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Study sets matching "heme onc"

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Study sets matching "heme onc"

43 terms
Heme/Onc
Causes of microcytic anemia:
beta-thalassemia minor:
beta-thalassemia major:
lead poisoning:
iron deficiency, chronic disease (late), thalassemia, lead po…
asymptomatic; increased HbA2 (5%) on electrophoresis
beta chain absent, severe anemia; marrow expansion leads to c…
microcytic anemia; inhibits ferrochelatase and ALA dehydratas…
Causes of microcytic anemia:
iron deficiency, chronic disease (late), thalassemia, lead po…
beta-thalassemia minor:
asymptomatic; increased HbA2 (5%) on electrophoresis
51 terms
Heme/onc
anemia from CKD treated with EPO leads…
hard unilat non-tender LN in submandib…
post splenectomy patients, increased r…
leukemoid rxn characteristics
iron - need supplementation
head and neck cancer -usually squamous cell carcinoma
impaired antibody mediated opsonization in phagocytosis
leukocyte > 50000, LAP score high
anemia from CKD treated with EPO leads…
iron - need supplementation
hard unilat non-tender LN in submandib…
head and neck cancer -usually squamous cell carcinoma
78 terms
HEME/ONC
MOA of Cromolyn Sodium
Fetal Erythropoiesis
enzyme inhibited by vitamin K
Vitamin K Activates ________
prevents mast cell degranulation used for asthma prophylaxis
Yolk Sac (3-8 weeks)... Liver (6wks- birth)... Spleen (10-28 weeks)…
epoxide reductase
Factors II, VII, IX, X, protein C and S
MOA of Cromolyn Sodium
prevents mast cell degranulation used for asthma prophylaxis
Fetal Erythropoiesis
Yolk Sac (3-8 weeks)... Liver (6wks- birth)... Spleen (10-28 weeks)…
62 terms
Heme/Onc
Contents to neutrophil specific granul…
Contents of neutrophil azurophilic gra…
Causes for eosinophilia (5)
3 things bradykinin does
ALP, collagenase, lysozyme, lactoferrin
proteinases, acid phosphatase, MPO, beta-glucuronidase
Neoplasia, Asthma, Allergic processes, Chronic adrenal insuff…
Increases vasodilation, bv permeability, and pain
Contents to neutrophil specific granul…
ALP, collagenase, lysozyme, lactoferrin
Contents of neutrophil azurophilic gra…
proteinases, acid phosphatase, MPO, beta-glucuronidase
36 terms
Heme/Onc
MCV <80... Dec Fe... Dec TIBC
MCV <80... Dec Fe... Inc TIBC
MCV <80... Fe normal... TIBC normal/dec
MCV >100... dec retics... inc homocysteine... n…
Anemia of chronic disease
Iron deficiency anemia
Lead poisoning... Thalassemia
Folic acid deficiency
MCV <80... Dec Fe... Dec TIBC
Anemia of chronic disease
MCV <80... Dec Fe... Inc TIBC
Iron deficiency anemia
11 terms
Heme/Onc
ALL
AML (M7 type assd with trisomy 21)
Hodgkin's lymphoma
Neuroblastoma
Fever, pallor, petechiae... Bone pain, refusal to bear weight... Ly…
Patient with trisomy 21... Fever, pallor, petechiae... Gum hyperpla…
Fever, weight loss, night sweats... Normal labs except elevated…
Ill-appearing child... Bone pain, fevers... Blue/purple eyelid disc…
ALL
Fever, pallor, petechiae... Bone pain, refusal to bear weight... Ly…
AML (M7 type assd with trisomy 21)
Patient with trisomy 21... Fever, pallor, petechiae... Gum hyperpla…
10 terms
Heme/Onc
Doxorubicin toxicities
Bleomycin toxicities
Vinblastine toxicities
dacarbazine toxicities
cardiotoxicity, myelosuppression, vesicant, alopecia, red/ora…
pulmonary fibrosis
neurotoxicity, constipation, vesicant
myelosuppression... n/v
Doxorubicin toxicities
