Study sets matching "glycerophospholipids"

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Study sets matching "glycerophospholipids"

6 terms
Glycerophospholipids
phosphatidic acid
phosphatidylcholine (PC)
phosphatidylserine (PS)
phosphatidylglycerol (PG)
H
-CH2CH2N(CH3)3+ (choline)
CH2CH(NH3+)COO- (serine)
CH2CHOHCH2OH (glycerol)
phosphatidic acid
H
phosphatidylcholine (PC)
-CH2CH2N(CH3)3+ (choline)
21 terms
Glycerophospholipids
Glycerophospholipids are a major compo…
Glycerophospholipids stucture
Possible headgroups for Glycerophospho…
Cardiolipin structure
Cell membranes... Lipoproteins... Bile... Lung surfactant
Glycerol backbone... 2 FA chains... Headgroup linked to the backbon…
Choline... Ethanolamine... Serine... Inositol... Glycerol
contains two glycerophospholipids linked covalently by a glyc…
Glycerophospholipids are a major compo…
Cell membranes... Lipoproteins... Bile... Lung surfactant
Glycerophospholipids stucture
Glycerol backbone... 2 FA chains... Headgroup linked to the backbon…
6 terms
Glycerophospholipids
phosphatidic acid
phosphatidylethanolamine (PE)
phosphatidylcholine (PC)
phosphatidylserine (PS)
H
-CH2CH2NH3 (ethanolamine)
-CH2CH2N+(CH3)3 (choline)
CH2CHCOO-NH3 (serine)
phosphatidic acid
H
phosphatidylethanolamine (PE)
-CH2CH2NH3 (ethanolamine)
Glycerophospholipids
phosphatidylethanolamine
Phophatidylcholine
Phosphatidylserine
Phosphatidylglycerol
(ethanolamine)... PE
(choline)... PC
(serine)... PS
(glycerol)... PG
phosphatidylethanolamine
(ethanolamine)... PE
Phophatidylcholine
(choline)... PC
7 terms
glycerophospholipids
Phosphodialic acid
phosphatidylethanolamine
Phophatidylcholine
Phosphatidylserine
-H
-CH2-CH2-NH3 (ethanolamine)
-CH2-CH2-N(CH3)3 (choline)
(serine)
Phosphodialic acid
-H
phosphatidylethanolamine
-CH2-CH2-NH3 (ethanolamine)
7 terms
glycerophospholipids
Phosphodialic acid
phosphatidylethanolamine
Phophatidylcholine
Phosphatidylserine
-H
-CH2-CH2-NH3 (ethanolamine)
-CH2-CH2-N(CH3)3 (choline)
(serine)
Phosphodialic acid
-H
phosphatidylethanolamine
-CH2-CH2-NH3 (ethanolamine)
glycerophospholipids
phosphatidylethanolamine
Phophatidylcholine
Phosphatidylserine
Phosphatidylglycerol
-CH2-CH2-NH3 (ethanolamine)
-CH2-CH2-N(CH3)3 (choline)
(serine)
(glycerol)
phosphatidylethanolamine
-CH2-CH2-NH3 (ethanolamine)
Phophatidylcholine
-CH2-CH2-N(CH3)3 (choline)
Glycerophospholipids
generic glycerophospholipid
phosphatidic acid
phosphatidylethanolamine
phosphatidylserine
X is H
X-O is ethanolamine
X-O is Serine
generic glycerophospholipid
phosphatidic acid
X is H
7 terms
Glycerophospholipids
phosphatidic acid
phosphatidylethanolamine
phosphatidylcholine
phosphatidylserine
-H
phosphatidic acid
-H
phosphatidylethanolamine
Glycerophospholipids
phosphatidic acid
phosphatidylethanolamine
phosphatidylcholine
phosphatidylserine
phosphatidic acid
phosphatidylethanolamine
6 terms
Glycerophospholipids
phosphatidic acid
phosphatidylethanolamine
phosphatidylcholine
phosphatidylserine
-H
phosphatidic acid
-H
phosphatidylethanolamine
glycerophospholipids
phosphatidylethanolamine
phosphatidate
phosphatidylcholine
phosphatidylserine
-H
phosphatidylethanolamine
phosphatidate
-H
Glycerophospholipids
Phosphatidic acid
Phosphatidylethanolamine
Phosphatidylcholine
phosphatidylserine
...
ethanolamine
choline
serine
Phosphatidic acid
...
