How can we help?

You can also find more resources in our Help Center.

Study sets matching "helper t cells"

Study sets
Classes
Users

Study sets matching "helper t cells"

28 terms
Helper T Cells
what is the main goal of Thelper cells?
which cytokines are produced by Th1 ce…
which cytokines are produced by Th2 ce…
what is the function of Th1 cells?
to direct immune reactions by both the innate and adaptive im…
IFNg
IL-4, 5, 6, and 13
to defend against intracellular pathogens via cell-mediated i…
what is the main goal of Thelper cells?
to direct immune reactions by both the innate and adaptive im…
which cytokines are produced by Th1 ce…
IFNg
9 terms
T Helper Cell Classification
TH1
TH2
TH9
TH17
activate macrophages
activate B cells... help product antibodies
clear parasitic worms
on mucous/skin layer border
TH1
activate macrophages
TH2
activate B cells... help product antibodies
8 terms
T Helper Cells
What are the central roles of T Helper…
Which T Helper cells activate macropha…
Which receptor complexes must form for…
Which cytokine do Th1 cells initially…
Activate macrophages and cytotoxic T cells
Th1 cells
TCR (CD4) and MHC 2 + Peptide... CD40L and CD40
Interferon gamma
What are the central roles of T Helper…
Activate macrophages and cytotoxic T cells
Which T Helper cells activate macropha…
Th1 cells
6 terms
T-helper cells
Th1
Th2
Th9
Th17
antiviral/microbial and cell mediated immunity, inflammation
immunity to parasites, allergens
immunity to helminths, inflammation
immunity to infections at mucocutaneous sites, inflammation
Th1
antiviral/microbial and cell mediated immunity, inflammation
Th2
immunity to parasites, allergens
5 terms
T helper cells
TH1
TH2
TH17
TFH
induces cytolytic immune response... activate T cytotoxic cells:…
induce humoral response... activate B cells by producing antibod…
induce an immune inflammatory response: IL-17 (neutrophils)... e…
T follicular helper cells that migrate to B cell follicle tha…
TH1
induces cytolytic immune response... activate T cytotoxic cells:…
TH2
induce humoral response... activate B cells by producing antibod…
46 terms
Cytokines & Helper T cells
IL-1 is secreted by:
IL-1 is AKA:
IL-1 causes (2)
IL-1:
macs
osteoclast-activating fx
fever & inflammation
Secreted by macs... AKA osteoclast-activating fx. ... Cz's fever &…
IL-1 is secreted by:
macs
IL-1 is AKA:
osteoclast-activating fx
25 terms
2. Helper T cell
60-80% of T cell=helper cell
secrete proteins assist system
B cell growth factor
interleukin for T cell growth
helper T cell
helper T cell
helper T cell
helper T cell
60-80% of T cell=helper cell
helper T cell
secrete proteins assist system
helper T cell
20 terms
Helper T cells
TH1 differentiation
TH1 secretion
TH1 function and pathogen
IFNy
IL12, IFNy
IFNy, IL2, TNFa
Activate macrophages and Tc cells. Intracellular bacteria
Augments phagocyte killing and antigen presentation. Promotes…
TH1 differentiation
IL12, IFNy
TH1 secretion
IFNy, IL2, TNFa
11 terms
Helper T- Cells
Secretes IFN-gamma
Secretes IL-4, IL-5, IL-10, and IL-13
Activates Macrophages and cytotoxic T…
Recruits eosinophils for parasite defe…
Th1
Th2
Th1
Th2
Secretes IFN-gamma
Th1
Secretes IL-4, IL-5, IL-10, and IL-13
Th2
10 terms
T Helper Cell Cytokines
IL-2
IFN-gamma
TNF-alpha
IL-4
source: Th1 and naive TH ... activity: ... 1. T cell proliferation…
source: TH1, CD8 cells, and NK cells ... 1. increase macrophage…
source: macrophages and TH1 ... 1. activates endothelium ... 2. in…
source: TH2 ... 1. B cell proliferation and differentiation +++…
IL-2
source: Th1 and naive TH ... activity: ... 1. T cell proliferation…
IFN-gamma
source: TH1, CD8 cells, and NK cells ... 1. increase macrophage…
5 terms
Activated T helper cells
Th1
Th2
Th17
Tfh
cytolytic response, IL-2, macrophage IFN-gamma; effective aga…
humoral response, IL-4,5,13; effective against helminths
inflammatory response, IL-17 neutrophils; effective against e…
migrates to follicle; responsible for B cell activation
Th1
cytolytic response, IL-2, macrophage IFN-gamma; effective aga…
Th2
humoral response, IL-4,5,13; effective against helminths
9 terms
T helper cells
Th1
Th2
Th9
Th17
anti-viral/microbial immunity, cell-mediated immunity, inflam…
