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Study sets matching "antiseizure"

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Study sets matching "antiseizure"

12 terms
Antiseizure
carbamazepine
valproate
lamotrigine
phenytoin
antiseizure... prolongs inactive state of Na+ channels after act…
antiseizure... prolongs inactive state of Na+ channels after act…
antiseizure... prolongs inactive state of Na+ channels after act…
antiseizure... prolongs inactive state of Na+ channels after act…
carbamazepine
antiseizure... prolongs inactive state of Na+ channels after act…
valproate
antiseizure... prolongs inactive state of Na+ channels after act…
37 terms
antiseizure
epilepsy
seizures
convulsions
causes of seizures
chronic, recurrent pattern of seizures... -neurologist... MOST pr…
abnormal electrical activity of the brain
: spasmodic contractions of involuntary muscles
Infectious Diseases- fever... Trauma... Metabolic disorders... Vascula…
epilepsy
chronic, recurrent pattern of seizures... -neurologist... MOST pr…
seizures
abnormal electrical activity of the brain
26 terms
Antiseizure
phenytoin
Fosphenytoin
Carbamazepine
Oxcarbazepine
blocks NA channels, decreases glutamate, generalized tonic-cl…
same as phenytoin but is more soluble prodrug for IV/IM
blocks high-frequency firing, generalized tonic-clonic/partia…
shorter half-life than CBZ, less potent, fewere ADEs, hyponat…
phenytoin
blocks NA channels, decreases glutamate, generalized tonic-cl…
Fosphenytoin
same as phenytoin but is more soluble prodrug for IV/IM
22 terms
Antiseizure
Phenytoin
Mephenytoin... Ethotoin
Carbamazepine
Oxcarbazepine
hydantoin... 불활성 소듐 채널 차단... 포타슘 칼슘 투과도 증가... 활동전위 형성억제... 침전 생겨서 주사로 맞지…
phenytoin 유사 약물
소듐 채널 차단... NE 방출 저해... partial seizure... tonic-clonic seizure, mania…
Carbazepine 유사, less potent
Phenytoin
hydantoin... 불활성 소듐 채널 차단... 포타슘 칼슘 투과도 증가... 활동전위 형성억제... 침전 생겨서 주사로 맞지…
Mephenytoin... Ethotoin
phenytoin 유사 약물
19 terms
Antiseizure
seizure
convulsion
epilepsy
Epilepsy is higher in what population?
brief episode of abnormal electrical activity in nerve cells…
tonic-clonic seizure, spasmodic contractions of involuntary m…
chronic or recurrent event, abnormal excessive electoral disc…
young children and older adults
seizure
brief episode of abnormal electrical activity in nerve cells…
convulsion
tonic-clonic seizure, spasmodic contractions of involuntary m…
42 terms
Antiseizure
result from bursts of abnormal synchro…
mechanism of action of antiseizure drugs
the binding of GABA causes _____ influ…
activation of these receptors enables…
seizures
induce hyperpolarization or inhibit depolarization
chloride
NMDA, AMPA, KA
result from bursts of abnormal synchro…
seizures
mechanism of action of antiseizure drugs
induce hyperpolarization or inhibit depolarization
18 terms
ANTISEIZURE
TEGRETOL
TOPAMAX
MYSOLINE
DEPAKOTE
CARBAMAZEPINE
TOPIRAMATE
PRIMIDONE
DIVALPROEX
TEGRETOL
CARBAMAZEPINE
TOPAMAX
TOPIRAMATE
10 terms
Antiseizure
phenobarbital (Luminal)
diazepam (Valium)... lorazepam (Ativan)... c…
phenytoin (Dilantin)
gabapentin (Neurontin)- neuropathic pa…
Barbituates... ACTION: decreases conduction through nerve pathwa…
Benzodiazepine... ACTION: potentiates effects of GABA... SE: CNS de…
Hydantoins... ACTION: decreases sodium influx... SE: CNS depression…
Gama-Aminobutyric Acid Analog... SE: CNS depression, N/V
phenobarbital (Luminal)
Barbituates... ACTION: decreases conduction through nerve pathwa…
diazepam (Valium)... lorazepam (Ativan)... c…
Benzodiazepine... ACTION: potentiates effects of GABA... SE: CNS de…
11 terms
Antiseizure
Phenytoin
Phenobarbital
Clonazepam
Diazepam
Dilantin (Hydantoin)
Solfoton, Luminal (Barbituate)
Klonopin (Benzo)
Valium (Benzo)
Phenytoin
Dilantin (Hydantoin)
Phenobarbital
Solfoton, Luminal (Barbituate)
25 terms
Antiseizure
Diazepam's trade name
Diazepam's therapeutic class
Diazepam's therapeutic use
Diazepam's pharmacologic class
Valium
antiseizure drug
adjunct in management of absence, tonic-clonic, & myoclonic
Benzpdiazepine; GABAa receptor agonist
Diazepam's trade name
Valium
Diazepam's therapeutic class
antiseizure drug
8 terms
Antiseizure
Ethosuximide
Carbamazepine
Valproate (valproic acid and sodium va…
Iamotrigine
MoA: blocks T-type calcium channels on thalamic relay neurons…
MoA: prolongs the inactive state of sodium channels following…
MoA: prolongs the inactive state of voltage-gated sodium chan…
MoA: prolong the inactive state of voltage-gated Na channels;…
Ethosuximide
MoA: blocks T-type calcium channels on thalamic relay neurons…
Carbamazepine
MoA: prolongs the inactive state of sodium channels following…
17 terms
Antiseizure
Dilantin
tonic/clonic
Swollen red gums, gums may grow over t…
More than initial drowsiness, ataxia,…
This drug binds to plasma proteins
Dilantin is for what type of seizures?