cardiotoxicity, myelosuppression, vesicant, alopecia, red/ora…
Bleomycin toxicities
pulmonary fibrosis
58 terms
Heme/Onc
nontender lymphad... +/- B symptoms
Lymphoma w/u
Lymphoma staging
Chemo peripheral neuropathy
Lymphoma
1. excisional bx of LN... - Nothing (fungus/Tb/bacteria)... - met... I…
CXR -> CT or Pet (bx for mets)... S1 1LN... S2 >=2LN not cross diap…
vincristine/vinblastin
nontender lymphad... +/- B symptoms
Lymphoma
Lymphoma w/u
1. excisional bx of LN... - Nothing (fungus/Tb/bacteria)... - met... I…
68 terms
heme/onc
methotrexate mech
methotrexate use
methotrexate tox
5-fu mech
folic acid analog, inhib DHF reductase. dec dTMP, dec DNA, de…
leukemia, lymphoma, choriocarcinoma, sarcoma. Abortion, ectop…
myelosupression, reversible with leucovorin (folinic acid). M…
pyrimadine analog, bioactivated to 5f-dUMP which bonds folic…
methotrexate mech
folic acid analog, inhib DHF reductase. dec dTMP, dec DNA, de…
methotrexate use
leukemia, lymphoma, choriocarcinoma, sarcoma. Abortion, ectop…
18 terms
heme/onc
teardorp RBC
sickle cell and hotel jolly bodies, au…
spoon nails
alcoholic
myelofibrois
spleen
iron deficiency anemia
folate deficiency
teardorp RBC
myelofibrois
sickle cell and hotel jolly bodies, au…
spleen
47 terms
Heme/onc
Glanzmans thrombasthenia
Bernard soulier syn
Storage pool dz
Thrombotic microangiopathy
Plt prob. Lack fibrinogen receptors,Plt gp2b3a. Sx mucocutane…
Lack vWF receptors. Sx mucocutaneous bleed. Dx thrombocytopen…
Defective Plt granule secretion, esp ADP. Sx mild dx-inc brui…
Causes: TTP, HUS, DIC, tumor, immune rxn. Leads to organ dysf…
Glanzmans thrombasthenia
Plt prob. Lack fibrinogen receptors,Plt gp2b3a. Sx mucocutane…
Bernard soulier syn
Lack vWF receptors. Sx mucocutaneous bleed. Dx thrombocytopen…
53 terms
Heme/Onc
Normal HGB for men and women
Normal TIBC
Normal serum Iron
What is a normal Mean corpuscular volu…
Women 12-16... Men 14-18
250-450
50-150
80-100
Normal HGB for men and women
Women 12-16... Men 14-18
Normal TIBC
250-450
215 terms
HEME-ONC
- XIII
- Bleeding time test
-Post traumatic bleeding
- Spontaneous, life threatening hemorr…
What factor does thrombin activate?
What test do you do to test vascular integrity and platelet f…
What will most like happen if the platelets fall below 50,000?
What if the platelets fall below 10,000 - 20,000?
- XIII
What factor does thrombin activate?
- Bleeding time test
What test do you do to test vascular integrity and platelet f…
168 terms
Heme-Onc-MSK Pictures
Arrow: Myeloid Blast
Normocytic
Macrocytic
Microcytic
Arrow: Myeloid Blast
Normocytic
55 terms
Heme-Onc-MSK Pictures
Precursor B lymphoblastic leukemia/lym…
Precursor B lymphoblastic leukemia/lym…
Precursor T lymphoblastic leukemia/lym…
Acute Myeloid Leukemia
Precursor B lymphoblastic leukemia/lym…
Precursor B lymphoblastic leukemia/lym…
38 terms
Heme/Onc
Pernicious Anemia
Anemia of Chronic Disease
Direct Coombs Test
Spinal cord compression
auto-Abs against intrinsic factor... Dx w/ anti-IF Abs... Most comm…
-Tx = Epo... -Ensure adequate Fe stores bc RBCs are production i…
Abs are attached to RBCs
1. IV glucocorticoids... 2. MRI
Pernicious Anemia
auto-Abs against intrinsic factor... Dx w/ anti-IF Abs... Most comm…
Anemia of Chronic Disease
-Tx = Epo... -Ensure adequate Fe stores bc RBCs are production i…
111 terms
Heme/Onc
what causes hypersegmented neutrophils
how do eosinphils kill helminths
chronic adrenal insufficiency causes o…
what cell contains heparin?
