Study sets matching "cerebral blood flow"
Study sets
Diagrams
Classes
Users
Normal cerebral blood flow in adults is…
cerebral blood flow is high related to…
What are the 4 metabolic factors that h…
Increased CO2 or H+ concentration resul…
15
metabolism
1. CO2 concentration... 2. Hydrogen ion concentration... 3. O2 conce…
increased
Normal cerebral blood flow in adults is…
15
cerebral blood flow is high related to…
metabolism
-2 Internal caratoid Arteries (Anterior…
-Opthalamic artery... -Choroidal artery... -A…
-Anterior spinal artery ... -Posterior spi…
At the base of the pons the vertebral a…
Brain is supplied by what blood vessels
Internal Carotid Branches
Vertebral Artery Branches
Basilar Artery Branches
-2 Internal caratoid Arteries (Anterior…
Brain is supplied by what blood vessels
-Opthalamic artery... -Choroidal artery... -A…
Internal Carotid Branches
arterial supply of heart
epicardial vs. endocardial arteries
arterial pressure and autoregulation in…
flow= change in pressure/resistance
- remember, left and right coronary arteries have origin in ro…
- Arterial blood vessels have to dive down into wall of blood…
- During systole, squeeze vessels on endocardial more than on…
- Effects more prominent on left side of heart due to increase…
arterial supply of heart
- remember, left and right coronary arteries have origin in ro…
epicardial vs. endocardial arteries
- Arterial blood vessels have to dive down into wall of blood…
How much CO does the brain receive? How…
What is higher arterial or intracranial…
what do the anterior and posterior circ…
what is the blood supply of the cerebel…
• Receives 15% cardiac output , 7.5 times metabolism/unit mass…
• Systemic arterial pressure > intracranial pressure... • Brain i…
Anterior circulation ... • 80% of blood supply ... • Derived from in…
Supplied by: ... - Branches from the basilar artery:... • Superior c…
How much CO does the brain receive? How…
• Receives 15% cardiac output , 7.5 times metabolism/unit mass…
What is higher arterial or intracranial…
• Systemic arterial pressure > intracranial pressure... • Brain i…
What arteries are considered pial arter…
How does astrocytes and parasites contr…
What is a neurovascular unit?
What is the metabolic demand of O2, CO…
basilar, circle of willis surrounded by CSF. Located in the pi…
astrocyte contribute to ion and water homeostasis. Pericytes r…
capillary, pericytes, astrocytes and neuron bundle.
20% O2, 15%CO, 25% of glucose. Glucose utilization remain cons…
What arteries are considered pial arter…
basilar, circle of willis surrounded by CSF. Located in the pi…
How does astrocytes and parasites contr…
astrocyte contribute to ion and water homeostasis. Pericytes r…
Internal Carotid
Opthalamic (Off of internal carotid)
Posterior communicating
Anterior choroidal (Off of internal car…
May be asymptomatic ... Contralateral hemiplegia ... Contralateral…
Visual symptoms
...
