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Study sets matching "cyclooxygenase 1"

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Study sets matching "cyclooxygenase 1"

90 terms
Unit 1: Cyclooxygenase Inhibitors
Cyclooxygenase inhibitors interact wit…
Cyclooxygenase inhibitors should not b…
Cyclooxygenase inhibitors should not b…
What is the prototype of cyclooxygenas…
anticoagulants, glucocorticoids, ACE inhibitors, ARBs and vac…
peptic ulcers and bleeding disorders
under 18, Reyes Syndrome
aspirin
Cyclooxygenase inhibitors interact wit…
anticoagulants, glucocorticoids, ACE inhibitors, ARBs and vac…
Cyclooxygenase inhibitors should not b…
peptic ulcers and bleeding disorders
26 terms
Pharm- Cyclooxygenase (COX) 1-2
COX 1 enzyme
NSAID'S ( treats pain, fever, inflamma…
NSAIDS function:
Pain scales
Converts arachidonic acid into prostaglandins... Stimulates the…
aspirin... Ibuprofen ( advil, motrin)... naproxen (Naprosyn, aleve)…
cause gastric upset, heatburn, gastric ulcer, may cause GI bl…
Face scale... and 0-10 scale
COX 1 enzyme
Converts arachidonic acid into prostaglandins... Stimulates the…
NSAID'S ( treats pain, fever, inflamma…
aspirin... Ibuprofen ( advil, motrin)... naproxen (Naprosyn, aleve)…
33 terms
Cyclooxygenase Inhibitors page 1-2
COX
housekeeping enzyme
day to day function
produces prostaglandin which protects…
cyclooxygenase
COX 1: function #1
COX 1: function #2
COX 1: function #3
COX
cyclooxygenase
housekeeping enzyme
COX 1: function #1
53 terms
cyclooxygenase inhibitors
cyclooxygenase inhibitors
cyclooxygenase inhibitors may be
cyclooxygenase inhibitors uses
cyclooxygenase inhibitors adverse effe…
work against receptors
an alternative to opiates will not cause respiratory depression
suppress inflammation... relieve pain... reduce fever
gastric ulceration ... bleeding ... renal impairement
cyclooxygenase inhibitors
work against receptors
cyclooxygenase inhibitors may be
an alternative to opiates will not cause respiratory depression
Cyclooxygenase Inhibitors
Cyclooxygenase Inhibitors
principal adverse effects of cyclooxyg…
Inhibition of COX-1 ("good COX")
Inhibition of COX-2 ("bad COX"):
Therepeutic Uses:... Suppress inflammation... Relieve pain... Reduce f…
Adverse effects... Gastric ulceration... Bleeding... Renal impairment
Beneficial effects: Protection against MI and stroke... Adverse…
Largely beneficial effects:... Suppression of inflammation... Allev…
Cyclooxygenase Inhibitors
Therepeutic Uses:... Suppress inflammation... Relieve pain... Reduce f…
principal adverse effects of cyclooxyg…
Adverse effects... Gastric ulceration... Bleeding... Renal impairment
18 terms
Cyclooxygenase Inhibitors
CYCLOOXYGENASE INHIBITORS Nonsteroidal…
mechanism of action for aspirin
Uses of aspirin
adverse effects of aspirin
Prototype: Aspirin
Irreversible inhibition of cyclooxygenase (COX-1 and COX-2) S…
Suppression of inflammation Analgesia Reduction of fever in a…
Gastric distress (heartburn and nausea) GI bleeding, gastric…
CYCLOOXYGENASE INHIBITORS Nonsteroidal…
Prototype: Aspirin
mechanism of action for aspirin
Irreversible inhibition of cyclooxygenase (COX-1 and COX-2) S…
7 terms
Prostaglandins & Cyclooxygenase
Prostaglandins
Prostaglandins differ from hormones in…
Some GENERAL effects of prostaglandins:
prostaglandins IN FETAL CHILD
-derivatives of fatty acids... -produced in most tissues... -origin…
-act locally (near site of synthesis)... -are metabolized rapidl…
-cause smooth muscle contraction (involuntary)... -constrict bro…
-involved in keeping Ductus Arteriosis open (channel from pul…
Prostaglandins
-derivatives of fatty acids... -produced in most tissues... -origin…
Prostaglandins differ from hormones in…
-act locally (near site of synthesis)... -are metabolized rapidl…
