Study sets matching "cancer terms drug"

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Study sets matching "cancer terms drug"

65 terms
Cancer Drugs/ Cancer Biology
What are the chemotherapy options for…
What chemotherapy agent is know for ca…
What is the MOA of Bleomycin?
What are some other side-effects of bl…
Vincristine, Bleomycin, and Cisplatin ... Mnemonic: Very Ballsy…
Bleomycin Baby
Inhibits synthesis of DNA; binds to DNA leading to single- an…
-Many dermatologic issues and hair loss... - Respiratory (rales,…
What are the chemotherapy options for…
Vincristine, Bleomycin, and Cisplatin ... Mnemonic: Very Ballsy…
What chemotherapy agent is know for ca…
Bleomycin Baby
125 terms
Cancer Drugs
alkylates DNA, causing cross-links (bi…
uses: Hodgkin's; non-Hodgkin's lymphom…
side effects: MYELOSUPPRESSION, naus…
ask if they want to bank sperm/eggs
cyclophosphamide
cyclophosphamide
cyclophosphamide
cyclophosphamide
alkylates DNA, causing cross-links (bi…
cyclophosphamide
uses: Hodgkin's; non-Hodgkin's lymphom…
cyclophosphamide
Cancer Drug
Class I
Class II
Class III
Mechlorethamine
Cell cycle nonspecific. eg alkylating agents- Mechlorethamine…
specific phase drugs. G1- prednisone. S- antimetabolites (cyt…
cycle specific, phase nonspecific. Targets replicating cells.…
Alkylating agent, DNA cross links, highly reactive, no CNS.…
Class I
Cell cycle nonspecific. eg alkylating agents- Mechlorethamine…
Class II
specific phase drugs. G1- prednisone. S- antimetabolites (cyt…
Cancer drug
Erlotinib (lung cancer , NSCLC)
Afatinib (NSCLC )
Crizotinib (NSCLC , ALK inibitor )
Certinib (NSCLC , ALK inhibitor )
EGFR inhibitor ... take on empty stomach ... no PPI ... AE: Rash (Acne…
EGFR inhibitor
ALK inhibitor , inhibit ALK fusion protein ... Decreased prolife…
Must take on empty stomach ... AE: GI tox, visual disturbance, Q…
Erlotinib (lung cancer , NSCLC)
EGFR inhibitor ... take on empty stomach ... no PPI ... AE: Rash (Acne…
Afatinib (NSCLC )
EGFR inhibitor
Cancer Drug
Methotrexate
Cytarabine
Fluorouracil
Capecitabine
MOA: folate antagonist... indications: tumors, RA and psoriasis…
MOA: pyrimidine antagonist... adverse reactions: myelosuppressi…
MOA: pyrimidine antagonist (often combined with leucovorin to…
MOA: pyrimidine antagonist (prodrug of fluorouracil)... indicat…
Methotrexate
MOA: folate antagonist... indications: tumors, RA and psoriasis…
Cytarabine
MOA: pyrimidine antagonist... adverse reactions: myelosuppressi…
7 terms
Drugs Cancer
Cyclophosphamide S/E
Doxovubicin S/E
Bleomycin S/E
Fluorouracil S/E
Renal Failure, Hemorrhagicaystitis, Alopecia, Atomatitis, Liv…
Cordiac toxicity/ Liver toxicity, Mod. BMD, Vesicant, Stomati…
Pheumototitis and Pulminary Fibrosis, Alopecia, N/V, Chills/…
Stomatitis, Alopecia, N/V , Gastitis, Diarrhea, BMD
Cyclophosphamide S/E
Renal Failure, Hemorrhagicaystitis, Alopecia, Atomatitis, Liv…
Doxovubicin S/E
Cordiac toxicity/ Liver toxicity, Mod. BMD, Vesicant, Stomati…
Cancer drugs
Mitotic Inhibitors- Block Mitosis
Alkylating agents- prevent cell growth…
Anti metabolies- work by interfering w…
Colony stimulating factors- encourage…