Regions: Lateral geniculate body, internal capsule, basal gang…
Internal Carotid
May be asymptomatic ... Contralateral hemiplegia ... Contralateral…
Opthalamic (Off of internal carotid)
Visual symptoms
Monro-Kelly Doctrine
Three compartments of skull
Three stages of compensation for raised…
Normal ICP value
- Skull is a rigid container of constant volume... - Increase in…
i) Brain 85%... ii) CSF 10%... iii) Blood 5%
1) Reduction in venous blood volume... 2) Reduction in CSF volume…
5-15mmHg
Monro-Kelly Doctrine
- Skull is a rigid container of constant volume... - Increase in…
Three compartments of skull
i) Brain 85%... ii) CSF 10%... iii) Blood 5%
cranial vault
CSF
extravascular compression
subtract
The __ - rigid structure with a fixed total volume:... brain (80%…
↑ in 1 must be offset by an equivalent ↓ in another to prevent…
↑ in ICP - __
if we go above the heart, you __ pressure due to gravity ... pre…
cranial vault
The __ - rigid structure with a fixed total volume:... brain (80%…
CSF
↑ in 1 must be offset by an equivalent ↓ in another to prevent…
Highly permeable
Slightly permeable
Impermeable
Tight junctions... Basement membrane... Podoc…
Permeability of BBB to water, CO2, O2, and most lipid-soluble…
Permeability of BBB to electrolytes (Na, K, Cl)
Permeability of BBB to proteins & other polar substances
4 components of BBB
Highly permeable
Permeability of BBB to water, CO2, O2, and most lipid-soluble…
Slightly permeable
Permeability of BBB to electrolytes (Na, K, Cl)
carotids, anterior cerebral artery, mid…
vertebrals/basilar, posterior cerebral…
superior cerebellar arteries
middle cerebral junction
anterior circulation
posterior circulation
Posterior... -basilar branches off into the ____ ____ _____
Anterior... -anterior cerebral branches to ___ ____ ____
carotids, anterior cerebral artery, mid…
anterior circulation
vertebrals/basilar, posterior cerebral…
posterior circulation
the anterior circulation of the brain:…
the posterior circulation of the brain:…
the circle of willis is the __ __ circle
the circle of willis is important __ bt…
internal carotid; anterior cerebral artery(ACA); anterior comm…
vertebral artery; basilar; posterior cerebral; posterior commu…
central arterial
anastomosis; 2; 2
the anterior circulation of the brain:…
internal carotid; anterior cerebral artery(ACA); anterior comm…
the posterior circulation of the brain:…
vertebral artery; basilar; posterior cerebral; posterior commu…
Anterior blood supply
Posterior blood supply
Circle of Willis
Pleural linkage
left and right carotid arteries --> internal carotid... 1. Anteri…
left and right subclavian arteries --> vertebral arteries -->…
convergence of internal carotid and vertebral arteries at the…
surface tension between the wet pleural linings draw the lungs…
Anterior blood supply
left and right carotid arteries --> internal carotid... 1. Anteri…
Posterior blood supply
left and right subclavian arteries --> vertebral arteries -->…
Cerebral Blood Flow
Arteries
Blood Flow from the Heart to the Brain
Circle of Willis
Cerebral Blood Flow
1) Deliver oxygen and nutrient-rich blood to the body... 2) Branc…
1) Anterior blood supply to the brain originates from left and…
1) The internal carotid and verterbral artery supplies converg…
Cerebral Blood Flow
Cerebral Blood Flow
Arteries
1) Deliver oxygen and nutrient-rich blood to the body... 2) Branc…
Intracranial pressure (ICP)
Brain tissue (78%), blood (12%), CSF (1…
Lipophilic (linezolid, metronidazole, f…
20%
Pressure inside skull and thus in brain tissue and CSF
Three essential components inside the skull:
Compounds that can pass the blood-CSF/BBB usually have this pr…
Brain is 2% of body weight, receives 11% of cardiac output, an…
Intracranial pressure (ICP)
Pressure inside skull and thus in brain tissue and CSF
Brain tissue (78%), blood (12%), CSF (1…
Three essential components inside the skull:
What is cerebral blood flow in ml/min?…
Below what cerebral blood flow does cer…
What are the two determinants of cerebr…
Cerebral perfusion pressure normally is…
Cerebral blood flow is 750 ml/min, 50 ml/100g/min, and 15% of…
