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Study sets matching "anticoags"

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Study sets matching "anticoags"

61 terms
Anticoags
endothelial damage activates
stimulates platelet aggregation
platelet aggregation initiates
extrinsic factor activated by
the intrinsic pathway... (fibrin growth and maintenance)... (PTT)
ADP
extrinsic pathway... (fibrin formation)... (PT)
tissue factor
endothelial damage activates
the intrinsic pathway... (fibrin growth and maintenance)... (PTT)
stimulates platelet aggregation
ADP
9 terms
Anticoags
Warfarin
Heparin
Enoxaparin
Tinzaparin
Jantoven, Coumadin
UFH
Lovenox
Innohep
Warfarin
Jantoven, Coumadin
Heparin
UFH
11 terms
Anticoags
Unfractionated heparin... MOA... Indication…
Enoxaparin... MOA... Indication... Toxicology
Foundaparinux... MOA... Indications... Toxicolo…
Warfarin... MOA... Indications... Toxicology... CI
Indirect thrombin inhibitors, Inhibits Xa and thrombin... -MI, a…
Indirect thrombin inhibitors, Inhibits Xa... -MI, angina... -Anemia…
Indirect thrombin inhibitors, Inhibits Xa ... -DVT... BBW... -Anemia,…
Coumarin anticoagulant... II, VII, IX, X, C, S... -Afib, cardiomyop…
Unfractionated heparin... MOA... Indication…
Indirect thrombin inhibitors, Inhibits Xa and thrombin... -MI, a…
Enoxaparin... MOA... Indication... Toxicology
Indirect thrombin inhibitors, Inhibits Xa... -MI, angina... -Anemia…
12 terms
Anticoags
Heparin
lovenox- enoxparin-LMW
Warfarin(coumadin)
aspirin
enhances action of anti-thrombin III, which inactivates throm…
binds to anti- thrombin III produces a change in AT which all…
viatmin k antagonist(II, VII, IX,X)reduce by 50%... prevent, no…
antiplatelet agent... blocks synthesis of thromboxane A2 and pre…
Heparin
enhances action of anti-thrombin III, which inactivates throm…
lovenox- enoxparin-LMW
binds to anti- thrombin III produces a change in AT which all…
anticoags
heparin indications
heparin actions
heparin adverse effects
heparin contraindications
- prevents and treats venous thrombosis (VT) and pulmonary em…
inhibits clot and thrombus production by blocking conversion…
hair loss, bruising, chills, fever, osteoporosis, suppression…
allergies, hemorrhage disorders, recent trauma, spinal punctu…
heparin indications
- prevents and treats venous thrombosis (VT) and pulmonary em…
heparin actions
inhibits clot and thrombus production by blocking conversion…
21 terms
anticoags
ufh vte proph dose
ufh vte tx dose
ufh ACS dose
lovenox
5000 units sc q 8-12hrs
80 units/kg bolus fb 18 units/kg/hr or 5000 units fb 1000 uni…
60 units/kg bolus fb 12 units/kg/hr (actual body weight)
enoxaparin
ufh vte proph dose
5000 units sc q 8-12hrs
ufh vte tx dose
80 units/kg bolus fb 18 units/kg/hr or 5000 units fb 1000 uni…
30 terms
Anticoags
Heparin
Enoxaparin
Dalteparin
Tinzaparin
Old standard - 5,000U IV bolus, 1,000-1,200U/hr... SQ - 5000U SQ…
- Low-Molecular-Weight heparin... - prophylaxis: 30mg SQ q12h, 4…
- Low-Molecular-Weight Heparin... - prophylaxis - 2500-5000 IU S…
- Low-Molecular-Weight heparin... - prophylaxis - none... - treatme…
Heparin
Old standard - 5,000U IV bolus, 1,000-1,200U/hr... SQ - 5000U SQ…
Enoxaparin
- Low-Molecular-Weight heparin... - prophylaxis: 30mg SQ q12h, 4…
38 terms
Anticoags
A very potent vasoconstrictor that hel…
Sequence of events in hemostasis
Steps during the "1ry hemostasis step"
In arterial thrombosis, the initial an…
endothelin
1. VasoC w/ endothelin... 2. Platelet adhesion, activation, aggr…
1. platelet adhesion... 2. shape change (flatten)... 3. degranulati…
platelet activation and form of platelet plug
A very potent vasoconstrictor that hel…
endothelin
Sequence of events in hemostasis
1. VasoC w/ endothelin... 2. Platelet adhesion, activation, aggr…
10 terms
Anticoags
Tx for HIT
LMWH Brand/Generics
Which drug neutralizes LMWH
Indirect Xa Inhibitor: Brand/Generic
Argatroban
Enoxaparin / Lovenox... Dalteparin / Fragmin
Protamine
Fondaparinux / Arixtra
Tx for HIT
Argatroban
LMWH Brand/Generics
Enoxaparin / Lovenox... Dalteparin / Fragmin
131 terms
Anticoags
What are the stages of hemostasis?
