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Study sets matching "genes pathology"

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Study sets matching "genes pathology"

50 terms
Genes for pathology
GNAS mutation
PRKAR1A mutation
cyclin D1 (CCND1) mutation
HRAS mutation
gain of function, GH-oma
gain of function, carney complex, germline mutation--atrial m…
amplified or mutated, gain of fxn, marker for aggressive pitu…
point mutation, gain of funcitoning, pituitary carcinoma warn…
GNAS mutation
gain of function, GH-oma
PRKAR1A mutation
gain of function, carney complex, germline mutation--atrial m…
15 terms
Pathology (Tumor Suppressor Genes)
Loss of function - APC
Loss of function - BRCA1/BRCA2
Loss of function - CDKN2A
Loss of function - DCC
Colorectal cancer associated with FAP
Breast and Ovarian Cancer (normally a DNA repair protein)
Melanoma ... Pancreatic Cancer... (p16 usually blocks G1-S phase)
Colon Cancer
Loss of function - APC
Colorectal cancer associated with FAP
Loss of function - BRCA1/BRCA2
Breast and Ovarian Cancer (normally a DNA repair protein)
15 terms
Pathology - Tumor Suppressor Genes
APC
BRCA1/BRCA2
CDKN2A
DCC
Colorectal Cancer (associated with FAP)
DNA Repair Protein --> Breast and Ovarian Cancer
p16, blocks G1-S Phase --> Melanoma, Pancreatic Cancer
Colon Cancer
APC
Colorectal Cancer (associated with FAP)
BRCA1/BRCA2
DNA Repair Protein --> Breast and Ovarian Cancer
15 terms
Pathology Tumor Supressor Genes
APC
BRCA1/BRCA2
CDKN2A
DCC
Colorectal Cancer
Breast Cancer... Ovarian Cancer
Melanoma... Pancreatic Cancer
Colon Cancer (DCC- Deleted in Colon Cancer)
APC
Colorectal Cancer
BRCA1/BRCA2
Breast Cancer... Ovarian Cancer
15 terms
Pathology: Tumor Suppressor Genes
APC in wnt signalling pathway
BRCA1/BRCA2 encodes DNA repair protein
DCC
DPC4 / SMAD4
Colorectal cancer and FAP
Breast cancer and ovarian cancer
Colon cancer
Pancreatic cancer
APC in wnt signalling pathway
Colorectal cancer and FAP
BRCA1/BRCA2 encodes DNA repair protein
Breast cancer and ovarian cancer
57 terms
Pathology Tumor Markers/Genes
Familial Adenomatous polyposis
HNPCC
inhibit CDKS
selective inhibition of cyclin D/CDK4…
APC mutation
defect in mismatch repair... MSH2 MLH1 PMS PMS2
CIP/WAF, p21, p27, p57
INK4: p15, p16, p18, p19... INK4a are in melanomas
Familial Adenomatous polyposis
APC mutation
HNPCC
defect in mismatch repair... MSH2 MLH1 PMS PMS2
33 terms
Pathology: Oncogenes and Tumor Suppressor Genes
Oncogenes
PDGFB ... Growth Factor
HER2/neu (ERB-B2)... Growth Factor recep…
RET... Growth Factor Receptor
Gain of function ➡️ Increase cancer risk. ... *Only need damage…
Platelet derived growth factor... Overexpression, leads to an a…
Tyrosine kinase... Overexpression of growth factor receptors th…
Tyrosine kinase... MEN 2A and B... Sporadic Medullary Carcinoma…
Oncogenes
Gain of function ➡️ Increase cancer risk. ... *Only need damage…
PDGFB ... Growth Factor
Platelet derived growth factor... Overexpression, leads to an a…
15 terms
Pathology (Tumor Suppressor Genes)
APC
BRCA1/2
CDKN2A
DCC
Colorectal carcinoma
DNA repair protein... Breast and ovarian cancer
p16, blocks G1-->S... Melanoma, pancreatic cancer
Colon cancer
APC
Colorectal carcinoma
BRCA1/2