Phosphatidylethanolamine
ethanolamine
5 terms
Glycerophospholipids
Phosphatidylcholine
Phosphatidylethanolamine
Phosphatidylserine
Phosphatidylglycerol
Phosphatidylcholine
Phosphatidylethanolamine
10 terms
Glycerophospholipids
What are the 3 major classes of lipids…
What is the common intermediate in the…
What are the components of glycerophos…
Where does the monoacylglycerol pathwa…
Glycerophospholipids, sphingolipids, sterols
Phosphatidate (diacylglycerol 3-phosphate)
Glycerol backbone, 2 fatty acid hydrocarbon chains, phosphory…
Enterocytes at the intestines to re-synthesise triacylglycerols
What are the 3 major classes of lipids…
Glycerophospholipids, sphingolipids, sterols
What is the common intermediate in the…
Phosphatidate (diacylglycerol 3-phosphate)
5 terms
Glycerophospholipids
phosphatidylcholine
phosphatidylethanolamine
phosphatidylglycerol
phosphatidylserine
phosphatidylcholine
phosphatidylethanolamine
Glycerophospholipids
Phosphatidylethanolamine
Phosphatidylcholine
Phosphatidylserine
Phosphatidylglycerol
autophagy
cell membranes, ectoplasmic leaflet
clearance of apoptotic cells by phagocyte
pulmonary surfactant
Phosphatidylethanolamine
autophagy
Phosphatidylcholine
cell membranes, ectoplasmic leaflet
5 terms
Glycerophospholipids
Parent compound of glycerophospholipids?
What is the most common glycerophospho…
What type of glycerophospholipid is th…
What type of bond links glycerophospho…
Phosphatidic acid
Diacylglycerols linked to head group alcohols through a phosp…
Phosphatidylcholine
Ester likage
Parent compound of glycerophospholipids?
Phosphatidic acid
What is the most common glycerophospho…
Diacylglycerols linked to head group alcohols through a phosp…
38 terms
Glycerophospholipids
How is fat stored?
Components of glycerophospholipids?
Two types of sphingolipids?
What linkage attaches FAs to glycerol?
TAG
Glycerol backbone... Two FAs... PO4- alcohol
Phospholipid... Glycolipid
Two ester linkages
How is fat stored?
TAG
Components of glycerophospholipids?