B12 (necessary for folate recycling) or folate def
major basic protein
eosinophils
basophils
what causes hypersegmented neutrophils
B12 (necessary for folate recycling) or folate def
how do eosinphils kill helminths
major basic protein
60 terms
Heme/Onc
Polycythemia
Hematocrit
Erythropoietin
Multiple Myeloma
Elevated HGB, RBC, or Hct
Percent of RBC to total blood volume
Hormone secreated by the kidney the influences RBC production…
monoclonal spike on serum electropharesis
Polycythemia
Elevated HGB, RBC, or Hct
Hematocrit
Percent of RBC to total blood volume
175 terms
heme-onc
heinz bodies seen in
microcytic target cells in
basphilic stippling can be 2/2
side effect of steroid use
G6PD... formed from oxidation of hemoglobin ... G6PD creates NADPH,…
thalassemia minor
lead poisoning (microcytic)... alcholism... thalassemias... its non sp…
inc hematocrit... gynecomastia... hepatotoxicity... dyslipidemia (inc…
heinz bodies seen in
G6PD... formed from oxidation of hemoglobin ... G6PD creates NADPH,…
microcytic target cells in
thalassemia minor
58 terms
heme-onc
as a nurse you need to think about wha…
CF patients get all vaccines and take…
normal newborns Hbg, hct, platelets
most common hematological disorder of…
handwashing
true
hgb-high... hgt-high... platelets-low
anemia. not disease itself, symptoms of underlying disorder
as a nurse you need to think about wha…
handwashing
CF patients get all vaccines and take…
true
78 terms
Heme/Onc
Platelets Normal Range
Platelet Dense Granules
Platelet Alpha Granules
Thrombopoietin
150,000-350,000/microliter
ADP, ATP, serotonin
plasma proteins
TPO... -produced in the liver (a little in the kidney)... -potent m…
Platelets Normal Range
150,000-350,000/microliter
Platelet Dense Granules
ADP, ATP, serotonin
36 terms
Heme/onc
increased MCHC
DIC is common presentation of what leu…
distinguishes leukemoid reaction form…
cell markers on reed-sternberg
hereditary spherocytosis
AML... see auer rods, increased circulating myeloblasts... associat…
increased leukocyte alkaline phosphatase
CD15 and CD30
increased MCHC
hereditary spherocytosis
DIC is common presentation of what leu…
AML... see auer rods, increased circulating myeloblasts... associat…
164 terms
Heme/Onc
Cl/HCO3 antiporter on RBCs
RBC lifespan
platelet lifespan
ADP, Ca, vWF, fibrinogen
allows for control of blood pH
120 days
8-10 days
contents of platelet granules
Cl/HCO3 antiporter on RBCs
allows for control of blood pH
RBC lifespan
120 days
100 terms
Heme/Onc
Acanthocyte (Spur Cell) - spikey
Burr Cell
Basophilic Stippling... (RNA clumps)
Bite Cells
Liver Disease... Abetalipoproteinemia
Uremia
*Lead poisoning... - alcohol abuse... - thalassemias... - anemia of ch…
G6PD deficiency
Acanthocyte (Spur Cell) - spikey
Liver Disease... Abetalipoproteinemia
Burr Cell
Uremia
197 terms
Heme/Onc
Microcytic Anemias: MCV < 80
Normocytic Anemias: MCV 80-100
Macrocytic Anemia: MCV > 100
Diseases that cause cold agglutinins:
Iron deficiency... Lead poison... Chronic disease... Sideroblastic ane…
Hemolytic... Chronic Disease... Hypovolemia
Folate deficiency... B12 deficiency... Liver disease... Alcohol Abuse
IgM... - Mycoplasma... - EBV
Microcytic Anemias: MCV < 80
Iron deficiency... Lead poison... Chronic disease... Sideroblastic ane…
Normocytic Anemias: MCV 80-100
Hemolytic... Chronic Disease... Hypovolemia
119 terms
Heme/Onc
MOA of Unfractionated Heparin
MOA of LMWH (Enoxaparin):
Hemophilia A deficiency =
Hemophilia B deficiency =
Activates Antithrombin III, Increases PTT
Factor Xa Inhibitor
Factor VIII
Factor IX
MOA of Unfractionated Heparin
Activates Antithrombin III, Increases PTT
MOA of LMWH (Enoxaparin):
Factor Xa Inhibitor
30 terms
Heme/Onc
Heparin
Warfarin
enoxaparin
Hemophilia
