Study sets matching "hematology 3"

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Study sets matching "hematology 3"

32 terms
Hematology #3
Histogram... a. R1... b. R2... c. R3... d. R4... 1.…
The basis for the Coulter principle of…
The method for determining Hemoglobin…
A complete blood count (CBC) report on…
1. d... 2. c... 3. a... 4. b
impedance of electrical current by the cells
cyanmethemoglobin method measured colorimetrically
possible presence of nRBCs or giant platelets
Histogram... a. R1... b. R2... c. R3... d. R4... 1.…
1. d... 2. c... 3. a... 4. b
The basis for the Coulter principle of…
impedance of electrical current by the cells
71 terms
Hematology 3
Diameter of rbc
Thickness of rbc
Rbc large surface area for
Where are they made?
7-8 microm
2.0-2.2 micro m
Gas exchange
Red bone marrow... 200 billion per day
Diameter of rbc
7-8 microm
Thickness of rbc
2.0-2.2 micro m
3 Hematology
Anemia
Hemorrhage
Lymphadenopathy
Lymphangitis
General term for a variety of disorders in which the body doe…
Heavy bleeding
Abnormally enlarged lymph nodes
Infection and inflammation of the lymph vessels
Anemia
General term for a variety of disorders in which the body doe…
Hemorrhage
Heavy bleeding
54 terms
Hematology 3
In intravascular hemolysis, what do th…
What prevents hemoglobin from passing…
When alpha and beta dimers have nothin…
If plasma hemoglobin is not bound to h…
haptoglobin
the liver removes the haptoglobin-hemoglobin complex
hemosiderin; renal tubular cells
converted to methemoglobin
In intravascular hemolysis, what do th…
haptoglobin
What prevents hemoglobin from passing…
the liver removes the haptoglobin-hemoglobin complex
Hematology 3
What are the causes of lymphadenopathy?
Describe the characteristics of follic…
What are plasma cell dyscrasias (PCDs)?
Describe the pathogenesis of multiple…
Reactive (benign) - most common to immune stimulus... Lymphoma (…
(T and ) B cell proliferation due to increased need for antib…
Monoclonal proliferation of immuoglobin-producing plasma cell…
Plasma cell over time in a step-wise fashion develop increasi…
What are the causes of lymphadenopathy?
Reactive (benign) - most common to immune stimulus... Lymphoma (…
Describe the characteristics of follic…
(T and ) B cell proliferation due to increased need for antib…
Hematology 3
What are the 3 inhibitors of coagulati…
How does antithrombin inhibit coagulat…
How does protein C inhibit coagulation?
Low-Molecular Weight Heparin (LMWH)
Blood flow alone... Antithrombin... Protein C
Inhibits thrombin and 12, 11, 10 and 9 (antithrombin III is t…
Along with cofactor protein S, inactivates factors 5 and 8... Re…
Outdated test to catalyze the neutralization of factor 10a
What are the 3 inhibitors of coagulati…
Blood flow alone... Antithrombin... Protein C
How does antithrombin inhibit coagulat…
Inhibits thrombin and 12, 11, 10 and 9 (antithrombin III is t…
3 - Hematology
pancytopenia
normal RBC range
normal Hgb range
<8 Hgb?... 8-10 Hgb?... >10 Hgb?