DNA repair protein... Breast and ovarian cancer
21 terms
Pathology: Tumor suppressor genes
Which tumor suppressor genes are mutat…
A lab allows for only 1 of a patient's…
A 32-year-old pt with breast cancer ha…
A pt's family history suggests a BRCA1…
TSC1, which produces the hamartin protein, and TSC2, which pr…
Yes, both alleles of a tumor suppressor gene must be mutated…
p53, a tumor suppressor, normally regulates the G1/S transiti…
The genes encode DNA repair proteins; they function as tumor…
Which tumor suppressor genes are mutat…
TSC1, which produces the hamartin protein, and TSC2, which pr…
A lab allows for only 1 of a patient's…
Yes, both alleles of a tumor suppressor gene must be mutated…
40 terms
Pathology Gene Associations
Primary Biliary Cirrhosis
PNH
Follicular Lymphoma
SLL/CLL
1. IgM antibody to PDC-E2... 2. AMA (antimitochondrial) Antibody
- Abscence of CD55, CD59... - "gets up multiple times in the nig…
1. CD10... 2. CD19... 3. CD20... 4. Surface IgG... 5. t(14:18)
1. CD5... 2. CD19... 3. CD20... 4. CD23... 5. Surface IgM
Primary Biliary Cirrhosis
1. IgM antibody to PDC-E2... 2. AMA (antimitochondrial) Antibody
PNH
- Abscence of CD55, CD59... - "gets up multiple times in the nig…
15 terms
Single-Gene Disorders: Pathology
Achondroplasia
Cystic Fibrosis
Duchenne Muscular Dystrophy
Ehlers-Danlos Syndrome
Defect in bone growth
Defective chloride channel
Defect in dystrophin
Collagen disorder
Achondroplasia
Defect in bone growth
Cystic Fibrosis
Defective chloride channel
17 terms
Pathology Match Gene
Horizontal Gaze Palsy with Progressive…
Congenital fibrosis of the extraocular…
Lissencephaly
Triad of Migrational disorder
mutation Robo3 axon guidance receptor
Mutation in KIF21A (codes for kinesin microtubule motor prote…
Chromosome 7 - Reelin... Chromosome 17 - LIS1 gene (Autosomal re…
Pachygyria - fewer & broader gyri... Lissencephaly - Smooth brai…
Horizontal Gaze Palsy with Progressive…
mutation Robo3 axon guidance receptor
Congenital fibrosis of the extraocular…
Mutation in KIF21A (codes for kinesin microtubule motor prote…
Human Pathology : Gene Transfer
The process by which naked DNA from a…
A capsid containing DNA or RNA injecte…
What are the two types of bacteriophag…
What are the two types of transduction?
Transformation
Bacteriophage (virus for bacteria)
1) Virulent (lytic) phage ... 2) Temperature (lysogenic) phage
1) generalized ... 2) specialized
The process by which naked DNA from a…
Transformation
A capsid containing DNA or RNA injecte…
Bacteriophage (virus for bacteria)
15 terms
FA PATHOLOGY tumor suppressor genes
APC
BRCA1/BRCA2
CDKN2A
DCC
colorectal ca (assoc'ed w/ FAP)
breast/ovarian ca
melanoma, pancreatic ca
colon ca
APC
colorectal ca (assoc'ed w/ FAP)
BRCA1/BRCA2
breast/ovarian ca
11 terms
Pathology- Neoplasia- Tumor Suppressor Genes
Rb
p53
BRCA1/2
p16
RetinoBlastoma, Osteosarcoma; inhibits E2F, blocks G1
TF for p21; blocks G1
Breast and Ovarian CA
Melanoma
Rb
RetinoBlastoma, Osteosarcoma; inhibits E2F, blocks G1
p53
TF for p21; blocks G1
12 terms
Human Pathology : Gene Transfer
The process by which naked DNA from a…
A capsid containing DNA or RNA injecte…
What are the two types of bacteriophag…
What are the two types of transduction?
