Study sets matching "helper t cells"

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Study sets matching "helper t cells"

T Helper Cell Classification
TH1
TH2
TH9
TH17
activate macrophages
activate B cells... help product antibodies
clear parasitic worms
on mucous/skin layer border
TH1
activate macrophages
TH2
activate B cells... help product antibodies
Helper T Cell Pathway
A stem cell destined to be a Helper T…
Matures into what type of naïve cell?
APC (Macrophage, Dendritic cell, B Cel…
Where does the APC display the antigen…
Thymosin
T-Helper Cell
Endocytosis
The major histocompatibility complex
A stem cell destined to be a Helper T…
Thymosin
Matures into what type of naïve cell?
T-Helper Cell
Helper T Cells
what is the main goal of Thelper cells?
which cytokines are produced by Th1 ce…
which cytokines are produced by Th2 ce…
what is the function of Th1 cells?
to direct immune reactions by both the innate and adaptive im…
IFNg
IL-4, 5, 6, and 13
to defend against intracellular pathogens via cell-mediated i…
what is the main goal of Thelper cells?
to direct immune reactions by both the innate and adaptive im…
which cytokines are produced by Th1 ce…
IFNg
25 terms
2. Helper T cell
60-80% of T cell=helper cell
secrete proteins assist system
B cell growth factor
interleukin for T cell growth
helper T cell
helper T cell
helper T cell
helper T cell
60-80% of T cell=helper cell
helper T cell
secrete proteins assist system
helper T cell
5 terms
Activated T helper cells
Th1
Th2
Th17
Tfh
cytolytic response, IL-2, macrophage IFN-gamma; effective aga…
humoral response, IL-4,5,13; effective against helminths
inflammatory response, IL-17 neutrophils; effective against e…
migrates to follicle; responsible for B cell activation
Th1
cytolytic response, IL-2, macrophage IFN-gamma; effective aga…
Th2
humoral response, IL-4,5,13; effective against helminths
T helper cells
Th1
Th2
Th9
Th17
anti-viral/microbial immunity, cell-mediated immunity, inflam…
immunity to extracell parasites, allergens
immunity to helminths, inflammation
immunity to infections at mucocutaneous sites, inflammation
Th1
anti-viral/microbial immunity, cell-mediated immunity, inflam…
Th2
immunity to extracell parasites, allergens
Helper T cells RAMS
Recognition
Activation
Mitosis
Specialization 2 fates
TCR of Helper T binds to matching antigen
CD4 protein associated with TCR binds to MHCII
many rounds of mitotic divisions to produce a population of i…
Majority become active helper T cells which circulate and rel…
Recognition
TCR of Helper T binds to matching antigen
Activation
CD4 protein associated with TCR binds to MHCII
12 terms
T-helper cell differentiation
Polarizing cytokines IL-2, TGF-beta
Master transcriptional regulator FOXP3…
IL-10, TGF-beta effector cytokines
Polarizing cytokines IL-1, IL-6, IL-23…
Turns on Master transcriptional regulator FOXP3 on T reg cell
Produces IL-10, TGF-beta effector cytokines
Results in regulation, suppression immune and inflammatory re…
Turns on master transcriptional regulator ROR-gamma-t on Th17…
Polarizing cytokines IL-2, TGF-beta
Turns on Master transcriptional regulator FOXP3 on T reg cell
Master transcriptional regulator FOXP3…
Produces IL-10, TGF-beta effector cytokines
5 terms
T helper cells
Th1
Th17
Th2
Tfh
Activates macrophages... IFN-gamma... GM-CSF... TNF-alpha... IL-2
enhances neutrophil response... IL-17/21/22/26
