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Study sets matching "antiviral"

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Study sets matching "antiviral"

22 terms
Antiviral
Antiviral development
Herpes Simplex Virus (HSV) ... Acyclovir
HSV Antiviral Agents... Valacyclovir prod…
HSV Antiviral Agents... Valganciclovir pr…
Prevention of Viral Entry... Targeting the RNA/DNA replication i…
1 st class. Guanine Nucleoside analogues.
HSV-1, HSV-2,VZV: Spectrum of activity.
CMV, EBV: Spectrum of activity.
Antiviral development
Prevention of Viral Entry... Targeting the RNA/DNA replication i…
Herpes Simplex Virus (HSV) ... Acyclovir
1 st class. Guanine Nucleoside analogues.
22 terms
antiviral
Nucleosides
Idoxuridine
Trifluridine
Cidofovir
generally prodrugs that need to be activated to the triphosph…
Pyrimidines... T analog. ... Prodrug... Opthalmic drops for HSV/VZV in…
Pyrimidines... Trifluoro derivative of thymidine... Prodrug... Better…
Pyrimidines... Acyclic cytidine pyrimidine nucleotide analog. ... R…
Nucleosides
generally prodrugs that need to be activated to the triphosph…
Idoxuridine
Pyrimidines... T analog. ... Prodrug... Opthalmic drops for HSV/VZV in…
24 terms
Antiviral
-avir
-ivir
-ovir
Enfuvirtide... Maraviroc
AIDS... (A for A)
Influenza... (i for i)
Herpes... prodrugs, nucleoSides... (Oh! I got herpes)
Blocks viral penetration
-avir
AIDS... (A for A)
-ivir
Influenza... (i for i)
28 terms
Antiviral
Acyclovir
Valacyclovir
Cidofovir
Famiciclovir
Guanine
Prodrug
Acyclic pyrimidine
Purine nucleoside analog of guanine... Prodrug... Oxidizes and beco…
Acyclovir
Guanine
Valacyclovir
Prodrug
33 terms
antiviral
virus
virus classification
Baltimore classification
dsDNA-RT virus
-obligate, intracellular parasite... -active - intracellular act…
-animal, plant, eukaryotic, bacteria
-nucleic acid... -single-stranded or double stranded... -+ strand m…
-contain partially closed (gapped) ds DNA which on infection…
virus
-obligate, intracellular parasite... -active - intracellular act…
virus classification
-animal, plant, eukaryotic, bacteria
10 terms
Antiviral
Amantadine
Oseltamivir
Lamivudine
Abacavir
PMS-AMANTADINE
TAMIFLU
HEPTOVIR
ZIAGEN
Amantadine
PMS-AMANTADINE
Oseltamivir
TAMIFLU
8 terms
Antiviral
Antiviral Drugs
Antiviral Drug Selectivity
Drugs for Herpes virus (1, 2, Zoster)-…
Retrovirus drug resistance
Has own gene... Target viral PRO
1. Prodrug that's activated by an ezn encoded by viral genome…
Acyclovir
Low fidelity (high error rate, no proof reading)... Rapid mutati…
Antiviral Drugs
Has own gene... Target viral PRO
Antiviral Drug Selectivity
1. Prodrug that's activated by an ezn encoded by viral genome…
16 terms
Antiviral
Idoxuridine... -THYMIDINE analog... -tripho…
Acyclovir... -GUANINE analog & purine ba…
6-deoxyacyclovir... -Xanthine oxidase re…
Valacyclovir... -amino acid ester prodru…
Idoxuridine... -THYMIDINE analog... -tripho…
Acyclovir... -GUANINE analog & purine ba…
125 terms
Antiviral
Antiviral activity is predominantly __…
Interferons inhibit what stage(s) of v…
Proteases inhibit what stage(s) of vir…
Neuraminidases inhibit what stage(s) o…
virustatic... - Allows for suppression of viral replication so…
Translation and Assembly
Post-translational modification via proteolytic cleavage
Release/budding
Antiviral activity is predominantly __…
virustatic... - Allows for suppression of viral replication so…
Interferons inhibit what stage(s) of v…
Translation and Assembly
8 terms
antiviral
nucleoside analogs MOA:
selective toxicity
antiviral drugs