53 terms
cyclooxygenase inhibitors
cyclooxygenase inhibitors
cyclooxygenase inhibitors may be
cyclooxygenase inhibitors uses
cyclooxygenase inhibitors adverse effe…
work against receptors
an alternative to opiates will not cause respiratory depression
suppress inflammation... relieve pain... reduce fever
gastric ulceration ... bleeding ... renal impairement
cyclooxygenase inhibitors
work against receptors
cyclooxygenase inhibitors may be
an alternative to opiates will not cause respiratory depression
33 terms
Med Chem Exam 3: Cyclooxygenase Hulme
Functional group necessary to induce a…
Three pockets necessary for COX binding
Cyclooxygenase adds 2 O2 molecules to…
What are three differences in COX2's t…
Sulfonamide... SO2NH2... (Also note, the more hydrophobic and bulky…
Isoleucine/Valine 523 - Valine is smaller and makes room for…
Heme
Those taken off the market:... More highly selective for COX 2 o…
Functional group necessary to induce a…
Sulfonamide... SO2NH2... (Also note, the more hydrophobic and bulky…
Three pockets necessary for COX binding
Isoleucine/Valine 523 - Valine is smaller and makes room for…
29 terms
Cyclooxygenase Inhibitors
Cyclooxygenase inhibitors
How does cyclooxygenase work?
COX 1
COX 2
COX inhibitors suppress inflammation (not acetaminophen), rel…
it is an enzyme that synthesizes prostaglandins; prostaglandi…
known as the good COX; primarily mediates beneficial processe…
known as the bad COX; produced mainly at sites of tissue inju…
Cyclooxygenase inhibitors
COX inhibitors suppress inflammation (not acetaminophen), rel…
How does cyclooxygenase work?
it is an enzyme that synthesizes prostaglandins; prostaglandi…
13 terms
Prostaglandins, Cyclooxygenase, and NSAIDS
Prostaglandins
Formation Process of Prostaglandins
Two types of Cyclooxygenase (COX)
Cox 1
promote inflammation and pain... IN THE GI: decrease stomach aci…
Arachidonic Acid + Cyclooxygenase = Prostaglandins
Cox 1 and Cox2
found everywhere in the body, housekeeping chores, good guys,…
Prostaglandins
promote inflammation and pain... IN THE GI: decrease stomach aci…
Formation Process of Prostaglandins
Arachidonic Acid + Cyclooxygenase = Prostaglandins
Pharm 71: Cyclooxygenase Inhibitors
NSAIDs
FG NSAID drugs
Non aspirin FG NSAIDs: profens, naprox…
aspirin
decreases inflammation, pain, fever... AE: gastric ulceration,…
aspirin, -profens, naproxyn, ketoprofen
inhibit COX-1 and COX-2; reversible ... treats inflammatory dis…
inhibit COX-1 and COX-2; irreversible; cardioprotective b/c i…
NSAIDs
decreases inflammation, pain, fever... AE: gastric ulceration,…
FG NSAID drugs
aspirin, -profens, naproxyn, ketoprofen
19 terms
306:Cyclooxygenase inhibitors
action of cyclooxygenase (at sites of…
action of cyclooxygenase in platelets
cyclooxygenase in kidneys
cyclooxygenase in brain
-converts arachidonic acid into prostaglandins which *promote…
-promotes synthesis of compound that stimulates clotting... -i…
maintains renal blood flow
mediates fever & pain perception
action of cyclooxygenase (at sites of…
-converts arachidonic acid into prostaglandins which *promote…
action of cyclooxygenase in platelets
-promotes synthesis of compound that stimulates clotting... -i…
17 terms
topic 39: prostaglandins and cyclooxygenase
prostaglandins are produced in _____ t…
prostaglandins act similar to _______…
how do prostaglandins act differently…
there are many classes of prostaglandi…
most
hormones
1. act locally ... 2. metabolize rapidly ... 3. act differently in…
chemical structure
prostaglandins are produced in _____ t…
most
prostaglandins act similar to _______…
hormones
8 terms
Cyclooxygenase Inhibitors & Glucocorticoids
What is the mechanism behind COX-1 and…
Adverse effects of inhibiting COX-1?
Adverse effects of inhibiting COX-2?
