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Study sets matching "fa biochem"

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Study sets matching "fa biochem"

185 terms
FA- Biochemistry
Gluconeogenesis rate limiting step
TCA Cycle rate limiting step
HMP Shunt rate limiting step
De novo pyrimidine synthesis rate limi…
Fructose-1,6-biphosphatase
Isocitrate Dehydrogenase
G6PD
Carbamoyl phosphate synthetase II
Gluconeogenesis rate limiting step
Fructose-1,6-biphosphatase
TCA Cycle rate limiting step
Isocitrate Dehydrogenase
109 terms
FA Biochemistry
Chromatin Structure
DNA Covalent Modifications
Nucleotides
De novo base synthesis
DNA (negative charge) coils around positively-chared histone…
DNA methylation:... - methylation of template strand to tell whi…
nucleoSide = base + Sugar... nucleoTide = base + sugar + phophaT…
Pyrimidines (ACP): Aspartate + Carbamoyl Phosphate... Purines (G…
Chromatin Structure
DNA (negative charge) coils around positively-chared histone…
DNA Covalent Modifications
DNA methylation:... - methylation of template strand to tell whi…
78 terms
FA Biochemistry
Histone structure
Structure of purine vs pyrimidine
Pyrimidine synthesis pathway
Purine salvage pathway
Histone structure
Structure of purine vs pyrimidine
353 terms
FA biochemistry
Histones are rich in
2 rings base
Amino acids necessary for purine synth…
Purines structure
lysine and arginine
purine
Glycine ... Aspartate ... Glutamine
Histones are rich in
lysine and arginine
2 rings base
purine
592 terms
FA Biochemistry
What forms a nucleosome?
What are histones rich in?
What is the purpose of H1 (Histone)?
When does DNA and Histone synthesis oc…
Negatively charged DNA that loops twice around a positively c…
Histones are rich in the amino acids Lysine and Arginine. Bot…
H1 binds to the nucleosome and to linker DNA thereby stabiliz…
During S phase
What forms a nucleosome?
Negatively charged DNA that loops twice around a positively c…
What are histones rich in?
Histones are rich in the amino acids Lysine and Arginine. Bot…
185 terms
FA- Biochemistry
Gluconeogenesis rate limiting step
TCA Cycle rate limiting step
HMP Shunt rate limiting step
De novo pyrimidine synthesis rate limi…
Fructose-1,6-biphosphatase
Isocitrate Dehydrogenase
G6PD
Carbamoyl phosphate synthetase II
Gluconeogenesis rate limiting step
Fructose-1,6-biphosphatase
TCA Cycle rate limiting step
Isocitrate Dehydrogenase
529 terms
FA Biochemistry
What forms a nucleosome?
What are histones rich in?
What is the purpose of H1 (Histone)?
When does DNA and Histone synthesis oc…
Negatively charged DNA that loops twice around a positively c…
Histones are rich in the amino acids Lysine and Arginine. Bot…
H1 binds to the nucleosome and to linker DNA thereby stabiliz…
During S phase
What forms a nucleosome?
Negatively charged DNA that loops twice around a positively c…
What are histones rich in?
Histones are rich in the amino acids Lysine and Arginine. Bot…
17 terms
FA Biochemistry
Metabolic process that occurs both in…
Marasmus
Fragile X syndrome
Kwashikor
HUGS... Heme synthesis... Urea Cycle... Gluconeogenises
Total calorie malnutrition resulting in issue muscle wasting,…
Trineucleotide expansion of CGG repeat associated with the X-…
protein deficiency leading to 1) Edema 2) Liver malfunction a…
Metabolic process that occurs both in…
HUGS... Heme synthesis... Urea Cycle... Gluconeogenises
Marasmus
Total calorie malnutrition resulting in issue muscle wasting,…
272 terms
Biochemistry FA
DNA
Histones
Nucleosome
H1
negative charge
Positive charge... arginine and lysine
histone octamer with DNA looped about twice. ... H2A... H2B... H3... H4…
linker histone outside the core nucleosome. ... Binds linker DNA…
DNA
negative charge
Histones
Positive charge... arginine and lysine
350 terms
BIOCHEMISTRY FA
What makes up a nucleosome bead?