PTT/intrinsic, antithrombin III,tx- protamine sulfate
PT/extrinsic, (2,7,9,10,C,S), teratogen,tx- vit. K
LMWH, Xa
clotting factors, X-linked-M-+FHx, OR acuired ab (AI, Lymphop…
Heparin
PTT/intrinsic, antithrombin III,tx- protamine sulfate
Warfarin
PT/extrinsic, (2,7,9,10,C,S), teratogen,tx- vit. K
15 terms
Heme/onc
Schistocytes - helmet cells found in
Patients with hereditary telangiectasi…
The lupus anticoagulant, an anti-phosp…
Negative family history positive Coomb…
DIC, HUS, TTP
pulmonary AVMs w/hemoptysis and right to left shunt physiolog…
prolonged PTT
AIHA - Autoimmune hemolytic anemia
Schistocytes - helmet cells found in
DIC, HUS, TTP
Patients with hereditary telangiectasi…
pulmonary AVMs w/hemoptysis and right to left shunt physiolog…
99 terms
heme/onc
macrocytic anemia
folate deficiency
b12 deficiency
iron deficiency anemia
production anemia so have decreased reticulocytes... can be meg…
comes from leafy greens and body has 3-6 week store... look for…
comes from animal products... need intact termial ileum and pari…
MC microcytic anemia... can be blood loss (gi bleed or gynecholo…
macrocytic anemia
production anemia so have decreased reticulocytes... can be meg…
folate deficiency
comes from leafy greens and body has 3-6 week store... look for…
103 terms
Heme & Onc B
Decreased iron due to chronic bleeding…
Findings in Iron deficiency anemia
Plummer Vinson syndrome
pathogenesis of alpha-thalassemia... wha…
Iron deficiency... decreased final step in heme synthesis... Reca…
Decreased iron, Increase TIBC, decreased ferritin... Microcytos…
Associated with Iron deficiency anemia. ... 1. iron deficiency…
Defect: alpha-globin gene deletions -> decreased alpha-globin…
Decreased iron due to chronic bleeding…
Iron deficiency... decreased final step in heme synthesis... Reca…
Findings in Iron deficiency anemia
Decreased iron, Increase TIBC, decreased ferritin... Microcytos…
30 terms
Heme/Onc
Argatroban, bivalidrudin
Apixaban, rivaroxaban
Alteplase (tPA), reteplase, tenecteplase
Aspirin
Inhibit thrombin directly. Used instead of heparin for antico…
Binds and directly inhibits activity of factor Xa... Increases…
thrombolytics... Directly or indirectly aid conversion of plasm…
Irreversibly inhibits cyclooxygenase (both COX1 and COX 2) en…
Argatroban, bivalidrudin
Inhibit thrombin directly. Used instead of heparin for antico…
Apixaban, rivaroxaban
Binds and directly inhibits activity of factor Xa... Increases…
11 terms
Heme/Onc
Acute Intermittent Porphorya
Lead Poisoning
Porphyria cutanea tarda
Platelet Disorders
Precipitated by drugs, alcohol, starvation... Affected: Porphobi…
Affected: Ferrocheletase (incorporates Iron into Protoporphyr…
Defect in Urobilinogen Decarboxylase. Buildup of Uroporphyrin…
Bleeding time increased. Platelet abnormalities --> micro hem…
Acute Intermittent Porphorya
Precipitated by drugs, alcohol, starvation... Affected: Porphobi…
Lead Poisoning
Affected: Ferrocheletase (incorporates Iron into Protoporphyr…
226 terms
Heme/Onc
erythrocytosis
anisocytosis
poikilocytosis
reticulocyte
polycythemia= increased hematocrit (increased RBC mass)
varying sizes of RBCs
varying shapes of RBCs
immature erythrocyte, marker of erythroid proliferation
erythrocytosis
polycythemia= increased hematocrit (increased RBC mass)
anisocytosis
varying sizes of RBCs
34 terms
HEME/ONC
Anemia S&S
Anemia Dx
Anemia Complications
Blood Transfusion Reactions
Decrease in hgb or RBC, and NOT inadequate... -fatigue/headache…
H&P... CBC... MCV, MCH... Pt energy and activity levels
-Infection... -Need for transfusion... -HF
Hemolytic: headache, chills, flank pain, N/V, shaking, DIC si…
Anemia S&S
Decrease in hgb or RBC, and NOT inadequate... -fatigue/headache…
Anemia Dx
H&P... CBC... MCV, MCH... Pt energy and activity levels