Describe patient teaching for both:
Inhibits COX enzyme and converts archidonic acid into prostan…
Renal impairment... Gastric ulceration... Bleeding
Renal impairment... Promotion of MI & Stroke
Administer before pain is severe.... Take with food to prevent g…
What is the mechanism behind COX-1 and…
Inhibits COX enzyme and converts archidonic acid into prostan…
Adverse effects of inhibiting COX-1?
Renal impairment... Gastric ulceration... Bleeding
7 terms
Cyclooxygenase Inhibitors: NSAIDS & Acetaminophen
Uses of Cyclo. Inhibitors
Adverse effects of cyclo. inhibitors
Inhibition of COX 1
Inhibition of COX-2
Suppresses inflammation... Relieve Pain... Reduce Fever
Gastric Ulceration... Renal Impairment... Bleeding
Renal Impairment... Gastric Ulceration... Renal Impairment... Protecti…
Reduce Fever... Reduce Pain... Protect against colorectal cancer
Uses of Cyclo. Inhibitors
Suppresses inflammation... Relieve Pain... Reduce Fever
Adverse effects of cyclo. inhibitors
Gastric Ulceration... Renal Impairment... Bleeding
43 terms
Pharm Cyclooxygenase inhibitors chap 71
cyclooxygenase inhibitors
Cyclooxygenase inhibitors... Uses
Cyclooxygenase inhibitors... adverse effe…
Cox 1 (4)
- helps stomach lining... - increases section of bicarb and prot…
suppress inflammation... relieve pain... reduce fever
gastric ulceration... bleeding... renal impairment
nonselective... protects gastric mucosa... supports renal function…
cyclooxygenase inhibitors
- helps stomach lining... - increases section of bicarb and prot…
Cyclooxygenase inhibitors... Uses
suppress inflammation... relieve pain... reduce fever
10 terms
PHARM - Cyclooxygenase inhibitors
3 functions of these medications
Cox 1
Cox 2
Cox 1 & Cox 2 inhibitors
suppression of inflammation ... relief of pain... reduction of feve
this is the good cox and is located in all tissues and the br…
the bad cox... this is only present at the site of tissue injury…
meds that do both will suppress inflammation, fever and pain…
3 functions of these medications
suppression of inflammation ... relief of pain... reduction of feve
Cox 1
this is the good cox and is located in all tissues and the br…
28 terms
Chapter 71:Cyclooxygenase Inhibitors: Nonsteroidal Antiinflammatory Drugs and Acetaminophen
Cyclooxygenase Inhibitors
Cyclooxygenase Inhibitors Adverse Effe…
1.Cyclooxygenase Inhibitors: Mechanism…
Inhibition of COX-1: Beneficial effects
Uses... -Suppress inflammation... -Relieve pain... -Reduce fever... Adver…
1.Gastric ulceration... 2. Bleeding... 3. Renal impairment
1. Inhibit cyclooxygenase (COX), the enzyme that converts ara…
Protection against myocardial infarction (MI) and stroke
Cyclooxygenase Inhibitors
Uses... -Suppress inflammation... -Relieve pain... -Reduce fever... Adver…
Cyclooxygenase Inhibitors Adverse Effe…
1.Gastric ulceration... 2. Bleeding... 3. Renal impairment
23 terms
Pharm II Cyclooxygenase Inhibitors
COX inhibitors a/e
COX in stomach
other functions of COX
COX 1
1. gastric ulceration... 2. bleeding... 3. renal impairment
1. reduces secretion of gastric acid... 2. increases secretion o…
in plts- stimulates aggregation... in bld vessels- CAUSES VASODI…
aka good Cox... mediates beneficial processes like gastric mucos…
COX inhibitors a/e
1. gastric ulceration... 2. bleeding... 3. renal impairment
COX in stomach
1. reduces secretion of gastric acid... 2. increases secretion o…
53 terms
Cyclooxygenase Inhibitor page 5-6
Advil, motrin
nonselective COX inhibitor
COX 1 and COX 2 irreversibly
antiinflammatory, analgesia, antipyretic
other names for Ibuprofen
ibuprofen is a what?
ibuprofen inhibits what?
ibuprofen has what?
Advil, motrin
other names for Ibuprofen
nonselective COX inhibitor
ibuprofen is a what?
