Study sets matching "antiviral"

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Study sets matching "antiviral"

Antiviral
Amantadine
Oseltamivir
Lamivudine
Abacavir
PMS-AMANTADINE
TAMIFLU
HEPTOVIR
ZIAGEN
Amantadine
PMS-AMANTADINE
Oseltamivir
TAMIFLU
8 terms
Antiviral
Antiviral Drugs
Antiviral Drug Selectivity
Drugs for Herpes virus (1, 2, Zoster)-…
Retrovirus drug resistance
Has own gene... Target viral PRO
1. Prodrug that's activated by an ezn encoded by viral genome…
Acyclovir
Low fidelity (high error rate, no proof reading)... Rapid mutati…
Antiviral Drugs
Has own gene... Target viral PRO
Antiviral Drug Selectivity
1. Prodrug that's activated by an ezn encoded by viral genome…
antiviral
nucleoside analogs MOA:
selective toxicity
antiviral drugs
nucleoside analog HIV reverse transcri…
nucleosides are precursors to nucleotides. (think nucleotide)…
viruses incorporate these "fakes" more rapidly than do cells
acyclovir (zovirax)- treat herpes simplex and herpes zoster (…
azidothymidine (AZT)- used to treat HIV... MOA: HIV is an RNA vi…
nucleoside analogs MOA:
nucleosides are precursors to nucleotides. (think nucleotide)…
selective toxicity
viruses incorporate these "fakes" more rapidly than do cells
Antiviral
Antiviral development
Herpes Simplex Virus (HSV) ... Acyclovir
HSV Antiviral Agents... Valacyclovir prod…
HSV Antiviral Agents... Valganciclovir pr…
Prevention of Viral Entry... Targeting the RNA/DNA replication i…
1 st class. Guanine Nucleoside analogues.
HSV-1, HSV-2,VZV: Spectrum of activity.
CMV, EBV: Spectrum of activity.
Antiviral development
Prevention of Viral Entry... Targeting the RNA/DNA replication i…
Herpes Simplex Virus (HSV) ... Acyclovir
1 st class. Guanine Nucleoside analogues.
22 terms
Antiviral
Oseltamivir and zanamivir
Oseltamivir
Zanamivir
Amantadine and rimantadine
These viral release inhibitors are effective against flu A/B
This viral release inhibitor is administered orally every year
This viral release inhibitor is administered via inhalation o…
These uncoating inhibitors are effective against flu A
Oseltamivir and zanamivir
These viral release inhibitors are effective against flu A/B
Oseltamivir
This viral release inhibitor is administered orally every year
antiviral
Nucleosides
Idoxuridine
Trifluridine
Cidofovir
generally prodrugs that need to be activated to the triphosph…
Pyrimidines... T analog. ... Prodrug... Opthalmic drops for HSV/VZV in…
Pyrimidines... Trifluoro derivative of thymidine... Prodrug... Better…
Pyrimidines... Acyclic cytidine pyrimidine nucleotide analog. ... R…
Nucleosides
generally prodrugs that need to be activated to the triphosph…
Idoxuridine
Pyrimidines... T analog. ... Prodrug... Opthalmic drops for HSV/VZV in…
24 terms
Antiviral
-avir
-ivir
-ovir
Enfuvirtide... Maraviroc
AIDS... (A for A)
Influenza... (i for i)
Herpes... prodrugs, nucleoSides... (Oh! I got herpes)
Blocks viral penetration
-avir
AIDS... (A for A)
-ivir
Influenza... (i for i)
28 terms
Antiviral
Acyclovir
Valacyclovir
Cidofovir
Famiciclovir
Guanine
Prodrug
Acyclic pyrimidine
Purine nucleoside analog of guanine... Prodrug... Oxidizes and beco…
Acyclovir
Guanine
Valacyclovir
Prodrug
42 terms
Antiviral
What is the infectious cycle for RNA V…
What is the infectious cycle for DNA v…
What is the infectious cycle for Retro…
Can you kill Viruses? Why or why not?