What is needed for hemostasis to be ph…
What is an embolism?
What are the fatalisties and major mor…
vasoconstriction... temporary blockage of a break by a platelet…
must maintain adequate perfusion of vital organs AND avoid ve…
the sudden obstruction of a blood vessel due to a blood clot…
cerebral embolism ... pulmonary embolism
What are the stages of hemostasis?
vasoconstriction... temporary blockage of a break by a platelet…
What is needed for hemostasis to be ph…
must maintain adequate perfusion of vital organs AND avoid ve…
27 terms
Anticoags
Aminocaproic Acid
Tranexamic Acid
Streptokinase
Alteplase
Inhibitor of Fibrinolysis
Inhibitors of Fibrinolysis
Thrombolytic
Thrombolytic
Aminocaproic Acid
Inhibitor of Fibrinolysis
Tranexamic Acid
Inhibitors of Fibrinolysis
21 terms
Anticoags
Anticoags are used for
Heparin is used for
Heparin prevents
Heparin lab
Preventing the formation of new clots. Help to prevent DVT, s…
Preventing DVT
Thrombosis formation
aPTT
Anticoags are used for
Preventing the formation of new clots. Help to prevent DVT, s…
Heparin is used for
Preventing DVT
33 terms
Anticoags
Cyclopentyltriazolopyrimidines
Thienopyridine
Aspirin
Tissue Plasminogen Activator
Ticagrelor (Brilinta)
Clopidogrel (Plavix), Prasugrel (Effient), Ticlopidine (Ticlid)
ASA
Alteplase, Reteplase, Tenecteplase
Cyclopentyltriazolopyrimidines
Ticagrelor (Brilinta)
Thienopyridine
Clopidogrel (Plavix), Prasugrel (Effient), Ticlopidine (Ticlid)
8 terms
Anticoags
Anticoagulants (What they do)
Anticoagulants (What they treat)
Dabigatran (g)
Enoxaparin (g)
Decrease clotting ability of blood
Prevent/treat harmful clots from forming...Treat blood vessel…
Pradaxa
Lovenox
Anticoagulants (What they do)
Decrease clotting ability of blood
Anticoagulants (What they treat)
Prevent/treat harmful clots from forming...Treat blood vessel…
30 terms
Anticoags
What do you use an antiplatelet for?
Antiplatelet cautions?
Antiplatelet adverse effects?
Antiplatelet d-d interactions?
Reduce risk of recurrent TIAs or strokes; MI prophylaxis
Bleeding disorder, recent surgery, closed-head injury
GI distress
Another drug that affects blood clotting (increases risk of e…
What do you use an antiplatelet for?
Reduce risk of recurrent TIAs or strokes; MI prophylaxis
Antiplatelet cautions?
