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Study sets matching "antimicrobial and antiviral"

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Study sets matching "antimicrobial and antiviral"

33 terms
Antiviral & Antimicrobial
Reyataz
Truvada
Valtrex
Zovirax
- atazanavir... - protease inhibitor... - HIV
- emtricitabine & tenofovir... - antiretroviral & reverse transc…
- valacyclovir... - antiviral
- acyclovir... - antiviral
Reyataz
- atazanavir... - protease inhibitor... - HIV
Truvada
- emtricitabine & tenofovir... - antiretroviral & reverse transc…
91 terms
Antimicrobials and Antivirals
Remembering Penicillin Names
*Mechanism of action: Penicillins
*Indications for Penicillin
Contraindications for Penicillin
End in -cillin.
Bactericidal.... Inhibits cell wall synthesis; disrupt cell wall…
Infections, depend on pathogen and PCN class: ... Gram + Strep,…
Allergy (very common, incidence up to 4%)
Remembering Penicillin Names
End in -cillin.
*Mechanism of action: Penicillins
Bactericidal.... Inhibits cell wall synthesis; disrupt cell wall…
63 terms
Antimicrobials, antivirals
Beta lactam antimicrobials
50S Protein Synthesis Inhibitors
30S Protein Synthesis Inhibitors
Anti-Mycobacterial Agents
Penicillin, ampicillin, methicillin, piperacillin, aztreonam,…
Chloramphenicol, Macrolides (erythromycin), Clindamycin
Aminoglycosides (Gentamicin), Tetracyclines
Rifampin, Isoniazid, Dapsone, Ethambutol, Pyrazinamide
Beta lactam antimicrobials
Penicillin, ampicillin, methicillin, piperacillin, aztreonam,…
50S Protein Synthesis Inhibitors
Chloramphenicol, Macrolides (erythromycin), Clindamycin
17 terms
Antimicrobials - Antivirals
Zanamivir, Oseltamivir
Ribavirin
Acyclovir, Famciclovir, Valacyclovir
Ganciclovir
Mechanism: inhibits influenza neuraminidase = decreases relea…
Mechanism: inhibits synthesis of guanine nucleotides by compe…
Mechanism: phosphorylated (activated only) by HERPES THYMIDIN…
Mechanism: phosphorylated by HUMAN THYMIDINE KINASE [forms a…
Zanamivir, Oseltamivir
Mechanism: inhibits influenza neuraminidase = decreases relea…
Ribavirin
Mechanism: inhibits synthesis of guanine nucleotides by compe…
54 terms
Antimicrobials and Antivirals
What are the five general mechanisms o…
What are the four general mechanisms o…
By what mechanism does MRSA have resis…
What are the two types of antibacteria…
Cell wall... Cell membrane... DNA synthesis... RNA synthesis... Folic aci…
Enzymatic destruction... Altered target site... Decreased uptake... In…
Altered target site
Concentration-dependent killing... Time-dependent killing
What are the five general mechanisms o…
Cell wall... Cell membrane... DNA synthesis... RNA synthesis... Folic aci…
What are the four general mechanisms o…
Enzymatic destruction... Altered target site... Decreased uptake... In…
antimicrobials, antivirals
concentration dependent killing
time dependent killing
PAE
cell wall inhibitors
higher concentration of drug=more rapid, complete killing of…
saturation of killing occurs at low multiples of MIC... efficacy…
post antibiotic effect... -period of time when drug concentratio…
B-lactams, glycopeptides
concentration dependent killing
higher concentration of drug=more rapid, complete killing of…
time dependent killing
saturation of killing occurs at low multiples of MIC... efficacy…
34 terms
Antimicrobials - Antivirals
Which protein is responsible for Viral…
What are the two "anti-flu" medications?
Zanamivir/Oseltamivir... -Mechanism... -Cl…
Ribavirin... -Mechanism... -Clinical Use... -…
Hemagglutinin... --> Binding and Entering... (hemagglutin-IN)... *N…
Zanamivir and Oseltamivir (tami*flu)
Mechanism... -block neuraminidase of Influenza virus (inhibits…
Mechanism... -inhibits Inosine Monophosphate Dehydrogenase (IM…
Which protein is responsible for Viral…
Hemagglutinin... --> Binding and Entering... (hemagglutin-IN)... *N…
What are the two "anti-flu" medications?