Glycerol backbone... Two FAs... PO4- alcohol
29 terms
Glycerophospholipide
Lecithin + Phosphatidylethanolamin
Lecithin
Lecithin
Lecithin
Nettoladung 0
polar: Cholin + Phosphat + Glycerin
1xStickstoff, 2xCO, 1xP
2xCarbon-Phosphorsäureester
Lecithin + Phosphatidylethanolamin
Nettoladung 0
Lecithin
polar: Cholin + Phosphat + Glycerin
MNE: Glycerophospholipids
Glycerophospholipid
Glycerophospholipid
Phosphatidic Acid
PE (Phosphatidylethanolamine)
Class of Lipids that is:... Amphipathic... Glycerol Backbone with 2…
Name this Glycerophospholipid:... Head Group=H... Charge=-1
Name this Glycerophospholipid:... Head Group=Ethanolamine... Charge=0
Glycerophospholipid
Class of Lipids that is:... Amphipathic... Glycerol Backbone with 2…
Glycerophospholipid
67 terms
Chapter 2 glycerophospholipids
3 types of lipids in animal membranes,…
fat (what kinds of membranes are they…
do all membranes have lipid rafts
why is bacterial membrane different
glycerophospholipid ... (usually the majority), sphingolipids, c…
triacylglycerols, not found in animal membranes
no. many internal membranes (golgi, mitochondira, lysozomes)…
bacteria like E coli do not have sphingolipids, cholesterol,…
3 types of lipids in animal membranes,…
glycerophospholipid ... (usually the majority), sphingolipids, c…
fat (what kinds of membranes are they…
triacylglycerols, not found in animal membranes
Lipids/Glycerophospholipids
Glycerolipids, Sphingolipids, Choleste…
Phosphatidylethanolamine
PhosphatidylCholine
PhosphatidylSerine
Major Membrane Lipids
Ethanolamine attachment to a glycerophospholipid, created wit…
Choline attachement to a glycerophospholipid, created with st…
Serine attachment to a glycerophosphoslipid, created from hea…
Glycerolipids, Sphingolipids, Choleste…
Major Membrane Lipids
Phosphatidylethanolamine
Ethanolamine attachment to a glycerophospholipid, created wit…
28 terms
MTC Glycerophospholipids
glycerophospholipids
sphingolipids
how do you make phosphatidyl serine
how can you make choline from ethanola…
have 2 FA and 1 glycerol and a head group on 3rd carbon... -used…
-contain sphingosine from serine... -have a fatty acid and eithe…
by switching it from ethanolamine... -to get back to ethanolamin…
methylate by 3-SAM
glycerophospholipids
have 2 FA and 1 glycerol and a head group on 3rd carbon... -used…
sphingolipids
-contain sphingosine from serine... -have a fatty acid and eithe…
Common Glycerophospholipids
Water... -H
Ethanolamine... -CH₂CH₂NH₃⁺
Choline... -CH₂CH₂N(CH₃)₃⁺
Serine... -CH₂CH(NH₃⁺)COO⁻
Phosphatic acid
Phosphatidylethanolamine
Phosphatidylcholine (lecithin)
Phosphatidylserine
Water... -H
Phosphatic acid
Ethanolamine... -CH₂CH₂NH₃⁺
Phosphatidylethanolamine
7 terms
Glycerophospholipids & spingolipids
surfactant in lungs
glycerophospholipids
functions of glycerophospholipids
glycerophospholipid synthesis... key reg…
- Can detect surfactant in amniotic fluid as lecithin:sphingo…
glycerol backbone... phosphate group... FA (usually 1 saturated FA,…
- Structural- plasma mem... - Phosphatidylcholine serves as sub…
Phosphatidic acid serves as precursor for all glycerophosphol…
surfactant in lungs
- Can detect surfactant in amniotic fluid as lecithin:sphingo…
glycerophospholipids
glycerol backbone... phosphate group... FA (usually 1 saturated FA,…
Glycerophospholipids & spingolipids
surfactant in lungs
How to detect surfactant in amniotic f…
major phospholipid component of surfac…
glycerophospholipids make-up
DPPC (glycerophospholipid), saturated FA so can tightly sit b…
lecithin:sphingomyelin (L/S) ratio
Lecithin = phosphatidylcholine =
glycerol backbone... phosphate group... FA (usually 1 saturated FA,…
surfactant in lungs
DPPC (glycerophospholipid), saturated FA so can tightly sit b…
