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Study sets matching "antigen processing and presentation"

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Study sets matching "antigen processing and presentation"

9 terms
Antigen processing/ antigen presentation
Antigen presentation
Antigen processing
For an immune response to occur ______…
B cells recognize and binds to antigens
Insertion of antigen fragment-MHC complex into plasma membrane
Digestion of antigen into fragments; connection of fragments…
B cells, T cells
in lymph, interstitial fluid, or blood plasma
Antigen presentation
Insertion of antigen fragment-MHC complex into plasma membrane
Antigen processing
Digestion of antigen into fragments; connection of fragments…
9 terms
Antigen Processing and Antigen Presentation
Describe the role, cell expression, pr…
Specify three isotypes of (a) human an…
Describe (a) the general structure of…
All nucleated cells express HLA-class…
MHC class I molecules are cell surface glycoproteins that pla…
In humans, the class I MHC molecules are HLA-A, HLA-B, and HL…
...
??
Describe the role, cell expression, pr…
MHC class I molecules are cell surface glycoproteins that pla…
Specify three isotypes of (a) human an…
In humans, the class I MHC molecules are HLA-A, HLA-B, and HL…
10 terms
Antigen Processing and Presentation
LMP2 and LMP7
PA28 Proteosome Activator
Immunoprotesome
TAP
subunits that replace....
binds to both ends of "barrel" shape generates immunoproteosome
ensures that protein is digested into peptides and that the p…
heterodimer (TAP 1 and TAP2 components) transporter associate…
LMP2 and LMP7
subunits that replace....
PA28 Proteosome Activator
binds to both ends of "barrel" shape generates immunoproteosome
27 terms
Antigen Processing and Presentation
what makes a professional antigen pres…
where are plasmacytoid DCs found?
where are classical or conventional DC…
what are the type 1 interferons?
they release co-stimulatory molecules
in the blood. They release IFNa and IFNb when activated by vi…
in lymphoid (non-migratory) and non-lymphoid tissues (migrato…
IFNa and IFNb. These activate cytotoxic T cells
what makes a professional antigen pres…
they release co-stimulatory molecules
where are plasmacytoid DCs found?
in the blood. They release IFNa and IFNb when activated by vi…
16 terms
MCH and Antigen Processing/Presentation
Major Histocompatibility Complex (MHC)
MHC genes
MHC Class I
MHC Class II
MHC proteins are the members of Ig supergene family... Presenta…
The MHC locus is called HLA (Human Leukocyte Antigens) on the…
Class I are encoded by regions A, B, and C in HLA complex... Pre…
Class II are encoded by the regions of DP, DQ, and DR in HLA…
Major Histocompatibility Complex (MHC)
MHC proteins are the members of Ig supergene family... Presenta…
MHC genes
The MHC locus is called HLA (Human Leukocyte Antigens) on the…
39 terms
15) Antigen Processing and Presentation
What is the purpose of MHC?
What is MHC restriction?
Why is MHC Class I on most cells?
Do resting T-cells express MHC Class I…
To present peptides to TCR
Specific TCR binds to a specific peptide that is presented by…
Because any cell is susceptible to viruses, therefore they ne…
No, Activated T-cells express MHC Class II molecules.
What is the purpose of MHC?
To present peptides to TCR
What is MHC restriction?
Specific TCR binds to a specific peptide that is presented by…
47 terms
HLA & Antigen presentation/processing
Human MHC known as?
What do differences in HLA molecules m…
Describe HLA genes.
The set of alleles on each chromosome…
Human Leukocyte Antigens (HLA)
Differences in HLA molecules expressed by an individual will…
Tightly linked cluster of genes that are highly polymorphic.…
Encode protein antigens central for immune system to discrimi…
Human MHC known as?
Human Leukocyte Antigens (HLA)
What do differences in HLA molecules m…
Differences in HLA molecules expressed by an individual will…
51 terms
Antigen Recognition , Processing and Presentation
Why does the immune system have to rec…
What does the immune system do to reco…
What proteins are involved in the "fil…
How many Classes of MHC are there?