Plant Alkaloids- periwinkle plant... vinblastine or vincristine…
cisplatin... cyclophosphamide... - can lead to leukemia 5-10 yrs af…
methotrexate ... - tx of psoriasis, RA, lupus... fluorouracil (Efu…
Epogen... Procrit... SE- headache... bone pain... dermatological reaction
Mitotic Inhibitors- Block Mitosis
Plant Alkaloids- periwinkle plant... vinblastine or vincristine…
Alkylating agents- prevent cell growth…
cisplatin... cyclophosphamide... - can lead to leukemia 5-10 yrs af…
Cancer Drugs
Methotrexate
5-Flurouracil
Vinblastine and Vincristine
Taxanes (Paclitaxel, Docetaxel)... Close…
Inhibits DHFR so Adenine, Guanine and Thymine cannot be made.…
Pyrimidine analog. Added to DNA and RNA. Disrupts, elongation…
From Vinca rosa. Bind to tubulin and break down microtubules.…
From Pacific Yew Tree. Block mitosis by stabilizing microtubu…
Methotrexate
Inhibits DHFR so Adenine, Guanine and Thymine cannot be made.…
5-Flurouracil
Pyrimidine analog. Added to DNA and RNA. Disrupts, elongation…
54 terms
Cancer Drugs
Methotrexate (MTX)... Class:... Mechanism of…
Leucovorin
6-mercaptopurine (6-MP; purinethol)... Cl…
Gemcitabine (GEMZAR)... Class:... MOA:... Admin…
Class: Cancer Drug; Antimetabolite, Folate Analog... Mechanism o…
Class: Cancer Drug; folate analog... Mechanism of Action: Leucov…
Class: Cancer Drug; Antimetabolite; Purine analog... Mechanism…
Class: Cancer Drug; Antimetabolite; Pyrimidine analog... Mechani…
Methotrexate (MTX)... Class:... Mechanism of…
Class: Cancer Drug; Antimetabolite, Folate Analog... Mechanism o…
Leucovorin
Class: Cancer Drug; folate analog... Mechanism of Action: Leucov…
9 terms
Cancer drug
Cisplatin, Carbplatin, oxaliplatin
Platinum is CCNS?
BEP regimen
adverse reaction of DLT
Platinum compounds
yes
Bleomycin... Etoposide... Platinol
...
Cisplatin, Carbplatin, oxaliplatin
Platinum compounds
Platinum is CCNS?
yes
30 terms
Cancer Drugs
Imatinib (Gleevec)
Erlotinib/Afatinib
Osimertinib
Crizotinib
BCR/ABL Tyrosine Kinase Inhibitor
EGFR Tyrosine Kinase Inhibitor
Second line EGFR T790M Tyrosine Kinase Inhibitor
ALK Tyrosine Kinase Inhibitor
Imatinib (Gleevec)
BCR/ABL Tyrosine Kinase Inhibitor
Erlotinib/Afatinib
EGFR Tyrosine Kinase Inhibitor
Cancer Drugs
Alemtuzumab (Campath)
Arsenic Trioxide (Trisenox)
Bendamustine (Treanda)
Bleomycin (Blenoxane)
MOA: AntiCD52 MAB... Indication: CLL... Side effects: Immunosuppres…
MOA: Differentiating agent... Indication: APL... Side effects: diff…
MOA: Alkylating agent... Indication: CLL, NHL... Side effects: Myel…
MOA: Inhibits DNA and RNA synthesis... Indication: HD and NHL... Si…
Alemtuzumab (Campath)
MOA: AntiCD52 MAB... Indication: CLL... Side effects: Immunosuppres…
Arsenic Trioxide (Trisenox)
MOA: Differentiating agent... Indication: APL... Side effects: diff…
Cancer Drugs
Imatinib
Panitumumab (Vectibix)
Vandetanib (Caprelsa)
ends in -nib
Leukemia cells in CML
Colorectal Cancer (EGFR Inhibitor)
Thyroid Cancer (EGFR Inhibitor)
Small molecule inhibitor (Inhibit inside cell)
Imatinib
Leukemia cells in CML
Panitumumab (Vectibix)
Colorectal Cancer (EGFR Inhibitor)
82 terms
Cancer Drugs
Azothioprine--> 6 mercaptopurine MOA
6-thioguanine is used when?