significant decrease in RBCs, WBCs, platelets
4.2-6.0 million/𝜇L
12-18 g/100mL
no exercise, basic ADLs ok... light exercise - walking... resistanc…
pancytopenia
significant decrease in RBCs, WBCs, platelets
normal RBC range
4.2-6.0 million/𝜇L
47 terms
Hematology Chapter 3
What is the purpose of filtration (in…
After age of 18, where is most of the…
Define anisocytosis
Define poikilocytosis
Remove old RBCs, those with inclusions and remove antibodies…
primarily in iliac crest and sternum
variation in size of a rbc
variation in shape of an rbc
What is the purpose of filtration (in…
Remove old RBCs, those with inclusions and remove antibodies…
After age of 18, where is most of the…
primarily in iliac crest and sternum
Hematology 3
kidney tests
Liver tests
Pancreas tests
Protein profile
BUN, CREA, PHOS, Ca
ALT, ALKP, GGT, ALB, TBIL, Bile acids
AMYL, LIPA
TP, ALB, GLOB
kidney tests
BUN, CREA, PHOS, Ca
Liver tests
ALT, ALKP, GGT, ALB, TBIL, Bile acids
52 terms
Hematology 3
Howell-Jolly Bodies
Basophilic Stippling
Pappenheimer Bodies
Heinz Bodies
Small, round bodies usually located eccentrically in the red…
Round or irregularly shaped granules of variable number and s…
Iron bodies usually found at the periphery of the cell; visib…
Composed of denatured or precipitated hemoglobin; not visible…
Howell-Jolly Bodies
Small, round bodies usually located eccentrically in the red…
Basophilic Stippling
Round or irregularly shaped granules of variable number and s…
Hematology 3
Lymph nodes - involved and swollen... Us…
Response to tissue hypoxia from anemia…
from disorders causing high blood cell…
causes similar to splenomegaly. Also s…
Lymphadenopathy:
EPO:
Splenomegaly
Hepatomegaly
Lymph nodes - involved and swollen... Us…
Lymphadenopathy:
Response to tissue hypoxia from anemia…
EPO:
Hematology 3
Decreased Hgb occurs with
Increased Hgb occurs with
Purpose of Diff Blood Test
Coulter
Anemia... Hyperthyroidism... Cirrhosis of liver... Severe hemorrhaging…
Polycythemia... COPD... CHF
Identify and count 5 types of WBC's in a sample... Can be done w…
Blood counter
Decreased Hgb occurs with
Anemia... Hyperthyroidism... Cirrhosis of liver... Severe hemorrhaging…
Increased Hgb occurs with
Polycythemia... COPD... CHF
33 terms
Hematology 3
Hemoglobin A1 Molecule
Normal Adult Hemoglobin Mixture
Hemoglobin Variants
Genes that code for Alpha and Beta cha…
each Hemoglobin can carry 4 oxygens, because 4 protein chains…
A1 (95-98%) - 2 alpha, 2 beta chains ... A2 (2-3%) - 2 alpha, 2…
occur when genetic mutations (sub & del) in the globin genes…
4 genes that code for alpha ... 2 genes that code for beta
Hemoglobin A1 Molecule
each Hemoglobin can carry 4 oxygens, because 4 protein chains…
Normal Adult Hemoglobin Mixture
A1 (95-98%) - 2 alpha, 2 beta chains ... A2 (2-3%) - 2 alpha, 2…
20 terms
Hematology 3
how do we diagnose ALL?
Auer rods are seen in...
Fragmented RBCs on peripheral smear ar…
Heinz bodies and bite cells are seen in
bone marrow biopsy... >20% of cells in bone marrow are lymphobla…
AML
microangiopathic Hemolytic anemia
G6PD def
how do we diagnose ALL?
bone marrow biopsy... >20% of cells in bone marrow are lymphobla…
Auer rods are seen in...
AML
101 terms
Hematology wk 3
PCV
Hb (in g/dl)
Retic count
Indices
What is the most simple and accurate test to perform for RBC…
1/3 of patients PCV
Test that determines bone marrow response to hypoxia/anemia?
What test helps to classify anemia?
PCV
What is the most simple and accurate test to perform for RBC…
Hb (in g/dl)
1/3 of patients PCV
Hematology 3
Which is usually higher, % polychromat…
What artifact can be mistaken for hypo…
Spherocytes have ____ MCV and _____ Hg…
In which species are spherocytes most…
% reticulocytes is higher, since not all reticulocytes ar pol…
Punched out RBCs; have robust color along the edges)
Normal; normal (appear smaller and darker d/t sphering)
Dogs; normally have prominent central pallor
Which is usually higher, % polychromat…
% reticulocytes is higher, since not all reticulocytes ar pol…
What artifact can be mistaken for hypo…
Punched out RBCs; have robust color along the edges)
12 terms
3) Hematology
1. _______ blood- red... 2. _______ blood…
1. ______ - the "mother cells" are the…
1. _______ - stimulate progenitor cell…
o 1. ____ & _____ phagocytize old RBCs…
1. Venous blood... 2. Arterial... 3. ½ ... 4. <1%... 5. 45%... 6. Plasma + F…
1. Pluripotent stem cells... 2. Progenitor cell... 3. Growth factor…
1. Hematopoietic growth factors... 2. Colony Stimulating Factor…
1. Liver & spleen... 2. Globulin ... 3. Iron... 4. Rest of molecule... 5.…
1. _______ blood- red... 2. _______ blood…
1. Venous blood... 2. Arterial... 3. ½ ... 4. <1%... 5. 45%... 6. Plasma + F…
1. ______ - the "mother cells" are the…
1. Pluripotent stem cells... 2. Progenitor cell... 3. Growth factor…
Hematology 3
What is hematopoiesis?