Side effects of DIlantin
Toxicity signs of Dilantin
Dilantin
This drug binds to plasma proteins
tonic/clonic
Dilantin is for what type of seizures?
14 terms
Antiseizure
Phenytoin
Carbamazepine
Valproic acid
Phenobarbital
all forms except absence, blockade of sustained high freq fir…
most forms except absence, partial with complex symptoms, man…
all types, esp absence, less effective in complex partial, ma…
enhance GABA inhibitory pathways, se-sedation, irritability,…
Phenytoin
all forms except absence, blockade of sustained high freq fir…
Carbamazepine
most forms except absence, partial with complex symptoms, man…
32 terms
antiseizure
function of drugs fo generalized seizu…
drugs for generalized seizures
category: hydantoins
phenytoin (dilantin)
stabilize neve membranes... effects mainly on CNS... effect entire
hydantoins-phenytoin (dilantin)... barbituates - phenobarbital (…
phenytoin (dilantin)
stabilize nerve membranes, reduce conduction = reduce movemen…
function of drugs fo generalized seizu…
stabilize neve membranes... effects mainly on CNS... effect entire
drugs for generalized seizures
hydantoins-phenytoin (dilantin)... barbituates - phenobarbital (…
16 terms
Antiseizure
valpoic acid
lamotrigine
phenobarbital
topiramate
S,C, T-C, A... -GABA & Na... -wt gain
S,C,T-C,A... -Na
S,C,T-C... -GABA
S,C,T-C... -GABA & Na
valpoic acid
S,C, T-C, A... -GABA & Na... -wt gain
lamotrigine
S,C,T-C,A... -Na
35 terms
Antiseizure
phenytoin, fosphenytoin
phenobarbital
Primidone
Ethosuximide
Block high-frequency firing of VG Na+channels (prolong inacti…
Inhance phasic GABA-A receptor--> prolong Cl- open... (post-synp…
Action similar to phenytoin... Meta to phenobarbital &PEMA, all…
Reduces low threshold Ca2+currents (T-type=pacemaker potentia…
phenytoin, fosphenytoin
Block high-frequency firing of VG Na+channels (prolong inacti…
phenobarbital
Inhance phasic GABA-A receptor--> prolong Cl- open... (post-synp…
16 terms
antiseizure
inhibitory: neuron ___________
gaba __--
excitatory: neuron__-
major excitatory neuron
hyperpolarization... cl in, k out... major: gaba
inhibits the generation of AP
depolarization... na in, ca out
gluatamate
inhibitory: neuron ___________
hyperpolarization... cl in, k out... major: gaba
gaba __--
inhibits the generation of AP
68 terms
Antiseizure
epilepsy
seizure
convulsions
causes of seizures
-chronic, recurrent pattern of seizures... Most prevalent…
abnormal electrical activity of the brain
spasmodic contractions of involuntary muscles
Infectious Diseases... Trauma- brain surgery inc risk ... Metabo…
epilepsy
-chronic, recurrent pattern of seizures... Most prevalent…
seizure
abnormal electrical activity of the brain
13 terms
antiseizure
phenytoin mechanism
phenytoin metabolism
time for phenytoin to reach steady state
what 2 drugs increase free levels of p…
non sedating, blocks sodium channels, highly bound to plasma…
non linear, shifts from 1st order to zero order at moderate t…
5-7 days at low concentration, 4-6 weeks at high conc.
sulfonamides and valproic acid displace it from albumin
phenytoin mechanism
non sedating, blocks sodium channels, highly bound to plasma…
phenytoin metabolism
non linear, shifts from 1st order to zero order at moderate t…
10 terms
Antiseizure
What classification of drug is lorazep…
You are working in the local ED and a…
You are an excellent nurse and immedia…
In the event that lorazepam is not rea…
Benzodiazepine
Drowsiness, Amnesia, sedation
not to exceed 2 mg/min.