Use of 6-azothiopurine
Side effects of 6 mercaptopurine and a…
purine analog... decrease de novo purine synthesis... activated by…
patients with gout
prevent organ rejection... rheumatoid arthritis... IBD... SLE
metabolized by xanthine oxidase
Azothioprine--> 6 mercaptopurine MOA
purine analog... decrease de novo purine synthesis... activated by…
6-thioguanine is used when?
patients with gout
44 terms
Cancer Drugs
Azathiprine
6-mercaptopurine
6-thioguanine
Cladribine
Class: Antimetabolite... Action: Purine (thiol) analog; decr de…
Class: Antimetabolite... Action: Purine (thiol) analog; decr de…
Class: Antimetabolite... Action: Purine (thiol) analog; decr de…
Class: Antimetabolite... Action: Purine analog; inhibition of D…
Azathiprine
Class: Antimetabolite... Action: Purine (thiol) analog; decr de…
6-mercaptopurine
Class: Antimetabolite... Action: Purine (thiol) analog; decr de…
14 terms
Cancer drugs
ATRA
Tamoxifen
Velcade
Zelboraf
Target: none... Type: Differentiation therapy... Treats: Acute pr…
Target: Estrogen receptor ... Type: Anti-estrogen... Treats: Brea…
Target: Proteasome... Type: Proteasome inhibitor... Treats: Multi…
Target: BRAF (receptor Ser/Thr kinase... Type: Kinase inhibitor…
ATRA
Target: none... Type: Differentiation therapy... Treats: Acute pr…
Tamoxifen
Target: Estrogen receptor ... Type: Anti-estrogen... Treats: Brea…
Cancer Drugs
_____ are the structural analogs of fo…
antimetabolites MOA
what is very specific about antimetabo…
what are the folate analogs?
antimotabolites
inhibit synthesis or compete w/ DNA or RNA synthesis
Act specifically in DNA synthesis (S) phase of cell cycle
Methotrexate... Pemetrexed
_____ are the structural analogs of fo…
antimotabolites
antimetabolites MOA
inhibit synthesis or compete w/ DNA or RNA synthesis
123 terms
cancer drugs
methotrexate (MTX), pemetrexed, palatr…
fluorouracil (5-FU), floxuridine (FUDR)
cladribine (leustatin) & fludarabine (…
indications for all antimetabolites
-treats cancer by interfering with folic acid: DNA is not pro…
treats cancer by interrupting metabolic pathways pyrdanine ba…
treats cancer by interrupts metabolic pathways of purine nucl…
- used in combo with other drugs to treat various types of ca…
methotrexate (MTX), pemetrexed, palatr…
-treats cancer by interfering with folic acid: DNA is not pro…
fluorouracil (5-FU), floxuridine (FUDR)
treats cancer by interrupting metabolic pathways pyrdanine ba…
20 terms
Cancer Drugs
Abraxane
Alimta
Xeloda, Teva-Capecitabine
Afinitor; Afinitor Disperz; Zortress
PACLitaxel... Antineoplastic Agent, Antimicrotubular; Antineopla…
PEMEtrexed... Antineoplastic Agent, Antimetabolite; Antineoplast…
Capecitabine... Antineoplastic Agent, Antimetabolite; Antineopla…
Everolimus... Antineoplastic Agent, mTOR Kinase Inhibitor; Immun…
Abraxane
PACLitaxel... Antineoplastic Agent, Antimicrotubular; Antineopla…
Alimta
PEMEtrexed... Antineoplastic Agent, Antimetabolite; Antineoplast…
Cancer Drugs
chemotherapeutic agent
When considering chemo agents used in…