34 terms
Cyclooxygenase Inhibitors: NSAIDS and Acetaminophen (Chapter 71)
Cyclooxygenase Inhibitors Uses
Cyclooxygenase Inhibitors Adverse Effe…
Drugs with anti-inflammatory propertie…
Drugs without anti-inflammatory proper…
Suppress inflammation... Relieve pain... Reduce fever
Gastric ulceration... Bleeding... Renal impairment... Cardiac effects
Aspirin, celecoxib, ibuprofen, and naproxen
Acetaminophen (Tylenol)
Cyclooxygenase Inhibitors Uses
Suppress inflammation... Relieve pain... Reduce fever
Cyclooxygenase Inhibitors Adverse Effe…
Gastric ulceration... Bleeding... Renal impairment... Cardiac effects
66 terms
ch 71: cyclooxygenase inhibitors: NSAIDs and acetaminophen
cyclooxygenase (COX)
COX-1... COX-2
nonsteroidal antiinflammatory drugs (N…
COX 1 and COX 2
all of the drugs discussed in this chapter inhibit _____(__)…
cyclooxygenase has two forms: ___and ____
the cyclooxygenase inhibitors fall into two major groups: ___…
what do the first generation NSAIDs inhibit?
cyclooxygenase (COX)
all of the drugs discussed in this chapter inhibit _____(__)…
COX-1... COX-2
cyclooxygenase has two forms: ___and ____
37 terms
NSAIDS and Cyclooxygenase
What does COX-1 do
What does COX-2 do
Inhibition of Cox 1
Inhibition of Cox 2
homeostatic functions (gastrointestinal tract, renal tract, p…
Inflammation - fever, vasodilation, etc.
undesirable... But can be beneficial - protects against MI and s…
desirable... Largely beneficial effects... suppression of inflammat…
What does COX-1 do
homeostatic functions (gastrointestinal tract, renal tract, p…
What does COX-2 do
Inflammation - fever, vasodilation, etc.
56 terms
Ch. 70 Cyclooxygenase Inhibitors: NSAIDs - KEY POINTS
NSAIDs are useful for
fever
Cyclooxygenase is an enzyme that
Cyclooxygenase is found in
1. supression of inflammation... 2. pain relief ... 3. fever reduct…
Elevated body temperature, usually above 101 F, or 38.3 C, re…
converts arachidonic acid into prostanoids (prostaglandins an…
all tissues and helps regulate multiple processes including p…
NSAIDs are useful for
1. supression of inflammation... 2. pain relief ... 3. fever reduct…
fever
Elevated body temperature, usually above 101 F, or 38.3 C, re…
32 terms
CYCLOOXYGENASE INHIBITORS: NSAIDs, COX-2 INHIBITORS, AND ACETAMINOPHEN
Cyclooxygenase Types
COX-1 Mechanism of action
COX-2 Mechanism of action
Cyclooxygenase inhibitors
COX-1 and COX-2
"Housekeeping" enzyme. ... 1. Produces prostaglandins to protect…
1. Produces prostaglandins involved in pain, inflammation, an…
Anti-inflammatory, pain relievers, and antipyretic. Only aspi…
Cyclooxygenase Types
COX-1 and COX-2
COX-1 Mechanism of action
"Housekeeping" enzyme. ... 1. Produces prostaglandins to protect…
56 terms
Ch. 70 Cyclooxygenase Inhibitors: NSAIDs - KEY POINTS
NSAIDs are useful for
fever
Cyclooxygenase is an enzyme that
Cyclooxygenase is found in
1. supression of inflammation... 2. pain relief ... 3. fever reduct…
Elevated body temperature, usually above 101 F, or 38.3 C, re…
converts arachidonic acid into prostanoids (prostaglandins an…
all tissues and helps regulate multiple processes including p…
NSAIDs are useful for
1. supression of inflammation... 2. pain relief ... 3. fever reduct…
fever
Elevated body temperature, usually above 101 F, or 38.3 C, re…
30 terms
Cyclooxygenase Inhibitors: Nonsteroidal Anti-Inflammatory Drugs and Acetaminophen
Cox Inhibitor uses:
Adverse effects of cox inhibitors:
Do cox inhibitors cause respiratory de…
What are the drugs with ANTI-inflammat…
Suppresses inflammation ... Relieves pain... Reduces fever (antipyr…
Gastric ulcerations... Bleeding... Renal Impairment
NO!!!