What is differentiation?
What is commitment?
What is maturation?
The process responsible for replacement of circulating blood…
The process responsible for generating the diverse cell popul…
Commitment is the term used to define the instance when to ce…
It encompasses the totality of phenomena that begins with com…
What is hematopoiesis?
The process responsible for replacement of circulating blood…
What is differentiation?
The process responsible for generating the diverse cell popul…
56 terms
Hematology 3
What does it mean when BM becomes "Fri…
What are the clinical features of MPN?
What is CML in MPN?
What are the clinical manifestations a…
Fibrosis refers to ↑ in fibroblasts and reticular fibers
Splenomegaly (60-100%)... Petechia/ecchymoses... Bruising, bleeding…
Has 3 phases: chronic followed by accelerated transition and/…
Fatigue... Low grade fever... Anorexia ... Weight loss ... Abdominal disc…
What does it mean when BM becomes "Fri…
Fibrosis refers to ↑ in fibroblasts and reticular fibers
What are the clinical features of MPN?
Splenomegaly (60-100%)... Petechia/ecchymoses... Bruising, bleeding…
Hematology 3
Type III Von Willebrand Disease
Type II Von Willebrand Disease
Type I Von Willebrand Disease
What is Von Willebrand Disease?
The protein is absent.
The protein is qualitatively abnormal.
The protein is quantitatively reduced
(Vascular Hemophilia) A heterogenous group of hereditary blee…
Type III Von Willebrand Disease
The protein is absent.
Type II Von Willebrand Disease
The protein is qualitatively abnormal.
18 terms
3 - hematology
what are the causes of macrocytic anemia
when can you give blood transfusion in…
what are the following levels in iron…
what is the most specific test for Iro…
1. b12 def ... 2. folic acid def ... 3. chronic alcohol use... 4. live…
til its about the 25% - 30% range. and you transfused packed…
platelets - elevated... RDW - Increased... Ferritin - Low... Reticuloc…
Bone marrow biopsy
what are the causes of macrocytic anemia
1. b12 def ... 2. folic acid def ... 3. chronic alcohol use... 4. live…
when can you give blood transfusion in…
til its about the 25% - 30% range. and you transfused packed…
38 terms
Hematology 3
What are the three types of transfusio…
Pt gets prominent urticaria after tran…
Pt gets fever, rigors and chills 1-6 h…
Pt gets fever, chills, burning at the…
1. Non-hemolytic febrile rxn... 2. Minor allergic rxn... 3. Hemolyt…
minor allergic rxn, antihistamines (if anaphylactic give epin…
Non-hemolytic febrile rxn, stop and give acetaminophen
Hemolytic transfusion rxn, stop and give IV fluids
What are the three types of transfusio…
1. Non-hemolytic febrile rxn... 2. Minor allergic rxn... 3. Hemolyt…
Pt gets prominent urticaria after tran…
minor allergic rxn, antihistamines (if anaphylactic give epin…
49 terms
Hematology 3
What are the functions of platelets? W…
What are the three steps to hemostasis?
What is involved in platelet activatio…
What is Von Willebrand factor?
Prevent injury to the vascular endothelium; prevent excessive…
Vascular spasm, platelet fibrin plug formation, coagulation
Collagen, lack of nitric oxide and prostacyclins, Von Willebr…
Factor that binds platelets together promoting aggregation an…
What are the functions of platelets? W…
Prevent injury to the vascular endothelium; prevent excessive…
What are the three steps to hemostasis?