nucleoside analog HIV reverse transcri…
nucleosides are precursors to nucleotides. (think nucleotide)…
viruses incorporate these "fakes" more rapidly than do cells
acyclovir (zovirax)- treat herpes simplex and herpes zoster (…
azidothymidine (AZT)- used to treat HIV... MOA: HIV is an RNA vi…
nucleoside analogs MOA:
nucleosides are precursors to nucleotides. (think nucleotide)…
selective toxicity
viruses incorporate these "fakes" more rapidly than do cells
22 terms
Antiviral
Oseltamivir and zanamivir
Oseltamivir
Zanamivir
Amantadine and rimantadine
These viral release inhibitors are effective against flu A/B
This viral release inhibitor is administered orally every year
This viral release inhibitor is administered via inhalation o…
These uncoating inhibitors are effective against flu A
Oseltamivir and zanamivir
These viral release inhibitors are effective against flu A/B
Oseltamivir
This viral release inhibitor is administered orally every year
42 terms
Antiviral
What is the infectious cycle for RNA V…
What is the infectious cycle for DNA v…
What is the infectious cycle for Retro…
Can you kill Viruses? Why or why not?
Utilizes cellular machinery to make more of their own acids…
Coated with envelope... Enters cell membrane ---> messes everyth…
Infectious virus binds to cell membranes, enters cell, takes…
No... Viruses are not alive... Use virustatic (not cidal) drugs
What is the infectious cycle for RNA V…
Utilizes cellular machinery to make more of their own acids…
What is the infectious cycle for DNA v…
Coated with envelope... Enters cell membrane ---> messes everyth…
7 terms
antiviral
idoxuridine
ganciclovir
vidarabine
ribavirin
antiviral... treat corneal infections... suppresses bone marrow
antiviral... treat cmv eye infections in aids... suppress bone ma…
antiviral... viral encephalitis... less toxic than other antivira…
antiviral... treat herpes lesions (topical_ influenza (aerosol)…
idoxuridine
antiviral... treat corneal infections... suppresses bone marrow
ganciclovir
antiviral... treat cmv eye infections in aids... suppress bone ma…
34 terms
Antiviral
maraviroc
docosanol
enfuvirtide
raltegravir
HIV... inhibit attachment
HSV... inhibit fusion
HIV... inhibit fusion
HIV... inhibit integration
maraviroc
HIV... inhibit attachment
docosanol
HSV... inhibit fusion
7 terms
Antiviral
acyclovir
acyclovir
antiretroviral
foscarnet and cidofovir
prototype antiviral
inhibits viral replication by interfering with attachment of…
agents that control HIV
antivirals that can cause renal toxicity
acyclovir
prototype antiviral
acyclovir
inhibits viral replication by interfering with attachment of…
10 terms
Antiviral
Cap tab syr amantadine
Cap susp oseltamvir
Tab soln lamivudine
Tab soln abacavir
Pms-Amantadine
Tamiflu
Heptovir
Ziagen
Cap tab syr amantadine
Pms-Amantadine
Cap susp oseltamvir
Tamiflu
6 terms
Antiviral
Efavirenz
Emtricitabine/ Tenofovir
Entecavir
Acyclovir
Sustiva
Truvada
Baraclude
Zovirax
Efavirenz
Sustiva
Emtricitabine/ Tenofovir
Truvada
33 terms
Antiviral
Antiviral Mechanism of Action
Assessment before administration
Antiviral Adverse effects
Therapeutic effect of antiviral
INHIBIT VIRAL REPLICATION... block activity of polymerase enzym…
-Head-to-toe physical ... -Medical and medication history... -Docum…
because viruses reproduce in human cells, selective killing i…
non-HIV antivirals and HIV antiretrovirals include eliminatio…
Antiviral Mechanism of Action
INHIBIT VIRAL REPLICATION... block activity of polymerase enzym…
Assessment before administration
