Study sets matching "cell mediated"

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Study sets matching "cell mediated"

Cell Mediated
The TCR differs from the BCR because...
what is found on all T-cells?
CD3
progenitor T-cells are released from b…
-its never secreted (always in membrane)... -must recognize Ag &…
CD3
-signaling molecule for T cells... -needed for T-cell activation
-move into thymus... -T-cell education
The TCR differs from the BCR because...
-its never secreted (always in membrane)... -must recognize Ag &…
what is found on all T-cells?
CD3
40 terms
Cell Mediated
The TCR differs from the BCR because...
what is found on all T-cells?
CD3
progenitor T-cells are released from b…
-its never secreted (always in membrane)... -must recognize Ag &…
CD3
-signaling molecule for T cells... -needed for T-cell activation
-move into thymus... -T-cell education
The TCR differs from the BCR because...
-its never secreted (always in membrane)... -must recognize Ag &…
what is found on all T-cells?
CD3
5 terms
Cell mediated
cell mediated
what are the three types of T cells?
what do cytotoxic T cells do?
what do T helper cells do?
thymus gland --> T lymphocytes (T cells)
1. cytotoxic T cells... 2. T helper cells... 3. T suppressor cells
directly kills cells (lysis)
controls the immune system, direct action of the system
cell mediated
thymus gland --> T lymphocytes (T cells)
what are the three types of T cells?
1. cytotoxic T cells... 2. T helper cells... 3. T suppressor cells
Cell Mediators
Mediator
Histamine
Serotinin
Lysosomal Enzymes
Source
Mast Cells, Basophills, platelets
Platelets
Nutrophils, Macrophages
Mediator
Source
Histamine
Mast Cells, Basophills, platelets
Cell mediators
C chemokines
Cc chemokines
Cc chemokines production
Cxc chemokines attrached
Attack precusor t cells
Attack monocytes
Made by marcophages
Neutrophils
C chemokines
Attack precusor t cells
Cc chemokines
Attack monocytes
10 terms
19_T CELL-MEDIATED IMMUNITY
Define the main molecules involved in…
primary T cell functions in combating…
central vs effector memory
adhesion molecules in T cell response
1. Specific recognition by the T cell receptor (TCR) of a pep…
1. Naïve T cells can only be activated by professional antige…
central memory - memory T cells maintained in the secondary l…
Adhesion molecules are critical in stabilizing the T cell-APC…
Define the main molecules involved in…
1. Specific recognition by the T cell receptor (TCR) of a pep…
primary T cell functions in combating…
1. Naïve T cells can only be activated by professional antige…
7 terms
Cell-Mediated Immunity Cells
B Cells
Plasma Cells
Helper T Cells
Cytotoxic T Cells
lymphocytes located in lymph nodes
Antibody Producing Machine
releases lymphokines which rids the body of antigens. They ar…
called the killer T's. Kills the virus-invaded body cells and…
B Cells
lymphocytes located in lymph nodes
Plasma Cells
Antibody Producing Machine
5 terms
61. CELL-MEDIATED IMMUNITY
How does Measles virus lead to decreas…
Measles and CMV effect on CMI
Test for Evaluation of Cell-mediated i…
In-vitro test for lymphoid cell compet…
Decreased IL-12 production from the macrophages
Decrease CMI ... Loss of PPD skin test ... reactivation of latent o…
1. In-vivo tests ... 2. In-vitro tests ... In-vivo tests:... 1. Skin…
1. Lymphocyte Blast Transformation for T cells (Phythemagglut…
How does Measles virus lead to decreas…
Decreased IL-12 production from the macrophages
Measles and CMV effect on CMI
Decrease CMI ... Loss of PPD skin test ... reactivation of latent o…
21 terms
T cell mediated immunity
naive t cell
effector t cell
3 molecules involved in movement of na…
l-selectin purpose
not stimulated with mhc antigen
stimulated and cascade activated
selectins (l-selectin), integrins (LFA-1), chemokines (CCL21,…
t cell rolling along hev
naive t cell
not stimulated with mhc antigen
effector t cell
stimulated and cascade activated
34 terms
T cell-mediated immunity
Naive T cells encounter antigen in the…
lymph node structure
accessory molecules for a TCR complex…
TCR co-receptors
-naive T cells circulate from LN to LN scanning the dendritic…
2x CD3 heterodimers, a zeta chain homodimer