Utilizes cellular machinery to make more of their own acids…
Coated with envelope... Enters cell membrane ---> messes everyth…
Infectious virus binds to cell membranes, enters cell, takes…
No... Viruses are not alive... Use virustatic (not cidal) drugs
What is the infectious cycle for RNA V…
Utilizes cellular machinery to make more of their own acids…
What is the infectious cycle for DNA v…
Coated with envelope... Enters cell membrane ---> messes everyth…
125 terms
Antiviral
Antiviral activity is predominantly __…
Interferons inhibit what stage(s) of v…
Proteases inhibit what stage(s) of vir…
Neuraminidases inhibit what stage(s) o…
virustatic... - Allows for suppression of viral replication so…
Translation and Assembly
Post-translational modification via proteolytic cleavage
Release/budding
Antiviral activity is predominantly __…
virustatic... - Allows for suppression of viral replication so…
Interferons inhibit what stage(s) of v…
Translation and Assembly
Antiviral
Aldara
Famvir
Tamiflu
Valtrex
Imiquimod- antiviral
Famciclovir
Oseltamvir-antiviral
Valacyclovir- antiviral
Aldara
Imiquimod- antiviral
Famvir
Famciclovir
Antiviral
Zovirax
Valcyte
Tamiflu
Aldara
Acyclovir
Valganciclovir
Oseltamivir
Imiqimod
Zovirax
Acyclovir
Valcyte
Valganciclovir
5 terms
Antiviral
Aldara
Famvir
Tamiflu
Valtrex
Imiquimod
Famciclovir
Olsetamivir
Valacyclovir
Aldara
Imiquimod
Famvir
Famciclovir
Antiviral
Aldara
Famvir
Tamiflu
Valtrex
Imiquimod
Famcyclovir
Oseltamivir
Valcyclovir
Aldara
Imiquimod
Famvir
Famcyclovir
antiviral
acyclovir
amantidine
zidovudine
efavirenz
nucleoside analogue-> herpes
viral replication inhibitor-> influenza
nucleoside reverse transcriptase inhibitor-> HIV
nonnucleoside reverse transcriptase inhibitor-> HIV
acyclovir
nucleoside analogue-> herpes
amantidine
viral replication inhibitor-> influenza
10 terms
Antiviral
amantadine
oseltamivir
lamivudine
abacavir
PMS amantadine
tamiflu
heptovir
Ziagen
amantadine
PMS amantadine
oseltamivir
tamiflu
33 terms
antiviral
virus
virus classification
Baltimore classification
dsDNA-RT virus
-obligate, intracellular parasite... -active - intracellular act…
-animal, plant, eukaryotic, bacteria
-nucleic acid... -single-stranded or double stranded... -+ strand m…
-contain partially closed (gapped) ds DNA which on infection…
virus
-obligate, intracellular parasite... -active - intracellular act…
virus classification
-animal, plant, eukaryotic, bacteria
Antiviral
Acyclovir
Amantadine
Famciclovir
Ganciclovir
Zovirax
Symmetrel
Famvir
Cytovene
Acyclovir
Zovirax
Amantadine
Symmetrel
33 terms
Antiviral
Antiviral Mechanism of Action
Assessment before administration
Antiviral Adverse effects
Therapeutic effect of antiviral
INHIBIT VIRAL REPLICATION... block activity of polymerase enzym…
-Head-to-toe physical ... -Medical and medication history... -Docum…
because viruses reproduce in human cells, selective killing i…
non-HIV antivirals and HIV antiretrovirals include eliminatio…
Antiviral Mechanism of Action
INHIBIT VIRAL REPLICATION... block activity of polymerase enzym…
Assessment before administration
-Head-to-toe physical ... -Medical and medication history... -Docum…
Antiviral
Agents for Influenza A and Respiratory…
AGENTS FOR INFLUENZA A AND RESPIRATORY…
Characteristics of Antiviral Drugs
Influenza A and Respiratory Viruses Dr…
amantadine (Symmetrel)... oseltamivir (Tamiflu)... ribavirin (Rebetr…
The exact mechanism of action of drugs that combat Influenza A…
Able to enter the cells infected with virus... Interfere with vi…
Action - Prevent shedding of the viral protein coat... Pharmaco…
Agents for Influenza A and Respiratory…
amantadine (Symmetrel)... oseltamivir (Tamiflu)... ribavirin (Rebetr…
AGENTS FOR INFLUENZA A AND RESPIRATORY…
The exact mechanism of action of drugs that combat Influenza A…
18 terms
Antiviral
Oseltamivir, zanamivir
Acyclovir, famciclovir, valacyclovir
Ganciclovir
Foscarnet
Action: Inhibiti neuraminidase -> dec. release of progeny vir…
Action: Guanosine analogs. Monophosphorylated by HSV/VZV thym…
Action: 5'-monophosphate formed by a CMV viral kinase. Guanos…
Action: Viral DNA/RNA polymerase inhibitor and HIV reverse tr…
Oseltamivir, zanamivir
Action: Inhibiti neuraminidase -> dec. release of progeny vir…
Acyclovir, famciclovir, valacyclovir
Action: Guanosine analogs. Monophosphorylated by HSV/VZV thym…
Antiviral
Flu A specific
Neuraminidase
HIV
Purine Nucleoside
Amantadine, rimantadine
Oseltamivir (Tamiflu)... Zanamivir (Relenza)
Antiretroviral therapy ART
Acyclovir (Zovirax)... Valscyclovir (valtrex)
Flu A specific
Amantadine, rimantadine
Neuraminidase
Oseltamivir (Tamiflu)... Zanamivir (Relenza)
44 terms
antiviral
viruses replicate by
attachment--> virus
HIV DRUG for inh of attachment
uncoting--? virus?