As with other chemo drugs, resistance…
Why is the ability of cancer cells to…
any drug that exerts selective toxicity, thus killing one gro…
kill a human cell inside of a human host
a single agent is used
because cancer is de facto, or made up of cells that have sig…
chemotherapeutic agent
any drug that exerts selective toxicity, thus killing one gro…
When considering chemo agents used in…
kill a human cell inside of a human host
17 terms
cancer drugs
Current Treatment Modalities of Cancer
Alkylating Agents
Alkylating Agent ex-Cyclophosphamide
Alkylating Agent ex-Busulphan
-Surgery ... -Radiotherapy ... -Chemotherapy... -Gene therapy ... -Immuno…
Produce highly reactive carbonium ion intermediates which tra…
-treat cancer, including leukemia and lymphomas... -converted to…
low doses toxic to granulocytes i.e. neutrophils, eosophils,…
Current Treatment Modalities of Cancer
-Surgery ... -Radiotherapy ... -Chemotherapy... -Gene therapy ... -Immuno…
Alkylating Agents
Produce highly reactive carbonium ion intermediates which tra…
25 terms
Cancer Drugs
Vincristine
Vinblastine
Paclitaxel (other taxols)
5-fluoruracil
MOA: Bind B-tubulin inhibit its polymerization into microtubu…
MOA: Bind B-tubulin inhibit its polymerization into microtubu…
MOA: Hyperstabilizes polymerized microtubules in M phase so m…
MOA: pyrimidine analog bioactivated to 5F-DUMP, covalently co…
Vincristine
MOA: Bind B-tubulin inhibit its polymerization into microtubu…
Vinblastine
MOA: Bind B-tubulin inhibit its polymerization into microtubu…
Cancer Drugs
Major effect of taxanes
Major effect of epipodophyllotoxins
Example of epipodophyllotoxins
Major effect of Camptothecins
Promoting tubulin polymerization
Inhibition of topoisomerase II
Etoposide
Inhibits topoisomerase I
Major effect of taxanes
Promoting tubulin polymerization
Major effect of epipodophyllotoxins
Inhibition of topoisomerase II
92 terms
Cancer drugs
Nitrogen mustards... Drug examples?
Nitrogen mustards... Usage?
Nitrogen mustards... Mechanism of action?
Nitrogen mustards... Adverse reactions?
Cyclophosphamide... Ifosfamide... Chlorambucil... Melfalan... Bendamustine
Breast cancer, lymphomas... Useful in marrow ablative regimens…
DNA alkylator... prodrug of phosphoramide mustard (active metab…
Myelosuppression, secondary leukemias. Acrolein, another meta…
Nitrogen mustards... Drug examples?
Cyclophosphamide... Ifosfamide... Chlorambucil... Melfalan... Bendamustine
Nitrogen mustards... Usage?
Breast cancer, lymphomas... Useful in marrow ablative regimens…
48 terms
Cancer drugs
Azathioprine
6-Mercaptopurine
Cladribine
Cytaranbine
antimetabolite, purine analog, activated by HGPRT to 6-MP, de…
antimetabolite, purine analogue, decreases purine synthesis
antimetabolite, adenosine analog which is not broken down by…
antimetabolite, pyrimidine analog, inhibits DNA polymerase
Azathioprine
antimetabolite, purine analog, activated by HGPRT to 6-MP, de…
6-Mercaptopurine
antimetabolite, purine analogue, decreases purine synthesis