MHC-TCR interactions are very weak without coreceptors... -corec…
Naive T cells encounter antigen in the…
-naive T cells circulate from LN to LN scanning the dendritic…
lymph node structure
15 terms
Cell Mediated Immunity
Types of CMI
Key T cell Receptors/Markers
TcR Characteristics
αβ TcR
1) Cytotoxicity by cytotoxic T cells (TC)... 2) Helper T cell (T…
3 key receptors/markers... • TcR - uniqiue to cell [undergo + a…
univalent... clonotypic... αβ (90-95% of T cells) or γδ heterodimer…
- recognize only peptide antigens (from "processed" foreign p…
Types of CMI
1) Cytotoxicity by cytotoxic T cells (TC)... 2) Helper T cell (T…
Key T cell Receptors/Markers
3 key receptors/markers... • TcR - uniqiue to cell [undergo + a…
T Cell Mediated Immunity
CD40L
Fas Ligand
Perforin
Granzymes
A membrane-bound cytokine expressed on effector Tcells (CD4+…
A membrane-bound cytokine expressed on the surface of CTLs (C…
Pokes wholes in the surface of an infected cell that has been…
Secreted by CTLs when inducing apoptosis of infected cells. I…
CD40L
A membrane-bound cytokine expressed on effector Tcells (CD4+…
Fas Ligand
A membrane-bound cytokine expressed on the surface of CTLs (C…
31 terms
T Cell-Mediated Immunity
Primary Concept of T-cell mediated imm…
T-cell mediated immunity
Activation of naïve T cells leads to t…
Naïve T cells undergo multiple steps b…
- Naïve T cells circulate through lymphoid tissues where they…
- Naïve T cell are constantly re-circulating through secondar…
- After T cells recognize peptides presented by antigen prese…
Primary Concept of T-cell mediated imm…
- Naïve T cells circulate through lymphoid tissues where they…
T-cell mediated immunity
- Naïve T cell are constantly re-circulating through secondar…
70 terms
Cell-Mediated Reactions
Cell-mediated immunity (CMI) includes
T-cell cytotoxicity
Naive CD8+ cells activated by
CD8+ undergo ______ before becoming ac…
T-cell cytotoxicity ... Delayed type hypersenstivity (DTH)
T mediated cellular cytotoxicity involving direct contact bw…
exposure to Ag-MHC I complexes ... +... interleukins (IL-2) produce…
proliferation & differentiation
Cell-mediated immunity (CMI) includes
T-cell cytotoxicity ... Delayed type hypersenstivity (DTH)
T-cell cytotoxicity
T mediated cellular cytotoxicity involving direct contact bw…
15 terms
Cell Mediated Immunity
T-Cell Independent B-Cell Activation
Effector Cells of CMI
Macrophages
Interferon Gamma
Occurs at a low level without T-Cell Help... Can Only produce Ig…
- Macrophages ... - Cytotoxic T Lymphocytes... - Natural Killer C…
M1 Macrophages activate TH1 Cytotoxic T-Cells- Kill the organ…
TH1 Cells will bathe the cell with interferon Gamma - key for…
T-Cell Independent B-Cell Activation
Occurs at a low level without T-Cell Help... Can Only produce Ig…
Effector Cells of CMI
- Macrophages ... - Cytotoxic T Lymphocytes... - Natural Killer C…
T-cell mediated immunity
T cells undergo development in the:
Secondary lymphoid tissue
Where do naive T cells encounter antig…
6 types of Effector T cells
Thymus where they migrate to peripheral lymphoid organs, wher…
Lymph nodes ... Spleen ... Peyer's Patch ... -Anatomical crossroads f…
Naive T cells encounter antigen during their recirculation th…
CD8 cytotoxic T cells ... CD4 TH1 cells ... CD4 TH2 cells ... CD4 TH17…
T cells undergo development in the:
Thymus where they migrate to peripheral lymphoid organs, wher…
Secondary lymphoid tissue
Lymph nodes ... Spleen ... Peyer's Patch ... -Anatomical crossroads f…
49 terms
Cell-Mediated Immunity-Goodrum
CD4
Cell mediated immunity
regulatory *helper T cell dependent ma…
Cell mediated immunity is transferred…
(Helper T cells)... regulate quantity & quality of immune syste…
refers to protective effects of:... *cytotoxic T cells & their…
By release of gamma interferon, helper T cells enhance macrop…
Humoral immunity can be transferred by plasma (just the antib…
CD4
(Helper T cells)... regulate quantity & quality of immune syste…
Cell mediated immunity
refers to protective effects of:... *cytotoxic T cells & their…
12 terms
cell mediated immune response
cell-mediated immunity
clonal selection
clone cells
what type of cells to T cells become?