NSAIDS (non-steroidal anti-inflammatory drugs) such as Aspiri…
Cox Inhibitor uses:
Suppresses inflammation ... Relieves pain... Reduces fever (antipyr…
Adverse effects of cox inhibitors:
Gastric ulcerations... Bleeding... Renal Impairment
72 terms
PMY302: Cyclooxygenase Inhibitors Non-Steroidal Anti-Inflammatory Drugs
COX
Cyclooxygenase Inhibitors
NSAID
Analgesic
Cyclooxygenase
Classical NSAID... 1. Analgesic, anti-inflammatory & antipyretic…
Non-Steroidal Anti-Inflammatory Drug
anti plain
COX
Cyclooxygenase
Cyclooxygenase Inhibitors
Classical NSAID... 1. Analgesic, anti-inflammatory & antipyretic…
48 terms
Ch. 71 - Cyclooxygenase Inhibitors: Nonsteroidal Antiinflammatory Drugs and Acetaminophen
COX (cyclooxygenase)
COX-1, COX-2
NSAIDs, acetaminohpen
first generation NSAIDs
an enzyme that converts arachidonic acid into prostanoids
Cyclooxygenase has two forms: _____ and _____
The COX inhibitors fall into two major groups: _____- and ___…
inhibit COX-1 and COX-2
COX (cyclooxygenase)
an enzyme that converts arachidonic acid into prostanoids
COX-1, COX-2
Cyclooxygenase has two forms: _____ and _____
62 terms
Endothelial injury and dysfunction terms
Actin
Adherens Junction
Advanced Glycation Endproducts (AGEs)
Angiogenesis
one of the three main cytoskeletal proteins in cells that for…
Mechanically attach cells (and their cytoskeletons) to their…
modifications of proteins or lipids that become nonenzymatica…
The process where new blood vessels form from existing vascul…
Actin
one of the three main cytoskeletal proteins in cells that for…
Adherens Junction
Mechanically attach cells (and their cytoskeletons) to their…
80 terms
pharmacology- drugs for diabetes, cyclooxygenase inhibitors, glucocorticoids.
Overview of diabetes mellitus
Type 1 diabetes.
Type 2 diabetes
3rd type of diabetes.
often called DM. disorder of carbohydrates metabolism. CHO al…
10% of population- pancreatic beta cells are destroyed and ca…
90% of the population- Pancreatic beta cells don't work right.
gestational diabetes for pregnant women.
Overview of diabetes mellitus
often called DM. disorder of carbohydrates metabolism. CHO al…
Type 1 diabetes.
10% of population- pancreatic beta cells are destroyed and ca…
34 terms
Chapter 71 Cyclooxygenase Inhibitors: Nonsteroidal Antiinflammatory Drugs and Acetaminophen
What does cyclooxygenase convert?
What are the 2 forms of cyclooxygenase?
What are the 2 main groups of cyclooxy…
What are the 2 divisions of NSAIDs?
Arachidonic acid into prostanoids
COX-1 COX-2
NSAIDs, acetaminophen
1. First generation: inhibit COX-1 and COX-2... 2. Second genera…
What does cyclooxygenase convert?
Arachidonic acid into prostanoids
What are the 2 forms of cyclooxygenase?
COX-1 COX-2
14 terms
T 1 Medication for Pain and Inflammation
Nonopiod Analgesics
Aptipyretic
analgesic
Salicylism
may have anti-inflammatory, antipyretic, and analgesic action…
...
...
...
Nonopiod Analgesics
may have anti-inflammatory, antipyretic, and analgesic action…
Aptipyretic
...
41 terms
Cyclooxygenase Inhibitors, Antiplatlets, and Anticoagulants
What are the 5 prototype NSAIDs?
What is key about NSAIDs?
What NSAID is typically prescribed for…
What NSAID is the biggest invader to t…
1.) ibuprofen... 2.) naproxen... 3.) indomethacin... 4.) sundilac... 5.)…
They have anti-inflammatory actions without being a steroid.
indomethacin
indomethacin
What are the 5 prototype NSAIDs?
1.) ibuprofen... 2.) naproxen... 3.) indomethacin... 4.) sundilac... 5.)…
What is key about NSAIDs?
They have anti-inflammatory actions without being a steroid.
