancomycin + aztreonam ( routine & MRSA)
25 terms
Antibiotics
by mouth or anus
by I.V. I.M. or subcutaneous
systematically absorbs through the skin
locally absorbed through the skin
Enteral
Paraenteral
Transdermal
Topical
by mouth or anus
Enteral
by I.V. I.M. or subcutaneous
Paraenteral
169 terms
Antibiotics
Beta-Lactam Antibiotics
MOA of Beta-Lactam Antibiotics
What are some methods of resistance th…
What are some subclasses Penicillin (P…
Penicillins... Cephalosporins... Carbapenems... Monobactams
Binds to PBP's --> activates bacterial autolytic enzymes that…
Beta-Lactamase (destroys the beta lactam ring → rendering ant…
Natural Penicillins... Antistaphylococcal Penicillins... Aminopenic…
Beta-Lactam Antibiotics
Penicillins... Cephalosporins... Carbapenems... Monobactams
MOA of Beta-Lactam Antibiotics
Binds to PBP's --> activates bacterial autolytic enzymes that…
126 terms
Antibiotics
If you have a Cardiothoracic surgery w…
If you have a Cardiothoracic surgery w…
If you have a Colorectal surgery what…
If you have a Colorectal surgery what…
Routine: Cefazolin... if MRSA: Cefazolin +vancomycin
Vancomycin + aztreonam ( routine & MRSA)
Ampicillin/sulbactam
Ciprofloxacin + metronidazole or... ciprofloxacin + clindamycin
If you have a Cardiothoracic surgery w…
Routine: Cefazolin... if MRSA: Cefazolin +vancomycin
If you have a Cardiothoracic surgery w…
Vancomycin + aztreonam ( routine & MRSA)
Antibiotics
Penicillin G
Penicillin V
Ampicillin
Amoxicillin
Penem: beta-lactam with a 5-member ring with sulfur... ♣ benzene…
Penem: beta-lactam with a 5-member ring with sulfur... ♣ phenoxy…
Penem: beta-lactam with a 5-member ring with sulfur... ♣ Amine g…
Penem: beta-lactam with a 5-member ring with sulfur... ♣ Amine g…
Penicillin G
Penem: beta-lactam with a 5-member ring with sulfur... ♣ benzene…
Penicillin V
Penem: beta-lactam with a 5-member ring with sulfur... ♣ phenoxy…
Antibiotics
What are the patient factors to consid…
What the antibiotic factors to conside…
What is MIC?
What are the pharmaco-dynamic determin…
Site and source of infection... Likely cause of infection at sit…
Spectrum of activity... Method of administration... Penetration to…
Minimum Inhibitory Capacity - the concentration under standar…
Different parameters predict response to therapy for differen…
What are the patient factors to consid…
Site and source of infection... Likely cause of infection at sit…
What the antibiotic factors to conside…
Spectrum of activity... Method of administration... Penetration to…
169 terms
Antibiotics
Beta-Lactam Antibiotics
MOA of Beta-Lactam Antibiotics
What are some methods of resistance th…
What are some subclasses Penicillin (P…
Penicillins... Cephalosporins... Carbapenems... Monobactams
Binds to PBP's --> activates bacterial autolytic enzymes that…
Beta-Lactamase (destroys the beta lactam ring → rendering ant…
Natural Penicillins... Antistaphylococcal Penicillins... Aminopenic…
Beta-Lactam Antibiotics
Penicillins... Cephalosporins... Carbapenems... Monobactams
MOA of Beta-Lactam Antibiotics
Binds to PBP's --> activates bacterial autolytic enzymes that…
24 terms
Antibiotics
Monobactams
Carbapenems
Glycopeptide
Daptomycin
Azetreonam... Bactericidal: inhibit penicillin binding proteins(…
Meropenem... Serious or highly resistant hospital infections... bro…
Vancomycin ... Use orally for C.difficile... Inhibits Cell wall syn…
Lipopeptide... BInds plasma membrane of gram positive organism i…
Monobactams
Azetreonam... Bactericidal: inhibit penicillin binding proteins(…
Carbapenems
Meropenem... Serious or highly resistant hospital infections... bro…
8 terms
Antibiotics
Penicillin and Cephalosporin
Sulfonamides and trimethoprim
synergistic effect
Aminoglycosides (streptomycin, gentami…
Block synthesis of peptidoglycan, causing the cell wall to lyse
Inhibit nucleic acid synthesis
Additive effect, achieved by multiple drugs working together,…
Block protein synthesis
Penicillin and Cephalosporin
Block synthesis of peptidoglycan, causing the cell wall to lyse
Sulfonamides and trimethoprim
Inhibit nucleic acid synthesis
181 terms
Antibiotics
What is the MOA of Penicillin G/V?