taking over transaltional machinery of the host ... -viral infec…
HIV
maraviroc
influenza A
viruses replicate by
taking over transaltional machinery of the host ... -viral infec…
attachment--> virus
HIV
antiviral
Amantadine
Oseltamir
Trifluridine
Acyclovir
Flu drug... Prophalaxis of Flu A; blocks M2 so uncoating doesn…
Flu drug... Prophalaxis/treatment of A/B... competitive inhibitor…
Herpes drug... Thymidine analog; interfaces DNA so synthesis c…
Herpes drug... Inhibits herpes DNA polymerase (phosphorylated…
Amantadine
Flu drug... Prophalaxis of Flu A; blocks M2 so uncoating doesn…
Oseltamir
Flu drug... Prophalaxis/treatment of A/B... competitive inhibitor…
36 terms
antiviral
HSV, VZV DOC
acyclovir ... chemistry, activation, MOA
acyclovir drug resistance
valacyclovir
acyclic drugs:... acyclovir, valacyclovir, penciclovir, famciclo…
guanosine analog... act: converted to acyclo-MP by viral thymidi…
gene mutations in tk and/or viral DNA polymerase
improved oral bioavailability
HSV, VZV DOC
acyclic drugs:... acyclovir, valacyclovir, penciclovir, famciclo…
acyclovir ... chemistry, activation, MOA
guanosine analog... act: converted to acyclo-MP by viral thymidi…
34 terms
Antiviral
Acyclovir
Penciclovir
Vidarabine
Vidarabine
H. simplex I and II ... H. zoster and Varicella ... not good for C…
inhibition of viral DNA polymerase... more stable than acyclovir…
--> arabinoside (active ) ... ใช้รักษา Herpetic keratinoconjunci…
2% IV - herpetic encephalopathy
Acyclovir
H. simplex I and II ... H. zoster and Varicella ... not good for C…
Penciclovir
inhibition of viral DNA polymerase... more stable than acyclovir…
Antiviral
acyclovir
famiciclovir
valacyclovir
oseltamivir
Zovirax... Sitavig
Famvir
Valtrex
Tamiflu
acyclovir
Zovirax... Sitavig
famiciclovir
Famvir
5 terms
Antiviral
Antiviral
Acyclovir
Idoxivridine
Interferon
Kills viruses
Zovirax... Used for feline herpes virus ... Treats the symptoms
Ophthalmic (eye) for feline herpes
Used for feline leukemia virus (FeLV)... Prolong quality of life…
Antiviral
Kills viruses
Acyclovir
Zovirax... Used for feline herpes virus ... Treats the symptoms
antiviral
valacyclovir HCI
famciclovir
oseltamivir
zanamivir
Valtrex
Famvir
Tamiflu
Relenza
valacyclovir HCI
Valtrex
famciclovir
Famvir
89 terms
Antiviral
Virus
Viral illnesses
Antiviral Dugs MOA
Antiviral Drugs cont
can't replicate on its own.... must attach to and enter a host c…
bothersome but survivable... can be prevented (HEPA A and B Chic…
-able to enter the cells infected with virus... - interfere with…
-best response to Antiviral drugs are in pt with competent im…
Virus
can't replicate on its own.... must attach to and enter a host c…
Viral illnesses
bothersome but survivable... can be prevented (HEPA A and B Chic…
Antiviral
type-specific surface proteins of infl…
antibody against hemagglutinin action
antibody against neuraminiase action
analog of sialic acid (drug class)
16 hemagglutinin (H) & 9 neuraminidase (N) subtypes
neutralize infectivity and prevent disease
reduce amount of virus released and spread
neuraminidase inhibitor
type-specific surface proteins of infl…
16 hemagglutinin (H) & 9 neuraminidase (N) subtypes
antibody against hemagglutinin action
neutralize infectivity and prevent disease