Vascular spasm, platelet fibrin plug formation, coagulation
24 terms
Hematology 3
another name for platelets
how are thrombocytes made
what do thrombocytes do
what does hemostasis mean
thrombocytes
they are fragments broken off megakaryocytes found in bone ma…
they activate clotting cascade which... converts fibrinogen to f…
hemo = blood... stasis = stop... therefore it is the stopping of bl…
another name for platelets
thrombocytes
how are thrombocytes made
they are fragments broken off megakaryocytes found in bone ma…
50 terms
Clinical Lab #3 Hematology
CBC
WBC function
WBC normal value
what does increased WBC cause?
complete blood count- series of tests to evaluate blood compo…
protect body against infection
4.4- 11.3 x10^3 cells/mm3
leukocytosis
CBC
complete blood count- series of tests to evaluate blood compo…
WBC function
protect body against infection
14 terms
Hematology week 3
What is blood composed of?
What is the process of Erythropoieses?
What are the steps for the maturation…
What are the maturation steps of the e…
Plasma, White blood cells, platelets, and red blood cells.
Stem Cell... CFU - GEMM - BFU-E, - CFU-E
Erythropoietin (EPO)
Pronormoblast... Basophilic normoblast... Polychromatophilic norm…
What is blood composed of?
Plasma, White blood cells, platelets, and red blood cells.
What is the process of Erythropoieses?
Stem Cell... CFU - GEMM - BFU-E, - CFU-E
24 terms
Hematology 3
What diseases has increased Fe and inc…
What disease has decreased Fe and decr…
What are iron and ferritin levels in t…
What disease has decreased serum iron…
hereditary hemochromatosis, lead poisoning
iron deficiency anemia
both normal (serum iron may be slightly elevated)
anemia of chronic disease
What diseases has increased Fe and inc…
hereditary hemochromatosis, lead poisoning
What disease has decreased Fe and decr…
iron deficiency anemia
Hematology Unit 3
Neutrophils and monocytes are direct d…
Neutrophils contain 4 different types…
Some eosinophil granules contain a cor…
Basophils and mast cells have high aff…
GMP
Secretory
Major basic protein
E
Neutrophils and monocytes are direct d…
GMP
Neutrophils contain 4 different types…
Secretory
Hematology-3
what are the 2 types of RBC arrangement?
what does rouleaux look like?
who is rouleaux normal in?
when do you see rouleaux in cats and d…
rouleaux and agglutination
stacking linear arrangement like coins
horses
inflammatory disease
what are the 2 types of RBC arrangement?
rouleaux and agglutination
what does rouleaux look like?
stacking linear arrangement like coins
3.3 - Hematology
BAS-
EOS-
granul-
LY- LYS-
base, basic (Greek Base)
dawn; bright red or pink color (Greek Base)
little grain, particle (Latin Base)
dissolution, lysis (Greek Base X2)
BAS-
base, basic (Greek Base)
EOS-
dawn; bright red or pink color (Greek Base)
66 terms
1.3 - Automated Hematology Analyzers
beckman-coulter, sysmex
flag
critical value
coulter
Most hematology analyzers used in the lab are manufactured by…
A message generated by the instrument is called a(n):
A result that represents a life-threatening condition is term…
Automated analyzers use this principle to count erythrocytes:
beckman-coulter, sysmex
Most hematology analyzers used in the lab are manufactured by…
flag
A message generated by the instrument is called a(n):
Hematology G.O. #3
Immune system
antigen
antigen
systemic
constellation of responses to attacks from outside the body
any substance that elicits an immune response
specific, recognizes and acts against particular antigens
memory, not confined to initial invasion site, throughout bod…
Immune system
constellation of responses to attacks from outside the body
antigen
any substance that elicits an immune response
hematology GO #3 pictures
schistocytes
Anaplasma marginale
Babesia canis
haemobartonella felis
schistocytes
Anaplasma marginale
Medical Hematology: Test 3
Coulter principle of cell counting
The number of voltage pulses is propor…
the height of the voltage pulse if pro…
Histograms provide information about
based on the detection and measurement of changes in electric…
the number of cells
the cell's volume/ size
erythrocyte, leukocyte, and platelet frequency. Also, leukocy…
Coulter principle of cell counting