What Penicillin is Oral?... What Penicil…
What is the Clinical Usage of Penicill…
What Toxicity can Penicillin G/V produ…
- bind penicillin-binding proteins (transpeptidases)... -*block…
Oral:... - Penicillin V... IV:... - Penicillin G
Bateriocidal against:... - gram-pos organisms... - gram-neg cocci... -…
- Hypersensitivity rxn... -*Hemolytic anemia
What is the MOA of Penicillin G/V?
- bind penicillin-binding proteins (transpeptidases)... -*block…
What Penicillin is Oral?... What Penicil…
Oral:... - Penicillin V... IV:... - Penicillin G
19 terms
Antibiotics
Amoxil, Trimox
Augmentin
Avelox
Bactrim, Septra
Amoxicillin
Amoxicillin-Clavulanate
Moxifloxacin
Sulfamethoxazole-Trimethoprim
Amoxil, Trimox
Amoxicillin
Augmentin
Amoxicillin-Clavulanate
31 terms
Antibiotics
CA-MRSA
CA-MRSA, Less Serous
Complicated Skin Infection... Suspected M…
Polymicrobial skin infections, could b…
Drug: Trimethoprim/Sulfametoxazole (Bactram)... ADR: ... -Hypersen…
I&D unless sever then Trimethoprim/Sulfametoxazole... ADR: ... -Hy…
Vancomycin... MOA:... Cell wall inhibitor, (block elongation)... ADR…
Piperacillin + Tazobactam... MOA: B-Lactam. Cell Wall Inhibitor…
CA-MRSA
Drug: Trimethoprim/Sulfametoxazole (Bactram)... ADR: ... -Hypersen…
CA-MRSA, Less Serous
I&D unless sever then Trimethoprim/Sulfametoxazole... ADR: ... -Hy…
42 terms
Antibiotics
Selective toxicity
Bacteriostatic... use
bactericidal... -use (2)
antibiotic vs antimicrobial
ability to kill or injure invading organisms without harming…
-inhibits bacterial growth... used when immune system can take…
killing of bacteria... use ... -during invasive infection... -immune…
antibiotic= natural... antimicrobial= synthetic
Selective toxicity
ability to kill or injure invading organisms without harming…
Bacteriostatic... use
-inhibits bacterial growth... used when immune system can take…
41 terms
Antibiotics
What's the appropriate antibiotic trea…
What's the appropriate antibiotic trea…
What's the appropriate antibiotic trea…
What's the appropriate antibiotic trea…
- Nafcillin... - Oxacillin... - Dicloxacillin... - Cephalexin... - Amoxic…
Mild:... - trimethoprim + sulfamethoxazole... Moderate:... - trimetho…
Allergic to β-lactams... - azithromycin... - clarithromycin... - clind…
Erysipelas... - penicillin V... - amoxicillin... - cephalexin
What's the appropriate antibiotic trea…
- Nafcillin... - Oxacillin... - Dicloxacillin... - Cephalexin... - Amoxic…
What's the appropriate antibiotic trea…
Mild:... - trimethoprim + sulfamethoxazole... Moderate:... - trimetho…
112 terms
Antibiotics
Penicillin: action
Where does penicillin bind to bacteria
are penicillins bacteriostatic or bact…
Why are penicillins generally safe to…
Weakens cell wall by disrupting synthesis ... Weakens cell wall…
at cell wall at PCN-Binding Proteins which are found during b…
bactericidal
Humans don't have cell walls
Penicillin: action
Weakens cell wall by disrupting synthesis ... Weakens cell wall…
Where does penicillin bind to bacteria
at cell wall at PCN-Binding Proteins which are found during b…
12 terms
Antibiotics
Penicillin
Vancomycin
tetracycline
sulfonamides
acts on cell wall synthesis
acts on cell wall synthesis
inhibit protein synthesis
antimetabolite action
Penicillin
acts on cell wall synthesis
Vancomycin
acts on cell wall synthesis
96 terms
Antibiotics
What are the patient factors to consid…
What the antibiotic factors to conside…
What is MIC?