37 terms
Antiviral
Nucleoside analog:purine
Nucleoside analog:pyrimidine
Cyclic amines analog
Herpes simplex Rx
Acyclovir Ganciclovir Vidarabine
Idoxuridine. AZT
Amantadine Rimantadine
Acyclovia/Valaciclovir... Famciclovir/Penciclovir... Trifluridine
Nucleoside analog:purine
Acyclovir Ganciclovir Vidarabine
Nucleoside analog:pyrimidine
Idoxuridine. AZT
5 terms
Antiviral
Acyclovir
Oseltamivir
Vaccine-Influenza
Vaccine-Influenza
-Zovirax
-Tamiflu
-Fluzone... -Fluarix
-FluMist
Acyclovir
-Zovirax
Oseltamivir
-Tamiflu
11 terms
Antiviral
Viruses
Herpes simplex virus and Varicella Zos…
Anitviral Drug (nonretroviral)cmv,
amantadine
unlike bacteria can only replicate inside host cells, such as…
Herpesvirdae family= HSV 1 mucutaneous herpes, usually in the…
tx viral infection not cause by hiv. tx influenza, hsv,vzv, h…
(symmeteral) antiviral ... only active against influenza a virus…
Viruses
unlike bacteria can only replicate inside host cells, such as…
Herpes simplex virus and Varicella Zos…
Herpesvirdae family= HSV 1 mucutaneous herpes, usually in the…
Antiviral
MOA
Primary Indication
Acyclovir
Famciclovir
Inhibits DNA synthesis and viral replication
Herpes Viral Infection
Zovirax
Famvir
MOA
Inhibits DNA synthesis and viral replication
Primary Indication
Herpes Viral Infection
Antiviral
virus
classifications
acute
slow
a minute infectious agent that is able to replicate only with…
actue, slow , chronic
quick (cold and flu)
maintains a progressive course (HIV, AIDS)
virus
a minute infectious agent that is able to replicate only with…
classifications
actue, slow , chronic
5 terms
Antiviral
Viruses are difficult to kill because...
Best responses to antiviral drugs are…
Oseltamivir (Tamiflu)
Respiratory Syncytial Virus (RSV)
they live inside cells
a healthy immune system
should be started with exposure or within 2 days of symptoms…
ribavirin (Virazole)
Viruses are difficult to kill because...
they live inside cells
Best responses to antiviral drugs are…
a healthy immune system
17 terms
Antiviral
Zovirax
Symmetrel
Famvir
Cytovene
Acyclovir
Amantadine
Famciclovir
Ganciclovir
Zovirax
Acyclovir
Symmetrel
Amantadine
Antiviral
topical cream or oral administration f…
not a good substrate for human tyrosin…
inhibits viral DNA polymerase and term…
produced by viral encoded thymidine ki…
Acyclovir
Acyclovir
Acyclovir
Acyclovir
topical cream or oral administration f…
Acyclovir
not a good substrate for human tyrosin…
Acyclovir
13 terms
Antiviral
Crixivan
Epivir (3TC)
Invirase
Kaletra
Indinavir
Lamivudine
Saquinavir
Lopinavir Ritonavir
Crixivan
Indinavir
Epivir (3TC)
Lamivudine
Antiviral
Antiviral drugs
Targets of antiviral drugs
Entry inhibitors
Non-nucleoside reverse transcriptase i…
-Narrow therapeutic index... -Targets viruses through nucleoside…
-viral uncoating... -nucleoside analogs... -non-nucleoside polymera…
-Prevent entry of virus to host cell... -block Gp41 on virus... -OR…
-Inhibits reverse transcriptase by binding at a different sit…
Antiviral drugs
-Narrow therapeutic index... -Targets viruses through nucleoside…
Targets of antiviral drugs
-viral uncoating... -nucleoside analogs... -non-nucleoside polymera…
Antiviral
Viral replication
Why are viruses difficult to kill?