It needs to be able to detect changes in the environment and…
It takes them down to its components, and runs things through…
Major Histocompatibility Complex (MHC)
I, II, and III
Why does the immune system have to rec…
It needs to be able to detect changes in the environment and…
What does the immune system do to reco…
It takes them down to its components, and runs things through…
12 terms
Antigen processing and presentation
General information about antigen pres…
Endogenous antigen pathway processing
Endogenous Peptide trafficking
TAP-1 & TAP-2
Protein antigens must be broken down into small peptides (pr…
o Processing of endogenous antigens occurs in the cytoplasm o…
o Processed peptides are located in the cytoplasm... o MHC class…
transporter associated with antigen processing
General information about antigen pres…
Protein antigens must be broken down into small peptides (pr…
Endogenous antigen pathway processing
o Processing of endogenous antigens occurs in the cytoplasm o…
56 terms
Antigen Processing and Presentation
MHC Restriction:... Self MHC restriction…
Antigen processing refers to ability o…
Antigen presentation is the process of…
MHC class 1
self
protein... MHC molecules
t cell
proteosome-depedent processing and association with class i i…
MHC Restriction:... Self MHC restriction…
self
Antigen processing refers to ability o…
protein... MHC molecules
26 terms
antigen processing and presentation
3 types of APCs
what do dendritic cells present ?
macrophages and B cells present to wha…
Class 2 pathway
dendritic cells... macrophages... b cells
Naive cells
effector cells
exogenous bacteria internalized and processed by APCS and pre…
3 types of APCs
dendritic cells... macrophages... b cells
what do dendritic cells present ?
Naive cells
51 terms
Antigen Processing and Presentation
Antigen Processing
Antigen Presentation
Antigen-Presenting Cells (APCs)
What type of lymphocyte recognizes pre…
The process by which antigen-presenting cells digest antigens…
The process by which APCs display antigenic fragments on cell…
Digest (process) and display (present) antigens
T-lymphocytes
Antigen Processing
The process by which antigen-presenting cells digest antigens…
Antigen Presentation
The process by which APCs display antigenic fragments on cell…
36 terms
antigen processing and presentation
function of antigen presentation cells
function of dendritic cells
function of macrophage
function of B lymphocytes
digestion and presentation
present antigen to NAIVE CD4+ and CD8+ T lymphocytes which in…
present antigens to differentiated CD4+ T lymphocytes in the…
present antigens to CD4+ during humoral immune response
function of antigen presentation cells
digestion and presentation
function of dendritic cells
present antigen to NAIVE CD4+ and CD8+ T lymphocytes which in…
26 terms
antigen processing and presentation
what do B cells bind to?
how do T cells recognize antigens?
CD8+ cytotoxic cells can bind to
Cd4+ helper cells can bind to
-antibody on B cells or free Ab can recognize intact antigen…
T cells recognize protein antigens as discrete peptides... --> r…
antigen complexed to MHC class I and respond by killing the i…
antigen complexed to mHC class II and respond by proliferatio…
what do B cells bind to?
-antibody on B cells or free Ab can recognize intact antigen…
how do T cells recognize antigens?
T cells recognize protein antigens as discrete peptides... --> r…
14 terms
Antigen processing and presentation
Self-restriction of T cells... - CD4+ an…
Evidence for self-MHC restriction of T…
Role of the antigen-presenting cells... -…
Experimental evidence for the necessit…
CD4+ and CD+ T cells can recognize antigen ONLY WHEN IT'S PRE…
- Show by Doherty and Zinkernagel... - MHC restricted T cytoxic…
- Previous, B and T cells were thought to recognize antigen i…
Ziegler and Unanuae revealed that whole antigen's can't be re…
Self-restriction of T cells... - CD4+ an…
CD4+ and CD+ T cells can recognize antigen ONLY WHEN IT'S PRE…
Evidence for self-MHC restriction of T…
- Show by Doherty and Zinkernagel... - MHC restricted T cytoxic…
26 terms
Antigen Processing and Presentation
CD8 T cells
CD4 T cells
TH1
TH2
CytoToxic and their main function is to kill cells that have…
General function is to help other cells on the immune system…
Activate tissue macrophages to phagocytes Kill EXTRAcellular…
Involved in stimulating B cells to make antibodies, which bin…
CD8 T cells
CytoToxic and their main function is to kill cells that have…
CD4 T cells
General function is to help other cells on the immune system…
55 terms
Antigen Processing and Presentation- IMMUNO
MHC class II
invariant chain
specialized MHC class II-like
cytosol
Peptides presented by ________ molecules are generated in aci…
The __________ directs newly synthesized MHC class II molecul…
A ____________ molecule catalyzes loading of MHC class II mol…
Peptides presented by MHC class I molecules are generated in…
MHC class II
Peptides presented by ________ molecules are generated in aci…
invariant chain
The __________ directs newly synthesized MHC class II molecul…
22 terms
Antigen Recognition Processing and Presentation