What are the pharmaco-dynamic determin…
Site and source of infection... Likely cause of infection at sit…
Spectrum of activity... Method of administration... Penetration to…
Minimum Inhibitory Capacity - the concentration under standar…
Different parameters predict response to therapy for differen…
What are the patient factors to consid…
Site and source of infection... Likely cause of infection at sit…
What the antibiotic factors to conside…
Spectrum of activity... Method of administration... Penetration to…
57 terms
Antibiotics
Site of Action (image)
What is the difference between a macro…
What drugs interfere with *peptidoglyc…
What drugs interfere with *peptidoglyc…
Though they have similar names and both inhibit bacterial rib…
Penicillins... Cephalosporins... Carbapenems... Monobactams (aztreonam)
Glycopeptides (vancomycin, bacitracin)
Site of Action (image)
What is the difference between a macro…
Though they have similar names and both inhibit bacterial rib…
Antibiotics
Background
Scientific
Scientific Slide 2
Economic
The discovery of antibiotics in the 20th century was a major…
• One of the major consequences of antibiotic resistance is h…
• Multi-Drug resistant organisms are important in healthcare…
• The cost of antibiotic resistance to the American economy w…
Background
The discovery of antibiotics in the 20th century was a major…
Scientific
• One of the major consequences of antibiotic resistance is h…
5 terms
Antibiotics
penicillin
cephalosporins
monobactams
carbapenems
p- amoxicillin
p- cephalexin (keflex)
p-azteonam (azactam)
p- impenem and cilastatin (Primaxin )
penicillin
p- amoxicillin
cephalosporins
p- cephalexin (keflex)
26 terms
Antibiotics
CAI (community associated infections)
HAI
Prevention of HAI
Assessment
Infection by person NOT hospitalized/had medical procedure w/…
- Infection during treatment/ other condition... - contracted in…
- hand washing ****... - antiseptics (bacteriostatic, used on li…
- allergies - chemicals, disinfectants, antiseptics ... - know s…
CAI (community associated infections)
Infection by person NOT hospitalized/had medical procedure w/…
HAI
- Infection during treatment/ other condition... - contracted in…
Antibiotics
Amoxil
Ancef
Augmentin
Bactrim
amoxicillin
cefazolin
amoxicillin & clavulanate
trimethoprim & sulfamethoxazole
Amoxil
amoxicillin
Ancef
cefazolin
Antibiotics
Penicillins
Penicillinase resistant, anti-staph pe…
Wide- spectrum penicillins
Extended spectrum
MOA: PBP, transpeptidase, autolytic enzymes... Use: gram+ cocci,…
Cloxacillin, oxacillin, naficillin, dicloxacillin, methicilli…
Amoxicillin, ampicillin... Use: haemophilus, E.coli, listeria, p…
Ticarcillin, carbenicillin, pipercillin, azeocillin, mezlocil…
Penicillins
MOA: PBP, transpeptidase, autolytic enzymes... Use: gram+ cocci,…
Penicillinase resistant, anti-staph pe…
Cloxacillin, oxacillin, naficillin, dicloxacillin, methicilli…
74 terms
Antibiotics
Penicillin G
Penicillin V
Penicillin G Benzathine
Penicillin G Procaine
Pfizerpen IV/PO
Pen VK IV/PO
Bicillin L-A IM
Wycillin IM
Penicillin G
Pfizerpen IV/PO
Penicillin V
Pen VK IV/PO
138 terms
Antibiotics
Aminoglycosides: Mechanism
Aminoglycoside: Administration
Aminoglycosides: Pharmacokinetics
Aminoglycoside: Spectrum
Bacteriocidal with concentration dependent killing activity.…
IV is common route like gentamicin IV. Streptomycin is IM (ra…
Extracellular fluid. Poor penetration into bronchial secretio…
Primarily Gm- aerobic bacteria: Acinetobacter, E. coli, Enter…
Aminoglycosides: Mechanism
Bacteriocidal with concentration dependent killing activity.…
Aminoglycoside: Administration
IV is common route like gentamicin IV. Streptomycin is IM (ra…
Antibiotics
Tenormin
Levaquin
Vancocin
Zosyn
atenolol
levofloxacin
vancomycin
piperacillin
Tenormin
atenolol
Levaquin
levofloxacin
62 terms
Antibiotics
prophylactic therapy
empiric therapy
definitive therapy
narrow
treatment with an antibiotic to prevent an infection
treatment when an antibiotic is given to patients who have a…
therapy that is customized to the culture and sensitivity res…
spectrum of antibiotic activity that inhibits gram positive o…
prophylactic therapy
treatment with an antibiotic to prevent an infection