Cancer Drugs
5-FU Class
5-FU MOA
Leucovorin and 5-FU
Toxicities of 5-FU
Fluorinated pyrimidine... Pro drug--Fluorodeoxyuridine monophosp…
Interferes with the function of thymidine synthase ... The metab…
Enhance the cytotoxicity as well as the antitumor activity
Myelosuppression, diarrhea and mucositis, hand-foot syndrome
5-FU Class
Fluorinated pyrimidine... Pro drug--Fluorodeoxyuridine monophosp…
5-FU MOA
Interferes with the function of thymidine synthase ... The metab…
Cancer Drugs
Rituximab (Rituxan)
Ifosphamide
Carboplatin
Etoposide
Allergic Reactions... Pre-medicate (Tylenol, Benadryl, Corticost…
Hemorrhagic cystitis ... Nursing Interventions: dipstick urine f…
3 problems:... 1) Peripheral Neuropathy... 2) Central Neurotoxicity…
Peripheral Neuropathy ... RICE therapy
Rituximab (Rituxan)
Allergic Reactions... Pre-medicate (Tylenol, Benadryl, Corticost…
Ifosphamide
Hemorrhagic cystitis ... Nursing Interventions: dipstick urine f…
43 terms
Cancer drugs
Alkylating Agent MOA/ Tox
cyclophosphamide
chlorambucil
carmustine
Transfer alkyl groups to N7 of guanine in DNA (cross- links s…
DNA alkylating agent (nitrogen mustard), activated in liver v…
DNA alkylating agent (nitrogen mustard), activated in liver v…
DNA alkylating agent (nitrosurea), alkylates N7 & O6 of guani…
Alkylating Agent MOA/ Tox
Transfer alkyl groups to N7 of guanine in DNA (cross- links s…
cyclophosphamide
DNA alkylating agent (nitrogen mustard), activated in liver v…
7 terms
Cancer Drugs
Cytoxan, Procytox
No brand
Purinethol
Lanvis
cyclophosphamide ; alkylating agents
methotrexate ; antimetabolite
6-mercaptopurine ; antimetabolite
6-thioguanine ; antimetabolite
Cytoxan, Procytox
cyclophosphamide ; alkylating agents
No brand
methotrexate ; antimetabolite
31 terms
Cancer Drugs
Non-Phase Specific Cancer Tx.
Phase Specific Cancer Tx.
Chemo Agents which are Non-Cytotoxic
Vesicants
*alkylators... *anthracyclines... *nitrosureas
*antimetabolites... *antimitotics
*bleomycin... *vincristine... *L-asparaginase... *hormones... *some biolo…
*anthracycline... *vincas... *mitomycin... *dactinomycin... *mechloretham…
Non-Phase Specific Cancer Tx.
*alkylators... *anthracyclines... *nitrosureas
Phase Specific Cancer Tx.
*antimetabolites... *antimitotics
189 terms
Cancer Drugs
5-FU drug type
5-FU treats
floxuridine drug type
floxuridine treats
antimetabolite (pyrimidine analog)
colon, (breast, ovarian, pancreatic, gastric)
antimetabolite (pyrimidine analog)
GI tumor metastasis to liver
5-FU drug type
antimetabolite (pyrimidine analog)
5-FU treats
colon, (breast, ovarian, pancreatic, gastric)
91 terms
Cancer Drugs
What are the Antimetabolite drugs?
What phase of the cell cycle do antime…
What is the mechanism of Methotrexate?
What is the clinical use of Methotrexa…
Methotrexate, 5-Fluorouracil, Ctyarabine, Azathioprine
S Phase
Folic acid analog that inhibits and irreversibly binds dihydr…
cancer-choriocarcinoma; rheumatoid arthritis; pregnancy-ectop…
What are the Antimetabolite drugs?