Zanamivir and Oseltamivir (tami*flu)
34 terms
Antimicrobials - Antivirals
Which protein is responsible for Viral…
What are the two "anti-flu" medications?
Zanamivir/Oseltamivir... -Mechanism... -Cl…
Ribavirin... -Mechanism... -Clinical Use... -…
Hemagglutinin... --> Binding and Entering... (hemagglutin-IN)... *N…
Zanamivir and Oseltamivir (tami*flu)
Mechanism... -block neuraminidase of Influenza virus (inhibits…
Mechanism... -inhibits Inosine Monophosphate Dehydrogenase (IM…
Which protein is responsible for Viral…
Hemagglutinin... --> Binding and Entering... (hemagglutin-IN)... *N…
What are the two "anti-flu" medications?
Zanamivir and Oseltamivir (tami*flu)
123 terms
Antimicrobial and Antiviral Medications
Paul Ehrich
Alexander Fleming
Ernst Chain & Howard Florey
Selman Waksman
-synthesized arsenic compound to treat syphyllis ... -searched f…
discovered Penecillin while working with staphyloccocus
successfully purified penecillin
isolated streptomycin from soil bacterium streptomyces griseus
Paul Ehrich
-synthesized arsenic compound to treat syphyllis ... -searched f…
Alexander Fleming
discovered Penecillin while working with staphyloccocus
28 terms
Pharm antiviral and antimicrobial
acyclovir
valacyclovir
peniclovir
famciclovir
antiviral, acyclic, ... used for HSV... topical, oral, IV... poor H2O…
antiviral... HSV, increased bioavailability than acyclovir
antiviral... HSV, longer intracelular 1/2 life; not a chain term…
antiviral... HSV, longer intracelular 1/2 life + increased bioav…
acyclovir
antiviral, acyclic, ... used for HSV... topical, oral, IV... poor H2O…
valacyclovir
antiviral... HSV, increased bioavailability than acyclovir
11 terms
Antimicrobial and antiviral drugs
Targets cell wall
Disruption of Cell membrane function
Inhibition of translation
Inhibition of metabolism
Pencillin, Cephalosporin, Vancomycin
Polymyxin
Tetracycline, Erythromycin, Streptomycin, Chloramphenicol
Sulfanimides
Targets cell wall
Pencillin, Cephalosporin, Vancomycin
Disruption of Cell membrane function
Polymyxin
194 terms
Pharmacology (Antimicrobial, Antifungal, Antiviral)
community acquired pneumonia (4 main b…
gram +
Staphylococcus aureus resistance commo…
pneumovax
Streptococcus pneumoniae... Moraxella catarrhalis... Hemophilus inf…
thick cell wall made up of peptidoglycan
Methicillin Resistance Staphylococcus Aureus (MRSA)
vaccine for S. pneumonia... older population
community acquired pneumonia (4 main b…
Streptococcus pneumoniae... Moraxella catarrhalis... Hemophilus inf…
gram +
thick cell wall made up of peptidoglycan
11 terms
Antimicrobial and Antiviral and Antipneumocystis
What is used to treat bacterial infect…
Patients with bacterial infections wil…
How do you identify the causative orga…
Examples of Antibiotics
Antibiotics
fever ... chills... yellow/green sputum... elevated WBC (>10,000mm3)
culture and sensitivity... gram stain
Penicillins: Ampicillin... Cephalosporins: Ceftriaxone... Aminoglyc…
What is used to treat bacterial infect…
Antibiotics
Patients with bacterial infections wil…
fever ... chills... yellow/green sputum... elevated WBC (>10,000mm3)
26 terms
Antimicrobial & antiviral therapy
Identification of MO
Susceptibility of MO to given drug
bacteriostatic
patient factors
antimicrobial antigens ... RNA or DNA sequencing ... patients thems…
MIC experimentally determined ... Patients should take a dose t…
Inhibit bacteria growth → allow patient to get rid of bacteri…
- Status of immune system ... - Status of renal function (adjust…
Identification of MO
antimicrobial antigens ... RNA or DNA sequencing ... patients thems…