Transformation
Bacteriophage (virus for bacteria)
1) Virulent (lytic) phage ... 2) Temperature (lysogenic) phage
1) generalized ... 2) specialized
The process by which naked DNA from a…
Transformation
A capsid containing DNA or RNA injecte…
Bacteriophage (virus for bacteria)
56 terms
Pathology Cancer Genes, Toxins, and Markers
ALK
BCR-ABL
BCL2
BRAF
oncogene, receptor tyrosine kinase; lung adenocarcinoma
oncogene; tk; t(9;22); CML and ALL
oncogene; antiapoptotic molecule; follicular and diffuse larg…
oncogene; serine and threonine kinase; melanoma, non-Hodgkin…
ALK
oncogene, receptor tyrosine kinase; lung adenocarcinoma
BCR-ABL
oncogene; tk; t(9;22); CML and ALL
25 terms
Pathology- Oncogenes/Tumor suppressor Genes
BCR-ABL
bcl-2
BRAF
c-kit
CML, ALL... -oncogene... (tyrosine kinase)
follicular and undifferentiated lymphomas... -oncogene... (anti-apo…
melanoma... -oncogene... (serine/threonine kinase)
Gastrointestinal stromal tumor (GIST)... -oncogene... (cytokine rec…
BCR-ABL
CML, ALL... -oncogene... (tyrosine kinase)
bcl-2
follicular and undifferentiated lymphomas... -oncogene... (anti-apo…
28 terms
Pathology- Oncogenes/Tumor suppressor Genes
BCR-ABL
bcl-2
BRAF
c-kit
CML, ALL... -oncogene... (tyrosine kinase)
follicular and undifferentiated lymphomas... -oncogene... (anti-apo…
melanoma... -oncogene... (serine/threonine kinase)
Gastrointestinal stromal tumor (GIST)... -oncogene... (cytokine rec…
BCR-ABL
CML, ALL... -oncogene... (tyrosine kinase)
bcl-2
follicular and undifferentiated lymphomas... -oncogene... (anti-apo…
96 terms
Test 3 Pathology, Histo, Genes
Cushings syndrome
Cushing Disease Histo
Primary adrenal neoplasm histo
Conn syndrome histo
Any condition resulting in excess cortisol levels
Adrenal glands with bilateral nodular cortical hyperplasia
Adrenal atrophy with diffuse nodular hyperplasia and lipid ce…
Spironolocatone bodies
Cushings syndrome
Any condition resulting in excess cortisol levels
Cushing Disease Histo
Adrenal glands with bilateral nodular cortical hyperplasia
16 terms
Pathology--Neoplasia; Tumor suppressor genes
Tumor suppressor genes
APC
BRCA1/BRCA2
CDKN2A
Loss of function = increase cancer risk; both alleles must be…
Colorectal cancer (associated with FAP)
Breast and ovarian cancer... DNA repair protein
Melanoma, pancreatic cancer... p16, blocks G1 to S phase
Tumor suppressor genes
Loss of function = increase cancer risk; both alleles must be…
APC
Colorectal cancer (associated with FAP)
57 terms
Oncogenes/Tumor Suppressor Genes/Pathology
Oncogenes
BCR-ABL 9-22
BCL-2
BRAF
Gain of Fxn -> Only need 1 allele damage --> Cancer
Gene Product: Tyrosine Kinase... Assoc Tumor: CML, ALL... Transloca…
Antiapoptotic Molecule... Follicular and undifferented lymphomas…
Serine/Threonine Kinase... Melanoma, Non Hodgkin
Oncogenes
Gain of Fxn -> Only need 1 allele damage --> Cancer
BCR-ABL 9-22
Gene Product: Tyrosine Kinase... Assoc Tumor: CML, ALL... Transloca…
16 terms
Pathology | Tumor Suppressor Genes (LOSS OF FUNCTION)
APC
BRCA1 and BRCA2
CPD4/SMAD4
DCC
Associated Tumor: Colorectal cancer... Gene Product:
Associated Tumor: Breast and Ovarian Cancer... Gene Product: DNA…
Associated Tumor: Pancreatic Cancer... Gene Product: Deleted in…
Associated Tumor: Colon Cancer... Gene Product: Deleted in Colon…
APC
Associated Tumor: Colorectal cancer... Gene Product:
BRCA1 and BRCA2
Associated Tumor: Breast and Ovarian Cancer... Gene Product: DNA…
39 terms
Block 2 Pathology 1: Associated Genes
Achondroplasia
Thanatophoric dysplasia
Osteogenesis imperfecta
Osteopetrosis
FGFR3
FGFR3
COL1A1 and COL1A2
CLCN7
Achondroplasia
FGFR3
Thanatophoric dysplasia
FGFR3
19 terms
USMLE: Pathology - Oncogenes and Tumor Suppressor Genes
abl
c-myc
bcl-2
Erb-B2
Oncogene... CML (9:22)
Oncogene... Burkitt's Lymphoma (8:14)
Oncogene... Follicular lymphoma (14;18)... Inhibits apoptosis
Oncogene... Breast, ovarian and gastric carcinomas
abl
Oncogene... CML (9:22)
c-myc
Oncogene... Burkitt's Lymphoma (8:14)
USMLE: Pathology - Oncogenes and Tumor Suppressor Genes
-BCR-abl
c-myc
bcl-2
Ras
Oncogene... tyrosine kinase... CML (9:22), ALL
Oncogene... trasncription factor... Burkitt's Lymphoma (8:14)