immunity to extracell parasites, allergens
immunity to helminths, inflammation
immunity to infections at mucocutaneous sites, inflammation
Th1
anti-viral/microbial immunity, cell-mediated immunity, inflam…
Th2
immunity to extracell parasites, allergens
8 terms
T Helper cells
TH0
TH1
TH2
TH9
undifferentiated T cells
help activate macrophages
help B cells produce antibodies
stimulates hematopoiesis and inhibits apoptosis
TH0
undifferentiated T cells
TH1
help activate macrophages
9 terms
Helper T cells RAMS
Recognition
Activation
Mitosis
Specialization 2 fates
TCR of Helper T binds to matching antigen
CD4 protein associated with TCR binds to MHCII
many rounds of mitotic divisions to produce a population of i…
Majority become active helper T cells which circulate and rel…
Recognition
TCR of Helper T binds to matching antigen
Activation
CD4 protein associated with TCR binds to MHCII
17 terms
Helper T cells
TCRϒσ
Helper T cell
Cytotoxic T cell
Activation of Naive Helper T-cells
-Aka intraepithelial lymphocytes... -receptors that are express…
-aka TH and CD4+... -help B cells produce antibodies to protein…
aka Tc, CD8+... -causes lysis of antigen-bearing target cells
respond only to processed antigen when it is presented by pro…
TCRϒσ
-Aka intraepithelial lymphocytes... -receptors that are express…
Helper T cell
-aka TH and CD4+... -help B cells produce antibodies to protein…
5 terms
T helper cells func
Cell mediated immune responses
Ab response, humoral immunity and chro…
Mucus production, pathogenesis of asthma
Pro inflamm cytokines assoc with autoi…
TH1 (T helper 1)
TH2
TH9
TH17
Cell mediated immune responses
TH1 (T helper 1)
Ab response, humoral immunity and chro…
TH2
12 terms
T-helper cell differentiation
Polarizing cytokines IL-2, TGF-beta
Master transcriptional regulator FOXP3…
IL-10, TGF-beta effector cytokines
Polarizing cytokines IL-1, IL-6, IL-23…
Turns on Master transcriptional regulator FOXP3 on T reg cell
Produces IL-10, TGF-beta effector cytokines
Results in regulation, suppression immune and inflammatory re…
Turns on master transcriptional regulator ROR-gamma-t on Th17…
Polarizing cytokines IL-2, TGF-beta
Turns on Master transcriptional regulator FOXP3 on T reg cell
Master transcriptional regulator FOXP3…
Produces IL-10, TGF-beta effector cytokines
12 terms
Helper T cells
Th1 cells secrete
Th1 cells activate
Th1 cells are activated by
Th1 cells are inhibited by
IFN-gamma
macrophages and cytotoxic T cells
INF-gamma and IL-12
IL-4 and IL-10 (from Th2 cells)
Th1 cells secrete
IFN-gamma
Th1 cells activate
macrophages and cytotoxic T cells
15 terms
T helper cell subsets
TGF-beta induces
Tregs express
Tregs produce
IL-12 induces
iTregs
FoxP3
IL-10, TGF-beta
Th1
TGF-beta induces
iTregs
Tregs express
FoxP3
21 terms
T Helper cell responses
Describe Th1 response... - when... - trigger…
Describe Th2 response... - when... - trigger…
Th17... - triggered by ... - cytokines
Treg... - function... - cytokines
- 1st, early, local, cellular ... - triggered by IL12... - cytokine…
- 2nd, later, systemic, antibody, allergies... - triggered by IL…
- TGF-beta + IL1 or IL23 for memory cells... -cytokines: 1L17
immunosuppresion/tolerance... - cytokines: TGF-beta, IL10
Describe Th1 response... - when... - trigger…
- 1st, early, local, cellular ... - triggered by IL12... - cytokine…
Describe Th2 response... - when... - trigger…
- 2nd, later, systemic, antibody, allergies... - triggered by IL…
56 terms
T Helper Cell Responses
Th1
Th1 cytokines and responses
Th2
Th2 cytokines
1st, early, local, cellular and antibody (triggered by IL12)
IFNgamma, IL2, LT-alpha (TNFb); DTH, anti-viral; anti-tumor,…
2nd, later, systemic, antibody, allergies (triggered by IL4)
IL4, IL5, IL10, IL13; B cells (IgG, IgE, IgA), Mast cells, M2…
Th1
1st, early, local, cellular and antibody (triggered by IL12)
Th1 cytokines and responses
IFNgamma, IL2, LT-alpha (TNFb); DTH, anti-viral; anti-tumor,…
110 terms
Helper T cell responses
Describe Th1
Th1 is triggered by what cytokine
Cytokines of Th1
Function of Th1 cytokines
1. 1st... 2. early... 3. local... 4. cellular and antibody
IL12
1. IFNgamma... 2. IL2... 3. LT-alpha (TNFb)