antigen presenting cells
antigen processing
antigen recognition
B cells
-macrophages: bind to antibodies that are stuck to an antigen…
-activated CD4+ and CD8+ cells bind to an antigen ... - present…
antigen must be a certain shape or structure to be able to be…
respond to antigens in their natural state... -B cell clones are…
antigen presenting cells
-macrophages: bind to antibodies that are stuck to an antigen…
antigen processing
-activated CD4+ and CD8+ cells bind to an antigen ... - present…
19 terms
Antigen Processing and Presentation
ThymoProteosome
TAP
Presentation of Self Antigen
Professional APC
Only in cortical thymic cells... Different enzyme (B5t)... Contribu…
Transports peptides to ER... Membrane spanning heterodimer... Needs…
Present self and non self... Hopefully tolerant to self and don'…
DC, MP, B... Have MHC-I and can be induced to express MHC-II... Abl…
ThymoProteosome
Only in cortical thymic cells... Different enzyme (B5t)... Contribu…
TAP
Transports peptides to ER... Membrane spanning heterodimer... Needs…
23 terms
Antigen Processing, Presentation and Recognition
MHC
restricted
process, present
accessory
Highly polymorphic genetic locus that encodes two classes of…
T cells are ___ to recognize either MHC 1 or MHC 2
Antigen presenting cells are needed to _________ and _______…
In antigen presentation & recognition, what molecule function…
MHC
Highly polymorphic genetic locus that encodes two classes of…
restricted
T cells are ___ to recognize either MHC 1 or MHC 2
52 terms
MHC and ANtigen Processing/Presentation
MHC 1
MHC 2
Proteasome
Interferon gamma
intracellular pathogens (viruses)... cytotoxic T cells... CD 8... 3 al…
Extracellular pathogens (bacteria)... helper T cells... 2 alpha and…
large barrel shaped protein used for the degradation of bad p…
induce the change of the structure of the proteasome in prese…
MHC 1
intracellular pathogens (viruses)... cytotoxic T cells... CD 8... 3 al…
MHC 2
Extracellular pathogens (bacteria)... helper T cells... 2 alpha and…
27 terms
Antigen Processing and Presentation
cellular immunity
humoral immunity
professional antigen presenting cells
what do APCs do?
adaptive immunity... immunity mediated by helper T cells and cy…
adaptive immunity... B cells and antibodies
dendritic cells... macrophages... B cells... able to activate naive…
capture pathogens and their products... process pathogens and p…
cellular immunity
adaptive immunity... immunity mediated by helper T cells and cy…
humoral immunity
adaptive immunity... B cells and antibodies
50 terms
Antigen presentation and processing
T cell antigens
T cell receptor
B cell antigens
B cell antigen receptor
peptides
TCR - not secreted
proteins... carbohydrates... lipids... nucleic acids
BCR (Ig, Ab)
T cell antigens
peptides
T cell receptor
TCR - not secreted
32 terms
11. Antigen Processing and Presentation
where is the piece of digested antigen…
class I MHC
class II MHC
class III MHC
in the cleft
-genes encode glycoproteins found on the surface of nearly AL…
genes encode glycoproteins expressed on antigen presenting ce…
genes encode various proteins involved in inflammation incl…
where is the piece of digested antigen…
in the cleft
class I MHC
-genes encode glycoproteins found on the surface of nearly AL…
65 terms
Antigen Processing and Presentation
APCs importance to adaptive immunity
Professional antigen presenting cells
non-professional APCs
Naive T cells
Initiation of adaptive immune response depends on ability of…
DCs, mphages & B cells are professional APCs: can activate na…
Other cells (non-professional APCs) can present Ag to effecto…
T cells that have not encountered antigen... circulating looking…
APCs importance to adaptive immunity
Initiation of adaptive immune response depends on ability of…
Professional antigen presenting cells
DCs, mphages & B cells are professional APCs: can activate na…
42 terms
Antigen Processing and Presentation
T Lymphocytes
APC
APC (MHC I)
APC (MHC II)
Adaptive arm... >T help for humoral immunity... >T cell mediated im…
*Antigen Presenting Cells (APCs)... -Present foreign antigen to…
Virtually ALL cells in the human body are capable of presenti…
Professional APCs process foreign antigen and present via MHC…
T Lymphocytes
Adaptive arm... >T help for humoral immunity... >T cell mediated im…
APC
*Antigen Presenting Cells (APCs)... -Present foreign antigen to…
16 terms
MHC Antigen Processing and Presentation
What is an allogenic vs. autologous tr…
Why do some transplants fail while oth…
What is MHC (Major Histocompatibility…
What is an antigen and how is it relat…
An allogenic transplant is when cells/tissue are implanted fr…
It is has to do with whether it is an allogenic or autologous…
It is a cluster of closely linked genes, also called human le…
An antigen is a molecule or portion of a molecules that can b…
What is an allogenic vs. autologous tr…
An allogenic transplant is when cells/tissue are implanted fr…
Why do some transplants fail while oth…
It is has to do with whether it is an allogenic or autologous…
18 terms
Antigen Processing and Presentation
Why do different antigens end up on di…
CD4 T-cells bind...