Oncogene... Follicular large B cell lymphoma (14;18)... anti- apopt…
Oncogene... Colon carcinoma
-BCR-abl
Oncogene... tyrosine kinase... CML (9:22), ALL
c-myc
Oncogene... trasncription factor... Burkitt's Lymphoma (8:14)
15 terms
Pathology_Tumor Supressor Genes_LOF, both alleles
Tumor suppressor gene: APC
Tumor suppressor gene: BRCA1/BRCA2
Tumor suppressor gene: CDKN2A
Tumor suppressor gene: DCC
Colorectal cancer (associated with FAP)
Gene product: DNA repair protein... Breast and ovarian cancer
Gene product: p16, blocks G1-->S phase... Melanoma, pancreatic c…
Colon cancer... DCC Deleted in Colon Cancer
Tumor suppressor gene: APC
Colorectal cancer (associated with FAP)
Tumor suppressor gene: BRCA1/BRCA2
Gene product: DNA repair protein... Breast and ovarian cancer
15 terms
First Aid - PATHOLOGY (Tumor Suppressor Genes)
APC
BRCA1, BRCA2
CDKN2A
DCC
Ch. 5: Colorectal cancer (FAP)
Ch17, Ch13: Breast and Ovarian Cancer ... Gene product: DNA repa…
Melanoma, Pancreatic cancer... p15, blocks G1 → S phase
Ch 18: Colon Cancer
APC
Ch. 5: Colorectal cancer (FAP)
BRCA1, BRCA2
Ch17, Ch13: Breast and Ovarian Cancer ... Gene product: DNA repa…
19 terms
USMLE: Pathology - Oncogenes and Tumor Suppressor Genes
abl
c-myc
bcl-2
Erb-B2
Oncogene... CML (9:22)
Oncogene... Burkitt's Lymphoma (8:14)
Oncogene... Follicular lymphoma (14;18)... Inhibits apoptosis
Oncogene... Breast, ovarian and gastric carcinomas
abl
Oncogene... CML (9:22)
c-myc
Oncogene... Burkitt's Lymphoma (8:14)
36 terms
Pathology-tumor markers, oncogenes, supressor genes
leukemia, sarcoma, papillary thyroid c…
ALP-alkaline phosphatase
AFP
B-hCG
radiation exposure increases risk of?
metastases to bone or liver, Paget dz of bone, seminoma (plac…
HCC, hepatoblastoma, yolk sac tumor, mixed germ cell tumor. (…
hydatiform moles, choriocarcinomas, gestational trophoblastic…
leukemia, sarcoma, papillary thyroid c…
radiation exposure increases risk of?
ALP-alkaline phosphatase
metastases to bone or liver, Paget dz of bone, seminoma (plac…
41 terms
Pathology Oncogenes/tumor supressor genes/markers
Oncogenes
BCR-ABL
bcl-2
BRAF
Gain of function increases cancer risk. Need damage to only 1…
CML AML;... Tyrosine Kinase
Follicular and undiferentiated lymphomas;... ANti-apoptotic mole…
Melanoma;... Serine/threonine kinase
Oncogenes
Gain of function increases cancer risk. Need damage to only 1…
BCR-ABL
CML AML;... Tyrosine Kinase
29 terms
FA Pathology- Oncogenes and Tumor Suppressor Genes and Neoplasms
Oncogenes names
Tumor SUppresor Genes names
ALK
BCR-ABL
ALK... BCR-ABL... BCL2... BRAF... C-MYC... c-KIT... HER2/neu (c-erbB2)... JAK2... KRA…
APC... BRCA1 & BRCA2... CDKN2A... DCC... DPC4/SMAD 4... MEN1... NF1... NF2... PTEN... Br…
Lung adenocarcinoma
ALL... CML
Oncogenes names
ALK... BCR-ABL... BCL2... BRAF... C-MYC... c-KIT... HER2/neu (c-erbB2)... JAK2... KRA…
Tumor SUppresor Genes names
APC... BRCA1 & BRCA2... CDKN2A... DCC... DPC4/SMAD 4... MEN1... NF1... NF2... PTEN... Br…
10 terms
Basic Structure of Genes and Chromosomes/Genetic Pathology
Silent mutation
Missense mutation
Nonsense mutation
Read through mutation
Change of nucleotide in codon but no change in amino acid
Change of nucleotide in codon leading to a change in amino acid
Change of nucleotide in codon changing amino acid to a stop c…
Change of nucleotide in codon changing stop amino acid to a n…
Silent mutation
Change of nucleotide in codon but no change in amino acid
Missense mutation
Change of nucleotide in codon leading to a change in amino acid
65 terms
Cancer genes and tissue mediators and other pathology terms
PDGF
FGF
EGF
TGF-beta
secreted by platelet and macrophage... vascular remodeling and S…
stimulate all aspect of angiogenesis... wound repair... embryo deve…
stimulate cell growth via tyrosine kinase
angiogenesis, fibrosis, cell cycle arrest
PDGF
secreted by platelet and macrophage... vascular remodeling and S…
FGF
stimulate all aspect of angiogenesis... wound repair... embryo deve…
54 terms
General Pathology - Week 8 - Genes and genetic disease
How many chromosomes does each human c…
What are the characteristic of a pair…
How many chromosomes do gametes have?