How to detect surfactant in amniotic f…
lecithin:sphingomyelin (L/S) ratio
8 terms
Degradation of Glycerophospholipids
Degrade Glycerophospholipids
Each phospholipase is specific for
Phospholipases A1 and A2
Arachidonic acid is often incorporated…
Phospholipases located in cell membranes or in lysozomes
Which bond it hydrolyzes
Important in remodeling reactions where FA is exchanged... Impor…
C2... Releasing it prior to eicosanoid synthesis
Degrade Glycerophospholipids
Phospholipases located in cell membranes or in lysozomes
Each phospholipase is specific for
Which bond it hydrolyzes
Naming Glycerophospholipids
Steric Acid
Oleic Acid
Linoleic Acid
α-Linoleic Acid
18 carbons and no double bonds
18 carbons and 1 double bonds
18 carbons and 2 double bonds
18 carbons and 3 double bonds (9,12,15)
Steric Acid
18 carbons and no double bonds
Oleic Acid
18 carbons and 1 double bonds
33 terms
Lecture 18: Glycerophospholipids
Basic Glycerophospholipid structure
3 things about G3P
2 steps to glycerolphospholipid synthe…
step 1 glycerolphospholipid synthesis
1. glycerol backbone... 2. phosphorylated alcohol... 3. two esterif…
1. intermediate in glycolysis ... 2. precursor for TAG synthesis…
1. phosphatidic acid synthesis from DHAP... 2. glycerophospholip…
DHAP reduced to G3P... fatty acyl CoA added to first and second…
Basic Glycerophospholipid structure
1. glycerol backbone... 2. phosphorylated alcohol... 3. two esterif…
3 things about G3P
1. intermediate in glycolysis ... 2. precursor for TAG synthesis…
55 terms
Triglycerides and Glycerophospholipids
What is the general structure of a tri…
What is the major function of TAGs?
What is an important effect of TAGs hy…
How does CHO and Protein polarity comp…
Glycerol backbone with ester linkages to SFAs and UFAs
Lipid storage
Affects ability to cross membranes
CHO and Proteins hydrophilic... Lipids hydrophobic
What is the general structure of a tri…
Glycerol backbone with ester linkages to SFAs and UFAs
What is the major function of TAGs?
Lipid storage
22 terms
T12 Glycerophospholipids
describe surfactant
define atelectasis
describe acute respiratory distress sy…
when does surfactant synthesis begin?
reduces surface tension and is required to allow alveoli to e…
collapsed alveoli, difficulty breathing
75% of gestation complete... use lecithin:sphingomyelin ratio
describe surfactant
reduces surface tension and is required to allow alveoli to e…
define atelectasis
collapsed alveoli, difficulty breathing
Common Class of Glycerophospholipids
Phosphatidic acid
Phosphatidylethanolamine
Phosphatidylcholine (lecithin)
Phosphatidylserine
Water
Ethanolamine
Choline
Serine
Phosphatidic acid
Water
Phosphatidylethanolamine
Ethanolamine
8 terms
Glycerophospholipids in Human Cell
phosphatidic acid (PA)
phosphatidycholine (PC, lecithin)
phosphoatidylethanolamine (PE, cephalin)
phosphatidylserine (PS)
- a precursor for the synthesis of all other glycerophospholi…
- PC = PA + choline... - the most abundant phospholipid... - stor…
- PE = PA + ethanolamine... - the second most abundant phosphol…
- PS = PA + serine... - less abundant than PC and PE, only foun…
phosphatidic acid (PA)
- a precursor for the synthesis of all other glycerophospholi…
phosphatidycholine (PC, lecithin)
- PC = PA + choline... - the most abundant phospholipid... - stor…
13 terms
Glycerophospholipid Synthesis
Describe the structure of TAG
Describe the general structure of sphi…
describe the general structure of eico…
describe the general structure of a gl…
3 fatty acids at the c1-c3 of a glycerol molecule
composed of a sphingosine, a fatty acid attached at c2 by an…
highly unsaturated fatty acids, derived from arachadonic acid.