empiric therapy
treatment when an antibiotic is given to patients who have a…
Antibiotics
Penicillins
Natural Penicillins: Penicillin VK and…
Anti-staph Penicillins - Oxacillin, Di…
Aminopenicllins: Amoxacillin and Ampic…
inhibit cell wall synthesis... broad distribution in body... ADR -…
gram positive - staph, strep, enterococcus, and anthrax... gram…
staphylococcal skin and soft tissue infections... some strep cov…
gram positive - staph aureus... gram negative - e. coli, h. flu…
Penicillins
inhibit cell wall synthesis... broad distribution in body... ADR -…
Natural Penicillins: Penicillin VK and…
gram positive - staph, strep, enterococcus, and anthrax... gram…
Antibiotics
Cephalosporin covering MRSA
Amoxicillin
Pneumococcus... Lyme involving brain and…
Avoid in neonates coz impaired biliary…
Ceftarloine
H.infl... E.coli... Listeria... Proteus... Salmonella
Ceftriaxone
Ceftriaxone
Cephalosporin covering MRSA
Ceftarloine
Amoxicillin
H.infl... E.coli... Listeria... Proteus... Salmonella
100 terms
Antibiotics
Chemical substances produced by variou…
ability to injure target cells or targ…
selective toxicity attacks certain che…
narrow spectrum... (Classification of an…
Antibiotics ... (synthetic antimicrobial agents. )
Selective toxicity
1. disruption of the bacterial cell wall ... 2. inhabitation of…
active again a few
Chemical substances produced by variou…
Antibiotics ... (synthetic antimicrobial agents. )
ability to injure target cells or targ…
Selective toxicity
51 terms
Antibiotics
Beta lactams
Fluoroquinolone drugs
1st line protozoan infections, anaerob…
Pseudomembranous colitis cause
penicillins and cephalosporins class
ciprofloxacin levofloxacin class
metronidazole (flagyl) uses
clindamycin danger
Beta lactams
penicillins and cephalosporins class
Fluoroquinolone drugs
ciprofloxacin levofloxacin class
Antibiotics
Aminoglycosides
Carbapenem
Cefepime
Cefotaxime, Ceftriaxone
Gentimicin, Tobramycin... Gram negative, Gram positive (synergy…
Meropenem, Imipenem-Cilastin, Ertapenem... Gram negative, Anaer…
Gram negative, some Gram positive, Pseudomonas
Gram negative, some Gram positive
Aminoglycosides
Gentimicin, Tobramycin... Gram negative, Gram positive (synergy…
Carbapenem
Meropenem, Imipenem-Cilastin, Ertapenem... Gram negative, Anaer…
49 terms
Antibiotics
Lincosamides
Steptogramins
Macrolides
Azalides and Ketolides
Binds to the 50S unit of bacterial ribosomes to suppress prot…
Pristinamycin in Europe only, quinupristin/dalfopristin bind…
Erythromycin, clarithromycin (Biaxin), dirithromycin (Dynabac…
Azithromycin (Zithromax) an azalide derived from erythromycin…
Lincosamides
Binds to the 50S unit of bacterial ribosomes to suppress prot…
Steptogramins
Pristinamycin in Europe only, quinupristin/dalfopristin bind…
11 terms
Antibiotics
General Rules
Aerobic Gm (+) ... SE
Aerobic Gm (-)... N M P H K
Anaerobic Gm (+)... C + Pepto
- All PCNs & Cephs should be taken on an empty stomach... or 1 h…
- Strep Pheumoniae... - Enterococci Faecalis... - Staph Aureus
- Neissera Gonorrhoeae... - Moraxella Catarrhalis... - Pseudomonas…
- Clostridia Difficille... - Pepto....
General Rules
- All PCNs & Cephs should be taken on an empty stomach... or 1 h…
Aerobic Gm (+) ... SE
- Strep Pheumoniae... - Enterococci Faecalis... - Staph Aureus
19 terms
Antibiotics
Beta-Lactams
Penicillin V & G (-)
Methicillin
Amoxicillin / Amplicillin
Cell wall ; Innate
Cell wall ; Narrow (+) and High Therapeutic Index. Bacteriost…
Cell Wall ; Narrow (+) and High Therapeutic Index. Bacteriost…
Cell Wall ; Broad and High Therapeutic Index. Bacteriostatic
Beta-Lactams
Cell wall ; Innate
Penicillin V & G (-)
Cell wall ; Narrow (+) and High Therapeutic Index. Bacteriost…
Antibiotics
Ginko indications
Ginko side effects
Ginko cautions
Ginko interactions
dementia, antioxidant, depression, sexual dysfunction, MS, gl…
transient headache, restlessness, anxiety, NVD, anorexia, fla…
Pregnancy, lactation, children, coagulation, platelet disorde…
Anticoagulants, MAIO, ASA, platelet inh, acetaminophen, +500…
Ginko indications
dementia, antioxidant, depression, sexual dysfunction, MS, gl…
Ginko side effects
transient headache, restlessness, anxiety, NVD, anorexia, fla…
antibiotics..