-Head-to-toe physical ... -Medical and medication history... -Docum…
16 terms
Antiviral
Antiretroviral MOA
Oseltamavir, Zanamivir
Acyclovir MOA
Acyclovir Use
Fusion (attachment via CCR5): Maraviroc... Fusion (penetration):…
influenze... inhibit neuraminidase; less release
guanosine analog; monophosphorylated by TK (HSV/VZV), other 2…
HSV, VZV... minimal against EBV... no effect on latent HSV and VZV…
Antiretroviral MOA
Fusion (attachment via CCR5): Maraviroc... Fusion (penetration):…
Oseltamavir, Zanamivir
influenze... inhibit neuraminidase; less release
23 terms
Antiviral
Agents for Influenza A and Respiratory…
AGENTS FOR INFLUENZA A AND RESPIRATORY…
Characteristics of Antiviral Drugs
Influenza A and Respiratory Viruses Dr…
amantadine (Symmetrel)... oseltamivir (Tamiflu)... ribavirin (Rebetr…
The exact mechanism of action of drugs that combat Influenza A…
Able to enter the cells infected with virus... Interfere with vi…
Action - Prevent shedding of the viral protein coat... Pharmaco…
Agents for Influenza A and Respiratory…
amantadine (Symmetrel)... oseltamivir (Tamiflu)... ribavirin (Rebetr…
AGENTS FOR INFLUENZA A AND RESPIRATORY…
The exact mechanism of action of drugs that combat Influenza A…
10 terms
Antiviral
amantadine
oseltamivir
lamivudine
abacavir
PMS amantadine
tamiflu
heptovir
Ziagen
amantadine
PMS amantadine
oseltamivir
tamiflu
21 terms
Antiviral
viral infections
herpes
influenza
MOA
caused by smaller agents than bacteria, direct contact, inges…
skin outbreak causing blister-like eruptions caused by a virus
respiratory tract infection
inhibit penetration of host cell
viral infections
caused by smaller agents than bacteria, direct contact, inges…
herpes
skin outbreak causing blister-like eruptions caused by a virus
8 terms
Antiviral
Acyclovir & Penciclovir
Cidofovir
Famciclovir
Ganciclovir
Acyclic Guanine
Acyclic pyrimidine nucleotide analog of cytosine
Synthetic purine nucleoside analog of guanine
Acyclic deoxyguanosine analog
Acyclovir & Penciclovir
Acyclic Guanine
Cidofovir
Acyclic pyrimidine nucleotide analog of cytosine
6 terms
Antiviral
HSV/VZV
CMV/Herpes
Flu
RSV
Acyclovir ... valacyclovir ... abreva
ganciclovir ... valganciclovir ... foscarnet ... cidofovir
Tamiflu ... Relenza ... Symmetrel ... Flumadine
Ribavirin
HSV/VZV
Acyclovir ... valacyclovir ... abreva
CMV/Herpes
ganciclovir ... valganciclovir ... foscarnet ... cidofovir
39 terms
Antiviral
Antivirals are virustatic meaning
Amantadine
Zanamivir
Oseltamivir
They don't destroy viruses. But slow the rate of virus replic…
Effective against influenza A only ... No longer recommended. Du…
Relenza inhaled powder tx and prophylaxis of Influenza A and B
Tamiflu caps and suspension tx of A and b influenza
Antivirals are virustatic meaning
They don't destroy viruses. But slow the rate of virus replic…
Amantadine
Effective against influenza A only ... No longer recommended. Du…
20 terms
Antiviral
Antiviral drugs
Targets of antiviral drugs
Entry inhibitors
Non-nucleoside reverse transcriptase i…
-Narrow therapeutic index... -Targets viruses through nucleoside…
-viral uncoating... -nucleoside analogs... -non-nucleoside polymera…
-Prevent entry of virus to host cell... -block Gp41 on virus... -OR…
-Inhibits reverse transcriptase by binding at a different sit…
Antiviral drugs
-Narrow therapeutic index... -Targets viruses through nucleoside…
Targets of antiviral drugs
-viral uncoating... -nucleoside analogs... -non-nucleoside polymera…
28 terms
Antiviral
Viral replication
Why are viruses difficult to kill?