activate cellular and antibody response to parasites... IL-4/5/1…
activates B cells and maturation of antibody response ... IL-21/…
Th1
Activates macrophages... IFN-gamma... GM-CSF... TNF-alpha... IL-2
Th17
enhances neutrophil response... IL-17/21/22/26
T Helper Cells Cytokines
TH1
TH17
TH2
TFH
iL-12 & ifn-gamma
Il-17 & il-6
Il-4, 5, 6, 10, 13
Il-21
TH1
iL-12 & ifn-gamma
TH17
Il-17 & il-6
T helper cells func
Cell mediated immune responses
Ab response, humoral immunity and chro…
Mucus production, pathogenesis of asthma
Pro inflamm cytokines assoc with autoi…
TH1 (T helper 1)
TH2
TH9
TH17
Cell mediated immune responses
TH1 (T helper 1)
Ab response, humoral immunity and chro…
TH2
T-helper cells
Th1
Th2
Th9
Th17
antiviral/microbial and cell mediated immunity, inflammation
immunity to parasites, allergens
immunity to helminths, inflammation
immunity to infections at mucocutaneous sites, inflammation
Th1
antiviral/microbial and cell mediated immunity, inflammation
Th2
immunity to parasites, allergens
5 terms
T helper cells
TH1
TH2
TH17
TFH
induces cytolytic immune response... activate T cytotoxic cells:…
induce humoral response... activate B cells by producing antibod…
induce an immune inflammatory response: IL-17 (neutrophils)... e…
T follicular helper cells that migrate to B cell follicle tha…
TH1
induces cytolytic immune response... activate T cytotoxic cells:…
TH2
induce humoral response... activate B cells by producing antibod…
T helper cells
TH1
TH2
TH17
iTreg
made by IL-12 and IFN-y
made by IL-4
IL-6 and IL-21
TGF-b
TH1
made by IL-12 and IFN-y
TH2
made by IL-4
46 terms
Cytokines & Helper T cells
IL-1 is secreted by:
IL-1 is AKA:
IL-1 causes (2)
IL-1:
macs
osteoclast-activating fx
fever & inflammation
Secreted by macs... AKA osteoclast-activating fx. ... Cz's fever &…
IL-1 is secreted by:
macs
IL-1 is AKA:
osteoclast-activating fx
T Helper Cell
TH1
TH17
TH2
TFH
IL-12 & IFN-gamma
IL-6 & IL-21
IL-4
IL-16 & IL-23 & TGF-beta
TH1
IL-12 & IFN-gamma
TH17
IL-6 & IL-21
Helper T cell pathway
Helper T Cell is *produced in red bone…
Then matures into a naive T helper cell
Antigen-Presenting Cell has *macrophag…
After the pathogen is taken in, Antige…
In the Thymus by Thymosin
...
Takes in the pathogen by endocytosis
...
Helper T Cell is *produced in red bone…
In the Thymus by Thymosin
Then matures into a naive T helper cell
...
Helper T cells
TH1 differentiation
TH1 secretion
TH1 function and pathogen
IFNy
IL12, IFNy
IFNy, IL2, TNFa
Activate macrophages and Tc cells. Intracellular bacteria
Augments phagocyte killing and antigen presentation. Promotes…
TH1 differentiation
IL12, IFNy
TH1 secretion
IFNy, IL2, TNFa
Helper T- Cells
Secretes IFN-gamma
Secretes IL-4, IL-5, IL-10, and IL-13
Activates Macrophages and cytotoxic T…
Recruits eosinophils for parasite defe…
Th1
Th2
Th1
Th2
Secretes IFN-gamma
Th1
Secretes IL-4, IL-5, IL-10, and IL-13
Th2
5 terms
T helper cells
Th0
CD8+ T cell
Th1
Th17
undifferentiated CD4+ T cell
Cytotoxic
Cell mediated activation: macrophage, Tc ... Inducing cytokines…
Enhance neutrophil response... Induced: IL-6, IL-21... Produce: I…
Th0
undifferentiated CD4+ T cell
CD8+ T cell
Cytotoxic
12 terms
Helper T cells
Th1 cells secrete
Th1 cells activate
Th1 cells are activated by
Th1 cells are inhibited by
IFN-gamma
macrophages and cytotoxic T cells
INF-gamma and IL-12
IL-4 and IL-10 (from Th2 cells)
Th1 cells secrete
IFN-gamma
Th1 cells activate
macrophages and cytotoxic T cells