How does DNA exist in the nucleus?
What are histones rich in?
What is Histone H1 and hwere is it?
negative phosphate on DNA wrapping TWICE around 8 POSITIVE HI…
condensed, chromatin form
Lysine (pos)... Arginine (pos)
the only histone not in nucleosome... lies on DNA inbetween nuc…
What makes up a nucleosome bead?
negative phosphate on DNA wrapping TWICE around 8 POSITIVE HI…
How does DNA exist in the nucleus?
condensed, chromatin form
759 terms
FA Biochemistry
which histone ties DNA-histone nucleos…
is DNA acidic or basic?
what type of aa are histones made of?…
is heterochromatic more accessible or…
H1
acidic
lysine and arginine; basic
less; more
which histone ties DNA-histone nucleos…
H1
is DNA acidic or basic?
acidic
13 terms
Biochemistry FA
Glycine, Glutamine, Aspartate
Hurler and Hunter Syndrome
Negative
Positive
Amino Acids necessary for purine synthesis
Lysosomal storage disorders that present with accumulation of…
What kind of charge is on DNA?
What kind of charge is on histone proteins?
Glycine, Glutamine, Aspartate
Amino Acids necessary for purine synthesis
Hurler and Hunter Syndrome
Lysosomal storage disorders that present with accumulation of…
759 terms
FA Biochemistry
which histone ties DNA-histone nucleos…
is DNA acidic or basic?
what type of aa are histones made of?…
is heterochromatic more accessible or…
H1
acidic
lysine and arginine; basic
less; more
which histone ties DNA-histone nucleos…
H1
is DNA acidic or basic?
acidic
17 terms
FA Biochemistry
Got This
Impact on patients
Performance of System as planned
Impact on other systems
You
Outcome measures?
Process measures?
Balancing measures?
Got This
You
Impact on patients
Outcome measures?
759 terms
FA Biochemistry
which histone ties DNA-histone nucleos…
is DNA acidic or basic?
what type of aa are histones made of?…
is heterochromatic more accessible or…
H1
acidic
lysine and arginine; basic
less; more
which histone ties DNA-histone nucleos…
H1
is DNA acidic or basic?
acidic
101 terms
FA Biochemistry
COP I
COP II
Clathrin
vimentin
golgi to golgi ... or golgi to ER
ER to golgi
golgi to lysosomes... or plasma membrane to endosomes
connective tissue
COP I
golgi to golgi ... or golgi to ER
COP II
ER to golgi
214 terms
FA Biochemistry
Chromatin structure
Heterochromatin
Euchromatin
DNA methylation
DNA exists in condensed chromatin form to fit into nucleus; (…
condensed, transcriptionally inactive, sterically inaccessibl…
Less condensed, transcriptionally active, sterically accessible
Template strand cytosine and adenine are methylated in DNA re…
Chromatin structure
DNA exists in condensed chromatin form to fit into nucleus; (…
Heterochromatin
condensed, transcriptionally inactive, sterically inaccessibl…
263 terms
fa biochemistry
What is the charge on DNA?
How many subunits make up a nucleosome…
How many times does DNA loop around ea…
What is the charge of the histone octa…
Negative
Eight; two of each of four histone types (H2A, H2B, H3, and H4
Two
Positive, giving the histones affinity for negatively charged…
What is the charge on DNA?