Bleeding disorder, recent surgery, closed-head injury
30 terms
Anticoags
hypercoagulability
acquired hypercoagulability
d-dimer
unfractionated heparin
predisposition for forming spontaneous blood clots, not readi…
IMHA, parvovirus enteritis, hyperadrenocorticism, PLE/PLN, IV…
_______ testing is a sensitive, but not specific, test that d…
binds antithrombin to make it about 1000x more effective at b…
hypercoagulability
predisposition for forming spontaneous blood clots, not readi…
acquired hypercoagulability
IMHA, parvovirus enteritis, hyperadrenocorticism, PLE/PLN, IV…
36 terms
Anticoags
Thrombocytes (platelets)
Blood plasma
Hemostasis
platelet plug formation
involved in blood clotting, lack is called thrombocytopenia
liquid part of the blood before clotting, Serum after clotting
The physiological processes that prevent blood loss. Included…
The inner surface of blood vessels is lined by endothelial ce…
Thrombocytes (platelets)
involved in blood clotting, lack is called thrombocytopenia
Blood plasma
liquid part of the blood before clotting, Serum after clotting
55 terms
Anticoags
anticoags are good for dealing with __…
what's a normal aPTT?
what is the normal range for PT?
a prolonged aPTT and normal PT suggest…
thrombin; fibrin
26-33 seconds
12-14 seconds
intrinsic
anticoags are good for dealing with __…
thrombin; fibrin
what's a normal aPTT?
26-33 seconds
72 terms
Anticoags
What are direct thrombin inhibitors?
CU of DTI?
What is CU of lepirudin and bivalirudin?
What is CU of Argatroban?
Hirudin, lepirudin and bivalirudin ... Argatroban... Dabigatran
Alternative to heparin
prevent thrombosis in patients with unstable angina and acute…
Prophoplaxis and trt of thrombosis in patients with HIT
What are direct thrombin inhibitors?
Hirudin, lepirudin and bivalirudin ... Argatroban... Dabigatran
CU of DTI?
Alternative to heparin
13 terms
anticoags
DOC DVT nad PE prophylaxis in pregnancy
DOC for stroke prevention in nonvalvul…
DOC for clotting issues with poor rena…
DOC for clotting issues with poor live…
enoxaparin or fondaparinux (replaces Warfarin tx)
dabigatran
argatroban
lepirudin
DOC DVT nad PE prophylaxis in pregnancy
enoxaparin or fondaparinux (replaces Warfarin tx)
DOC for stroke prevention in nonvalvul…
dabigatran
152 terms
Anticoag
Hemostasis
Thrombosis
Thrombus
Purpose of hemostasis/thrombosis
Process or cessation of blood loss from damaged vessel
Formation and propagation of a blood clot within the vasculat…
Product of thrombosis... A fibrin clot that adheres to a vessel…
Minimizes blood loss... Dynamic process to maintain fluidity of…
Hemostasis
Process or cessation of blood loss from damaged vessel
Thrombosis
Formation and propagation of a blood clot within the vasculat…
14 terms
anticoag
n/a
Lovenox
Fragmin
Innohep
Heparin
Enoxaparin
Daltaparin
Tinzaparin
n/a
Heparin
Lovenox
Enoxaparin
10 terms
Anticoag
Heparin
Enoxaparin; dalteparin
Argatroban
Bivalirudin
antithrombin cofactor --> decreased thrombin/Fx10... Immediate.…
LMWH - more on factor Xa... better bioavailability
Hirudin - leeches - inhibit thrombin directly
Hirudin - leeches - inhibiting thrombin directly
Heparin
antithrombin cofactor --> decreased thrombin/Fx10... Immediate.…
Enoxaparin; dalteparin
LMWH - more on factor Xa... better bioavailability
16 terms
Anticoag
VTE treatment
VTE prophylaxis
Afib
biprosthetic heart w/ previous embolism
2-3 INR for 3-6mo
2-3 INR for life
2-3INR for life
2-3INR for 3 mo, then reassess
VTE treatment
2-3 INR for 3-6mo
VTE prophylaxis
2-3 INR for life
10 terms
Anticoag
Lovenox
Fragmin
Arixtra
Xarelto
Enoxaparin
Dalteparin
Fondaparinux
Rivaroxaban
Lovenox
Enoxaparin
Fragmin
Dalteparin
46 terms
Anticoag
What defines HIT
Preferred anticoag in HIT
Unfractionated heparin MOA
UH prophylaxis of VTE dose
Plt drop by >50%... Stop heparin and warfarin... Give vit K