-begins with activation of a small number of T cells by a spe…
-the process by which a lymphocyte divides several times (pro…
-the result of clonal selection. ... -cells that can recognize t…
-they become either effector cells (cell killers)... , or memory…
cell-mediated immunity
-begins with activation of a small number of T cells by a spe…
clonal selection
-the process by which a lymphocyte divides several times (pro…
Adaptive: Antibody mediated vs. Cell Mediated
cytokines
non-specific host defense
specific immunity (adaptive)
antigen presenting cells
released after a foreign invader interacts with phagocytes, i…
innate immunity
acquired immunity
macrophages, dendritic cells and B cells. ... express HLA class…
cytokines
released after a foreign invader interacts with phagocytes, i…
non-specific host defense
innate immunity
T Cell-Mediated Immunity
Three Major Functions of T-Lymphocytes
How do some pathogens evade T cell kil…
Examples of pathogens that can evade T…
Examples of pathogens that infect epit…
1. Activation of phagocytes... 2. Direct killing of infected cel…
a) survive within phagolysosomes... b) escape from phagolysosome…
a) Intracellular bacteria... - mycobacteria... - listeria monocytog…
a) Viruses... - all ... b) Rickettsiae... c) Protozoa... - plasmodium fal…
Three Major Functions of T-Lymphocytes
1. Activation of phagocytes... 2. Direct killing of infected cel…
How do some pathogens evade T cell kil…
a) survive within phagolysosomes... b) escape from phagolysosome…
61 terms
Cell-mediated immunity (DONE)
What percent of peripheral blood T cel…
What is the action of T-helper lymphoc…
Regulatory T cells
What percent of peripheral blood T cel…
~65%
-also called effector T cells or TH cells... -help induce activa…
-abbreviated Treg, formally known as suppressor T-lymphocytes…
~35%
What percent of peripheral blood T cel…
~65%
What is the action of T-helper lymphoc…
-also called effector T cells or TH cells... -help induce activa…
7 terms
cell mediated immunity
cd4
cd8
class I MHC
antigen presenting cells
t cells, helper
t cells, cytotoxic (killer)
found on all body cells except RBCs, identifies self vs non s…
dendritic cells and macrophages
cd4
t cells, helper
cd8
t cells, cytotoxic (killer)
45 terms
Cell-Mediated Immunity
humoral immunity
effector B cells (plasma cells)
antibodies
cell-mediated immunity
antimicrobial defense provided by antibodies
____________________ secrete antibodies in humoral immunity
__________ attach to microbes and speed their destruction and…
antimicrobial defense mediated by effector t cells
humoral immunity
antimicrobial defense provided by antibodies
effector B cells (plasma cells)
____________________ secrete antibodies in humoral immunity
51 terms
B Cell Mediated Diseases
The Hypersensitivities (4 Types = Medi…
Which Hypersensitivity Reactions are A…
Type I, II, III Mechanism, Response Ti…
Allergic Diseases Associated with (2)
Type I, II, & III
IgE & Mast Cells
The Hypersensitivities (4 Types = Medi…
Which Hypersensitivity Reactions are A…
Type I, II, & III
46 terms
15 - Cell mediated immunity
Antibodies binds to _________ microbes
2 Major effects of antibodies binding…
*Cell mediated immunity targets* _____…
2 kinds of intracellular microbes:
- extracellular
1) opsonization (via phagocytes - macrophages & neutrophils)…
- intracellular microbes
1) microbes that are living in phagocytes (surviving in the p…
Antibodies binds to _________ microbes
- extracellular
2 Major effects of antibodies binding…
1) opsonization (via phagocytes - macrophages & neutrophils)…
31 terms
T cell mediated pathophysiology
What is hypersensitivity?