glyerol backbone, 2 fatty acids esterified at c1 and c2. and…
Describe the structure of TAG
3 fatty acids at the c1-c3 of a glycerol molecule
Describe the general structure of sphi…
composed of a sphingosine, a fatty acid attached at c2 by an…
51 terms
Glycerophospholipids and Lipid Signaling
common name for Phosphatidylcholine
composition of surfactant
major GPL of surfactant
all GPL have this backbone
lecithin
80% glycerophospholipid, 10% cholesterol and 10% protein
dipalmitoylphosphatidylcholine
glycerol-3-PO3
common name for Phosphatidylcholine
lecithin
composition of surfactant
80% glycerophospholipid, 10% cholesterol and 10% protein
7 terms
glycerophospholipids x groups
if no x group just an H
ethanolamine
choline
serine
phosphatidic acid
phosphotidylethanolamine
phosphatidylcholine
phosphatidylserine
if no x group just an H
phosphatidic acid
ethanolamine
phosphotidylethanolamine
34 terms
12: Glycerophospholipids and Lipid Signaling
Surfactant
Atelectasis
Acute Respiratory Distress Syndrome (R…
Surfactant synthesis is initiated in f…
Phospholipid-rich lipoprotein... Reduces surface tension... Require…
Collapse of alveoli due to lack of surfactant
Immaturity of fetal lungs at birth --> inadequate synthesis o…
75%... After 30 weeks gestation-- starts to appear in amniotic f…
Surfactant
Phospholipid-rich lipoprotein... Reduces surface tension... Require…
Atelectasis
Collapse of alveoli due to lack of surfactant
Glycerophospholipid classes
plasmalogens
phosphatidates
water (type of phosphatidate)
Ethanolamine (type of phosphatidate)
...
...
PA - phosphatidic acid... Net charge = -1
PE - phosphatidylethanolamine ... Net charge = 0
plasmalogens
...
phosphatidates
...
21 terms
Glycerophospholipid Metabolism
What is surfactant?
What cell secretes surfactant?
What is DPPC?
How is lecthin measured from amniotic…
A phospholipid rich lipoprotein that reduces surface tension…
Type II cell, begins at 30 week gestation when it starts to a…
The major phospholipid and surface active component of surfac…
Sphingomyelin: lecthin ratio... -sphingomyelin is not in surfact…
What is surfactant?
A phospholipid rich lipoprotein that reduces surface tension…
What cell secretes surfactant?
Type II cell, begins at 30 week gestation when it starts to a…
25 terms
Glycerophospholipid Synthesis
What are the three main types of membr…
Describe the general structure of a gl…
What is the simplest glycerophospholip…
What are the different classifications…
Glycerophospholipids, sphingolipids, cholesterol
Glycerol backbone with a phosphorylated alcohol and two carbo…
Phosphatidic acid. Phosphate contains a H group. This is the…
Phosphatidic acid = H... Phosphatidylethanolamine = ethanolamine…
What are the three main types of membr…
Glycerophospholipids, sphingolipids, cholesterol
Describe the general structure of a gl…
Glycerol backbone with a phosphorylated alcohol and two carbo…
40 terms
Glycerophospholipid Metabolism
Review: Fatty Acyl Chains ... 1. Palmiti…
What are Glycophopholipids a Derivativ…
What does a phospholipase cleave?
PLA1... PLA2... PLC... PLD
1. Palmitate= 16:0... 2. Stearate= 18:0... 3. Oleate= 18:1 ... 4. Lino…
Phosphatidic Acid (PA) ... Formed by condensation of : Phosphat…
Ester bonds on phospholipids at the single bonded oxygen
Phospholipase A1 -> cleaves first ester bond (carbon 3) ... Pho…
Review: Fatty Acyl Chains ... 1. Palmiti…
1. Palmitate= 16:0... 2. Stearate= 18:0... 3. Oleate= 18:1 ... 4. Lino…
What are Glycophopholipids a Derivativ…
Phosphatidic Acid (PA) ... Formed by condensation of : Phosphat…
Glycerophospholipid metabolism
What are cardiolipins?
What is the syndrom associated with Ca…
What are plasmalogens?
What is Newmann-Pick disease A and B?