Argatroban IV
Binds antithrombin and inactivates thrombin factor IIa and fa…
5000 units sq q 8-12h
What defines HIT
Plt drop by >50%... Stop heparin and warfarin... Give vit K
Preferred anticoag in HIT
Argatroban IV
24 terms
Anticoag
fondaparinux
enoxaparin
unfractionated heparin
Eliquis
heparin
heparin (LMWH)
heparin
Newer direct FXa inhibitor
fondaparinux
heparin
enoxaparin
heparin (LMWH)
34 terms
Anticoag
Unfractionated heparin MOA
Unfractionated heparin side effects
Unfractionated heparin contraindications
Unfractionated heparin uses
Suppresses coagulation by helping antithrombin inactivate fac…
hemorrhage, HIT, hypersensitivity, spinal/epidural hematoma
bleeding, thrombocytopenia, eye/brain/spinal cord surgery, lu…
PREGNANCY, MASSIVE DVT, PE, evolving stroke, during open hear…
Unfractionated heparin MOA
Suppresses coagulation by helping antithrombin inactivate fac…
Unfractionated heparin side effects
hemorrhage, HIT, hypersensitivity, spinal/epidural hematoma
51 terms
anticoag
Para enteral anticoagulation
HIT and HITT
unfractionated heparin moa
UFH vte ppx dosing
unfractionated heparin and enoxaparin (Lovenox)
unexplained platelet drop by 50% from baseline from IgG immun…
binds to antithrombin, inactivates thrombin (factor 2a) and 1…
5000 SC q8-12
Para enteral anticoagulation
unfractionated heparin and enoxaparin (Lovenox)
HIT and HITT
unexplained platelet drop by 50% from baseline from IgG immun…
62 terms
Anticoag
UF heparin, LMWH & Fondapiranux MOA
LMWHs MOA?
Direct Thrombin Inhibitors
IV DTIs... a. Name them... b. Notes
Bind to antithrombin (AT).... AT inactivates thrombin and other…
Inhibit Xa more specifically than UF
Argatroban... Dabigatran (Pradaxa)
a. Argatroban... b. clinically important because they DO NOT cro…
UF heparin, LMWH & Fondapiranux MOA
Bind to antithrombin (AT).... AT inactivates thrombin and other…
LMWHs MOA?
Inhibit Xa more specifically than UF
64 terms
Anticoag
UFH ACS/STEMI Dose and Body weight
aPTT monitoring and tx rang
HIT + cardiac surgery/PCI required - A…
Rivaroxaban dose for VTE px for knee/h…
60 unit/kg IV bolus (Max 4000 units) + 12 units/kg/hr (max 10…
6 hours after initiation of UFH and q6 hours til range of 1.5…
bivalirudin
10mg daily... do not use if crcl <30
UFH ACS/STEMI Dose and Body weight
60 unit/kg IV bolus (Max 4000 units) + 12 units/kg/hr (max 10…
aPTT monitoring and tx rang
6 hours after initiation of UFH and q6 hours til range of 1.5…
28 terms
anticoag
dalteparin
enoxaparin
tinzaparin
hirudin
LMWH
LMWH
LMWH
direct thrombin inhibitors
dalteparin
LMWH
enoxaparin
LMWH
10 terms
Anticoag
protamine neutralization reverses what…
is rate of administration or route of…
after protamine administration, ACT va…
what does ATIII inhibit?
only reverses IIa and leaves factor Xa inhibition intact
rate is more important in preventing adverse hemodynamic effe…
10%
thrombin, as well as IX, X, XI, XII
protamine neutralization reverses what…
only reverses IIa and leaves factor Xa inhibition intact
is rate of administration or route of…
rate is more important in preventing adverse hemodynamic effe…
14 terms
Anticoag
Binding to AT
Factor Xa Inhibitor
Selective Indirect factor Xa Inhibitor…
Direct Thrombin Inhibitor ... (factor IIa)
UF... LMWH... Ifondaparinux
LMWH... Enoxaparin... Dalteparin
Fondaparinux
Dabigatran
Binding to AT
UF... LMWH... Ifondaparinux
Factor Xa Inhibitor
LMWH... Enoxaparin... Dalteparin
19 terms
Anticoag
Heparin 5000u sq q8h pre epidural
Heparin 5000u sq q8h post epidural
Heparin 5000u sq q8h during
Enoxaparin 30-40mg sq qd pre epidural
Prophylaxis ... 8-12 hr
Prophylaxis ... 2 hr
Prophylaxis Not enough study
Prophylaxis... Crcl>30 - 12hr... Crcl<30 - 24hr
Heparin 5000u sq q8h pre epidural
Prophylaxis ... 8-12 hr
Heparin 5000u sq q8h post epidural
Prophylaxis ... 2 hr
41 terms
Anticoag
Aspirin. USE.