Diabetes is an example of what type of…
Poison Ivy is an example of what type…
How does a mononuclear cell infiltrate…
An immune effector response to a typically non-pathogenic ant…
Type 4 - think T cells
Type 4 - contact hypersensitivity, delayed type hypersensitiv…
lots of round blue immune cells
What is hypersensitivity?
An immune effector response to a typically non-pathogenic ant…
Diabetes is an example of what type of…
Type 4 - think T cells
Cell Mediated Immunity
What are expressed on surface of T cel…
What is structure of TCR
Draw what a T cell receptor looks like
Describe the 3D structure of T-cell re…
B cells express surface immunolobulins... T cells express T-cell…
they have similar structure to Ig... 2 polypeptide chains that a…
It has a purple regions for alpha portion and a blue region f…
What are expressed on surface of T cel…
B cells express surface immunolobulins... T cells express T-cell…
What is structure of TCR
they have similar structure to Ig... 2 polypeptide chains that a…
28 terms
Cell-mediated immunity
CD4+ T cells
Th2 cells
Th17 cells
CD8+ T cells
1. Recognise peptide - MHC Class 2 complex... 2. Upon binding to…
Activate B cells to produce antibodies via IL-4 and IL-13
Inflammatory response via IL-17 and IL-22
1. Recognise peptide - MHC class 1 complex... 2. Upon binding to…
CD4+ T cells
1. Recognise peptide - MHC Class 2 complex... 2. Upon binding to…
Th2 cells
Activate B cells to produce antibodies via IL-4 and IL-13
20 terms
Cell Mediated Immunity & HIV
Adaptive Immunity
Helper T Lymphocytes
Cytotoxic T Lymphocytes
Regular T Lymphocytes
*Problem: Viruses can get inside cells... -need other mechanism…
Activates Cytotoxic T cells & B Lymphocytes (activates specif…
Destroy viral infected cells; occasionally bacterial infected…
Destroy, inactivate, or stimulate the development of Lymphocy…
Adaptive Immunity
*Problem: Viruses can get inside cells... -need other mechanism…
Helper T Lymphocytes
Activates Cytotoxic T cells & B Lymphocytes (activates specif…
Cells of Cell-Mediated Immunity
T Helper Cell (Th1)
T Helper Cell (Th2)
T Helper Cell (Th17)
Cytotoxic T Lymphocyte (CTL)
activates cells related to cell-mediated immunity, macrophage…
stimulates production of eosinophils, IgM, and IgE
recruits neutrophils; stimulates production of antimicrobial…
destroys target cells on contact, generated from T cytotoxic…
T Helper Cell (Th1)
activates cells related to cell-mediated immunity, macrophage…
T Helper Cell (Th2)
stimulates production of eosinophils, IgM, and IgE
Cell-Mediated Immunity
T lymphocytes
T cell maturation
T cells (αβ CD4)
CD4 glycoprotein
All have TCR and CD3... Maturation begins in the bone marrow and…
...
T Helper cells: 2 types, 1 and 2... Fight extracellular infectio…
On T-helper cells... Binds MHC1
T lymphocytes
All have TCR and CD3... Maturation begins in the bone marrow and…
T cell maturation
...
27 terms
T Cell-Mediated Immunity
What do Dendritic cells do for T cells
The process of dendritic cells maturing
The change of dendtric cells by locati…
The five different ways dendritic cell…
-they carry antigens from sites of infection to T cells in se…
Mature in transit from infected tissue to lymphoid organ:... -i…
-peripheral tissue: will contain both MHC and lysosomal prote…
1) Endocytosis where MHC II presents bacteria to CD4... 2) Macro…
What do Dendritic cells do for T cells
-they carry antigens from sites of infection to T cells in se…
The process of dendritic cells maturing
Mature in transit from infected tissue to lymphoid organ:... -i…
25 terms
Cell Mediated Reactions
What pathway does Fas/FasL trigger?
What pathway do granzymes trigger?
What Cytokines are release by CTCL?
Granzymes
JUN Kinase--> Caspase 8
Downstream Caspase--> mitochondria and DNA fragmentation
INF-G and TNF-A
Proteases that degrade cellular components once activated in…
What pathway does Fas/FasL trigger?
JUN Kinase--> Caspase 8
What pathway do granzymes trigger?
Downstream Caspase--> mitochondria and DNA fragmentation
15 terms
Cell mediated Immunity- 2
How do the cytokines of TH1 and TH2 di…
What stimulates TH1 and TH2 differenti…
How are macrophages activated?