Susceptibility of MO to given drug
MIC experimentally determined ... Patients should take a dose t…
37 terms
Antiviral Agents (Antimicrobial Pharmacology)
What are the antiherpetic drugs? (3)
How is acyclovir phosphorylated? (2)
What is the mechanism of action of acy…
How does viruses gain resistance to ac…
1) Acyclovir... 2) Ganciclovir... 3) Foscarnet
1) Monophosphorylated by viral thimidine kinase (TK)... 2) Furth…
It is incorporated into the viral DNA molecule, and acts as a…
By "not having" the TK enzyme
What are the antiherpetic drugs? (3)
1) Acyclovir... 2) Ganciclovir... 3) Foscarnet
How is acyclovir phosphorylated? (2)
1) Monophosphorylated by viral thimidine kinase (TK)... 2) Furth…
105 terms
GI antimicrobials/ antiviral
Ceftriaxone trade name:
Ceftriaxone main category:
Ceftriaxone subclass:
Ceftriaxone MOA:
Rocephin
antibiotic
Cephalosporins
3rd generation cephalosporin- same MOA as 2nd gen cephs but d…
Ceftriaxone trade name:
Rocephin
Ceftriaxone main category:
antibiotic
57 terms
Pharm- Antimicrobial/Antifungal/Antiviral
Sulfadiazine... Sulfisoxazole... Sulfamethox…
Take sulfonamides in combo with
Metraonidazole
Nitrofurantoin
DNA- affecting drug --> folate synthesis inhibitor --> sulfon…
Trimethoprim (DHFR inhibitor)
DNA- affecting drug --> DNA Damaging Drugs --> nitroimidazole…
DNA- affecting drug --> DNA Damaging Drugs --> nitrofuran (br…
Sulfadiazine... Sulfisoxazole... Sulfamethox…
DNA- affecting drug --> folate synthesis inhibitor --> sulfon…
Take sulfonamides in combo with
Trimethoprim (DHFR inhibitor)
64 terms
Pharm IV: Antimicrobials and antivirals
MOA of quinolones
MOA of penicillin
Drug used for MRSA *
Vancomycin MOA
** Inhibit DNA gyrase
Block cell wall synthesis by inhibiting peptidoglycan cross-l…
Vancomycin
Blocks cell wall synthesis by sequestration
MOA of quinolones
** Inhibit DNA gyrase
MOA of penicillin
Block cell wall synthesis by inhibiting peptidoglycan cross-l…
20 terms
Antimicrobials: Antibiotics, Antifungals, and Antivirals
Amoxicillin
Penicillin
Piperacillin/Tazobactam
Trimethoprim / Sulfamethoxazole
Brand name: Dispermox or Moxatag?... Category: Antimicrobial... C…
Brand name: Permapen?... Category: Antimicrobial... Class: Antibi…
Brand name: Zosyn... Category: Antimicrobial... Class: Antibiotic…
Brand name: Bactrim... Category:Antimicrobial... Class: Antibioti…
Amoxicillin
Brand name: Dispermox or Moxatag?... Category: Antimicrobial... C…
Penicillin
Brand name: Permapen?... Category: Antimicrobial... Class: Antibi…
116 terms
Antimicrobials, Chemotherapy, and Antivirals
combined antibiotic therapy
indications for combined antibiotic th…
inherent resistance
acquired resistance
-should avoid if possible... -bactericidal + bactericidal: syner…
-severe infections w/ unknown etiology... -mixed infections... -to…
related to genetic characteristic of bacteria; pattern is pre…
adaptation to toxicity of antibiotics; unpredictable
combined antibiotic therapy
-should avoid if possible... -bactericidal + bactericidal: syner…
indications for combined antibiotic th…
-severe infections w/ unknown etiology... -mixed infections... -to…
47 terms
3-4 Antimicrobials and Antivirals
Antimicrobial agents
Microbiocidal
Microbiostatic
Disinfectants
General term that refers to group of drugs that includes anti…
Agents that kill
Agents that inhibit growth
Non-selective agents typically used on non-living surfaces... Ex…
Antimicrobial agents
General term that refers to group of drugs that includes anti…
Microbiocidal
Agents that kill
65 terms
3-5 Antimicrobials and Antivirals