Negative
How many subunits make up a nucleosome…
Eight; two of each of four histone types (H2A, H2B, H3, and H4
173 terms
Biochemistry FA
Vitamin A (retinol)
Vitamin B1 (thiamine)
Dry beriberi (B1 deficiency)
Wet beriberi (B1 deficiency)
What vitamin deficiency causes: night blindness, dry skin
What vitamin deficiency causes: beriberi and wernicke-korsako…
Nerve damage with symmetrical muscle wasting caused by a vita…
Dilated cardiomyopathy with edema, caused by a vitamin defici…
Vitamin A (retinol)
What vitamin deficiency causes: night blindness, dry skin
Vitamin B1 (thiamine)
What vitamin deficiency causes: beriberi and wernicke-korsako…
43 terms
Biochemistry FA
Glucogenic
Glucogenic/ketogenic
ketogenic
acidic
met, val, his
ile, phe, thr, trp
leu, lysine
asp, glu, negatively charged at body pH
Glucogenic
met, val, his
Glucogenic/ketogenic
ile, phe, thr, trp
568 terms
FA - Biochemistry
Chromatin structure
Heterochromatin
Euchromatin
Purines
Negatively charged DNA loops twice around histone octamer (2…
Condensed, transcriptionally inactive ("H eteroC hromatin = H…
Less condensed, transcriptionally active (Eu = true, "truly t…
A, G 2 Rings ("PUR e A s G old = PUR ines") <img src="67b - P…
Chromatin structure
Negatively charged DNA loops twice around histone octamer (2…
Heterochromatin
Condensed, transcriptionally inactive ("H eteroC hromatin = H…
120 terms
FA biochemistry
I cell disease (inclusion cell disease…
COP I
COP II
SRP (signal recognition particle)
inherited lysosomal storage disorder; defect in N-acetylgluco…
Golgi to Golgi (retrograde); cis-Golgi to ER.
ER to cis-Golgi (anterograde).
signal to direct proteins from ribosomes to RER. defect= prot…
I cell disease (inclusion cell disease…
inherited lysosomal storage disorder; defect in N-acetylgluco…
COP I
Golgi to Golgi (retrograde); cis-Golgi to ER.
173 terms
FA Biochemistry
What vitamin deficiency causes: night…
What vitamin deficiency causes: beribe…
Nerve damage with symmetrical muscle w…
Dilated cardiomyopathy with edema, cau…
Vitamin A (retinol)
Vitamin B1 (thiamine)
Dry beriberi (B1 deficiency)
Wet beriberi (B1 deficiency)
What vitamin deficiency causes: night…
Vitamin A (retinol)
What vitamin deficiency causes: beribe…
Vitamin B1 (thiamine)
76 terms
FA Biochemistry
Histones are composed primarily of whi…
What is the function of the H1 histone?
Which phase of the cell cycle does DNA…
Which DNA bases are on the template st…
Lysine & Arginine because they are + charged.
Stabilizes the chromatin fiber by binding to the nucleosome a…
S phase
Cytosine, Adenine... Allows mismatch repair enzymes to distingui…
Histones are composed primarily of whi…
Lysine & Arginine because they are + charged.
What is the function of the H1 histone?
Stabilizes the chromatin fiber by binding to the nucleosome a…
39 terms
FA Biochemistry
Which ones are the fat solube vitamins?
Where does the absorption happen?
Why are fat soluble vitamins more toxi…
What are some diseases that can cause…
ADEK
gut (ileum) and pancreas
they accumulate in the fat
CF, sprue, mineral oil intake, malabsorption syndromes (steat…
Which ones are the fat solube vitamins?
ADEK
Where does the absorption happen?
gut (ileum) and pancreas
31 terms
FA Biochemistry
8 y/o pt presents with severe sunburn,…
15 y/o presents to psychiatrist discus…
Xanthine oxidase inhibitors?
In base excision repair (versus nucleo…
xeroderma pigmentosum ... ineffective pyrimidine dimer NUCLEOTI…
Lesch-Nyhan syndrome... inability to salvage purines/pyrimidine…
allopurinol... febuxostat
DNA-Polymerase Beta (B)
8 y/o pt presents with severe sunburn,…
xeroderma pigmentosum ... ineffective pyrimidine dimer NUCLEOTI…
15 y/o presents to psychiatrist discus…
Lesch-Nyhan syndrome... inability to salvage purines/pyrimidine…
237 terms
FA_Biochemistry
Chromatin Structure
Core Histones
Linker Histone
Heterochromatin
(-) DnA loops twice around (+) histone... "beads on a string"... co…
H2A... H2B... H3... H4... histone= octamer (two of each form the nucleos…
H1... binds the nucleosome to 'linker DNA'
condensed... dark on EM... transcriptionally inactive- sterically i…
Chromatin Structure
(-) DnA loops twice around (+) histone... "beads on a string"... co…
Core Histones
H2A... H2B... H3... H4... histone= octamer (two of each form the nucleos…
33 terms
Biochemistry_FA
PRPP... -Explain this molecule's usefulne…
Le - flew - Know - Mine... MOA... cue: _____…
Myco - phen - olate ... MOA... Michael owns…
Ribavirin... MOA... Riba Mcantyer walks wit…
Beginning molecule for purine synthesis
Di - hydro - orotate - dehydrogenase... Di stands for two. Hydr…
IMP Dehyrogenase... (LIMP)... Michael owns a pen. He is always la…
IMP Dehyodrogenase ... (LIMP)... Riba Mcantyer walks with a limp!