CD8 T -cells bind...
Which cells can initiate adaptive immu…
Antigens are in different compartments within cell... Hence, th…
MHC class II... (4 D regions)
MHC class I... (alpha beta region)
B-cells... Macrophages... Dendritic cells... They posses both MHC cla…
Why do different antigens end up on di…
Antigens are in different compartments within cell... Hence, th…
CD4 T-cells bind...
MHC class II... (4 D regions)
16 terms
Antigen processing and presentation
What are the three major antigen prese…
What is the action of dendritic cells?
What is the action of macrophages
What is the action of B-lymphocytes
1. Dendritic cells... 2. Macrophages... 3. B lymphocytes... Plus vasc…
Presents antigens to the naive T cell and primes T lymphocytes
Development of the effector arm of CD4+ T cells
Presentation to T helper cells in humoral immunity
What are the three major antigen prese…
1. Dendritic cells... 2. Macrophages... 3. B lymphocytes... Plus vasc…
What is the action of dendritic cells?
Presents antigens to the naive T cell and primes T lymphocytes
8 terms
Processing and Presentation of Antigens
MHC Class 1
CD8+ cytotoxic T Cells
MHC Class II
MHC Class II Invariant Chain
Endogenous Pathway [intracellular Microbes] - Kill Me... - Al…
Recognize the combination of *MHC Class I and altered self pe…
Exogenous Pathway [Help Me]... - Only on APC [Antigen Presentin…
Blocks groove of molecules - Can only be loaded with things t…
MHC Class 1
Endogenous Pathway [intracellular Microbes] - Kill Me... - Al…
CD8+ cytotoxic T Cells
Recognize the combination of *MHC Class I and altered self pe…
10 terms
Antigen Processing and Presentation
Describe the big picture of the immune…
How does antigen activation differ bet…
What are the two major groups of T cel…
Where are MCH I molecules made? How ab…
1) Antigens are captured and transported to the adaptive/inna…
T-cells require processed antigens to be activated, B-cells c…
CD8 (Cytotoxic T cells) MCH I... CD4 (Helper T cells) MCH II
All nucleated cells... MCH II is only in professional antigen pr…
Describe the big picture of the immune…
1) Antigens are captured and transported to the adaptive/inna…
How does antigen activation differ bet…
T-cells require processed antigens to be activated, B-cells c…
51 terms
MHC Processing/Antigen Presentation
infecting pathogen has been phagocytos…
Upon phagocytosis, macrophage
increase permeability of vasculature i…
hotdog analogy
macrophages and DC in tissues
secretes inflammatory cytokines and chemokines
attraction of neutrophils and delivery of soluble protective…
can't have hotdog without both bun and dog, just like MHC can…
infecting pathogen has been phagocytos…
macrophages and DC in tissues
Upon phagocytosis, macrophage
secretes inflammatory cytokines and chemokines
40 terms
Antigen Processing and Presentation
What is the basic action of the antige…
Protein antigens that are present in t…
Antigens internalized from the extrace…
T or F? Most cytosolic protein antigen…
Convert protein antigens present in the cytosol or internaliz…
class I-associated
class II MHC molecules
True
What is the basic action of the antige…
Convert protein antigens present in the cytosol or internaliz…
Protein antigens that are present in t…
class I-associated
51 terms
Antigen Processing and Presentation
T/F antigen processing and presentatio…
the name for the complex of foreign an…
encode glycoproteins found on the surf…
glycoproteins expressed on antigen pre…
T... F (do not recognize own body antigens normally)... T... T... T... F (lo…
human leukocyte antigen (HLA)
Class I MHC
Class II MHC
T/F antigen processing and presentatio…
T... F (do not recognize own body antigens normally)... T... T... T... F (lo…
the name for the complex of foreign an…
human leukocyte antigen (HLA)
42 terms
Antigen Processing and Presentation
What is antigen processing and present…
What are the three professional antige…
What do dendritic cells do?