Methotrexate, 5-Fluorouracil, Ctyarabine, Azathioprine
What phase of the cell cycle do antime…
S Phase
21 terms
Cancer Drugs
Doxorubicin, Daunorubicin
Methotrexate
5-FU
6-MP
Generates free radicals and intercalates DNA
Inhibits DHF reductase
Inhibits thymidylate synthase
Inhibits PRPP amidotransferase
Doxorubicin, Daunorubicin
Generates free radicals and intercalates DNA
Methotrexate
Inhibits DHF reductase
55 terms
Cancer Drugs
Traditional Cytotoxic chemotherapy (Qu…
Hormonal agents (Quick overview)
Tyrosine Kinase Inhibitors (Quick over…
Traditional Cytotoxic Chemo
-Not very specific... -Have lots of ADR ... -Hits everything
-Anti-hormonal agents
-Hits the receptors on the cell surface that stimulate signal…
-Target all rapidly dividing cells including cancer cells and…
Traditional Cytotoxic chemotherapy (Qu…
-Not very specific... -Have lots of ADR ... -Hits everything
Hormonal agents (Quick overview)
-Anti-hormonal agents
63 terms
Cancer Drugs (Drug type)
5-FU drug type
floxuridine drug type
capecitabine drug type
6-mercaptopurine (6-MP) drug type
pyrimidine analog
pyrimidine analog
pyrimidine analog
purine analog
5-FU drug type
pyrimidine analog
floxuridine drug type
pyrimidine analog
13 terms
Cancer Drugs
Cyclophosphamide
Cisplatin
5-Fluorouracil
Cytarabine
Class: Alkylating Agent... MOA: Forms alkyl radicals ... Pharm: p…
Class: Platinum Complex... MOA: Produces inter-strand and intra…
Class: Pyrimidine analogue... MOA: Thymidylate synthase inhibit…
Class: Pyrimidine analogue... MOA: DNA polymerase inhibitor... Ph…
Cyclophosphamide
Class: Alkylating Agent... MOA: Forms alkyl radicals ... Pharm: p…
Cisplatin
Class: Platinum Complex... MOA: Produces inter-strand and intra…
63 terms
Cancer Drugs (Drug type)
5-FU drug type
floxuridine drug type
capecitabine drug type
6-mercaptopurine (6-MP) drug type
pyrimidine analog
pyrimidine analog
pyrimidine analog
purine analog
5-FU drug type
pyrimidine analog
floxuridine drug type
pyrimidine analog
50 terms
cancer drugs
Azathioprine/6MU MOA
Azathoprine/6MU drug interaction
what drug is a purine analog and is us…
5FU MOA
purine (T) analog= acts to decrease de novo purine synthesis…
can not give with Allopurinol (or febuxostat) for gout b/c th…
Cladribine
pyrimidine analog (acts like dUMP) --> inhibits thymidylate s…
Azathioprine/6MU MOA
purine (T) analog= acts to decrease de novo purine synthesis…
Azathoprine/6MU drug interaction
can not give with Allopurinol (or febuxostat) for gout b/c th…
Cancer Chemotherapy Drug Info
Nitrogen Mustards Drug
Nitrogen Mustards Drug
Nitrogen Mustards Drug
Nitrogen Mustards Drug
Cylophoaphamide
Chlorambucil
Lomustine
Mechlorethamine
Nitrogen Mustards Drug
Cylophoaphamide
Nitrogen Mustards Drug
Chlorambucil
Cancer drugs +
Capecitabine
Cladribine
Cytarabine
Gemcitabine
Antimetabolite... DNA/RNA synthesis inhibitor... They mimic nucleot…
Antimetabolite... DNA/RNA synthesis inhibitor... They mimic nucleot…
Antimetabolite... DNA/RNA synthesis inhibitor... They mimic nucleot…
Antimetabolite... DNA/RNA synthesis inhibitor... They mimic nucleot…
Capecitabine
Antimetabolite... DNA/RNA synthesis inhibitor... They mimic nucleot…
Cladribine
Antimetabolite... DNA/RNA synthesis inhibitor... They mimic nucleot…
96 terms
Cancer drugs
Drugs that suppress oncogenes are ____…
Drugs that activate tumor suppressor g…
Proteasome inhibitor drugs are used to…
Drugs that fight cancer can disrupt __…
Tyrosine kinase inhibitors
monoclonal antibodies; p53
apoptosis; immortalization of cancer cells
angiogenesis; the patients immune system
Drugs that suppress oncogenes are ____…
Tyrosine kinase inhibitors
Drugs that activate tumor suppressor g…
monoclonal antibodies; p53
26 terms
Cancer Drugs
Monofunctional alkylating agents
Bifunctional alkylating agents
Nitrogen mustards
Mechlorethamine
induce mismatching of DNA base pairs