93 terms
Heme/Onc
Anemia Compensation
Cryoprecipitate
FFP
Intravascular hemolysis- transfusion
Increased CO (HR and SV)... Increased extraction ratio... Right shi…
Contains factor 8 and fibrinogen... Give for Hemophilia A, decre…
Contains all clotting factors... Give for high PT/PTT, coagulopa…
Acute hemolytic transfusion reactions... ABO-mismatched blood- w…
Anemia Compensation
Increased CO (HR and SV)... Increased extraction ratio... Right shi…
Cryoprecipitate
Contains factor 8 and fibrinogen... Give for Hemophilia A, decre…
heme/onc
content of dense granules
content of alpha granules
petechiae
poikilocytosis
calcium, ADP
vWF, fibrinogen
result of thrombocytopenia
varying shapes (RBCs)
content of dense granules
calcium, ADP
content of alpha granules
vWF, fibrinogen
116 terms
Heme/onc
large granular lymphocyte (LGL)
the most common malignancy-related cau…
Bisphosphonates are powerful inhibitor…
most appropriate for this patient with…
Felty syndrome
Metastatic tumors originating from lung cancer and cutaneous…
osteoclast-mediated bone resorption
leucovorin, 5-fluorouracil, and oxaliplatin (FOLFOX)
large granular lymphocyte (LGL)
Felty syndrome
the most common malignancy-related cau…
Metastatic tumors originating from lung cancer and cutaneous…
27 terms
Heme/onc
Dx tests for breast cancer
Breast utz
Autoimmune hemolysis
Cold agglutinin disease
FNA- best initial biopsy; small sample... CNB- large sample; de…
Distinguishes cysts from solid lesions; perform when it's pai…
Microspherocytes; warm IgG... Most accurate test- Coombs test... T…
IgM against EBV, waldenstrom macroglobulinemia, mycoplasma pn…
Dx tests for breast cancer
FNA- best initial biopsy; small sample... CNB- large sample; de…
Breast utz
Distinguishes cysts from solid lesions; perform when it's pai…
124 terms
Heme/Onc
RBC membrane antiporter
Platelet vWF receptor
Platelet fibrinogen receptor
Macrophage surface marker
HCO3-/Cl-
GpIb
GpIIb/IIIa
CD14
RBC membrane antiporter
HCO3-/Cl-
Platelet vWF receptor
GpIb
26 terms
Heme/Onc
AML =... Acute Myelogenic Leukemia
CNS Leukemia =
Major AML complication?
APL =... Acute Promyelocytic Leukemia
Causes/RFs =... maturation arrest and subsequent proliferation o…
Causes/RFs =... Occurs in < 5% of AML,... Pt w/ circulating blast c…
Tumor Lysis Syndromed
Causes =... In 10% on AML cases... M3 classification,... Involves t(1…
AML =... Acute Myelogenic Leukemia
Causes/RFs =... maturation arrest and subsequent proliferation o…
CNS Leukemia =
Causes/RFs =... Occurs in < 5% of AML,... Pt w/ circulating blast c…
6 terms
Heme/Onc
Microcytic Anemia, hypochromic (MCV<80)
Macrocytic anemia, MCV>100
Nonhemolytic, normocytic anemia
Intrinsic Hemolytic, normocytic anemia
-Iron deficiency... -alpha-thalassemia... -Beta-thalassemia... -lead p…
-megaloblastic anemia... -folate deficiency... -B12 deficiency... -oro…
-anemia of chronic disease... -aplastic anemia
-Hereditary spherocytosis... -G6PD deficiency... -Pyruvate kinase d…
Microcytic Anemia, hypochromic (MCV<80)
-Iron deficiency... -alpha-thalassemia... -Beta-thalassemia... -lead p…
Macrocytic anemia, MCV>100
-megaloblastic anemia... -folate deficiency... -B12 deficiency... -oro…
55 terms
Heme/Onc
Immune Thrombocytopenic Purpura (ITP)
Microangiopathic Hemolytic Anemia
TPP
HUS
-autoimmune production of IgG against platelet antigens (GpII…
TTP and HUS... -pathologic formation of microthrombi in small ve…
-decreased ADAMTS13 (enzyme that cleaves vWF multimer into sm…
-endothelial damage by drugs or infection... -seen in children w…
Immune Thrombocytopenic Purpura (ITP)
-autoimmune production of IgG against platelet antigens (GpII…
Microangiopathic Hemolytic Anemia
TTP and HUS... -pathologic formation of microthrombi in small ve…