Viral illnesses
Antiviral drugs
Virus can't replicate on its own -- uses host cell... Uses host…
Because they live inside the cell
Bothersome, but survivable
Kill or suppress the virus by destroying virions or inhibitin…
Viral replication
Virus can't replicate on its own -- uses host cell... Uses host…
Why are viruses difficult to kill?
Because they live inside the cell
10 terms
Antiviral
Amantadine
Oseltamivir
Lamivudine
Abacavir
Pms-amantadine(cap, tab, syr)
Tamiflu (cap,sup)
Heptovir(tab,soln)
Ziagen(tab,soln)
Amantadine
Pms-amantadine(cap, tab, syr)
Oseltamivir
Tamiflu (cap,sup)
44 terms
antiviral
viruses replicate by
attachment--> virus
HIV DRUG for inh of attachment
uncoting--? virus?
taking over transaltional machinery of the host ... -viral infec…
HIV
maraviroc
influenza A
viruses replicate by
taking over transaltional machinery of the host ... -viral infec…
attachment--> virus
HIV
23 terms
antiviral
Amantadine
Oseltamir
Trifluridine
Acyclovir
Flu drug... Prophalaxis of Flu A; blocks M2 so uncoating doesn…
Flu drug... Prophalaxis/treatment of A/B... competitive inhibitor…
Herpes drug... Thymidine analog; interfaces DNA so synthesis c…
Herpes drug... Inhibits herpes DNA polymerase (phosphorylated…
Amantadine
Flu drug... Prophalaxis of Flu A; blocks M2 so uncoating doesn…
Oseltamir
Flu drug... Prophalaxis/treatment of A/B... competitive inhibitor…
36 terms
antiviral
HSV, VZV DOC
acyclovir ... chemistry, activation, MOA
acyclovir drug resistance
valacyclovir
acyclic drugs:... acyclovir, valacyclovir, penciclovir, famciclo…
guanosine analog... act: converted to acyclo-MP by viral thymidi…
gene mutations in tk and/or viral DNA polymerase
improved oral bioavailability
HSV, VZV DOC
acyclic drugs:... acyclovir, valacyclovir, penciclovir, famciclo…
acyclovir ... chemistry, activation, MOA
guanosine analog... act: converted to acyclo-MP by viral thymidi…
34 terms
Antiviral
Acyclovir
Penciclovir
Vidarabine
Vidarabine
H. simplex I and II ... H. zoster and Varicella ... not good for C…
inhibition of viral DNA polymerase... more stable than acyclovir…
--> arabinoside (active ) ... ใช้รักษา Herpetic keratinoconjunci…
2% IV - herpetic encephalopathy
Acyclovir
H. simplex I and II ... H. zoster and Varicella ... not good for C…
Penciclovir
inhibition of viral DNA polymerase... more stable than acyclovir…
8 terms
antiviral
new HIV meds
HSV med
valacyclovir
protease inhibitors risk
triumeq ... elvitegravir (EVG) or viteka... cobstat or tybost
acyclovir, gangliocyclovir... guanosine neuucloside analog... thym…
valacyclovir is an esterified or pro-drug form of acylovir
lipodystrophy
new HIV meds
triumeq ... elvitegravir (EVG) or viteka... cobstat or tybost
HSV med
acyclovir, gangliocyclovir... guanosine neuucloside analog... thym…
11 terms
antiviral
Acycolvir
Vancyclovir
Oseltamivir
Zanamivir
Selectivy toxicity - thymidine kinase phosphorlayted ... Confusi…
more effective in treating recurrent symptoms
influenza... better 1 year
influenze ... better 7 years (inhalant)
Acycolvir
Selectivy toxicity - thymidine kinase phosphorlayted ... Confusi…
Vancyclovir
more effective in treating recurrent symptoms
49 terms
Antiviral
Antivirals
For Herpes Infections - Nucleoside ana…
acyclovir (parenteral, oral, topical)
valacyclovir (oral)
...