Faulty TH1 development translates into…
- cytokines of TH1 are macrophage activating... - cytokines of T…
- Viruses can induce dendritic cells to secrete IL12 that cau…
- CD 40 on the macrophage bind to CD40 Ligand on TH1... - releas…
- increased susceptibility to infections
How do the cytokines of TH1 and TH2 di…
- cytokines of TH1 are macrophage activating... - cytokines of T…
What stimulates TH1 and TH2 differenti…
- Viruses can induce dendritic cells to secrete IL12 that cau…
34 terms
Cell-Mediated Immune Responses
what are 2 ways that T cells can elimi…
Do CH4+ cells interact with B cells to…
Do we ever see naive T cells circulati…
What happens to a T cell after antigen…
(1) Directly by killing the infected cell via CD8_+... (2) Indir…
Hell yeah they do
Yes, this is where they circulate to look for antigens that t…
Clonal expansion and T cell differentiation
what are 2 ways that T cells can elimi…
(1) Directly by killing the infected cell via CD8_+... (2) Indir…
Do CH4+ cells interact with B cells to…
Hell yeah they do
32 terms
T-cell mediated immunity
what are the main points of how T cell…
CD8 t cells recognise
CD4 TH1 or TH2 (helper) recognise
where does CD8 bind to on MHC class1
Ig and TCR are specific to antigens... Ig and TCR are structural…
MHC class 1 peptides
MHC class 2 peptides
alpha 3 domain
what are the main points of how T cell…
Ig and TCR are specific to antigens... Ig and TCR are structural…
CD8 t cells recognise
MHC class 1 peptides
Cell-Mediated Effector Responses
What are the 4 subgroups of CD4+ T cel…
What are the 2 subgroups of CD8+ T cel…
Technically, what is the difference be…
What are the effector B cells and what…
1) Th - produce cytokines to regulate immune response... 2) Tdth…
1) Tc - produce cytokines that kill target cells... 2) Ts - prod…
APC = Exclusively used for class II presentation... Target cell…
Plasma cell, produce Ab
What are the 4 subgroups of CD4+ T cel…
1) Th - produce cytokines to regulate immune response... 2) Tdth…
What are the 2 subgroups of CD8+ T cel…
1) Tc - produce cytokines that kill target cells... 2) Ts - prod…
20 terms
Cell mediated Immunity-1
Where do naive T lymphocytes first... enc…
What provides 1st signal for T cell ac…
blocking costimulators may... be a strate…
How do T lymphocytes respond after ant…
Secondary Lymphoid organs
When TCR (of native cell) binds to MHC class
...
1. clonal expansion of antigen specific clones... 2. naive t-cel…
Where do naive T lymphocytes first... enc…
Secondary Lymphoid organs
What provides 1st signal for T cell ac…
When TCR (of native cell) binds to MHC class
25 terms
functions of cell-mediated immunity and antibody-mediated immunity
antigen
complete antigen
Immunogenicity
reactivity
A substance that has immunogenicity and reactivity; contracti…
A substance that has immunogenicity and reactivity
-ability to provoke an immune response by stimulating the pro…
-the ability of the antigen to react specifically with the an…
antigen
A substance that has immunogenicity and reactivity; contracti…
complete antigen
A substance that has immunogenicity and reactivity
Cell mediated immunity
Which of the following are antigen pre…
helper t cells interact with target ce…
helper t cells secrete ______ to stimu…
helper t cells interact with class 1 m…
macrophages and b cells
antigen-MHC protein complexes
cytokines
false
Which of the following are antigen pre…
macrophages and b cells
helper t cells interact with target ce…
antigen-MHC protein complexes
Cell Mediated Immunity
________- delays allergic reaction fro…
What's an example T- Delayed Hypersens…
Cytotoxic Cells (TC Cells) / Killer T-…
________- creates gaps "holes" in plas…
T- Delayed Hypersensitivity
Poison Ivy, Hives, PPD Reading for TB
CD 8 Cells
Perforin
________- delays allergic reaction fro…
T- Delayed Hypersensitivity
What's an example T- Delayed Hypersens…
Poison Ivy, Hives, PPD Reading for TB
22 terms
T cell mediated immunity
Why are DCs highly effective APCs and…
DF macropinocytosis
Where are immature and mature DCs
what determines homing
DS can move from site of infection to secondary lymphoid orga…
how DCs capture pathogens that are not recognized by receptor…
Tissue... lymph nodes, because they develop highly eleaborated…
chemokines and CAMs
Why are DCs highly effective APCs and…
DS can move from site of infection to secondary lymphoid orga…
DF macropinocytosis
how DCs capture pathogens that are not recognized by receptor…
Cell Mediated Cytotoxicity
What is cytotoxicity?