Reverse Transcriptase
Nucleoside reverse transcriptase inhib…
What drug is the "backbone" of a HIV t…
Non-Nucleoside Reverse Transcriptase I…
-Convert viral RNA to double stranded cDNA, which is able to…
-Inhibits reverse transcriptase enzyme by mimicking naturally…
Retrovir (Zidovudine, AZT)
-Inhibits reverse transcriptase by binding directly to the en…
Reverse Transcriptase
-Convert viral RNA to double stranded cDNA, which is able to…
Nucleoside reverse transcriptase inhib…
-Inhibits reverse transcriptase enzyme by mimicking naturally…
10 terms
Antimicrobials antivirals antifungals
ANTIFUNGALS
Amphotericin B
Ampicillin
GENTAMICIN
Amphotericin b cause renal impairment.... Wear gloves when apply…
Systemic antifungal ... ROUTE ONLY IV... no breast feeding if on am…
antiinfective- broadnspectrum... Tx otitis media resp infection,…
ANTI INFECTIVES ... TX..enterococcal and TB... ROUTE. IM,IV Q6 HOUR…
ANTIFUNGALS
Amphotericin b cause renal impairment.... Wear gloves when apply…
Amphotericin B
Systemic antifungal ... ROUTE ONLY IV... no breast feeding if on am…
20 terms
Antimicrobials II & Antivirals
Protein synthesis inhibitors
Nucleic acid inhibitors
Ribosomes
Aminoglycosides
Aminoglycosides (30S), macrolides (50S), tetracyclines (30S),…
Fluroquinolones
Bacteria: 30S (binding of aminoacyl tRNA to aminoacyl site (A…
Gentamicin, Tobramycin, Amikacin, Neomycin, Streptomycin... - Bi…
Protein synthesis inhibitors
Aminoglycosides (30S), macrolides (50S), tetracyclines (30S),…
Nucleic acid inhibitors
Fluroquinolones
19 terms
Antimicrobials/Antibiotics/Antivirals
Salvaran
Sulfa drugs
Isoniazid
Quinolones
Some dyes bind to bacterial cells to inhibit or kill it but d…
When added to bacterial cultures, sulfa drugs bind to the act…
For treatment of TB... A vitamin analog that inhibits synthesis…
Broad spectrum... Inhibit bacterial DNA gyrase and prevent DNA s…
Salvaran
Some dyes bind to bacterial cells to inhibit or kill it but d…
Sulfa drugs
When added to bacterial cultures, sulfa drugs bind to the act…
PBD - Antimicrobials, Antivirals, Antifungals
prophylactic therapy
preemptive therapy
empiric therapy
definitive therapy
prevent infection or dangerous disease in someone not yet inf…
early targeted therapy in pt who is asymptomatic but infected
therapy to a symptomatic pt without an organism infection
known organism - tx with an antibiotic streamlined based on s…
prophylactic therapy
prevent infection or dangerous disease in someone not yet inf…
preemptive therapy
early targeted therapy in pt who is asymptomatic but infected
59 terms
USMLE: Antimicrobials V - antivirals
Inhibit influenza neuraminidase --> r…
Treatment and prevention of both influ…
Acyclovir, ValAcylovir, Famciclovir: c…
Guanosine analogs: mechanism
Oseltamivir, zanamivir
Oseltamivir, zanamivir
HSV and VZV. Weak activity against EBV. (No activity against…
Monophosphorylated by HSV/VZV thymidine kinase and not phosph…
Inhibit influenza neuraminidase --> r…
Oseltamivir, zanamivir
Treatment and prevention of both influ…
Oseltamivir, zanamivir
20 terms
Antimicrobials - antibiotics, antifungals, & antivirals
Amoxicillan
Penicillan
Piperacillan/tazobactam
Trimethoprim/sulfamethazole
N/A
N/A
Zosyn
Bactrim
Amoxicillan
N/A
Penicillan
N/A
10 terms
Antimicrobials (Antibiotics, Antifungals & Antivirals)
Lopinavir / Ritonavir (Kaletra)
Enfuvirtide (Fuzeon)
Maraviroc (Selzentry)
Raltegravir (Isentress)
Protease Inhibitor; Antiretroviral agent... MOA [L]: binds to HI…
Fusion inhibitor; antiretroviral... MOA: prevents the HIV envelo…
Antiretroviral; CCR5 antagonist... MOA: CCR5 is a co-receptor th…