Diazepam (Valium)
What classification of drug is lorazep…
Benzodiazepine
You are working in the local ED and a…
Drowsiness, Amnesia, sedation
Antiseizure
Benzodiazepines
Carbamazepine (Tegretol)
Divalproex (Depakote, Valcote)
Ethosuximide (Zarontine)
increase GABA-ergic neurotransmission
decrease Na+ channel activity... like phenytoin but less CNS dep…
slows NA+ channel recovery... inhibits T-type Ca2+ channels... incr…
inhibits T-type Ca2+ channels
Benzodiazepines
increase GABA-ergic neurotransmission
Carbamazepine (Tegretol)
decrease Na+ channel activity... like phenytoin but less CNS dep…
39 terms
Antiseizure
how do benzodiazepines work?
what are the three main indications fo…
can most benzodiazepines be safely adm…
name two major adverse effects of benz…
they bind to the GABA receptor-chloride channel complex and i…
anxiety, insomnia, seizures
no
CNS depression, anterograde amnesia. sedation may decrease ov…
how do benzodiazepines work?
they bind to the GABA receptor-chloride channel complex and i…
what are the three main indications fo…
anxiety, insomnia, seizures
26 terms
Antiseizure
phenytoin
fosphenytoin
carbamazepine
oxcarbazepine
cyclic ureide... block high frequency firing of VG Na+ channels…
cyclic ureide... block high frequency firing of VG Na+ channels…
tricyclic... blocks high-frequency firing of VG Na+ channels ... de…
tricyclic... blocks high-frequency firing of VG Na+ channels ... de…
phenytoin
cyclic ureide... block high frequency firing of VG Na+ channels…
fosphenytoin
cyclic ureide... block high frequency firing of VG Na+ channels…
32 terms
antiseizure
drug of choice of myclonic seizure
what is partial seizures
generazized serizuires
secndary genrazlied seizure
levetiracetam
portion of te brain... consciousness preserve
both hemispheres... consciousness not preserved
partial seizure can also sprread and involve both meispheres
drug of choice of myclonic seizure
levetiracetam
what is partial seizures
portion of te brain... consciousness preserve
20 terms
Antiseizure
1st generation drugs are effective in…
What are mechanisms of action for 1st…
Carbamazepine
Lamotrigine
generalized tonic-clonic... partial seizures
prolong inactivation of voltage-sensitive Na channels, potent…
tricyclic compound related to TCA with broad spectrum of acti…
Treatment: partial seizures, generalized toni-clonic, lennox-…
1st generation drugs are effective in…
generalized tonic-clonic... partial seizures
What are mechanisms of action for 1st…
prolong inactivation of voltage-sensitive Na channels, potent…
Antiseizures
Tonic clonic and partial
Absence seizure
Myoclonic seizures
Simple Partial Seizures
Carbamazepine, lamotrigine, phenytoin, valproic acid
Clonazepam, ethosuximide, valproic acid
Clonazepam, lamotrigine, valproic acid
preserved consciousness, convulsive jerking, paresthesia, psy…
Tonic clonic and partial
Carbamazepine, lamotrigine, phenytoin, valproic acid
Absence seizure
Clonazepam, ethosuximide, valproic acid
23 terms
Antiseizures
Diazepam
Lorazepam
Carbamazepine
Eslicarbazepine
Benzodiazepines: enhanced GABA-mediated behavior --> reduces…
Benzodiazepines: enhanced GABA-mediated behavior --> reduces…
MOA: blocks sodium channels --> stops repetitive action poten…
MOA: blocks sodium channels --> stops repetitive action poten…
Diazepam
Benzodiazepines: enhanced GABA-mediated behavior --> reduces…
Lorazepam
Benzodiazepines: enhanced GABA-mediated behavior --> reduces…
40 terms
Antiseizures
What is a seizure?
What can cause seizures?
Epilepsy
Partial(Focal)
"Turning all of the lights all at once?"... Consistent ... Please…
Illness, trauma, tumor, fever, mental thangssss... Epilepsy !…
Chronic recurring seizures ... 2 unprovoked seizures separated…
Simple~ no loss in consciousness... Complex~impaired consciousn…
What is a seizure?