96 terms
Heme/Onc
smear of peripheral blood: neutrophils…
anemia
acute anemia
chronic anemia
never let monkeys eat bananas
What is the most common childhood hematologic problem
anemia that presents w/tachycardia, flow murmur, poor exercis…
anemia that is well tolerated in children and present w/tachy…
smear of peripheral blood: neutrophils…
never let monkeys eat bananas
anemia
What is the most common childhood hematologic problem
98 terms
Heme & Onc C
Compare Leukemia vs. lymphoma
Acute inflammatory response to infecti…
Compare Hodgkin vs. non Hodgkin lympho…
What are Reed-Sternberg cells
Leukemia: lymphoid or myeloid neoplasms with widespread invol…
Leukemoid reaction... Constrast with CML (also increase WBC cou…
Note that prognosis is better with Hodgkins. ... Reed Sternberg…
Distinctive tumor giant cell seen in HODGKIN DISEASE. ... Binuc…
Compare Leukemia vs. lymphoma
Leukemia: lymphoid or myeloid neoplasms with widespread invol…
Acute inflammatory response to infecti…
Leukemoid reaction... Constrast with CML (also increase WBC cou…
Heme/Onc
Apixaban
Rivaroxaban
Alteplase (tPA)
Reteplase (rPA)
Direct Factor Xa inhibitor
Direct Factor Xa inhibitor
Thrombolytics, convert plasminogen to plasmin... Toxicity: BLEED…
Thrombolytics, convert plasminogen to plasmin... Toxicity: BLEED…
Apixaban
Direct Factor Xa inhibitor
Rivaroxaban
Direct Factor Xa inhibitor
128 terms
Heme/Onc
Characterization of anemia in Anemia a…
Characterization of iron deficiency an…
Reticulocyte cellular hemoglobin (CHr)
Soluble transferrin receptor (sTfR)
normocytic, normochromic. Characterized by normal size and he…
microcytic and hypochormic
Useful for the early detection of iron restriction to the ery…
Produced when erythroblasts become fully hemoglobinized and s…
Characterization of anemia in Anemia a…
normocytic, normochromic. Characterized by normal size and he…
Characterization of iron deficiency an…
microcytic and hypochormic
38 terms
HEME-ONC
ALL PEAK AGE
ALL CLIN, LABS
ALL XRAY "leukemic lines"
ALL STANDARD RISK (75-90% survival)
4yo
fever, pallor/bleeding (anemia/thrombocytopenia in 90%), LAN,…
at metaphyses
age b/w 1-10yo, WBC at dx <50K, no prior steroids, no CNS/tes…
ALL PEAK AGE
4yo
ALL CLIN, LABS
fever, pallor/bleeding (anemia/thrombocytopenia in 90%), LAN,…
70 terms
Heme-Onc
extrinisic pathway
intrinsic pathway
PT
PTT
7 activated by tissue factor released from platelets ... -7 acti…
12 activates 11 activates 9 - with 8 released from VWF... -9-8 t…
extrinsic pathway measurement - factor 7... -warfarin
intrinsic pathway measurement - everything but 7 and 13... -hepa…
extrinisic pathway
7 activated by tissue factor released from platelets ... -7 acti…
intrinsic pathway
12 activates 11 activates 9 - with 8 released from VWF... -9-8 t…
79 terms
heme-onc
neutrophils- specific granules
neutrophils-azurophilic granules
eosinophils
basophil
smaller and more numerous; contain ALP, lysozyme, lactotransf…
(lysosomes) larger, less numerous-contain proteinase, acid pe…
protect against helminths and make histaminase and arylsulfat…
dense basophilic granules with heparin, histamine, leukotrien…
neutrophils- specific granules
smaller and more numerous; contain ALP, lysozyme, lactotransf…
neutrophils-azurophilic granules
(lysosomes) larger, less numerous-contain proteinase, acid pe…
10 terms
Heme/Onc
Differential for anterior mediastinal…
+Myeloperoxidase
Smudge Cells
other cell lines in CLL vs. CML
"4T's" - teratoma (including germ cell tumors), thymoma, thyr…
seen in myeloblasts in AML
CLL
CLL: granulocytopenia, anemia, thrombocytopenia... CML: iincreas…
Differential for anterior mediastinal…
"4T's" - teratoma (including germ cell tumors), thymoma, thyr…
+Myeloperoxidase
seen in myeloblasts in AML
4 of 10