10 terms
T Helper Cell Cytokines
IL-2
IFN-gamma
TNF-alpha
IL-4
source: Th1 and naive TH ... activity: ... 1. T cell proliferation…
source: TH1, CD8 cells, and NK cells ... 1. increase macrophage…
source: macrophages and TH1 ... 1. activates endothelium ... 2. in…
source: TH2 ... 1. B cell proliferation and differentiation +++…
IL-2
source: Th1 and naive TH ... activity: ... 1. T cell proliferation…
IFN-gamma
source: TH1, CD8 cells, and NK cells ... 1. increase macrophage…
15 terms
T helper cell subsets
TGF-beta induces
Tregs express
Tregs produce
IL-12 induces
iTregs
FoxP3
IL-10, TGF-beta
Th1
TGF-beta induces
iTregs
Tregs express
FoxP3
T Helper Cell Responses
Th1
Th1 cytokines and responses
Th2
Th2 cytokines
1st, early, local, cellular and antibody (triggered by IL12)
IFNgamma, IL2, LT-alpha (TNFb); DTH, anti-viral; anti-tumor,…
2nd, later, systemic, antibody, allergies (triggered by IL4)
IL4, IL5, IL10, IL13; B cells (IgG, IgE, IgA), Mast cells, M2…
Th1
1st, early, local, cellular and antibody (triggered by IL12)
Th1 cytokines and responses
IFNgamma, IL2, LT-alpha (TNFb); DTH, anti-viral; anti-tumor,…
110 terms
Helper T cell responses
Describe Th1
Th1 is triggered by what cytokine
Cytokines of Th1
Function of Th1 cytokines
1. 1st... 2. early... 3. local... 4. cellular and antibody
IL12
1. IFNgamma... 2. IL2... 3. LT-alpha (TNFb)
1. DTH... 2. anti-viral... 3. anti-tumor... 4. inflammation... 5. B cells…
Describe Th1
1. 1st... 2. early... 3. local... 4. cellular and antibody
Th1 is triggered by what cytokine
IL12
17 terms
Helper T cells
TCRϒσ
Helper T cell
Cytotoxic T cell
Activation of Naive Helper T-cells
-Aka intraepithelial lymphocytes... -receptors that are express…
-aka TH and CD4+... -help B cells produce antibodies to protein…
aka Tc, CD8+... -causes lysis of antigen-bearing target cells
respond only to processed antigen when it is presented by pro…
TCRϒσ
-Aka intraepithelial lymphocytes... -receptors that are express…
Helper T cell
-aka TH and CD4+... -help B cells produce antibodies to protein…
5 terms
Helper T Cell Subsets
Th1
Th2
Th17
Naive T cell receptors
source: macrophages... defining cytokines: IFN-gamma... host defens…
source: eosinophils and mast cells... defining cytokines: IL-4,…
source: neutrophils... defining cytokines: IL-17, IL-22... host def…
CCR7 (binds to CCL19/21)is their chemokine receptor ... L-select…
Th1
source: macrophages... defining cytokines: IFN-gamma... host defens…
Th2
source: eosinophils and mast cells... defining cytokines: IL-4,…
T helper cells
Th1
Th2
Th17
Tfh
induced by IL-12 and IFNy, makes IL-2 and IFNy, IFNa - helps…
Induced by IL-4, Makes IL-4, IL-5, IL-13, Mucus/mucosal immun…
Induced by IL-6, TGF-B, IL-23 - Makes IL-17, IL-22 - Activate…
Induced by IL-6, makes IL-21 - class switching
Th1
induced by IL-12 and IFNy, makes IL-2 and IFNy, IFNa - helps…
Th2
Induced by IL-4, Makes IL-4, IL-5, IL-13, Mucus/mucosal immun…
T Helper Cell Functions
Th1
Th2
Th3
Th17
- anti-viral/microbial immunity... - cell-mediated immunity... - in…
- immunity to extracellular parasites... - allergens
- immunity to helminths... - inflammation
- immunity to infections at mucocutaneous sites... - inflammation
Th1
- anti-viral/microbial immunity... - cell-mediated immunity... - in…
Th2
- immunity to extracellular parasites... - allergens
17 terms
T Helper Cells
Th cells express
What does CD4 do
What does the Th do?