require metabolism to active triphosphates, have activity aga…
Antivirals, For Herpes Infections - Nucleoside analogues, req…
Prodrug of acyclovir, For Herpes Infections - Nucleoside anal…
Antivirals
...
For Herpes Infections - Nucleoside ana…
require metabolism to active triphosphates, have activity aga…
14 terms
antiviral
Stage I
Stage II
Stage III
stage IV
HIV infection is asymptomatic & not categorized as AIDS
includes minor mucocutaneous manifestations and recurrent upp…
includes unexplained chronic diarrhea for longer than a month…
includes toxoplasmosis of the brain, candidiasis of the esoph…
Stage I
HIV infection is asymptomatic & not categorized as AIDS
Stage II
includes minor mucocutaneous manifestations and recurrent upp…
30 terms
Antiviral
Amantadine
Zanamivir
Oseltamivir
Iodoxuridine
Flu symmetric tricyclic amines uncoating inhibitor
Flu substrate analogues neuraminidase inhibitor relenza
Flu substrate analogues neuraminidase inhibitor Tamiflu
Herpes uridine derivatives thymidylate kinase inhibitor IUdR
Amantadine
Flu symmetric tricyclic amines uncoating inhibitor
Zanamivir
Flu substrate analogues neuraminidase inhibitor relenza
Antiviral
Osetamivir
Zanamivir
Peramivir
Amantadine
Neuraminidase inhibitor ... - Treatment and prophylaxis of infl…
Neuraminidase inhibitor ... - Treatment and prophylaxis of infl…
Neuraminidase inhibitor ... - Treatment and prophylaxis of infl…
Viral uncoating inhibitor... - Resistance - don't use for flu…
Osetamivir
Neuraminidase inhibitor ... - Treatment and prophylaxis of infl…
Zanamivir
Neuraminidase inhibitor ... - Treatment and prophylaxis of infl…
16 terms
Antiviral
type-specific surface proteins of infl…
antibody against hemagglutinin action
antibody against neuraminiase action
analog of sialic acid (drug class)
16 hemagglutinin (H) & 9 neuraminidase (N) subtypes
neutralize infectivity and prevent disease
reduce amount of virus released and spread
neuraminidase inhibitor
type-specific surface proteins of infl…
16 hemagglutinin (H) & 9 neuraminidase (N) subtypes
antibody against hemagglutinin action
neutralize infectivity and prevent disease
17 terms
Antiviral
acyclovir
ganciclovir
cidofovir, foscarnet
ribavirin
guanosine anolog, HSV, VZV, nephropathy
guanosine analog, CMV
viral DNA polymerase inhibitor, CMV retinitis in IC patients,…
guanine nucleotide synthesis, RSV, HCV
acyclovir
guanosine anolog, HSV, VZV, nephropathy
ganciclovir
guanosine analog, CMV
21 terms
Antiviral
Acyclovir
Valacyclovir
Famicyclovir
Trifluridine
HHV 2,3. vThymidine kinase, DNA polymerase, chain termination
HHV 2,3. vThymidine kinase, DNA polymerase, chain termination
HHV 2,3. vThymidine kinase, DNA polymerase, chain termination
Ocular HHV 1,2. Inhibits vDNA synthesis
Acyclovir
HHV 2,3. vThymidine kinase, DNA polymerase, chain termination
Valacyclovir
HHV 2,3. vThymidine kinase, DNA polymerase, chain termination
Antiviral
acyclovir
famiciclovir
valacyclovir
oseltamivir
Zovirax... Sitavig
Famvir
Valtrex
Tamiflu
acyclovir
Zovirax... Sitavig
famiciclovir
Famvir
66 terms