EEG evidence of cerebral ischemia appears when cerebral blood…
The two determinants of cerebral blood flow are cerebral vascu…
Cerebral perfusion = MAP-ICP. Note: MAP is mean arterial press…
What is cerebral blood flow in ml/min?…
Cerebral blood flow is 750 ml/min, 50 ml/100g/min, and 15% of…
Below what cerebral blood flow does cer…
EEG evidence of cerebral ischemia appears when cerebral blood…
Several metabolic factors that contribu…
A fall in arterial pressure below what…
Where is metabolic rate the highest in…
What type of brain injury occurs in "sh…
Carbon dioxide concentration, hydrogen ion concentration, oxyg…
60 mm Hg
Gray (as this is where the neuronal cell bodies lie)
Coup and contrecoup
Several metabolic factors that contribu…
Carbon dioxide concentration, hydrogen ion concentration, oxyg…
A fall in arterial pressure below what…
60 mm Hg
What percentage of resting C.O does the…
What potentially regulates blood flow i…
What is the connection between CO2, PH…
Why is a build up of H+ in cerebral tis…
15%, 750-950 ml/min
Astrocyte foot processes
Any substance that decreases cerebral PH leads to an increase…
Inhibits neuronal function,... Increase cerebral blood flow via v…
What percentage of resting C.O does the…
15%, 750-950 ml/min
What potentially regulates blood flow i…
Astrocyte foot processes
Several metabolic factors that contribu…
A fall in arterial pressure below what…
Where is metabolic rate the highest in…
What type of brain injury occurs in "sh…
Carbon dioxide concentration, hydrogen ion concentration, oxyg…
60 mm Hg
Gray (as this is where the neuronal cell bodies lie)
Coup and contrecoup
Several metabolic factors that contribu…
Carbon dioxide concentration, hydrogen ion concentration, oxyg…
A fall in arterial pressure below what…
60 mm Hg
Relationship between pCO2 and Cerebral…
How is H+ regulated in cerebral tissue
O2 defeciency leads to
Astrocytes
Direct Relationship ... (CO2 + H2O -> H2CO3 -> H+ HCO3-)... H+ acts…
Increases in blood flow, allows delivery of H+ ions and CO2 aw…
Vasodilation (increases blood flow)
Star shaped non-neuronal cells that support, protect neurons,…
Relationship between pCO2 and Cerebral…
Direct Relationship ... (CO2 + H2O -> H2CO3 -> H+ HCO3-)... H+ acts…
How is H+ regulated in cerebral tissue
Increases in blood flow, allows delivery of H+ ions and CO2 aw…
What are the two major arterial supply…
Where does the internal carotid artery…
Where does the vertebral-basilar system…
Which parts of the CNS are supplied by…
Vertebral-basilar (posterior cerebral artery) and internal car…
Carotid canal
Foramen magnum
Anterior: frontal, parietal, temporal lobes
What are the two major arterial supply…
Vertebral-basilar (posterior cerebral artery) and internal car…
Where does the internal carotid artery…
Carotid canal
Pial arteries:
• Capillaries, pericytes, astrocytes, a…
influence arteriole and capillary... funct…
contribute to vessel stability and... rele…
• Basilar, circle of Willis and the 3... branching arteries (ante…
"neurovascular unit".
Astrocytes
pericytes
Pial arteries:
• Basilar, circle of Willis and the 3... branching arteries (ante…
• Capillaries, pericytes, astrocytes, a…
"neurovascular unit".
What is cerebral blood flow in ml/min?…
Below what cerebral blood flow does cer…
What are the two determinants of cerebr…
Cerebral perfusion pressure normally is…
Cerebral blood flow is 750 ml/min, 50 ml/100g/min, and 15% of…
EEG evidence of cerebral ischemia appears when cerebral blood…
The two determinants of cerebral blood flow are cerebral vascu…
Cerebral perfusion = MAP-ICP. Note: MAP is mean arterial press…
What is cerebral blood flow in ml/min?…
Cerebral blood flow is 750 ml/min, 50 ml/100g/min, and 15% of…
Below what cerebral blood flow does cer…
EEG evidence of cerebral ischemia appears when cerebral blood…
stroke
Brachiocephalic artery
common
tumor
lack of oxygenated artery blood to part of the brain
send blood to head and arms -R
what term means it will split
relatively slow and progressive
stroke
lack of oxygenated artery blood to part of the brain
Brachiocephalic artery
send blood to head and arms -R