Antiretroviral, HIV strand transfer inhibitor (integrase inhi…
Lopinavir / Ritonavir (Kaletra)
Protease Inhibitor; Antiretroviral agent... MOA [L]: binds to HI…
Enfuvirtide (Fuzeon)
Fusion inhibitor; antiretroviral... MOA: prevents the HIV envelo…
35 terms
Antimicrobials, Antifungals, Antivirals
antagonism
synergism
antibiotic
antibacterial
reaction of two drugs that REDUCE bactericidal rate than of e…
reaction of two drugs that together INCREASE the bactericidal…
kills or inhibits growth of bacteria - produced by other orga…
kills or inhibits growth of bacteria - is synthetic and creat…
antagonism
reaction of two drugs that REDUCE bactericidal rate than of e…
synergism
reaction of two drugs that together INCREASE the bactericidal…
24 terms
antimicrobials, antifungals, antivirals
bacteria
viruses
penicillin
ciprofloxacin
large group of one celled organisms without nucleus
minute infections cell particles , not rly living organisms
antibiotic used for infections, allergic reactions are commmo…
antibiotic used for prophylactic reasons- for people who have…
bacteria
large group of one celled organisms without nucleus
viruses
minute infections cell particles , not rly living organisms
55 terms
Antimicrobials: Antivirals (HIV)
What is the scene for NRTIs (nucleosid…
Name the NRTIs
MOA of NRTIs
What molecular aspect of NRTIs leads t…
Dining Room
Abacavir... Didanosine... Emtricitabine... Lamivudine... Stavudine... Tenofo…
competivitive inhibition of HIV reverse transcriptase via inc…
absent hydroxyl at 3' end-> inhibition of 3' to 5' phosphodie…
What is the scene for NRTIs (nucleosid…
Dining Room
Name the NRTIs
Abacavir... Didanosine... Emtricitabine... Lamivudine... Stavudine... Tenofo…
28 terms
Antimicrobials: Antivirals (other)
What is the scene for HSV/VZV drugs
What drugs are used as tx & prophylaxi…
Similarities between Acyclovir/Valacyc…
MOA of Acyclovir/Valacyclovir/Famciclo…
You are Now Free to Move About the Ganglia
Acyclovir, Valacyclovir, Famciclovir, Foscarnet, Cidofovir
MOA & clinical use
guanosine nucleoside analog that is monophosphorylated to Acy…
What is the scene for HSV/VZV drugs
You are Now Free to Move About the Ganglia
What drugs are used as tx & prophylaxi…
Acyclovir, Valacyclovir, Famciclovir, Foscarnet, Cidofovir
74 terms
antimicrobials: antivirals, antiretrovirals, antiparasites
acyclovir
valacyclovir
penciclovir
famciclovir
antiherpes/varicella zoster
antiherpes/varicella zoster
antiherpes/varicella zoster
antiherpes/varicella zoster
acyclovir
antiherpes/varicella zoster
valacyclovir
antiherpes/varicella zoster
46 terms
Antimicrobials/Antivirals warnings
Sulfonamide
Nitroheteroaromatics
Quinolones
Penicillin
∙ Allergic Reaction ... ∙ Stevens Johnson Syndrome
∙ Carcinogenicity... ∙ Slows alcohol metabolism - "hangover"
∙ Tendonitis... ∙ Tendon rupture... ∙ Not for Myasthenia Gravis pat…
∙ Haptens... ∙ Allergic reaction is immediate onset... ∙ Cardiovasc…
Sulfonamide
∙ Allergic Reaction ... ∙ Stevens Johnson Syndrome
Nitroheteroaromatics
∙ Carcinogenicity... ∙ Slows alcohol metabolism - "hangover"
46 terms
Antimicrobials,Antivirals & Chemo drugs
penicillin:mechanism of action... use?
vancomycin.drug class + mechanism of a…
metronidazole:drug class?... mechanism of…
sulphonamides
binds to transpeptidase preventing transpeptidation of NAM/NA…
complex glycopeptide, steric hindrance, prevents transglycosy…
5 nitroimidazole... inhibits respiratory electron transport chai…
inhibits DHO (dihydropteroate synthase) converts PABA to fola…
penicillin:mechanism of action... use?