Aspirin. MOA
CLOPIDOGREL & TICLOPIDINE. MOA.
CLOPIDOGREL contraindication
transient cerebral ischemia, MI, decrease mortality in post M…
Aspirin inhibits TXA2 synthesis by irreversible acetylation o…
Irreversible inhibitors of P2Y12, one of the two... subtypes of…
omeprazole, poor metabolizers of CYP2C19
Aspirin. USE.
transient cerebral ischemia, MI, decrease mortality in post M…
Aspirin. MOA
Aspirin inhibits TXA2 synthesis by irreversible acetylation o…
29 terms
anticoag
prophylaxis dose of rivaraoxaban
ppy dose of apixaban
dalteparin ppy dose
enox treatment of STEMI
10mg po daily ... don't use if clcr<30
2.5mg po bid
2500-5000 unit sq daily
<75 yo ... 30mg IV bolus PLUS 1mg/kg sq dose followed by 1mg/kg…
prophylaxis dose of rivaraoxaban
10mg po daily ... don't use if clcr<30
ppy dose of apixaban
2.5mg po bid
18 terms
Anticoag
Angiomax generic
Eliquis generic
Fragmin generic
Xarelto generic
Bivalirudin
Apixaban
Dalteparin
Rivaroxaban
Angiomax generic
Bivalirudin
Eliquis generic
Apixaban
Anticoag
The pharmacist is counseling AT, a pat…
A hospitalized patient developed a pul…
A patient has developed heparin-induce…
A pharmacist working in an inpatient m…
B... C... D... E... Incorrect... Other signs of bleeding could include pain…
B... Incorrect... Continuation of the parenteral anticoagulant sho…
B... Correct... Argatroban is FDA approved for use in HIT and is r…
B... C... D... E
The pharmacist is counseling AT, a pat…
B... C... D... E... Incorrect... Other signs of bleeding could include pain…
A hospitalized patient developed a pul…
B... Incorrect... Continuation of the parenteral anticoagulant sho…
52 terms
Anticoag
Heparin VTE treatment dosing
Heparin ACS treatment dosing
Dosing of protamine
aPTT monitoring
80 units/kg IV bolus followed by 18 units/kg/hr infusion
60 units/kg IV bolus followed by 12 units/kg/hr infusion
1 mg protamine will reverse 100 units of heparin ... Max 50 mg
6 hrs after initiation and every 6 hrs until the therapeutic…
Heparin VTE treatment dosing
80 units/kg IV bolus followed by 18 units/kg/hr infusion
Heparin ACS treatment dosing
60 units/kg IV bolus followed by 12 units/kg/hr infusion
28 terms
Anticoag
DVT's
Pulmonary Embolism
Complications of VTE, what they cause
venous thrombosis:
proximal or distal in leg, ... low mortality ... clot=thrombus is r…
may be fatal within minutes of symptoms ... -25% pts = sudden d…
chronic thromboembolic pulmonary HTN (CTPH)... Bleeding risk d/t…
occurs in NORMAL TISSUES and d/t: ... low blood flow & hypercoag…
DVT's
proximal or distal in leg, ... low mortality ... clot=thrombus is r…
Pulmonary Embolism
may be fatal within minutes of symptoms ... -25% pts = sudden d…
32 terms
Anticoag
Virchows Triad
Risk Factors for VTE
Golden hour
PE signs & sx
1. Decreased BF... 2. Changes in intrinsic properties of blood... 3…
-Age... -Hx of VTE... -Venous Stasis (major surg, obesity)... -Vascula…
Most pts with PE die within 1 hr
-dyspnea... -pleuritic chest pain... -hemoptysis
Virchows Triad
1. Decreased BF... 2. Changes in intrinsic properties of blood... 3…
Risk Factors for VTE
-Age... -Hx of VTE... -Venous Stasis (major surg, obesity)... -Vascula…
35 terms
Anticoag
Heparin, Lovenox, fondaparinux MOA?