1. DTH... 2. anti-viral... 3. anti-tumor... 4. inflammation... 5. B cells…
Describe Th1
1. 1st... 2. early... 3. local... 4. cellular and antibody
Th1 is triggered by what cytokine
IL12
5 terms
Helper T Cell Subsets
Th1
Th2
Th17
Naive T cell receptors
source: macrophages... defining cytokines: IFN-gamma... host defens…
source: eosinophils and mast cells... defining cytokines: IL-4,…
source: neutrophils... defining cytokines: IL-17, IL-22... host def…
CCR7 (binds to CCL19/21)is their chemokine receptor ... L-select…
Th1
source: macrophages... defining cytokines: IFN-gamma... host defens…
Th2
source: eosinophils and mast cells... defining cytokines: IL-4,…
11 terms
Helper T Cells
Secretes IFN-Y
Secretes Il4,5,6,13
Activates macrophages and cytotoxic ly…
Inhibited by Il4 and Il10 (From Th2 ce…
Th1 Cells
Th2 Cells
Th1 Cells
Th1
Secretes IFN-Y
Th1 Cells
Secretes Il4,5,6,13
Th2 Cells
17 terms
Helper T cells
TCRϒσ
Helper T cell
Cytotoxic T cell
Activation of Naive Helper T-cells
-Aka intraepithelial lymphocytes... -receptors that are express…
-aka TH and CD4+... -help B cells produce antibodies to protein…
aka Tc, CD8+... -causes lysis of antigen-bearing target cells
respond only to processed antigen when it is presented by pro…
TCRϒσ
-Aka intraepithelial lymphocytes... -receptors that are express…
Helper T cell
-aka TH and CD4+... -help B cells produce antibodies to protein…
8 terms
Helper T-Cells
Th1
Th2
Th1
Th2
Secretes IFN-Gamma
Secretes IL-4, 5, 10, 13
Activates macrophages and cytotoxic T cells
Recruits eosinophils for defense and promotes IgE
Th1
Secretes IFN-Gamma
Th2
Secretes IL-4, 5, 10, 13
10 terms
T Helper Cell Cytokines
IL-12, IFN-gamma
IL-12, IFN-gamma
IL-6, IL-21
IL-6, IL-17
Induces Th1
Released by Th1
Induces Th17
Released by Th17
IL-12, IFN-gamma
Induces Th1
IL-12, IFN-gamma
Released by Th1
5 terms
Helper T cells
TH1
TH2
TH17
Tfh
induces a cytolytic immune response... IL-2 (activates T cells)…
induce a humoral response... IL-4, IL-5, IL-13 (activate B cells)
induce inflammatory response... IL-17 (activates neutrophils)
migrate to B cell follicles... activate B cells
TH1
induces a cytolytic immune response... IL-2 (activates T cells)…
TH2
induce a humoral response... IL-4, IL-5, IL-13 (activate B cells)
8 terms
T Helper Cell Functions
Th1
Th2
Th3
Th17
- anti-viral/microbial immunity... - cell-mediated immunity... - in…
- immunity to extracellular parasites... - allergens
- immunity to helminths... - inflammation
- immunity to infections at mucocutaneous sites... - inflammation
Th1
- anti-viral/microbial immunity... - cell-mediated immunity... - in…
Th2
- immunity to extracellular parasites... - allergens
15 terms
Helper T-Cells and Cytokines
cytokines
types of cytokines
Th0
Th1
produced by t-cells ... regulate immune system
interferons... interleukins ... tumour necrosis factor ... CSF ... chemok…
naive t-cell from thymus ... promoted by IL12/ IL 4
cytokine production ... IFN gamma - activates macrophages ... promo…
cytokines
produced by t-cells ... regulate immune system
types of cytokines
interferons... interleukins ... tumour necrosis factor ... CSF ... chemok…
27 terms
T helper cell responses
Where do plasmacytoid Dendritic cells…
Cell surface markers for Plasmacytoid…
What cytokines do plasmacytoid dendrit…
Do follicular dendritic cells process…
Spleen, lymph nodes and blood, react to antigens in the blood…
CD 4 and MHCII
Interferon alpha/beta and IL-12... Many other inflammatory cytok…
NO
Where do plasmacytoid Dendritic cells…
Spleen, lymph nodes and blood, react to antigens in the blood…
Cell surface markers for Plasmacytoid…
CD 4 and MHCII
10 terms
Helper T cells
TH1
activation of macrophages by TH1
TH2 cells
cytokine interaction of macrophages an…
Produce:... -IFN gamma which stimulates B cells to produce antib…
-T cell, when activated, will express CD40L, stimulating macr…
IL4 and 5 are key cytokines made by TH2.... -IL5 activates eosin…
APC with ingested microbes produce IL12 which activate Naive…
TH1
Produce:... -IFN gamma which stimulates B cells to produce antib…
activation of macrophages by TH1
-T cell, when activated, will express CD40L, stimulating macr…
30 terms
T Helper Cell Subsets
What is the function of Th1?