PRPP... -Explain this molecule's usefulne…
Beginning molecule for purine synthesis
Le - flew - Know - Mine... MOA... cue: _____…
Di - hydro - orotate - dehydrogenase... Di stands for two. Hydr…
333 terms
Step 1 Biochemistry FA
Orotic Aciduria... 1. Pathology... 2. Presen…
Adenosine Deaminase Deficiency... 1. Path…
Lesch Nyhan Syndrome... 1. Pathology... 2. B…
Inclusion Cell Disease... 1. Pathology... 2.…
1. UMP Synthase deficiency which prevents conversion of oroti…
1. Deficiency in adenosine deaminase resulting in elevated ad…
1. Deficiency in HGPRT so there is reduced purine salvage and…
1. Inability to add mannose 6-phosphate so enzymes get secret…
Orotic Aciduria... 1. Pathology... 2. Presen…
1. UMP Synthase deficiency which prevents conversion of oroti…
Adenosine Deaminase Deficiency... 1. Path…
1. Deficiency in adenosine deaminase resulting in elevated ad…
333 terms
Step 1 Biochemistry FA
Orotic Aciduria... 1. Pathology... 2. Presen…
Adenosine Deaminase Deficiency... 1. Path…
Lesch Nyhan Syndrome... 1. Pathology... 2. B…
Inclusion Cell Disease... 1. Pathology... 2.…
1. UMP Synthase deficiency which prevents conversion of oroti…
1. Deficiency in adenosine deaminase resulting in elevated ad…
1. Deficiency in HGPRT so there is reduced purine salvage and…
1. Inability to add mannose 6-phosphate so enzymes get secret…
Orotic Aciduria... 1. Pathology... 2. Presen…
1. UMP Synthase deficiency which prevents conversion of oroti…
Adenosine Deaminase Deficiency... 1. Path…
1. Deficiency in adenosine deaminase resulting in elevated ad…
333 terms
Step 1 Biochemistry FA
Orotic Aciduria... 1. Pathology... 2. Presen…
Adenosine Deaminase Deficiency... 1. Path…
Lesch Nyhan Syndrome... 1. Pathology... 2. B…
Inclusion Cell Disease... 1. Pathology... 2.…
1. UMP Synthase deficiency which prevents conversion of oroti…
1. Deficiency in adenosine deaminase resulting in elevated ad…
1. Deficiency in HGPRT so there is reduced purine salvage and…
1. Inability to add mannose 6-phosphate so enzymes get secret…
Orotic Aciduria... 1. Pathology... 2. Presen…
1. UMP Synthase deficiency which prevents conversion of oroti…
Adenosine Deaminase Deficiency... 1. Path…
1. Deficiency in adenosine deaminase resulting in elevated ad…
115 terms
FA HY Biochemistry- Nutrition
what are the fat soluble vitamins?
absorption of fat soluble vitamins is…
why is toxicity for vitamins A, D, E,…
what are the common causes of fat solu…
A... D... E ... K
gut... ileum... pancreas
because they accumulate in fat
malabsorption syndromes (CF, Celiac)... mineral oil intake
what are the fat soluble vitamins?
