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Study sets matching "hiv block pharmacology"

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Study sets matching "hiv block pharmacology"

12 terms
HIV pharmacology
NRTI
NNRTI
PI
Integrase Inhibitor
Inhibits HIV DNA synthesis from RNA template by terminating D…
Allosteric RT inhibitor
Inhibits HIV polyprotein cleavage
Inhibits HIV DNA integration into host genome
NRTI
Inhibits HIV DNA synthesis from RNA template by terminating D…
NNRTI
Allosteric RT inhibitor
47 terms
HIV Pharmacology
Ritonavir... Cobicistat
Abacavir... Zidovudine... TAF... TDF... Didanosine…
Nevirapine... Delavirdine... Efavirenz... Etrav…
Amprenavir... Atazanavir... Darunavir... Fosamp…
Commonly used boosters for ART
NRTI drugs
NNRTI drugs
Protease inhibitor drugs
Ritonavir... Cobicistat
Commonly used boosters for ART
Abacavir... Zidovudine... TAF... TDF... Didanosine…
NRTI drugs
33 terms
HIV Pharmacology
maraviroc
enfuvirtide
gravir
abacavir
CCR5 antagonists
fusion inhibitor
integrase inhibitors
nucleoside/nucleotide reverse transcriptase inhibitors
maraviroc
CCR5 antagonists
enfuvirtide
fusion inhibitor
17 terms
HIV Pharmacology
K103N
HLA-B*5701
Nevirapine
Efavirenz
___ mutations provide resistance for NNRTIs such as efavirenz
Presence of ___ allele increases risk of life-threatening hyp…
___ is contraindicated in women with CD4 >250; men CD4 >400.…
During pregnancy, avoid ___
K103N
___ mutations provide resistance for NNRTIs such as efavirenz
HLA-B*5701
Presence of ___ allele increases risk of life-threatening hyp…
101 terms
HIV and HIV Pharmacology
Describe the genome of all retroviridae
What does the PRO gene of HIV encode f…
What does the POL gene of HIV encode f…
What does the ENV gene of HIV encode f…
All are single stranded and positive sense RNA. ... They have a…
Protease
Reverse Transcriptase and Integrase... *some people include the…
Envelope proteins gp 120 and gp41
Describe the genome of all retroviridae
All are single stranded and positive sense RNA. ... They have a…
What does the PRO gene of HIV encode f…
Protease
88 terms
HIV Pharmacology
What do you need for HAART?
Name the 7 NRTIs?
What are the most common pairings of N…
What NRTI pair is in Truvada?
Highly Active Anti-retroviral therapy:... 3 active drugs... 2 NRT…
Abacavir... Didanosine... Emtricitabine... Lamivudine... Stavudine... Tenofo…
Tenofovir + Emtricitabine (Truvada)... Abacavir + Lamivudine (Ep…
Tenofovir + Emtricitabine
What do you need for HAART?
Highly Active Anti-retroviral therapy:... 3 active drugs... 2 NRT…
Name the 7 NRTIs?
Abacavir... Didanosine... Emtricitabine... Lamivudine... Stavudine... Tenofo…
10 terms
HIV Pharmacology
Drugs ending with the suffix -navir al…
Mechanism of protease inhibitors?
NRTI's (nucleoside reverse transcripta…
Which NRTI is the only nucleotide RTI?
Protease Inhibitors
Prevent cleavage of polypeptide products of HIV mRNA via inhi…
Inhibit nucleoside binding to reverse transcriptase and termi…
Tenofovir, think T for nucleoTide
Drugs ending with the suffix -navir al…
Protease Inhibitors
Mechanism of protease inhibitors?