binds to transpeptidase preventing transpeptidation of NAM/NA…
vancomycin.drug class + mechanism of a…
complex glycopeptide, steric hindrance, prevents transglycosy…
35 terms
Antimicrobial therapy/ antifungal and antiviral drugs
most common fungi
aspergillius spp
endemic mycoses
cryptococcus spp
C.albicans... -commo for oral and esophageal thrush
mold... cause of invasive infection in severely immunocompromise…
geographic regions... -histoplasmosis spp in louisville
cause of invasive infections in aids pts
most common fungi
C.albicans... -commo for oral and esophageal thrush
aspergillius spp
mold... cause of invasive infection in severely immunocompromise…
81 terms
Antimicrobial Drugs [Antibiotics, Antivirals, Antifungals]
Chemotherapy - term coined by Paul Ehr…
Antibiotics - chemical substance produ…
Why would microorganisms produce antib…
Where do antibiotics come from?
He discovered a drug treatment for syphilis; he also develope…
History: One of the first antibiotics was penicillin, discove…
To stay competitive with other microorganisms. ... Natural selec…
Various molds and fungus
Chemotherapy - term coined by Paul Ehr…
He discovered a drug treatment for syphilis; he also develope…
Antibiotics - chemical substance produ…
History: One of the first antibiotics was penicillin, discove…
15 terms
Microbiology chapter 20: antimicrobial & antiviral
How is the microbe that makes penicill…
Define and contrast the terms chemothe…
Which would be safest: an antimicrobia…
In what clinical situation is it most…
Penicillin is made by a fungus, and streptomycin is made by a…
chemotherapeutic - chemical that is in medication that attack…
high therapeutic index - If the TI is small, the drug must be…
if you don't know what the diagnosis is and need to be used r…
How is the microbe that makes penicill…
Penicillin is made by a fungus, and streptomycin is made by a…
Define and contrast the terms chemothe…
chemotherapeutic - chemical that is in medication that attack…
11 terms
Immunosuppressants, Antivirals, and Antimicrobials Part I
Calcineurin inhibitors
Drugs to treat Herpes simplex and Vari…
Drugs for treatment of cytomegalovirus…
Drugs for hepatitis
• Cyclosporine (Sandimmune, Neoral)... • Tacrolimus (Prograf)
• Acyclovir (Zovirax)... • Valacyclovir (Valtrex)
• Gangciclovir (Cytovene)
• Interferon alfa... • Ribavirin (Rebetrol)... • Boceprevir (Victre…
Calcineurin inhibitors
• Cyclosporine (Sandimmune, Neoral)... • Tacrolimus (Prograf)
Drugs to treat Herpes simplex and Vari…
• Acyclovir (Zovirax)... • Valacyclovir (Valtrex)
82 terms
Deja Review: Antimicrobials- Antiviral Agents
What enzyme adds the first phosphate t…
True or false? Monophosphorylated acyc…
How does acyclovir triphosphate work a…
How does acyclovir triphoshpate work a…
viral thymidine kinase
false (host cell kinases are responsible for these reactions)
Inhibits viral DNA replication by competing with deoxyguanosi…
lacks the ribosyl 3' hydroxyl group
What enzyme adds the first phosphate t…
viral thymidine kinase
True or false? Monophosphorylated acyc…
false (host cell kinases are responsible for these reactions)
79 terms
Immunosuppressants, antivirals, antimicrobials part 1
immunosuppressants indications
calcineurin inhibitors
interleuken-2 function
cyclosporine (sandimmune/ neoral)... Clas…
1.prevent organ rejection ... 2. treat autoimmune disease (RA, S…
most effective immunosuppressant ... when calcineurin is inhibit…
responsible for activation of T cells and turn B cells to pla…
(calcineurin inhibitor/immunosupressant) ... -Less effective tha…
immunosuppressants indications
1.prevent organ rejection ... 2. treat autoimmune disease (RA, S…
calcineurin inhibitors
most effective immunosuppressant ... when calcineurin is inhibit…
36 terms
Ch 17 Antimicrobials, Antifungals, and Antivirals
Aerobic bacteria
Anaerobic bacteria
Antibacterial drugs
Antibiotic
bacteria that live in an environment containing oxygen
bacteria that live in an environment free of oxygen
drugs with the ability for destruction or inhibition of growt…