A... D... E ... K
absorption of fat soluble vitamins is…
gut... ileum... pancreas
112 terms
FA Biochemistry: Molecular
histones are rich in these 2 aa's
histone acetylation increases/decrease…
histone methylation usually increases/…
DNA methylation at CpG islands increas…
lys, arg
increases
decreases
decreases
histones are rich in these 2 aa's
lys, arg
histone acetylation increases/decrease…
increases
569 terms
FA 2014 - (General) Biochemistry
Chromatin structure
Heterochromatin
Euchromatin
Purines
Negatively charged DNA loops twice around histone octamer (2…
Condensed, transcriptionally inactive ("H eteroC hromatin = H…
Less condensed, transcriptionally active (Eu = true, "truly t…
A, G 2 Rings ("PUR e A s G old = PUR ines")
Chromatin structure
Negatively charged DNA loops twice around histone octamer (2…
Heterochromatin
Condensed, transcriptionally inactive ("H eteroC hromatin = H…
13 terms
FA Biochemistry - Vitamin Names
Vitamin A
Vitamin B1
Vitamin B2
Vitamin B3
Retinol
Thiamine
Riboflavin
Niacin
Vitamin A
Retinol
Vitamin B1
Thiamine
56 terms
FA Biochemistry - Molecular
Nucleotide: base + sugar + _____
Purines have ____ ring(s)
Pyrimidines have ____ ring(s)
Amino acids necessary for purine synth…
Phosphate (nucleoside is just base + sugar)
2
1 (CUT the PY)
GAG (glycine, aspartate, glutamine)
Nucleotide: base + sugar + _____
Phosphate (nucleoside is just base + sugar)
Purines have ____ ring(s)
2
333 terms
Step 1 Biochemistry FA
Orotic Aciduria... 1. Pathology... 2. Presen…
Adenosine Deaminase Deficiency... 1. Path…
Lesch Nyhan Syndrome... 1. Pathology... 2. B…
Inclusion Cell Disease... 1. Pathology... 2.…
1. UMP Synthase deficiency which prevents conversion of oroti…
1. Deficiency in adenosine deaminase resulting in elevated ad…
1. Deficiency in HGPRT so there is reduced purine salvage and…
1. Inability to add mannose 6-phosphate so enzymes get secret…
Orotic Aciduria... 1. Pathology... 2. Presen…
1. UMP Synthase deficiency which prevents conversion of oroti…
Adenosine Deaminase Deficiency... 1. Path…
1. Deficiency in adenosine deaminase resulting in elevated ad…
35 terms
FA - Biochemistry - Metabolism
Progressive neurodegeneration, cherry-…
Enzyme deficiency in Tay-Sachs disease
Accumulated substrate in Tay-Sachs dis…
Inheritance pattern of Tay-Sachs disease
Tay-Sachs disease
Hexosaminidase A
GM2 ganglioside
AR
Progressive neurodegeneration, cherry-…
Tay-Sachs disease
Enzyme deficiency in Tay-Sachs disease
Hexosaminidase A
47 terms
FA Biochemistry - Genetics
Both allele contribute to the phenotyp…
Phenotype varies among individuals wit…
Not all individuals with a mutant geno…
One gene contributes to multiple pheno…
Codominance
Variable expressivity
Incomplete penetrance
Pleiotropy
Both allele contribute to the phenotyp…
Codominance
Phenotype varies among individuals wit…
Variable expressivity
34 terms
FA Biochemistry - Cellular
Cell cycle checkpoints are regulated by
Site of synthesis of secretory proteins
rER in neurons
Site of synthesis of cytosolic and org…
Cyclins, CDKs, tumor suppressors
rER
Nissl bodies
Free ribosomes
Cell cycle checkpoints are regulated by
Cyclins, CDKs, tumor suppressors
Site of synthesis of secretory proteins
rER
146 terms
FA Biochemistry - Metabolism
Ethanol --____--> Acetaldehyde --____-…
Inhibits alcohol dehydrogenase (ethano…
Inhibits acetaldehyde dehydrogenase (a…
Increased NADH/NAD+ ratio (ex: ethanol…
Alcohol DH, Acetaldehyde DH (both steps create NADH, which di…
Fomepizole
Disulfiram
Ketogenesis, lipogenesis
Ethanol --____--> Acetaldehyde --____-…
Alcohol DH, Acetaldehyde DH (both steps create NADH, which di…
Inhibits alcohol dehydrogenase (ethano…
Fomepizole
333 terms
Step 1 Biochemistry FA
Orotic Aciduria... 1. Pathology... 2. Presen…
Adenosine Deaminase Deficiency... 1. Path…