What is the karyotype?
46 chromosomes.... 23 pairs:... 22 pairs autosomes... 1 pair sex chrom…
Female - XX... Male - XY
23 chromosomes... 22 autosomes... 1 sex chromosome
The number and visual appearance of the chromosomes in the ce…
How many chromosomes does each human c…
46 chromosomes.... 23 pairs:... 22 pairs autosomes... 1 pair sex chrom…
What are the characteristic of a pair…
Female - XX... Male - XY
27 terms
SGU Pathology StepPrep Oncogenes and Tumor suppressor genes
APC
BRCA1/BRCA2
CDKN2A
DCC
Tumor suppressor gene... Associated condition: Colorectal cancer…
Tumor suppressor gene... Associated condition: Breast and ovaria…
Tumor suppressor gene... Associated condition: Melanoma (boys of…
Tumor suppressor gene... Associated condition: Colon cancer... Gene…
APC
Tumor suppressor gene... Associated condition: Colorectal cancer…
BRCA1/BRCA2
Tumor suppressor gene... Associated condition: Breast and ovaria…
94 terms
First Aid General Pathology Cancers, Tumor Markers, and Genes
Neoplasm associated with Down Syndrome
Neoplasm associated with Xeroderma pig…
Neoplasm associated with atrophic gast…
Neoplasm associated with tuberous scle…
ALL, AML
malanoma, Squamos cell carcinoma, basal cell carcinoma
gastric adenocarcinoma
astrocytoma, angiomyolipoma, cardiac rhabdomyoma
Neoplasm associated with Down Syndrome
ALL, AML
Neoplasm associated with Xeroderma pig…
malanoma, Squamos cell carcinoma, basal cell carcinoma
22 terms
Molecular Pathology (I) - Tumor suppressor gene, oncogene & cell cycle
Activating oncogene... - activating mecha…
Point mutation
Chromosomal translocation (1)
Chromosomal translocation (2)
Abnormal gene expression ... - (changes in regulation of gene ex…
KRAS: lung, colon and pancreatic cancers... - mutation in codon…
C-myc: Burkitt's lymphoma... - t(8q24, 14q32)... - leads to fusion…
Philadelphia chromosome t(9q, 22q): CML: chronic myeloid leuk…
Activating oncogene... - activating mecha…
Abnormal gene expression ... - (changes in regulation of gene ex…
Point mutation
KRAS: lung, colon and pancreatic cancers... - mutation in codon…
15 terms
FA pathology: Tumor-suppressors LOF mutations - associated cancers and gene products
APC
BRCA1 and BRCA2
CPD4/SMAD4
DCC
Colorectal carcinoma related to FAP
Breast and ovarian cancer... DNA repair protein
Pancreatic cancer
Colon cancer
APC
Colorectal carcinoma related to FAP
BRCA1 and BRCA2
Breast and ovarian cancer... DNA repair protein
20 terms
Single Gene Diseases Overview-Mode of inheritance, pathology, other things
Achondroplasia
Cystic Fibrosis (CF)
Duchenne Muscular Dystrophy (DMD) and…
Ehlers-Danlos Syndrome
AD-FGFR3-dominant neg.... new mutations (80%)/reduced fitn…
AR-CFTR (salt transport)... heterozygote advantage-typhoid fev…
XR-dystrophin... new mutations-large target
AR-enzymes processing collagen and AD-collagen genes. dom…
Achondroplasia
AD-FGFR3-dominant neg.... new mutations (80%)/reduced fitn…
Cystic Fibrosis (CF)
AR-CFTR (salt transport)... heterozygote advantage-typhoid fev…
10 terms
FA pathology: Oncogene GOF mutations - associated cancers and gene products
BCR-ABL
BCL2
BRAF
C-kit
CML, ALL... Tyrosine kinase
Follicular lymphoma... Anti-apoptotic molecule
Melanoma... Serine/Threonine kinase
Gastrointestinal stromal tumor... Cytokine receptor
BCR-ABL
CML, ALL... Tyrosine kinase
BCL2
Follicular lymphoma... Anti-apoptotic molecule
52 terms
First Aid 2016 Pathology: Oncogenes, Tumor Suppressor Genes, Oncogenic Microbes, and Carcinogens
oncogenes need mutation to _ allele/s…
ALK
BCR-ABL
BCL-2
gain of function; one allele
Oncogene - Receptor tyrosine kinase... Lung adenocarcinoma