Viral illnesses
Antiviral drugs
Virus can't replicate on its own -- uses host cell... Uses host…
Because they live inside the cell
Bothersome, but survivable
Kill or suppress the virus by destroying virions or inhibitin…
Viral replication
Virus can't replicate on its own -- uses host cell... Uses host…
Why are viruses difficult to kill?
Because they live inside the cell
19 terms
Antiviral
Acyclovir (zovirax) MOA
Acyclovir (zovirax) USE
Acyclovir (zovirax) AE
Acyclovir (zovirax) dosage
suppression of viral DNA synthesis
first line agent for most infections caused by HSV and VZV ... h…
n/v/d, HA, vertigo... crystallization in kidney... increased SCr/BU…
oral... IV... topical
Acyclovir (zovirax) MOA
suppression of viral DNA synthesis
Acyclovir (zovirax) USE
first line agent for most infections caused by HSV and VZV ... h…
6 terms
Antiviral
Acyclovir
Ganciclovir
Oseltamivir
Indinavir
HSV 1 2 VZV
CMV
Influenza virus A,B
Protease inhibitor HIV
Acyclovir
HSV 1 2 VZV
Ganciclovir
CMV
9 terms
antiviral
Antiviral
Idoxuridine/Trifluridine
Cytarabine/Vidarabine
Ribavarin
1. lessens severity of virus, not curative... 2. not a lot of an…
-herpes, poxvirus... -topical only... -herpes keratitis
-DNA virus... -topical, IV... -cat keratitis
-Influenza A, B... -oral, IV, aerosol
Antiviral
1. lessens severity of virus, not curative... 2. not a lot of an…
Idoxuridine/Trifluridine
-herpes, poxvirus... -topical only... -herpes keratitis
Antiviral
Neuroaminidase inhibitor ... Inhibit rele…
Nucleic acid inhibitors
Uncoating inhibitors
Protein synthesis inhibitors
Oseltamivir ... Zanamivir
1-guanosine analogue... 2- guanine nucleotide synthesis ... 3- vira…
Amantadine ... Rimantadine
Inf a
Neuroaminidase inhibitor ... Inhibit rele…
Oseltamivir ... Zanamivir
Nucleic acid inhibitors
1-guanosine analogue... 2- guanine nucleotide synthesis ... 3- vira…
16 terms
Antiviral
Components of a Virion
DNA caused viruses
DNA Virus Replication
RNA Virus Replication
DNA or RNA... Protein coat(Capsid)... +/- external lipoprotein
Poxvirus(Small pox)... Herpesvirus(Chickenpox, shingles, cold so…
DNA enters host nucleus, host RNA poly transcripts DNA into m…
mRNA synthesized in virion from viral RNA. Host cell translat…
Components of a Virion
DNA or RNA... Protein coat(Capsid)... +/- external lipoprotein
DNA caused viruses
Poxvirus(Small pox)... Herpesvirus(Chickenpox, shingles, cold so…
antiviral
new HIV meds
HSV med
valacyclovir
protease inhibitors risk
triumeq ... elvitegravir (EVG) or viteka... cobstat or tybost
acyclovir, gangliocyclovir... guanosine neuucloside analog... thym…
valacyclovir is an esterified or pro-drug form of acylovir
lipodystrophy
new HIV meds
triumeq ... elvitegravir (EVG) or viteka... cobstat or tybost
HSV med
acyclovir, gangliocyclovir... guanosine neuucloside analog... thym…
12 terms
Antiviral
Tamiflu
Relenza
Zovirax
Valtrex
oseltamivir
zanamivir
acyclovir
Valacyclovir
Tamiflu
oseltamivir
Relenza
zanamivir
Antiviral
indication
Dosage / administration
contraindication
side effects
viral infections / influenza
oral
hypersensitivity
generally well tolerated (can decrease renal function)
indication
viral infections / influenza
Dosage / administration
oral
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