After it recognizes MHC 2 and peptide…
CD4
Co receptor for MHC 2 proteins found on antigen presenting ce…
Recognizes MHC 2 and peptide
The activated Th release lymphokines
Th cells express
CD4
What does CD4 do
Co receptor for MHC 2 proteins found on antigen presenting ce…
17 terms
Helper T cells
TCRϒσ
Helper T cell
Cytotoxic T cell
Activation of Naive Helper T-cells
-Aka intraepithelial lymphocytes... -receptors that are express…
-aka TH and CD4+... -help B cells produce antibodies to protein…
aka Tc, CD8+... -causes lysis of antigen-bearing target cells
respond only to processed antigen when it is presented by pro…
TCRϒσ
-Aka intraepithelial lymphocytes... -receptors that are express…
Helper T cell
-aka TH and CD4+... -help B cells produce antibodies to protein…
Helper T-Cells
Th1
Th2
Th1
Th2
Secretes IFN-Gamma
Secretes IL-4, 5, 10, 13
Activates macrophages and cytotoxic T cells
Recruits eosinophils for defense and promotes IgE
Th1
Secretes IFN-Gamma
Th2
Secretes IL-4, 5, 10, 13
10 terms
T Helper Cell Cytokines
IL-12, IFN-gamma
IL-12, IFN-gamma
IL-6, IL-21
IL-6, IL-17
Induces Th1
Released by Th1
Induces Th17
Released by Th17
IL-12, IFN-gamma
Induces Th1
IL-12, IFN-gamma
Released by Th1
T helper Cells
types
Dendritic cells
activation
TH17
Naive = quiescent... 0-generic help... 1-early local, cell mediated…
Directors... Plasmacytoid DC's primary role is to make Cytokines…
needs 3 interactions... MHC X TCR& CD4... B7-1,2 X CD28 & CTLA-4
earlier responder, induced by IL1,23 & TGF-bt... makes IL17 to g…
types
Naive = quiescent... 0-generic help... 1-early local, cell mediated…
Dendritic cells
Directors... Plasmacytoid DC's primary role is to make Cytokines…
21 terms
T Helper cell responses
Describe Th1 response... - when... - trigger…
Describe Th2 response... - when... - trigger…
Th17... - triggered by ... - cytokines
Treg... - function... - cytokines
- 1st, early, local, cellular ... - triggered by IL12... - cytokine…
- 2nd, later, systemic, antibody, allergies... - triggered by IL…
- TGF-beta + IL1 or IL23 for memory cells... -cytokines: 1L17
immunosuppresion/tolerance... - cytokines: TGF-beta, IL10
Describe Th1 response... - when... - trigger…
- 1st, early, local, cellular ... - triggered by IL12... - cytokine…
Describe Th2 response... - when... - trigger…
- 2nd, later, systemic, antibody, allergies... - triggered by IL…
T-Helper Cells
T-helper cells
Naturally active immunity
Artificially active immunity
Naturally passive immunity
released by an antigen and help the immune response (B/T cell…
exposed to chicken pox and get sick, develop antibodies for c…
injected dead toxin for immune system to recognize and create…
receive antibodies through mother, birth
T-helper cells
released by an antigen and help the immune response (B/T cell…
Naturally active immunity
exposed to chicken pox and get sick, develop antibodies for c…
Helper T Cells
Secretes IFN-Y
Secretes Il4,5,6,13
Activates macrophages and cytotoxic ly…
Inhibited by Il4 and Il10 (From Th2 ce…
Th1 Cells
Th2 Cells
Th1 Cells
Th1
Secretes IFN-Y
Th1 Cells
Secretes Il4,5,6,13
Th2 Cells
T-Helper Cells Subtypes
Th1
Th2
Th17
Treg
macrophage and CD8+ T cell activation, important for intracel…
activation of basophils, eosinophils, mast cells and mucous s…
inflammatory response, inhibit Treg in mass amounts
regulation, immuno-suppresion & self tolerance
Th1
macrophage and CD8+ T cell activation, important for intracel…
Th2
activation of basophils, eosinophils, mast cells and mucous s…
Helper T cells
TH1
TH2
TH17
Tfh
induces a cytolytic immune response... IL-2 (activates T cells)…
induce a humoral response... IL-4, IL-5, IL-13 (activate B cells)
induce inflammatory response... IL-17 (activates neutrophils)
migrate to B cell follicles... activate B cells
TH1
induces a cytolytic immune response... IL-2 (activates T cells)…
TH2
induce a humoral response... IL-4, IL-5, IL-13 (activate B cells)
10 terms
Helper T cells
TH1
activation of macrophages by TH1
TH2 cells
cytokine interaction of macrophages an…
Produce:... -IFN gamma which stimulates B cells to produce antib…
-T cell, when activated, will express CD40L, stimulating macr…
IL4 and 5 are key cytokines made by TH2.... -IL5 activates eosin…
APC with ingested microbes produce IL12 which activate Naive…
TH1
Produce:... -IFN gamma which stimulates B cells to produce antib…
activation of macrophages by TH1
-T cell, when activated, will express CD40L, stimulating macr…
T helper cells
Cd8 cytotoxicity t cells
TH1 helper cells
TH2 helper cells
TH17 helper cells
kill virus effected cells
provide help for b cells for antibody production... activate inf…
provide help for b cells for antibody production... (IGE for all…
enhance neutrophil response... promote barrier(fungi)
Cd8 cytotoxicity t cells
kill virus effected cells
TH1 helper cells
provide help for b cells for antibody production... activate inf…
Helper T-cells
Helper T-cells
What proteins do Helper T-cells have o…
What do CD4 proteins recognize?