What do macrophages do?
The process by which antigen-presenting cells digest antigens…
Dendritic cells, macrophages, B lymphocytes
Present antigen to naive CD4+ and CD8+ T lymphocytes so they…
Present antigens to differentiated CD4+ T lymphocytes in the…
What is antigen processing and present…
The process by which antigen-presenting cells digest antigens…
What are the three professional antige…
Dendritic cells, macrophages, B lymphocytes
20 terms
Antigen processing and Presentation
What is class restriction?
What is MHC restricted?
What does antigen presentation by clas…
What is a targeted cell?
refers to the fact that CD4 T cells recognize MHC class II mo…
my T cells recognize my MHC molecule
targets cell for destruction by CTLs
a cell targeted for destruction by CTLs
What is class restriction?
refers to the fact that CD4 T cells recognize MHC class II mo…
What is MHC restricted?
my T cells recognize my MHC molecule
18 terms
Immunology: Antigen Processing and Presentation
Helper T Cell
Helper T Cell
Cytotoxic T Cell
Cytotoxic T Cell
Type of T Cell that recognizes MHC Class II
Type of T Cell that is positive for CD4
Type of T Cell that recognizes MHC Class I
Type of T Cell that is positive for CD8
Helper T Cell
Type of T Cell that recognizes MHC Class II
Helper T Cell
Type of T Cell that is positive for CD4
34 terms
Antigen Processing and Presentation
What type of cells are appropriate for…
Which MHC class do CD8 T cells interac…
Which MHC class has β2-microglobulin (…
What does MHC class I consist of?
T cells
MHC class I
MHC class I
3 a chains and b2-microglobulin (b2M)
What type of cells are appropriate for…
T cells
Which MHC class do CD8 T cells interac…
MHC class I
16 terms
Antigen Processing and Presentation
Describe the results of variability in…
What is the purpose of MHC?
Compare MHC Class I vs. Class II produ…
Describe the types of peptides that fi…
Since the specific peptides are so unique, it increases MHC v…
it binds peptide fragments from pathogens and displays them o…
Class I: the antigenic peptide comes from a virus or tumor an…
-anchor residues... -Internal pathogens/proteins broken down by…
Describe the results of variability in…
Since the specific peptides are so unique, it increases MHC v…
What is the purpose of MHC?
it binds peptide fragments from pathogens and displays them o…
27 terms
Antigen Processing and Presentation
what makes a professional antigen pres…
where are plasmacytoid DCs found?
where are classical or conventional DC…
what are the type 1 interferons?
they release co-stimulatory molecules
in the blood. They release IFNa and IFNb when activated by vi…
in lymphoid (non-migratory) and non-lymphoid tissues (migrato…
IFNa and IFNb. These activate cytotoxic T cells
what makes a professional antigen pres…
they release co-stimulatory molecules
where are plasmacytoid DCs found?
in the blood. They release IFNa and IFNb when activated by vi…
46 terms
antigen processing and presentation
What are the 3 professional APCs?
What do DCs present to?
What do macrophages present to?
What do B lymphocytes present to?
1. DCs... 2. macrophages... 3. B lymphocytes
CD4 and CD8, naive T cells
CD4 lymphocytes in the effector phase of cell-mediated immunity
CD4 lymphocytes (Th cells) during humoral immune response
What are the 3 professional APCs?
1. DCs... 2. macrophages... 3. B lymphocytes
What do DCs present to?