Cytokine environment with IFN-g + IL-1…
Transcription factor Tbet?
Th1 Transcription factor?
Macrophages activation + Cell mediated CTL
Th1
Th1
Tbet
What is the function of Th1?
Macrophages activation + Cell mediated CTL
Cytokine environment with IFN-g + IL-1…
Th1
17 terms
T Helper Cells
Th cells express
What does CD4 do
What does the Th do?
After it recognizes MHC 2 and peptide…
CD4
Co receptor for MHC 2 proteins found on antigen presenting ce…
Recognizes MHC 2 and peptide
The activated Th release lymphokines
Th cells express
CD4
What does CD4 do
Co receptor for MHC 2 proteins found on antigen presenting ce…
8 terms
Helper T-cells
Helper T-cells
What proteins do Helper T-cells have o…
What do CD4 proteins recognize?
What completes the activation of the H…
CD4 protein, MHC-2
CD4
MHC-2
The release of IL-1
Helper T-cells
CD4 protein, MHC-2
What proteins do Helper T-cells have o…
CD4
18 terms
T helper cell subpopulations
what cytokines induce differentiation…
what cytokines induce differentiation…
what cytokines induce differentiation…
what cytokines induce differentiation…
IL-12... INF-GAMMA
IL-6... IL-21
IL-4
IL-16... TGF-BETA... IL-23
what cytokines induce differentiation…
IL-12... INF-GAMMA
what cytokines induce differentiation…
IL-6... IL-21
28 terms
Helper T Cells
what is the main goal of Thelper cells?
which cytokines are produced by Th1 ce…
which cytokines are produced by Th2 ce…
what is the function of Th1 cells?
to direct immune reactions by both the innate and adaptive im…
IFNg
IL-4, 5, 6, and 13
to defend against intracellular pathogens via cell-mediated i…
what is the main goal of Thelper cells?
to direct immune reactions by both the innate and adaptive im…
which cytokines are produced by Th1 ce…
IFNg
12 terms
Cytokines T Helper cells (review)
IL-2
IL-2
IL-4
IL-4
proliferation of T cells
Produced by Th1 and Th2
Proliferation of Bcells... Th0--> Th2
Produced by Th2
IL-2
proliferation of T cells
IL-2
Produced by Th1 and Th2
10 terms
Immunoglobulins and T Helper cell types
IgM
IgD
IgA
IgG
first Ig, pentamer, fixes complement, primarily in blood.
monomeric or dimeric, primarily neutralization, blood and tis…
monomer, fixes complement, neutralization, dominant Ig in blo…
IgM
first Ig, pentamer, fixes complement, primarily in blood.