"Turning all of the lights all at once?"... Consistent ... Please…
What can cause seizures?
Illness, trauma, tumor, fever, mental thangssss... Epilepsy !…
26 terms
Antiseizures
Phenytoin MOA
Phenytoin side effects
Primidone MOA
Carbamazepine MOA
decreases activity of Na+ channels... Also affects K+ and Ca2+…
Double vision ... Ataxia... Gingival hyperplasia... Hirsutism
decreases activity of Na+ channels
decreases activity of Na+ channels
Phenytoin MOA
decreases activity of Na+ channels... Also affects K+ and Ca2+…
Phenytoin side effects
Double vision ... Ataxia... Gingival hyperplasia... Hirsutism
11 terms
Antiseizures
Phenobarbitol
Diazepam
Gabapentin
Phenytoin
- 2-3wk to reach ther levels... - Long acting= long half-life... -…
- 1st line of tx during seizure, IV... - O2 and pt on bedrest fo…
- at bedtime... - Give with food... - Blocks tetany
- drug of choice, oldest... - Highly protein bound... - Tx seizures…
Phenobarbitol
- 2-3wk to reach ther levels... - Long acting= long half-life... -…
Diazepam
- 1st line of tx during seizure, IV... - O2 and pt on bedrest fo…
13 terms
Antiseizures
What are the warning for oxcarbazepine?
What is suggested with oxcarbazepine f…
What are the warnings for phenytoin?
Is genetic screening suggested for phe…
May lead to Steven-Johnson Syndrome and toxic epidermal necro…
genetic screening
SJS/TEN (toxic epidermal necrolysis)
No
What are the warning for oxcarbazepine?
May lead to Steven-Johnson Syndrome and toxic epidermal necro…
What is suggested with oxcarbazepine f…
genetic screening
19 terms
Antiseizure Agents
Epilepsy
Heterogenous symptom complex
Seizures
Sacire
3rd most common neurologic disorder
A chronic disorder characterized by recurrent seizures
From the latin word sacire... Finite episodes of the brain dysfu…
It means "to take possession of"
Epilepsy
3rd most common neurologic disorder
Heterogenous symptom complex
A chronic disorder characterized by recurrent seizures
169 terms
Antiseizure Drugs
Symptoms of seizure vary. Why?
A ______ seizure is one that is associ…
What are the 2 generalized seizures?
(t/f) Partial seizures are associated…
it depends on what part of the brain is being effected
partial
grand mal and absence
false, they are not
Symptoms of seizure vary. Why?
it depends on what part of the brain is being effected
A ______ seizure is one that is associ…
partial
Antiseizure drugs
Epilepsy... epidemiology
Therapy is symptomatic
Compliance with medication is a majo…
Epilepsy is a CHRONIC brain disorder c…
1% of the world's population has epilepsy... ~2.5 million people…
-Available drugs inhibit seizures, but effective prophylaxis…
Need for long-term therapy ... Unwanted effects are common for m…
recurrent and unpredictable seizures
Epilepsy... epidemiology
1% of the world's population has epilepsy... ~2.5 million people…
Therapy is symptomatic
-Available drugs inhibit seizures, but effective prophylaxis…
83 terms
Antiseizure Drugs
Important Drugs:
Antiseizure Drugs: target
Seizure: classification (2)... -How are t…
Partial Seizures: (2)
1. Phenytoin... 2. Fosphenytoin... 3. Carbamazepine... 4. Phenobarbita…
normal neurons --> limit seizure spread
1. Partial: unilateral onset (may generalize)... -Often associat…
1. Simple: no loss of consciousness, motor, sensory, other, 3…
Important Drugs:
1. Phenytoin... 2. Fosphenytoin... 3. Carbamazepine... 4. Phenobarbita…
Antiseizure Drugs: target
normal neurons --> limit seizure spread
169 terms
Antiseizure Drugs
Symptoms of seizure vary. Why?
A ______ seizure is one that is associ…
What are the 2 generalized seizures?