Antiviral
anti influenza agents
amantadine drug type
rimantadine drug type
only use of amantadine and rimantadine
amantadine, rimantadine, oseltamivir
anti influenza agent
anti influenza agent
prophylaxis and treatment of influenza A viruses
anti influenza agents
amantadine, rimantadine, oseltamivir
amantadine drug type
anti influenza agent
33 terms
Antiviral
Amantadine
Zanamivir and oseltamivir
Zanamivir
Oseltamivir
Tx for Anti-parkinson's
Influenza types A & B
Effective when administered before and after the exposure
Effective when administered within 2 days of influenza symptoms
Amantadine
Tx for Anti-parkinson's
Zanamivir and oseltamivir
Influenza types A & B
52 terms
Antiviral
topical cream or oral administration f…
not a good substrate for human tyrosin…
inhibits viral DNA polymerase and term…
produced by viral encoded thymidine ki…
Acyclovir
Acyclovir
Acyclovir
Acyclovir
topical cream or oral administration f…
Acyclovir
not a good substrate for human tyrosin…
Acyclovir
24 terms
Antiviral
virus
classifications
acute
slow
a minute infectious agent that is able to replicate only with…
actue, slow , chronic
quick (cold and flu)
maintains a progressive course (HIV, AIDS)
virus
a minute infectious agent that is able to replicate only with…
classifications
actue, slow , chronic
37 terms
Antiviral
Nucleoside analog:purine
Nucleoside analog:pyrimidine
Cyclic amines analog
Herpes simplex Rx
Acyclovir Ganciclovir Vidarabine
Idoxuridine. AZT
Amantadine Rimantadine
Acyclovia/Valaciclovir... Famciclovir/Penciclovir... Trifluridine
Nucleoside analog:purine
Acyclovir Ganciclovir Vidarabine
Nucleoside analog:pyrimidine
Idoxuridine. AZT
19 terms
Antiviral
Acyclovir (zovirax) MOA
Acyclovir (zovirax) USE
Acyclovir (zovirax) AE
Acyclovir (zovirax) dosage
suppression of viral DNA synthesis
first line agent for most infections caused by HSV and VZV ... h…
n/v/d, HA, vertigo... crystallization in kidney... increased SCr/BU…
oral... IV... topical
Acyclovir (zovirax) MOA
suppression of viral DNA synthesis
Acyclovir (zovirax) USE
first line agent for most infections caused by HSV and VZV ... h…
11 terms
Antiviral
Viruses
Herpes simplex virus and Varicella Zos…
Anitviral Drug (nonretroviral)cmv,
amantadine
unlike bacteria can only replicate inside host cells, such as…
Herpesvirdae family= HSV 1 mucutaneous herpes, usually in the…
tx viral infection not cause by hiv. tx influenza, hsv,vzv, h…
(symmeteral) antiviral ... only active against influenza a virus…
Viruses
unlike bacteria can only replicate inside host cells, such as…
Herpes simplex virus and Varicella Zos…
Herpesvirdae family= HSV 1 mucutaneous herpes, usually in the…
34 terms
Antiviral
M2 inhibitor... works only for influenza A
Neuraminidase inhibitors... also known as…
Neuraminidase inhibitors... COPD exacerba…
respiratory syncytial virus... guanosine…
amantidine
oseltamivir
zanamivir
Ribaviron
M2 inhibitor... works only for influenza A
amantidine
Neuraminidase inhibitors... also known as…
oseltamivir
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