IgD
18 terms
helper t cells and b cells
drives differentiation of Th1
drives differentiation of Th2
drives differentiation of Th17
effector function of Th1
IL-12(or IFN gamma)
IL-4
IL-6, TGFbeta, and IL-23
prodcue the cytolkines (interferon gamma and tumor necrosisis…
drives differentiation of Th1
IL-12(or IFN gamma)
drives differentiation of Th2
IL-4
63 terms
^_^ Immunity 13 -_- T Helper Cells
(quiz) stray cat; enlarged & ulcerated…
(quiz) What do you expect the result o…
(quiz) These same individuals might al…
Specific antibody of which of the foll…
c. protozoa
B. Lower ratio of IFN gamma/IL4
B. Mycobacteria tuberculosis
IgE
(quiz) stray cat; enlarged & ulcerated…
c. protozoa
(quiz) What do you expect the result o…
B. Lower ratio of IFN gamma/IL4
19 terms
micro: interleukin/T helper cells
IL-1
IL-2
IL-3
IL-4
Induces T helper cell synthesis of IL-2; activates T cells; i…
Stimulates antibody synthesis, T cytotoxic cells, and natural…
Stimulates hematopoiesis
Induces isotype switching
IL-1
Induces T helper cell synthesis of IL-2; activates T cells; i…
IL-2
Stimulates antibody synthesis, T cytotoxic cells, and natural…
8 terms
HIV Infection of T-Helper Cells
1. Attachment
2. Penetration
3. Uncoating
4a. vDNA synthesis and integration
Envelope protein binds CD4 receptor and viral envelope fuses…
Viral capsid (containing 2 vRNA, 2 reverse transcriptase and…
Capsid breaks apart allowing vRNA and enzymes access to cytop…
Reverse transcriptase makes dsDNA from vRNA; Integrase insert…
1. Attachment
Envelope protein binds CD4 receptor and viral envelope fuses…
2. Penetration
Viral capsid (containing 2 vRNA, 2 reverse transcriptase and…
16 terms
Differentiation of T Helper Cell Subsets
Th0
Microbes that Stimulate a Strong initi…
Default Loop Production of IL-4 and pr…
All Th Cells have
Mature, Naive Th Cells... - Can make any of the cytokines... - Stim…
Produce TH1 Cells (Cell mediated immunity)
TH2 Cells
CD3+ and CD4+
Th0
Mature, Naive Th Cells... - Can make any of the cytokines... - Stim…
Microbes that Stimulate a Strong initi…
Produce TH1 Cells (Cell mediated immunity)
T lymphocytes & T helper cell activation
DiGeorge's Syndrome:
Thymus size:
T cell antigen receptor (TCR):
Activation of naive T helper cells >:
Children born w/o a thymus, do not have mature T cells
Thymus decreases in size at post-puberty ("thymic involution"…
Antigen specificity, acquired in thymus... disulfide-linked hete…
Th0 cells, which will progress into one of the following phen…
DiGeorge's Syndrome:
Children born w/o a thymus, do not have mature T cells
Thymus size:
Thymus decreases in size at post-puberty ("thymic involution"…
63 terms
^_^ Immunity 13 -_- T Helper Cells
(quiz) stray cat; enlarged & ulcerated…
(quiz) What do you expect the result o…
(quiz) These same individuals might al…
Specific antibody of which of the foll…
c. protozoa
B. Lower ratio of IFN gamma/IL4
B. Mycobacteria tuberculosis
IgE
(quiz) stray cat; enlarged & ulcerated…
c. protozoa
(quiz) What do you expect the result o…
B. Lower ratio of IFN gamma/IL4
16 terms
Immuno Chapter 8 - T Helper Cells
Th1 driven by
Th2 driven by
Th17 driven by
Tfh driven by
IL12, IFNy (positive feedback)
IL4 (positive feedback)
IL6, IL21 (positive feedback)
IL16, TGFbeta, IL23
Th1 driven by
IL12, IFNy (positive feedback)
Th2 driven by
IL4 (positive feedback)
40 terms
Video Najeeb T helper and B cells, Complement
Who does a macrophage present its anti…
What is clonal selection?
What is IL-1?
What is B7 and CD28?
To lymphocyte which has TCR receptor (to antigen) as well as…
When a macrophage presents its antigen to many lymphocytes bu…
When macrophage successfully presents antigen to T helper 2-c…
Second signal... When a macrophage successfully presents antigen…
Who does a macrophage present its anti…
To lymphocyte which has TCR receptor (to antigen) as well as…
What is clonal selection?
When a macrophage presents its antigen to many lymphocytes bu…
Exam 3: T Helper Cell Responses
The cell responsible for producing mem…
The cell responsible for production of…
The cell responsible for production of…
What is a common feature of T cell res…
T helper cells
Cytolytic T cells
B cells
They must interact with other cells to perform their functions
The cell responsible for producing mem…
T helper cells
The cell responsible for production of…
Cytolytic T cells
5 terms
Cancer/HIV/AIDS/Helper-T Cells
Characteristics of cancer cells
Origin of cancer
Regulation of cell division
Helper-T Cells
-Genetic disorder: Mutations cause cells to develop into a tu…
Mutations in four classes of genes are associated with cancer…
-Proto-oncogenes are part of a stimulatory pathway in the cel…
-Antigen-presenting cells present an antigen which the helper…
Characteristics of cancer cells
-Genetic disorder: Mutations cause cells to develop into a tu…
Origin of cancer
Mutations in four classes of genes are associated with cancer…
1 of 10