(t/f) Partial seizures are associated…
it depends on what part of the brain is being effected
partial
grand mal and absence
false, they are not
Symptoms of seizure vary. Why?
it depends on what part of the brain is being effected
A ______ seizure is one that is associ…
partial
18 terms
Antiseizure Agents
Tegretol
Topamax
Mysoline
Depakote
carbamazepine
topiramate
primidone
divalproex
Tegretol
carbamazepine
Topamax
topiramate
18 terms
antiseizure agents
tegretol
topamax
mysoline
depakote
carbamazepine
topiramate
primidone
divalproex
tegretol
carbamazepine
topamax
topiramate
8 terms
Antiseizure 3
Trileptal
Dilantin
Zonegran
Gabitril
Oxcarbazepine
Phenytoin
Zonisamide
Tiagabine
Trileptal
Oxcarbazepine
Dilantin
Phenytoin
119 terms
Antiseizure Drugs
True or False... Complete understanding…
What is the difference in location for…
True or False... GABA-A receptors have a…
This drug alloesterically binds to the…
True
GABA-A are located in the CNS. Thus, antiseizure... GABA-B are…
True... This is significant because Non-benzodiazepine hyponoti…
Barbiturates (Phenobarbital, mephobarbital, primidone and man…
True or False... Complete understanding…
True
What is the difference in location for…
GABA-A are located in the CNS. Thus, antiseizure... GABA-B are…
55 terms
Antiseizure Drugs-
What drugs bind the inactive sodium ch…
Phenytoin
Phenytoin is a?
Fosphenytoin
Phenytoin... lamotrigine... oxcarbazepine... carbamazepine... valproate... t…
hydantoins
What drugs bind the inactive sodium ch…
Phenytoin... lamotrigine... oxcarbazepine... carbamazepine... valproate... t…
Phenytoin
18 terms
Antiseizure Agents
ativan
valium
luminal
Trileptal
lorazepam
diazepam
phenobarbital
oxcarbazepine
ativan
lorazepam
valium
diazepam
18 terms
Antiseizure Agents
Tegretol
Topamax
Mysoline
Depakote
carbamazepine
topiramate
primidone
divalproex
Tegretol
carbamazepine
Topamax
topiramate
18 terms
Antiseizure Agents
Tegretol
Topamax
Mysoline
Depakote
carbamazepine
topiramate
primidone
divalproex
Tegretol
carbamazepine
Topamax
topiramate
13 terms
Antiseizure Overview
what is the difference between a seizu…
what causes seizures?
epilepsy
what are the three types of seizures
a seizure may be characterized with or without visible change…
low blood sugar, fever, electrolyte imbalance, drug overdose,…
it is the excessive discharge or nerve cells caused by abnorm…
*partial: localized, only affect one hemisphere of the brain…
what is the difference between a seizu…
a seizure may be characterized with or without visible change…
what causes seizures?
low blood sugar, fever, electrolyte imbalance, drug overdose,…
12 terms
Antiseizure Agents
Carbamazepine
Valproate
Ethosuximide
Diazepam
asdf
...
...
...
Carbamazepine
asdf
Valproate
...
18 terms
antiseizure agents
tegretol
topamax
mysoline
depakote
carbamazepine
topiramate
primidone
divalproex
tegretol
carbamazepine
topamax
topiramate
25 terms
Antiseizure Drugs
Diazepam: trade name
Diazepam: therapeutic class
Diazepam: therapeutic use
Diazepam: pharmacologic class
Valium
antiseizure drug
adjunct in management of absence, tonic-clonic, and myoclonic…
benzodiazepine;... GABA-A receptor agonist
Diazepam: trade name
Valium
Diazepam: therapeutic class
antiseizure drug
12 terms
Flynt Antiseizure
GENERALIZED ANTI-SEIZURE MEDS
HYDANTOINS
BARBITUATES (Phenobarbital)
MODIFIES INHIBITORY NEUROTRANSMITTER G…
HYDANTOINS: phenitoin, fosphenytoin)... BARBITUATES: phenobarbit…
Interfere W/ Sodium Influx... Anti-siezure med that also has -AN…
Generalized seizure, also sedative/ hypnotic... -used as pre-op…
Theraputic class: ANTICONVULSANT, also antiglaucoma agent, DI…
GENERALIZED ANTI-SEIZURE MEDS
HYDANTOINS: phenitoin, fosphenytoin)... BARBITUATES: phenobarbit…
HYDANTOINS
Interfere W/ Sodium Influx... Anti-siezure med that also has -AN…
63 terms
Antiseizure drugs
electroencephalogram
maximal electroshock (MES) test
maximal electroshock (MES) test
vagus nerve stimulation (VNS)
respond to ethosuximide and valproate but can be exacerbated…
with suppression of the tonic extensor phase, identifies drug…
the major initial screen for new drugs has led predominantly…
nonpharmacologic treatment for epilepsy now widely approved f…
electroencephalogram
respond to ethosuximide and valproate but can be exacerbated…
maximal electroshock (MES) test
with suppression of the tonic extensor phase, identifies drug…
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