Two phospholipids esterified to an additional glycerol via ph…
Barth syndrome: X-linked myopathy involving Cardiolipin remod…
Ether linked alkene at SN-1 position. ... Phosphatidalcholine.…
Dysfunctional sphingomyelinase which causes accumulation of s…
What are cardiolipins?
Two phospholipids esterified to an additional glycerol via ph…
What is the syndrom associated with Ca…
Barth syndrome: X-linked myopathy involving Cardiolipin remod…
8 terms
Biosynthesis of triacylglycerols and glycerophospholipids
Phosphatidic acid is the precursor for
For triacylglycerol biosynthesis, phos…
1,2-diacylglycerols are then converted…
Rapidly growing cells need more
both triacylglycerol and glycerophospholipids
1,2-diacylglycerol
third fatty acyl-CoA
phospholipids for membranes
Phosphatidic acid is the precursor for
both triacylglycerol and glycerophospholipids
For triacylglycerol biosynthesis, phos…
1,2-diacylglycerol
18 terms
lipid terms + glycerophospholipids, ch 10
In triacylglycerol, the first point of…
fatty acid structure
wax
most lipids are polar or non polar? ex…
carbon # 2
carboxylic acid + hydrocarbon chain ... may have: OH, branches,…
esters of long chain sat & unsat fatty acids (C 14 - C 36) wi…
most polar & membrane...... except triacylglyceride (storage)... m…
In triacylglycerol, the first point of…
carbon # 2
fatty acid structure
carboxylic acid + hydrocarbon chain ... may have: OH, branches,…
60 terms
Glycerophospholipids and Lipid Signaling
Respiratory distress syndrome RSD
consequence of preterm birth?
type 2 cell in the lung
another name for lecithin is
Caused by immaturity of the fetal lungs at birth and *inadequ…
cerebral hemorrhage... -death, retardation, paralysis, cerebral…
produces surfactant for the lungs, in lamellar bodies(*ex…
phosphatidylcholine... -major PL in surfactant
Respiratory distress syndrome RSD
Caused by immaturity of the fetal lungs at birth and *inadequ…
consequence of preterm birth?
cerebral hemorrhage... -death, retardation, paralysis, cerebral…
Glycerophospholipids and Lipid Signaling
Respiratory distress syndrome
type 2 cell in the lung
another name for lecithin is
When does surfactant start appearing i…
Caused by immaturity of the fetal lungs at birth and inadequa…
produces surfactant for the lungs
phosphatidylcholine
30 weeks gestation
Respiratory distress syndrome
Caused by immaturity of the fetal lungs at birth and inadequa…
type 2 cell in the lung
produces surfactant for the lungs
10 terms
8.3 Glycerophospholipids
What are glycerophospholipids?
Are phospholipids always considered gl…
If a phospholipid contains unsaturatio…
Name the 6 glycerophospholipids
1,2-diacylglycerol that has a phosphate group esterified at c…
No, there are phospholipids that do not have a glycerol backb…
2-position for unsaturation... 1-position for saturation
Phosphatidycholine... Phosphatidylethanolamine... Phosphatidylserin…
What are glycerophospholipids?
1,2-diacylglycerol that has a phosphate group esterified at c…
Are phospholipids always considered gl…
No, there are phospholipids that do not have a glycerol backb…
5 terms
Lipids: Phosphoacylglycerols/Glycerophospholipids
Structure
Phosphate may have a
These are important components of
Simplest form
Glycerol backbone with 2 fatty acids and a phosphate
Head group attached
Cell membrane
Phosphatidic acid
Structure
Glycerol backbone with 2 fatty acids and a phosphate
Phosphate may have a
Head group attached
5 terms
Know general structures and names of glycerophospholipids
Glycerophospholipids
Phosphatidylethanolamines
phosphatidylcholine
phosphatidylserine
An amphipathic lipid with a glycerol backbone; fatty acids ar…
Glycerophospholipids
An amphipathic lipid with a glycerol backbone; fatty acids ar…
Phosphatidylethanolamines
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