natural or synthetic substance, originally derived from plant…
Aerobic bacteria
bacteria that live in an environment containing oxygen
Anaerobic bacteria
bacteria that live in an environment free of oxygen
41 terms
Antimicrobial, Antiviral and Antifungal - Pharmacology MCQ ACEM
Sulphonamides are a structural analogu…
Regarding amphotericin B, which of the…
Regarding zidovudine (AZT), which of t…
Regarding cephalosporins, which of the…
3. PABA... Sulphonamides aka "Folate Antagonist", are DNA synth…
4. It can cause fever, headache and confusion... - In parenter…
3. It has a short T1/2... - T1/2 - 1hr... - PRIMARILY RENAL elimin…
- Ceftazidime is a THIRD generation CS. They have expanded Gr…
Sulphonamides are a structural analogu…
3. PABA... Sulphonamides aka "Folate Antagonist", are DNA synth…
Regarding amphotericin B, which of the…
4. It can cause fever, headache and confusion... - In parenter…
9 terms
Antimicrobial Medication - Mechanisms of Action of Antiviral Drugs
Targets of antiviral drugs
Viral uncoating
Amantadine & Rimantadine
Nucleoside analogs
1. Viral uncoating... 2. Nucleotide analogs... 3. Non-nucleoside po…
1. Amantadine ... 2. Rimantadine
Similar in chemical structure and mechanism of action. Mode o…
1. Zidovudine ... 2. Didanosine... 3. Lamivudine
Targets of antiviral drugs
1. Viral uncoating... 2. Nucleotide analogs... 3. Non-nucleoside po…
Viral uncoating
1. Amantadine ... 2. Rimantadine
34 terms
Antimicrobial Drugs - Antibacterial, Antifungal and Antiviral. (chapter 10)
Chemicals that affect physiology in an…
Chemotherapeutic agents
Antimicrobial agents
Semisynthetics
...
Drugs that act against diseases
Drugs that treat infections
Chemically altered antibiotics that are more... effective than n…
Chemicals that affect physiology in an…
...
Chemotherapeutic agents
Drugs that act against diseases
16 terms
20 antimicrobial drugs: Broad/antiviral/Antiprotozoal
1st antibiotic
First anti-tubercular drug
chemotherapeutic
antibiotic
penicillin
streptomycin
a chemical for therapeutic purposes (from a chemical
soil fungal molds (form an organism
1st antibiotic
penicillin
First anti-tubercular drug
streptomycin
131 terms
Antimicrobial 7 (antiviral)- start of exam 3
viruses are the smallest form of life,…
Viruses encode for only a few proteins…
the naked virus is enclosed by a nucle…
What is different about the enveloped…
20-300nm... wide range
nucleocapsid... polymerase... receptor
capsomers... - inside the nucleocapsid is all the DNA/RNA
has a matrix protein surrounded by a lipid bilayer with glyco…
viruses are the smallest form of life,…
20-300nm... wide range
Viruses encode for only a few proteins…
nucleocapsid... polymerase... receptor
29 terms
Antimicrobial Therapy: Antimycobacterials, Antifungals, Antivirals, Antiparasitics
TB drugs: Rifamycin
TB drugs: Isoniazid
TB drugs: Pyrazinamide
TB drugs: Ethambutol
Mechanism Inhibit bacterial DNA-dependent RNA polymerase... Exam…
Mechanism Inhibition of mycolic acid biosynthesis... Dosing PO/…
Mechanism Metabolized via pyrazinamidase to pyrazinoic acid... D…
Mechanism Inhibition of mycobacterial cell wall formation... Dos…
TB drugs: Rifamycin
Mechanism Inhibit bacterial DNA-dependent RNA polymerase... Exam…
TB drugs: Isoniazid
Mechanism Inhibition of mycolic acid biosynthesis... Dosing PO/…
44 terms
14,15- Intro to Antimicrobials, Antifungals, Antivirals
ß-lactams (inhibitors of polymer cross…
Where is murein found in bacteria?
Synthesis of Murein monomer enzymes
Inhibitors of Murein enzymes
Target cell wall synthesis by inhibiting the action of transp…
Gram positive- outside of cell membrane... Gram negative- within…
MurA- take enolpyruvate from PEP to UDP-NAG... MurB- reduce UDP-…
Fosfomycin- PEP analog that inhibits MurA... Cycloserine- inhibi…
ß-lactams (inhibitors of polymer cross…
Target cell wall synthesis by inhibiting the action of transp…
Where is murein found in bacteria?
Gram positive- outside of cell membrane... Gram negative- within…
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