Oncogene - Tyrosine kinase... CML (a/w t(9;22) translocation)…
Oncogene - Antiapoptotic molecule... Follicular and diffuse l…
oncogenes need mutation to _ allele/s…
gain of function; one allele
ALK
Oncogene - Receptor tyrosine kinase... Lung adenocarcinoma
71 terms
Pathology: Wound healing (p. 223), Paraneoplastic syndromes (p. 229), Oncogenes, tumor suppressor genes, oncogenic microbes, carcinogens
PDGF role
FGF
EGF
TGF-beta
Secreted by activated platelets and macrophages --> induce va…
STimulates angiogenesis
Stimulates cell growth via tyrosine kinase (eg, EGFR/ErbB1)
Angiogenesis, fibrosis, cell cycle arrest
PDGF role
Secreted by activated platelets and macrophages --> induce va…
FGF
STimulates angiogenesis
38 terms
Genes
Gene Expression
Knockout/null alleles
one-gene, one-enzyme hypothesis
Genes
the process of translating the information in ... DNA into funct…
What are non-functioning alleles called?
proposed that each gene contains the ... information needed to m…
contain the instructions for making proteins
Gene Expression
the process of translating the information in ... DNA into funct…
Knockout/null alleles
What are non-functioning alleles called?
58 terms
Patho/Pharm Genes
Genes
What is the smallest functional unit o…
Allele
Phenotype
a specific segment of DNA that contains the code for a proteins
gene
an alternate form of a gene
the expression of a genetic trait resulting from a particular…
Genes
a specific segment of DNA that contains the code for a proteins
What is the smallest functional unit o…
gene
178 terms
pathology
heart muscles become enlarged as a for…
cell death... can be caused by ischemia,…
reduced blood supply
enlarged cells - resulting in increase…
what will the heart do in response to increased hemodynamic l…
what is the end result of progressive cell injury
ischemia
hypertrophy
heart muscles become enlarged as a for…
what will the heart do in response to increased hemodynamic l…
cell death... can be caused by ischemia,…
what is the end result of progressive cell injury
27 terms
genes
Cells
Chromosomes
Genetic Information
Chromosomes in human body
everything is made up of cells and they contain a nucleus
structure of nuclei acids and proteins carrying genetic infor…
parts of building and operating instructions for entire organ…
46
Cells
everything is made up of cells and they contain a nucleus
Chromosomes
structure of nuclei acids and proteins carrying genetic infor…
76 terms
Pathology
BRCA1 and BRCA 2
philadelphia chromosome (:22 in chroni…
Dominant negative effect
Oncogenes
Are tumor suppressor genes whose protein products function in…
produced from a reciprocal translocation invloving the ABL on…
loss of one allele leads to disease, Osteogenesis imperecta,…
c-myc in burkitts lymphoma
BRCA1 and BRCA 2
Are tumor suppressor genes whose protein products function in…
philadelphia chromosome (:22 in chroni…
produced from a reciprocal translocation invloving the ABL on…
32 terms
Patho-Ch. 4: genes and genetic diseases
transcription
translation
polypoid cell
Aneuploidy
cells that have more than normal diploid chromosomes (>46) ... l…
do not contain a multiple of 23 chromosomes... trisomy: contains…
transcription
translation
27 terms
Path genes
mutation of MAML2 in the notch signali…
mutation of APC gene
MAML2
N-MYC
mucoepidermoid carcinoma (parotid gland)
5q21, Wnt signaling
notch signaling
double minutes
mutation of MAML2 in the notch signali…
mucoepidermoid carcinoma (parotid gland)
mutation of APC gene
5q21, Wnt signaling
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