electrophilic agents cross link both strands of DNA resulting…
require activation to aziridinium ion that attacks nuclophile…
Nitrogen mustard, bifunctional, interstrand, SE: myelosupress…
Monofunctional alkylating agents
induce mismatching of DNA base pairs
Bifunctional alkylating agents
electrophilic agents cross link both strands of DNA resulting…
10 terms
Cancer Drug considerations
Cyclophosphamide, cisplatin
Cisplatin, alkylators, bleomycin, and…
thioguanine, flurouricil, cytarabine
Thioguanine, cytarabine
Resistance Mechanism... Induction of thiol containing proteins o…
Resistance Mechanism:... Induction of DNA repair enzymes
Resistance Mechanism:... Decreased enzymatic activation of pro-d…
Resistance Mechanism:... Increased enzymatic destruction of drug
Cyclophosphamide, cisplatin
Resistance Mechanism... Induction of thiol containing proteins o…
Cisplatin, alkylators, bleomycin, and…
Resistance Mechanism:... Induction of DNA repair enzymes
45 terms
cancer drugs
When are antihistamines used as antiem…
State the 4 antihistamines that are us…
What are the SE's of antihistamine ant…
What class of antiemetics are used for…
for motion caused nausea:... 1. motion sickness... 2. vertigo... 3.…
1. dramamine ... 2. benadryl... 3. atarax/vistaril... 4. Hyoscine
1. **sedating... 2. dizziness... 3. HA... 4. laziness (lassitude)... 5.an…
phenothiazines
When are antihistamines used as antiem…
for motion caused nausea:... 1. motion sickness... 2. vertigo... 3.…
State the 4 antihistamines that are us…
1. dramamine ... 2. benadryl... 3. atarax/vistaril... 4. Hyoscine
28 terms
Anti Cancer Drug MOAs
Methotrexate
5-FU
Cytarabine
Azathioprine
Inhibits dihydrofolate reductase
Inhibits thymidilate synthase
Inhibits DNA polymerase
Decreases de novo purine synthesis
Methotrexate
Inhibits dihydrofolate reductase
5-FU
Inhibits thymidilate synthase
30 terms
Cancer Drugs
Gompertzian tumor growth
Log Kill Model
Chemotherapeutic agents work by...
Alkylating Agents work by
Growth fraction of a tumor declines exponentially over time
Given dose kills constant fraction of cells, not a constant n…
first order kinetics
cross-linking dna. They form highly reactive carbonium ion in…
Gompertzian tumor growth
Growth fraction of a tumor declines exponentially over time
Log Kill Model
Given dose kills constant fraction of cells, not a constant n…
29 terms
Anti-Cancer Drug List
Actinomycin D
Anastrozole
Asparaginase (L-asparaginase)
Bevacizumab
Mechanism of Action:intercalates into DNA and blocks RNA an…
Mechanism of Action: CYP19 aromatase inhibitor... *Usual Route…
Mechanism of Action: degrades asparagine in the circulation…
Mechanism of Action: antibody against VEGF... *Usual Route of…
Actinomycin D
Mechanism of Action:intercalates into DNA and blocks RNA an…
Anastrozole
Mechanism of Action: CYP19 aromatase inhibitor... *Usual Route…
Cancer Drugs (drug class)
Ifosfamide (Nitrogen Mustard)
Carmustine (Nitrosourea)
Streptozocin (Nitrosourea)
Temozolomide (Triazines & Hydrazines)
Ifex (Nitrogen Mustard)
Bicnu, Gliadel (Nitrosourea)
Zanosar (Nitrosourea)
Temodar (Triazines & Hydrazines)
Ifosfamide (Nitrogen Mustard)
Ifex (Nitrogen Mustard)
Carmustine (Nitrosourea)
Bicnu, Gliadel (Nitrosourea)
25 terms
Cancer Drugs
Ifex
Paraplatin
Leukeran
Cytoxan
Ifosfamide
Carboplatin
Chlorambucil
Cyclophosphamide
Ifex
Ifosfamide
Paraplatin
Carboplatin
Cancer Terms
cancer
benign cancer
malignant cancer
metastasis
A disease in which some body cells grow and divide uncontroll…
does not invade surrounding tissue or spread to other parts o…
cancer that spreads around the body... grows beyond size of beni…
describes the spreading of malignant tumors
cancer
A disease in which some body cells grow and divide uncontroll…
benign cancer
does not invade surrounding tissue or spread to other parts o…
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