Cell-mediated cytotoxicity is an essen…
What are the two cell types?
What are the two types of T Cells?
The ways in which leukocytes recognize and destroy other cells
- Intracellular pathogens, most notably viruses... - Intracellul…
Nk cells and T cells
T Helper cells and Cytotoxic T Lymphocytes (CTLs)
What is cytotoxicity?
The ways in which leukocytes recognize and destroy other cells
Cell-mediated cytotoxicity is an essen…
- Intracellular pathogens, most notably viruses... - Intracellul…
19 terms
T Cell Mediated Diseases
When T cell respond to what 5 things t…
Delayed type hypersensitivity has a me…
Delayed type hypersensitivity does not…
Do CD8+ cells play a part in delayed t…
autoantigen... persistent antigen... inappropriate antigen... transpla…
cell mediated immunity
antibodies... CD4+ Th1 T cells... macrophages
They often play a part in the response
When T cell respond to what 5 things t…
autoantigen... persistent antigen... inappropriate antigen... transpla…
Delayed type hypersensitivity has a me…
cell mediated immunity
24 terms
2-Cell Mediated Immunity
Immature dendritic cells are found whe…
Langerhan cells are immature __
Which marker is a co-stimulator locate…
MHC II markers are found on which type…
Skin/mucosa... Yes
Dendritic cells
B7
Antigen presenting cells
Immature dendritic cells are found whe…
Skin/mucosa... Yes
Langerhan cells are immature __
Dendritic cells
12 terms
Cell Mediated Immune Effector Mechanisms
T-cell Cytotoxicity
Cytotoxic T-Cell Mechanisms
Medical Examples of T-Cell Cytotoxicity
CD8+ CTLs are activated by APCs and CD…
Cytotoxicity involving direct contact between CTLs and target…
CTLs mediate the cellular lysis of targetcells via *Perforins…
Protective Mechanisms: ... 1. Viral infections... 2. Cancer - immun…
T-cell Cytotoxicity
Cytotoxicity involving direct contact between CTLs and target…
Cytotoxic T-Cell Mechanisms
CTLs mediate the cellular lysis of targetcells via *Perforins…
Cell-mediated immunity
cell-mediated immunity
Step 1
TCRs
CD3 Proteins
-moderated by T-cells... -T-cells make up 2/3 of circulating lym…
-T-cells are mobilized when they encounter a cell such a dend…
-T-cell receptors on membranes... -responsible for recognizing t…
-closely associated with TCR... -transmit signal into the cell... -…
cell-mediated immunity
-moderated by T-cells... -T-cells make up 2/3 of circulating lym…
Step 1
-T-cells are mobilized when they encounter a cell such a dend…
15 terms
cell/antibody mediated immunity
cell mediated
cell mediated
cell mediated
cell mediated
antigen is processed
cytotoxic T cells eliminate invader
memory cells are produced
effective against intracellular pathogens
cell mediated
antigen is processed
cell mediated
cytotoxic T cells eliminate invader
5 terms
Cell Mediated Response Cycle
Step 1
Step 2
Step 3
Step 4
Helper T cells are activated when a specific Pathogen enters…
Helper T cells will begin to replicate, creating two, new dif…
Some Helper T Cells will seek out B Cells
Killer T Cells then release Cytokines into the body fluid; Cy…
Step 1
Helper T cells are activated when a specific Pathogen enters…
Step 2
Helper T cells will begin to replicate, creating two, new dif…
31 terms
T cells and cell-mediated immunity
T cell
antigen recognition
costimulation
interleukin-2
only becomes activated if its antigen receptor binds to the f…
antigen receptor's T cell binds to the foreign antigen
second stimulating signal required to activate a T cell
aka IL-2
T cell
only becomes activated if its antigen receptor binds to the f…
antigen recognition
antigen receptor's T cell binds to the foreign antigen
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