Prevent cleavage of polypeptide products of HIV mRNA via inhi…
37 terms
HIV Pharmacology
What is used for prophylaxis when CD4…
What do you need to treat prophylactic…
What is used for prophylaxis when CD4…
What do you need to treat prophylactic…
TMP-SMX
Pneumocystics pneumonia
TMP-SMX
Penumocystis pneumonia and toxoplasmosis
What is used for prophylaxis when CD4…
TMP-SMX
What do you need to treat prophylactic…
Pneumocystics pneumonia
11 terms
HIV Pharmacology
Class? - Darunavir
Class? - Ritonavir
Class? - Atazanavir
Class? - Emtricitabine+Tenofovir
Protease inhibitor, brand name Prezista
Protease inhibitor, brand name Norvir
Protease inhibitor, brand name Reyataz
Two nucleoside reverse transcriptase inhibitors. Truvada, com…
Class? - Darunavir
Protease inhibitor, brand name Prezista
Class? - Ritonavir
Protease inhibitor, brand name Norvir
33 terms
HIV Pharmacology
HAART
example of nucleoside reverse transcri…
therapeutic uses of nucleoside reverse…
administration of nucleoside reverse t…
highly active antiretroviral therapy; 3-4 drugs used at the s…
zidovudine (retrovir)
HIV-1; can be used in pregnant women; can prevent encephalopa…
oral, IV; dose can be reduced if side effects are too severe;…
HAART
highly active antiretroviral therapy; 3-4 drugs used at the s…
example of nucleoside reverse transcri…
zidovudine (retrovir)
26 terms
HIV Pharmacology
Viral Replication
How do we monitor disease progression…
Initial Infection Manifestations
Acute Infection Manifestations
A virus cannot replicate on its own, it must enter a host cel…
We monitor the CD4+ and Viral load count and also observe for…
Flu-like symptoms: Fever, swollen lymph nodes, sore throat, h…
Flu-like symptoms: Fever, swollen lymph nodes, sore throat, h…
Viral Replication
A virus cannot replicate on its own, it must enter a host cel…
How do we monitor disease progression…
We monitor the CD4+ and Viral load count and also observe for…
141 terms
HIV Pharmacology
why ART treatment cannot cure HIV infe…
resistance against HIV-1 acquisition
NRTI drugs
NNRTI drugs
IV Latent Reservoir... Functional proviruses that remains in T-c…
Homozygosity for a 32-bp deletion in the CCR5 allele
Abacavir (ABC)... Didanosine (ddI)... Emtricitabine (FTC)... Lamivu…
Delavirdine (DLV)... Efavirenz (EFV)... Etravirine (ETR)... Nevirap…
why ART treatment cannot cure HIV infe…
IV Latent Reservoir... Functional proviruses that remains in T-c…
resistance against HIV-1 acquisition
Homozygosity for a 32-bp deletion in the CCR5 allele
17 terms
HIV Pharmacology
K103N
HLA-B*5701
Nevirapine
Efavirenz
___ mutations provide resistance for NNRTIs such as efavirenz
Presence of ___ allele increases risk of life-threatening hyp…
___ is contraindicated in women with CD4 >250; men CD4 >400.…
During pregnancy, avoid ___
K103N
___ mutations provide resistance for NNRTIs such as efavirenz
HLA-B*5701
Presence of ___ allele increases risk of life-threatening hyp…
85 terms
HIV pharmacology
name the NRTIs
name the NNRTIs
name the PIs
name the INSTIs
emtricitabine (FTC)... lamivudine (3TC)... zidovudine (AZT, ZDV)... te…
efavirenz (EFV)... nevirapine (NVP)... etravirine (ETV)... Rilpivirine…
lopinavir (LPV)... Ritonavir (RTV and /r)... darunavir (DRV)... atazan…
raltegravir (RAL)... elvitegravir (EVG)... Dolutegravir (DTG)
name the NRTIs
emtricitabine (FTC)... lamivudine (3TC)... zidovudine (AZT, ZDV)... te…
name the NNRTIs
efavirenz (EFV)... nevirapine (NVP)... etravirine (ETV)... Rilpivirine…
16 terms
HIV (Pharmacology)
v1- human t cell leukemia, v2- hairy t…
bind cd4 receptors on gp120 and gp 41…
max suppresion of viral load <50 copie…
resistance; tropism ccr5 vs cxcr4; con…
Retroviruses HTLV1/HTLV2?