What completes the activation of the H…
CD4 protein, MHC-2
CD4
MHC-2
The release of IL-1
Helper T-cells
CD4 protein, MHC-2
What proteins do Helper T-cells have o…
CD4
T helper cell responses
Where do plasmacytoid Dendritic cells…
Cell surface markers for Plasmacytoid…
What cytokines do plasmacytoid dendrit…
Do follicular dendritic cells process…
Spleen, lymph nodes and blood, react to antigens in the blood…
CD 4 and MHCII
Interferon alpha/beta and IL-12... Many other inflammatory cytok…
NO
Where do plasmacytoid Dendritic cells…
Spleen, lymph nodes and blood, react to antigens in the blood…
Cell surface markers for Plasmacytoid…
CD 4 and MHCII
8 terms
T Helper Cells
What are the central roles of T Helper…
Which T Helper cells activate macropha…
Which receptor complexes must form for…
Which cytokine do Th1 cells initially…
Activate macrophages and cytotoxic T cells
Th1 cells
TCR (CD4) and MHC 2 + Peptide... CD40L and CD40
Interferon gamma
What are the central roles of T Helper…
Activate macrophages and cytotoxic T cells
Which T Helper cells activate macropha…
Th1 cells
18 terms
T helper cell subpopulations
what cytokines induce differentiation…
what cytokines induce differentiation…
what cytokines induce differentiation…
what cytokines induce differentiation…
IL-12... INF-GAMMA
IL-6... IL-21
IL-4
IL-16... TGF-BETA... IL-23
what cytokines induce differentiation…
IL-12... INF-GAMMA
what cytokines induce differentiation…
IL-6... IL-21
9 terms
Helper T cells
Th1 cells activate macrophages and cyt…
Which cytokines work to activate Th1 c…
A pt with a viral infection recovers a…
Th2 cells activate eosinophils and B c…
IFN-γ
IFN-γ and IL-12
Cytotoxic T cells (Th1 also activated macrophages)
IL-4, IL-5, IL-10, and IL-13
Th1 cells activate macrophages and cyt…
IFN-γ
Which cytokines work to activate Th1 c…
IFN-γ and IL-12
T helper Cells
T helper 1
T helper 2
T helper 17
T reg
APC says cytolytic response is needed... IL-2 (miracle grow for…
APC says humoral response is needed (IL4, IL5, IL13)... Helmith…
Inflammatory response (IL17)... Production of more PNMS... Inflamm…
Stop the immune response from continuing (IL 10 and TGF - beta)
T helper 1
APC says cytolytic response is needed... IL-2 (miracle grow for…
T helper 2
APC says humoral response is needed (IL4, IL5, IL13)... Helmith…
8 terms
T Helper cells
TH0
TH1
TH2
TH9
undifferentiated T cells
help activate macrophages
help B cells produce antibodies
stimulates hematopoiesis and inhibits apoptosis
TH0
undifferentiated T cells
TH1
help activate macrophages
6 terms
T-Helper (Th) Cells: Th1
What are Th1 cells activated by?
What do Th1 cells produce? What happens?
What do activated macrophages do?
What is Th1 involved in?
MHC II antigens presented on macrophages
Cytokines that stimulate macrophages to take up and kill cert…
Kill intracellular bacteria that would normally multiply
Cell mediated immunity
What are Th1 cells activated by?
MHC II antigens presented on macrophages
What do Th1 cells produce? What happens?
Cytokines that stimulate macrophages to take up and kill cert…
T helper cells
IFN - y
TNF a
TNF B
IL 2
Macrophage activity... Increased expression of class 1+2... MHC exp…
Macrophage activation... Activation of endothelium
Macrophage activation... Neutrophil activation... Kills tumour cells
T cell growth... CTL growth and activation
IFN - y
Macrophage activity... Increased expression of class 1+2... MHC exp…
TNF a
Macrophage activation... Activation of endothelium
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