based on the detection and measurement of changes in electric…
The number of voltage pulses is propor…
the number of cells
112 terms
Hematology week 2-3
RBC development
3 effects of EPO
PPSC
Stages of RBC Maturation
Stimulus for RBC production=hypoxia.... -kidneys recognize then…
1. stimulus PPSC to differentiate into rubriblast.... 2. increas…
Pluripotential Stem Cell.... -in bone marrow.... -can become anythi…
PPSC-> Rubriblast-> Prorubricyte-> Rubricyte-> Metarubricyte-…
RBC development
Stimulus for RBC production=hypoxia.... -kidneys recognize then…
3 effects of EPO
1. stimulus PPSC to differentiate into rubriblast.... 2. increas…
29 terms
Hematology (PP3)
Accuracy
Precision
reliability
primary standards
nearness to the true value
how close together repeated results are
the ability to retain accuracy and precision over time
reference material of known, fixed composition from manufactu…
Accuracy
nearness to the true value
Precision
how close together repeated results are
14 terms
HEMATOLOGY PRACITCAL #3
whole blood is added to a diluent whic…
diluent of what?
sample to total volume
dilution factor:
lyses the mature red blood cells to remove them from view
1% ammonium oxalate
1:100... 0.020 mL + 1.98 mL = 2mL total volume
df= 1/x = 0.020 mL blood /2mL total volume= ... 0.020 x= 2 ... x= 1…
whole blood is added to a diluent whic…
lyses the mature red blood cells to remove them from view
diluent of what?
1% ammonium oxalate
Hematology Ch3
Antigen
Anaplasia
Atrophy
Dysplasia
a toxin or other foreign substance that induces an immune res…
highly pleomorphic and bizarre cytologic features associated…
decrease in number of size of cells that can lead to a decrea…
If cell division becomes poorly regulated, cells may lose som…
Antigen
a toxin or other foreign substance that induces an immune res…
Anaplasia
highly pleomorphic and bizarre cytologic features associated…
18 terms
Lab Hematology (3)
mean corpuscular volume (MCV)
hypochromic
red cell distribution width (RDW)
mean corpuscular hemoglobin (MCH)
size of cells ... = Hct/RBC... units: femtoliters... normal: 80-98 fL
decide by looking at smear... >1/3 central pallor
variance of RBC size... = (SD of RBC volume/mean RBC volume)100…
= Hgb/RBC (g/L)/10^12/L)... units: picograms/RBC... normal: 25-34
mean corpuscular volume (MCV)
size of cells ... = Hct/RBC... units: femtoliters... normal: 80-98 fL
hypochromic
decide by looking at smear... >1/3 central pallor
23 terms
Lab #3 Hematology 2
hemoglobinometer
female hematocrit percentage
male hematocrit percentage
heparinized capillary tube
directly measures the amount of hemoglobin in a sample in gra…
35-48%
39-54%
thin tube used for collecting blood samples
hemoglobinometer
directly measures the amount of hemoglobin in a sample in gra…
female hematocrit percentage
35-48%
27 terms
Ch.3 Hematology
Erythroblastic Island:
Culling
Hyperplasia:
Hypoplasia:
composite of erythroid cells in the bone marrow that surround…
filtering and destroying senescent/damaged red cells by the s…
increase in the number of cells per unit volume of tissue. Th…
condition of underdeveloped tissue or organ usually caused by…
Erythroblastic Island:
composite of erythroid cells in the bone marrow that surround…
Culling
filtering and destroying senescent/damaged red cells by the s…
125 terms
Hematology Unit 3 Exam
# of copies of each globin chain gene
A₁ chains
Hb S mutation
Hb C mutation
4 α, γ... 2 β, δ
αβ
Val subs Glu in the NH β chain terminus
Lys subs GLu in the NH terminal of β
# of copies of each globin chain gene
4 α, γ... 2 β, δ
A₁ chains
αβ
42 terms
1.1.3 Hematology (3)
pancytopenia suggests:... what is failin…
clinical manifestations of aplastic an…
fatigue... cardiopulmonary compromise... pro…
physical exam stuff for aplastic anemia
aplastic anemia... marrow failure... - injury to pluripotent stem…
fatigue... cardiopulmonary compromise... progressive cytopenias... rec…
aplastic anemia
pallor... petechiae (most common)... no hepatosplenomegaly... no lymph…
pancytopenia suggests:... what is failin…
aplastic anemia... marrow failure... - injury to pluripotent stem…
clinical manifestations of aplastic an…
fatigue... cardiopulmonary compromise... progressive cytopenias... rec…
WEEK3.HEMATOLOGY
Steps, hypoxia to normal.