CD4 and CD8, naive T cells
18 terms
Immunology: Antigen Processing and Presentation
Helper T Cell
Helper T Cell
Cytotoxic T Cell
Cytotoxic T Cell
Type of T Cell that recognizes MHC Class II
Type of T Cell that is positive for CD4
Type of T Cell that recognizes MHC Class I
Type of T Cell that is positive for CD8
Helper T Cell
Type of T Cell that recognizes MHC Class II
Helper T Cell
Type of T Cell that is positive for CD4
40 terms
Antigen Processing and Presentation
What is the basic action of the antige…
Protein antigens that are present in t…
Antigens internalized from the extrace…
T or F? Most cytosolic protein antigen…
Convert protein antigens present in the cytosol or internaliz…
class I-associated
class II MHC molecules
True
What is the basic action of the antige…
Convert protein antigens present in the cytosol or internaliz…
Protein antigens that are present in t…
class I-associated
25 terms
Antigen presentation and processing
How do peptides bind to MHC?
How do we find out the anchor residues…
Dominant anchor residue =
How does knowledge of anchor residues…
Bind to 'anchor' side chains
Sequence peptides, and see where the common sequences are
amino acids required in the epitope for that MHC to present it
We know what amino acids are required for the vaccine to be p…
How do peptides bind to MHC?
Bind to 'anchor' side chains
How do we find out the anchor residues…
Sequence peptides, and see where the common sequences are
42 terms
Antigen Processing and Presentation
How is HLA diversity important clinica…
What is HLA?
What are the 2 types of HLA?
What do T cells see?
Determines disease susceptibility... MHC/HLA matching to decreas…
Human MHC known as "Human Leukocyte Antigens" ... Antigen-presen…
Class I (intracellular pathogens) and Class II (extracellular…
HLA + peptide of pathogen
How is HLA diversity important clinica…
Determines disease susceptibility... MHC/HLA matching to decreas…
What is HLA?
Human MHC known as "Human Leukocyte Antigens" ... Antigen-presen…
30 terms
Antigen Processing and Presentation
Ag processing?
Ag presentation?
What do MHC class I molecules present?
What do MHC class II molecules present?
Ability of APC to breakdown Ag into peptides and associate th…
Process of displaying peptide Ag in context of MHC to T cell
degradation products derived from intracellular (endogenous)…
fragments derived from extracellular (exogenous) proteins tha…
Ag processing?
Ability of APC to breakdown Ag into peptides and associate th…
Ag presentation?
Process of displaying peptide Ag in context of MHC to T cell
15 terms
12 - Antigen processing and presentation
3 types of APCs
(endogenous/exogenous) antigen is pres…
2 ways of engulphing exogenous antigen…
2 types of endogenous antigens
dendritic cells, b-cells, macrophages
Exogenous antigens are presented on the MHCII to the Th2 (CD4…
pinocytosis (no recognition of PAMP)... phagocytosis (recogniti…
virus and tumor
3 types of APCs
dendritic cells, b-cells, macrophages
(endogenous/exogenous) antigen is pres…
Exogenous antigens are presented on the MHCII to the Th2 (CD4…
74 terms
Immunology Antigen Processing and Presentation
Process by which antigen-presenting ce…
Cells that do the digestion (processin…
What cells recognize the presented ant…
Cells that present the antigen to naïv…
Antigen processing and presentation
Antigen presenting cells (APC)
T lymphocytes
Dendritic cells
Process by which antigen-presenting ce…
Antigen processing and presentation
Cells that do the digestion (processin…
Antigen presenting cells (APC)
12 terms
Antigen Processing & Presentation
What does intracellular antigen proces…
Which MHC presents intracellular antig…
Which MHC presents extracellular antig…
What is MHC-I composed of?
Antigen is taken up from extracellular space into a vesicle w…
MHC-I
MHC-II
Transmembrane polypeptide... Antigenic peptide... B-2 microglobulin
What does intracellular antigen proces…
Antigen is taken up from extracellular space into a vesicle w…
Which MHC presents intracellular antig…
MHC-I
94 terms
Immuno - Antigen Processing & Presentation
Major histocompatibility complex (MHC)…
3 varieties of epitopes
Polygenic epitopes
Polymorphic epitopes
A system of gene products used for specifically recognizing &…
Polygenic, polymorphic, & promiscuous
Several genes exist for a given MHC class
A large number of alleles exist for a given gene
Major histocompatibility complex (MHC)…
A system of gene products used for specifically recognizing &…
3 varieties of epitopes
Polygenic, polymorphic, & promiscuous
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