Lesch Nyhan Syndrome... 1. Pathology... 2. B…
Inclusion Cell Disease... 1. Pathology... 2.…
1. UMP Synthase deficiency which prevents conversion of oroti…
1. Deficiency in adenosine deaminase resulting in elevated ad…
1. Deficiency in HGPRT so there is reduced purine salvage and…
1. Inability to add mannose 6-phosphate so enzymes get secret…
Orotic Aciduria... 1. Pathology... 2. Presen…
1. UMP Synthase deficiency which prevents conversion of oroti…
Adenosine Deaminase Deficiency... 1. Path…
1. Deficiency in adenosine deaminase resulting in elevated ad…
26 terms
FA Biochemistry - Nutrition
All water-soluble vitamins wash out ea…
Vitamin A derivative that is teratogen…
Antioxidant; constituent of visual pig…
Beriberi is caused by
B12, B9
Isotretinoin
Vitamin A (retinol)
Vitamin B1 deficiency (Ber1Ber1)
All water-soluble vitamins wash out ea…
B12, B9
Vitamin A derivative that is teratogen…
Isotretinoin
377 terms
FA HY Biochemistry- Metabolism
which metabolic pathways take place in…
which metabolic pathways take place in…
which metabolic pathways take place bo…
what is the rate determining enzyme of…
1. Fatty acid oxidation (β oxidation), ... 2. acetyl-CoA product…
1. glycolysis... 2. fatty acid synthesis... 3. HMP shunt... 4. protein…
1. Heme synthesis... 2. Urea cycle... 3. Gluconeogenesis... Hugs take 2
PFK-1
which metabolic pathways take place in…
1. Fatty acid oxidation (β oxidation), ... 2. acetyl-CoA product…
which metabolic pathways take place in…
1. glycolysis... 2. fatty acid synthesis... 3. HMP shunt... 4. protein…
10 terms
FA Biochemistry - Lab Techniques
The steps of PCR
Southern blot
Northern blot
Western blot
Denaturation (95), annealing (55), elongation (72)
DNA
RNA
Protein
The steps of PCR
Denaturation (95), annealing (55), elongation (72)
Southern blot
DNA
377 terms
FA Biochemistry I
What are nucleosomes?
What is the linker histone?
What amino acids are histones rich in?
What happens in mitosis?
neg charged DNA looping around histone octomer to form nucleo…
H1
lysine, arginine
DNA condenses to form chromosomes, DNA/histone synthesis in S…
What are nucleosomes?
neg charged DNA looping around histone octomer to form nucleo…
What is the linker histone?
H1
24 terms
Biochemistry FA2016
Carbohydrates
Lipids
Proteins
Nucleic Acids
Used to store short-term energy
Used to store long-term energy, and form outer membranes of t…
Used to regulate cell processes (transporting, signaling, rec…
Used to carry the instructions for life (genetic info)
Carbohydrates
Used to store short-term energy
Lipids
Used to store long-term energy, and form outer membranes of t…
137 terms
FA HY Biochemistry- Genetics
What is codominance?
what is an example of codominance?
what is variable expressivity?
what is an example of variable express…
both alleles contribute to the phenotype of the heterozygote
Blood groups A, B, AB
phenotype varies among individuals with same genotype
2 patients with neurofibromatosis 1 (NF1) may have varying di…
What is codominance?
both alleles contribute to the phenotype of the heterozygote
what is an example of codominance?
Blood groups A, B, AB
164 terms
FA Biochemistry II
What inhibits oxphos complex I?
What inhibits oxphos complex III?
What inhibits oxphos complex IV?
What inhibits oxphos complex V?
rotenone
antimycin A
cyanide, CO
oligomycin
What inhibits oxphos complex I?
rotenone
What inhibits oxphos complex III?
antimycin A
41 terms
FA Biochemistry--Molecular
In what form does DNA exist in the nuc…
Is DNA positively or negatively charged?
Are histones positively or negatively…
How many times does the negatively cha…
Condensed chromatin
Negatively
Positively
Twice
In what form does DNA exist in the nuc…
Condensed chromatin
Is DNA positively or negatively charged?
Negatively
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