10 terms
IMMUNE SYSTEM 1
Cyclooxygenase Inhibitors
First Line Defence: Strengthen Immune
Misconceptions
Andrographis paniculata
oOligomeric Proanthocyandins (OPC'S)... •Down regulate the activ…
oEchinacea angustifolia/ purpurea=ALKYLAMINES... oAndrographis p…
•Echinacea depletes the immune system when used for periods l…
=energetically cold--->preferably taken in combination with w…
Cyclooxygenase Inhibitors
oOligomeric Proanthocyandins (OPC'S)... •Down regulate the activ…
First Line Defence: Strengthen Immune
oEchinacea angustifolia/ purpurea=ALKYLAMINES... oAndrographis p…
19 terms
Chapter 71 Cyclooxygenase Inhibitors: Nonsteroidal Anti-Inflammatory Drugs and Acetaminophen
COX-1
COX-2
first generation NSAIDS
second generation NSAIDS
mediates house keeping chores. is named the "good cox" becaus…
produced mainly at sites of tissue injury. named the "bad cox…
inhibit COX 1 and 2. these are used to treat inflammatory dis…
inhibit COX 2 only. should work to suppress inflammation caus…
COX-1
mediates house keeping chores. is named the "good cox" becaus…
COX-2
produced mainly at sites of tissue injury. named the "bad cox…
11 terms
Pharmacology
pharmacokinetics
pharmacodynamics
agonist
A
what body dose to drug? (absorption, distribution, elimination)
drug does the body
drugs that favors the active conformation of receptor
which drug is more potent?
pharmacokinetics
what body dose to drug? (absorption, distribution, elimination)
pharmacodynamics
drug does the body
72 terms
MSK
axilla/lateral thorax: artery and nerve
surgical neck of humerus: artery and n…
midshaft of humerus: artery and nerve
distal humerus/cubital fossa: artery a…
long thoracic n. | lateral thoracic a.
axillary n. | posterior cirumflex artery
radial n. | deep brachial a.
median n. | brachial a.
axilla/lateral thorax: artery and nerve
long thoracic n. | lateral thoracic a.
surgical neck of humerus: artery and n…
axillary n. | posterior cirumflex artery
70 terms
Spring '15 Pharm Hormones/NSAIDS Week 13
The precursor of all our eicosanoids is
Four metabolic pathways for arachidoni…
Here is a picture of the 2 arachidonic…
Is COX1 found in all cells
Arachidonic Acid (eicosanoids are metabolites of arachidonic…
Lipoxygenases, Epoxygenases(Cp450s), PGH synthase (aka - Cycl…
Yes, the main prostanoids for 'house-keeping' (help to *balan…
The precursor of all our eicosanoids is
Arachidonic Acid (eicosanoids are metabolites of arachidonic…
Four metabolic pathways for arachidoni…
Lipoxygenases, Epoxygenases(Cp450s), PGH synthase (aka - Cycl…
154 terms
PCOL: Pharmacology of Hemostasis and Thrombosis
What are the 5 different types of *ant…
What are the 6 different types of *ant…
What are the 4 different types of Thro…
To what pharmacologic class do Cycloox…
1. Cyclooxygenase Inhibitors ... 2. Phosphodiesterase Inhibitor…
1. Warfarin... 2. Unfractionated & Low-Molecular-Weight-Heparin…
1. Streptokinase ... 2. Recombinant Tissue Plasminogen Activato…
Antiplatelet Agents
What are the 5 different types of *ant…
1. Cyclooxygenase Inhibitors ... 2. Phosphodiesterase Inhibitor…
What are the 6 different types of *ant…
1. Warfarin... 2. Unfractionated & Low-Molecular-Weight-Heparin…
154 terms
PCOL: Pharmacology of Hemostasis and Thrombosis
What are the 5 different types of *ant…
What are the 6 different types of *ant…
What are the 4 different types of Thro…
To what pharmacologic class do Cycloox…
1. Cyclooxygenase Inhibitors ... 2. Phosphodiesterase Inhibitor…
1. Warfarin... 2. Unfractionated & Low-Molecular-Weight-Heparin…
1. Streptokinase ... 2. Recombinant Tissue Plasminogen Activato…
Antiplatelet Agents
What are the 5 different types of *ant…