CBC includes
CBC used to evaluate
CBC specimen
Hypoxia detected (low O2, low RBC), ... High EPO production... Stim…
Red blood cell count... WBC count... Hemoglobin... hematocrit... MVC, MCH…
anemia... leukemia... reaction to inflammation and infections... perip…
whole blood
Steps, hypoxia to normal.
Hypoxia detected (low O2, low RBC), ... High EPO production... Stim…
CBC includes
Red blood cell count... WBC count... Hemoglobin... hematocrit... MVC, MCH…
289 terms
Hematology part 3
cause of iron deficiency anemia
cause of megaloblastic anemia
explanation of iron deficiency anemia
explanation of megaloblastic anemia
iron deficiency
vit B12 or folic acid deficiency
cytoplasm lags behind nucleus in maturation due to inadequate…
nucleus lags behind cytoplasm in maturation. cells grow large…
cause of iron deficiency anemia
iron deficiency
cause of megaloblastic anemia
vit B12 or folic acid deficiency
78 terms
Hematology Mini 3
Primary hemostasis
Secondary hemostasis
Neural stimulation and endothelin
GPIb receptor
Formation of a weak platelet plug
Stabilization of platelet plug mediated by coagulation cascade
Transient vasoconstriction of damaged vessel
Receptor platelets use to bind to vWF
Primary hemostasis
Formation of a weak platelet plug
Secondary hemostasis
Stabilization of platelet plug mediated by coagulation cascade
25 terms
Hematology Week 3
White cell counts
Manual WBC
Leukocytosis
Leukopenia
Can be counted using manual or automated techniques, manual m…
Counts any nuclei including any nucleated red cells, f seen o…
An increase in the number of white cells above normal for the…
A decrease in the total white cell count below normal for the…
White cell counts
Can be counted using manual or automated techniques, manual m…
Manual WBC
Counts any nuclei including any nucleated red cells, f seen o…
19 terms
Hematology - Week 3
Leukocytosis
Leukopenia
Leukemoid
Thrombocytosis
An increase in the number of white cells above normal for the…
a decrease in the total number of white cell count below norm…
A marked leukocytosis
Increase in the number of thrombocytes. cell count above norm…
Leukocytosis
An increase in the number of white cells above normal for the…
Leukopenia
a decrease in the total number of white cell count below norm…
130 terms
Hematology Week 3
4 steps to evaluating RBC status
What is the cause of microcytic hypoch…
What are the causes of normocytic norm…
Can hyperchromic be absolute or relati…
1) Look at MCV... 2) Look at MCHC... 3) Look at absolute retic coun…
Iron deficiency
New anemias... Renal failure and bone marrow toxins (decreased p…
No, it is always artifact
4 steps to evaluating RBC status
1) Look at MCV... 2) Look at MCHC... 3) Look at absolute retic coun…
What is the cause of microcytic hypoch…
Iron deficiency
75 terms
Lab 3 hematology
4-6 million cells per cubic millimeter
4800-10,800 cells per cubic millimeter
Never Let Monkeys Eat Bananas
Neutrophils, lymphocytes, monocytes, e…
What is an average total RBC count?
What is an average total WBC count?
What acronym helps me remember what makes up WBC count?
What are the five things that make up a WBC count?
4-6 million cells per cubic millimeter
What is an average total RBC count?
4800-10,800 cells per cubic millimeter
What is an average total WBC count?
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