UFH prevents the conversion of ?
Direct thrombin inhibitor
Advantage of IV direct thrombin inhibi…
Undirect thrombin inhibitor ... Bind to AT, and inactivates thro…
fibrinogen to fibrin
Pradaxa, Argatroban
do not cross-react with heparin-induced thrombocytopenia anti…
Heparin, Lovenox, fondaparinux MOA?
Undirect thrombin inhibitor ... Bind to AT, and inactivates thro…
UFH prevents the conversion of ?
fibrinogen to fibrin
21 terms
anticoag
VTE ppx
VTE tx duration
HITT
UFH
UFH 5000u SC Q8-12... enoxaparin 30mg SC BID or 40mg daily; 30mg…
provoked DVT: treat for 3 months... unprovoked: longer than 3 mo…
IgG reaction; antibodies against heparin and PF4... occurs 5-14…
binds to antithrombin and inactivates thrombin (Factor IIa) a…
VTE ppx
UFH 5000u SC Q8-12... enoxaparin 30mg SC BID or 40mg daily; 30mg…
VTE tx duration
provoked DVT: treat for 3 months... unprovoked: longer than 3 mo…
25 terms
Anticoag
Fragmin
Lovenox
Argatroban
Angiomax
Dalteparin... LMWH
Enoxaparin... LMWH
Direct Thrombin Inhibitor
Bivalirudin... Direct Thrombin Inhibitor
Fragmin
Dalteparin... LMWH
Lovenox
Enoxaparin... LMWH
10 terms
Anticoag
Prasugrel Brand name?
Prasugrel drug category
Prasugrel dose contraindications
Prasugrel dosing
Effient
1) Antiplatelet;... 2) Thienopyridine;... 3) P2Y12
1) Greater than or equal to 75;... 2) Less than 60 kilograms (kg…
1) 60 mg loading dose then;... 3) 10 mg daily plus aspirin 81mg…
Prasugrel Brand name?
Effient
Prasugrel drug category
1) Antiplatelet;... 2) Thienopyridine;... 3) P2Y12
25 terms
Anticoag
heparin half life
Mean dose to achieve 0.1-0.3 u/ml aPTT…
average heparin Vd
Weight to use in heparin dosing if pt…
60 min
10,000 u SQ BID
60 ml/kg
take 1/3 of difference between TBW and IBW and add to IBW (ho…
heparin half life
60 min
Mean dose to achieve 0.1-0.3 u/ml aPTT…
10,000 u SQ BID
41 terms
Anticoag
What is the process of converting inso…
What is the use of drugs to prevent co…
What is intravascular coagulation of t…
What type of clot is it when you bleed…
coagulation
anti-coagulation
thrombosis
white clot (platelet plug/primary hemostasis)
What is the process of converting inso…
coagulation
What is the use of drugs to prevent co…
anti-coagulation
14 terms
Anticoag.
Dabigatran (DTi oral)
Warfarin (vit k antagonist)
Lepirudin (DTi)
Desirudin (DTi)
Pradaxa
Coumadin/Jantoven
Refludan
Iprivask
Dabigatran (DTi oral)
Pradaxa
Warfarin (vit k antagonist)
Coumadin/Jantoven
32 terms
Anticoag
The pharmacist is counseling AT, a pat…
A hospitalized patient developed a pul…
A patient has developed heparin-induce…
A pharmacist working in an inpatient m…
B... C... D... E... Incorrect... Other signs of bleeding could include pain…
B... Incorrect... Continuation of the parenteral anticoagulant sho…
B... Correct... Argatroban is FDA approved for use in HIT and is r…
B... C... D... E
The pharmacist is counseling AT, a pat…
B... C... D... E... Incorrect... Other signs of bleeding could include pain…
A hospitalized patient developed a pul…
B... Incorrect... Continuation of the parenteral anticoagulant sho…
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