1. Cyclooxygenase Inhibitors ... 2. Phosphodiesterase Inhibitor…
What are the 6 different types of *ant…
1. Warfarin... 2. Unfractionated & Low-Molecular-Weight-Heparin…
96 terms
PSD Drug List 1
Abilify generic
Abilify category
Abilify indication
Abilify monitoring
Aripiprazole
Atypical antipsychotic
Schizophrenia, bipolar disorder, depression
Blood sugar, mental health
Abilify generic
Aripiprazole
Abilify category
Atypical antipsychotic
76 terms
IS-II Med Chem Lecture 1
Cyclooxygenase (COX)... • Phospholipase A…
Arachidonic Acid And PGF2α Numbering
COX-1 Versus COX-2... • Structurally very…
Cyclooxygenase (COX)... • Phospholipase A2 (PLA2) liberatess* ar…
COX-1 Versus COX-2... • Structurally very similar... • Physiologica…
Cyclooxygenase (COX)... • Phospholipase A…
Cyclooxygenase (COX)... • Phospholipase A2 (PLA2) liberatess* ar…
Arachidonic Acid And PGF2α Numbering
21 terms
Prostaglandin Biochemistry
Eicosatrienoic Acid
Arachidonic Acid
Eicosapentaenoic Acid
Products Formed from Arachidonic Acid
PGE1
Most imprt substrate b/c most abundant ... PGE2
PGE3
Eicosatrienoic Acid
PGE1
Arachidonic Acid
Most imprt substrate b/c most abundant ... PGE2
46 terms
Chapter 25 Antiinflammatory Drugs
Inflammation
TABLE 25-1 CARDINAL SIGNS OF INFLAMMAT…
Pathophysiology of Inflammation
Prostaglandins
Inflammation is a response to tissue injury and infection. Th…
• Erythema (redness)- redness occurs in the first phase of in…
The five cardinal signs of inflammation, are redness, swellin…
Prostaglandins (chemical mediators) have many effects: vasodi…
Inflammation
Inflammation is a response to tissue injury and infection. Th…
TABLE 25-1 CARDINAL SIGNS OF INFLAMMAT…
• Erythema (redness)- redness occurs in the first phase of in…
58 terms
MCDB 126A MT1 updated
Pharmacodynamics
Pharmacokinetics
Cyclooxygenase
Aspirin
Study of binding of drugs to drug receptors
Distribution, metabolism and elimination of drugs in the system
An enzyme that produces prostaglandins and thromboxane, which…
A drug that reduces inflammation, blood clotting, fever, and…
Pharmacodynamics
Study of binding of drugs to drug receptors
Pharmacokinetics
Distribution, metabolism and elimination of drugs in the system
193 terms
inflammation 2
histamine... serotonin
mast cells ... basophils ... platelets
widely distributed
dilation
what are the vasoactive amines
what specific cells contain histamine
is histamine found in pocketed areas or widely distributed
does histamine cause dilation or constriction of arterioles
histamine... serotonin
what are the vasoactive amines
mast cells ... basophils ... platelets
what specific cells contain histamine
18 terms
Micro/path boards
Enterotoxin producing bact
Transformation DNA pick up must be dsDNA
Exoenzyme S
Pseudomonas aeruginosa
E.coli, S.aureus, V.cholerae
True, DNAase will degrade one of the strands
impair the fx of phagocytic cells in the blood stream + inter…
G(-), aerobic rod, obligate aerobe, flourescent pigment, resi…
Enterotoxin producing bact
E.coli, S.aureus, V.cholerae
Transformation DNA pick up must be dsDNA
True, DNAase will degrade one of the strands
19 terms
Pharma Seminar 5: Analgetika 2
Cyclooxygenase 1
ASS (Acetylsalicylsäure)
Paracetamol
Metamizol
= COX 1... Enzym; Geschw. Bestimmender Schritt der Prostaglandin…
Chem. Eigenschaften:... pKs: 3,5, große Hydrophobe Ringstruktu…
...
Analgetikum, Antipyretikum (Fiebersenkend)... Wirkung... Hemmung…
Cyclooxygenase 1
= COX 1... Enzym; Geschw. Bestimmender Schritt der Prostaglandin…
ASS (Acetylsalicylsäure)
Chem. Eigenschaften:... pKs: 3,5, große Hydrophobe Ringstruktu…
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