fidaxomicin (dificid) indication
important teaching pt for fidaxomicin
telithromycin (ketek) what class?
telithromycin (ketek) is useful for___…
a macrolide for Tx of c-diff assoc. diarrhea; ... not systemical…
used only for c-diff & don't skip doses or stop course early…
ketolide name the drug
macrolide resistant, gram + bacteria
fidaxomicin (dificid) indication
a macrolide for Tx of c-diff assoc. diarrhea; ... not systemical…
important teaching pt for fidaxomicin
used only for c-diff & don't skip doses or stop course early…
139 terms
Antibiotics
What occurs from abx use, every time s…
What 'style' of abx cause collateral d…
What type of collateral damage occurs…
What is the single biggest risk factor…
Collateral damage
Oral
Creates a predominance of obligate anaerobes whos activity in…
Abx
What occurs from abx use, every time s…
Collateral damage
What 'style' of abx cause collateral d…
Oral
102 terms
Antibiotics
Bacteriocidal drugs
Bacteriostatic drugs
B-lactams, penicillin, cephalosporin,…
Treating Staph with penicillin
- kill the bacteria... - Aminoglycosides... - beta lactams... - vancom…
- retard the growth of the bacteria but don't actually kill t…
- bind PBP - transpeptidases and block cross linking
- Staph make B-lactamase that inactivates ampicillin, amoxici…
Bacteriocidal drugs
- kill the bacteria... - Aminoglycosides... - beta lactams... - vancom…
Bacteriostatic drugs
- retard the growth of the bacteria but don't actually kill t…
55 terms
Antibiotics
Zovirax
Albenza
Amoxil
Augmentin
Acyclovir
Albendazole
Amoxicillin
Amoxicillin/Clavulanate
Zovirax
Acyclovir
Albenza
Albendazole
antibiotics
bacitracin
glycopeptides (vancomycin)
teixobactin
disruption of cell membrane function
binds to the membrane protein, inhibiting the addition of new…
MOA: binds to peptides (short amino acid chains) on glycan st…
company developed ichip to grow soil bacteria that can't be c…
MOA: acts as detergents; attach to LSP's and phospholipids in…
bacitracin
binds to the membrane protein, inhibiting the addition of new…
glycopeptides (vancomycin)
MOA: binds to peptides (short amino acid chains) on glycan st…
42 terms
Antibiotics
Sulphonamides
Tetracyclines
Aminoglycosides
Aminoglycoside resistance
Acts but inhibiting folic acid synthesis
S-Subunit inibitors causing a missense/nonsense mutation
S-Subunit inibitors
add extra polar group to the molecule so to make it unable to…
Sulphonamides
Acts but inhibiting folic acid synthesis
Tetracyclines
S-Subunit inibitors causing a missense/nonsense mutation
Antibiotics
Bactericidal
Bacteriostatic
Bactericidal
Bacteriostatic
Kills population of bacteria
Prevents reproduction of bacteria
Penicillins, cephalosporins, fluoroquinolones, aminoglycoside…
Sulphonamides, trimethoprim, tetracyclines, chloramphenicol,…
Bactericidal
Kills population of bacteria
Bacteriostatic
Prevents reproduction of bacteria
21 terms
Antibiotics
Antibiotic
Chemotherapeutic agent
Broad spectrum
Narrow spectrum
large group of chemical substance, as penicillin or streptomy…
The use of a chemical agent to treat an infection
antibiotic that is therapeutically effective against a wide r…
an antibiotic that is specifically effective against a limite…
Antibiotic
large group of chemical substance, as penicillin or streptomy…
Chemotherapeutic agent
The use of a chemical agent to treat an infection
19 terms
Antibiotics
Amoxicillin
Amoxicillin-Clavulanate
Moxifloxacin
Sulfamethoxazole-Trimethoprim
Amoxil, Trimox
Augmentin
Avelox
Bactrim, Septra
Amoxicillin
Amoxil, Trimox
Amoxicillin-Clavulanate
Augmentin
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