What does the HIV virus bind to? what do they encode?
Goals of therapy for HIV?
Tx considerations in HIV?
v1- human t cell leukemia, v2- hairy t…
Retroviruses HTLV1/HTLV2?
bind cd4 receptors on gp120 and gp 41…
What does the HIV virus bind to? what do they encode?
10 terms
HIV Pharmacology
Goals of therapy
NRTI or NA
NNRTI
INSTI
-Prevention of progression... -Prevention of transmission... -Undet…
Nucleoside analog reverse transcriptase inhibitors
Non-nucleoside analog reverse transcriptase inhibitors
Intergrase stand transfer inhibitor
Goals of therapy
-Prevention of progression... -Prevention of transmission... -Undet…
NRTI or NA
Nucleoside analog reverse transcriptase inhibitors
48 terms
Pharmacology of HIV
- attachment... - penetration... - uncoating…
attachment
penetration
uncoating
steps in viral replication
surface proteins of the virus interact with specific receptor…
enveloped viruses (e.g., HIV, influenza virus) penetrate cell…
this process makes the nucleic acid available for transcripti…
- attachment... - penetration... - uncoating…
steps in viral replication
attachment
surface proteins of the virus interact with specific receptor…
60 terms
HIV Pharmacology
Which NRTI does NOT have to be renally…
Which NRTI has to be taken on an empty…
Do NRTIs have any CYP450 interactions?
NRTI ADRs:... as a class
Abacavir... (Abacavir and Zidovudine do not undergo renal elimi…
Didanosine... (The rest of the NRTIs can be taken with or witho…
No... (However, P-gp inhibitors, such as cobicistat, increase T…
-Lactic acidosis... -Hepatic steatosis... -Lipodystrophy
Which NRTI does NOT have to be renally…
Abacavir... (Abacavir and Zidovudine do not undergo renal elimi…
Which NRTI has to be taken on an empty…
Didanosine... (The rest of the NRTIs can be taken with or witho…
49 terms
HIV Pharmacology
What are gp120 and gp41?
What is the concept of a virus binding…
What are the two co-receptors necessar…
What occurs during the immune compensa…
they are env proteins, responsible for binding and entry of t…
tropism
CXCR4 and CCR5
host cells are able fight off infection, leads to recovery of…
What are gp120 and gp41?
they are env proteins, responsible for binding and entry of t…
What is the concept of a virus binding…
tropism
77 terms
HIV Pharmacology
HIV
AIDS
ElISA
HIV RNA
CD4 count never lower than 200 cells/mm3
CD4 count has been > or = 200 cells/mm3 at some point in time
-detects HIV 1 antibodies... -99+% sensitive/specific... -false pos…
detect viremia 2wks prior to antibody formation
HIV
CD4 count never lower than 200 cells/mm3
AIDS
CD4 count has been > or = 200 cells/mm3 at some point in time
42 terms
HIV pharmacology
why can't ART treatment cure HIV infec…
Nucleoside reverse transcriptase inhib…
NRTIs: Mechanisms of resistance includ…
pyrophosphorolysis
- HIV latent reservoir: Functional proviruses that remains in…
1. Competitive inhibition of HIV reverse transcriptase by inc…
Mutations at or near the drug-binding site of the reverse tra…
Reverse reaction of DNA polymerization... - enables reverse tran…
why can't ART treatment cure HIV infec…
- HIV latent reservoir: Functional proviruses that remains in…
Nucleoside reverse transcriptase inhib…
1. Competitive inhibition of HIV reverse transcriptase by inc…
94 terms
HIV pharmacology
NRTI MoA
What are the major DI of NRTIs
Acronym for class related AEs of NRTIs
PML stands for? (NRTIs)
Competitive inhibition of RT and disruption of chain elongation
uncommon
PML
Peripheral neuropathy, pancreatitis... myelosupression, myopathy…
NRTI MoA
Competitive inhibition of RT and disruption of chain elongation
What are the major DI of NRTIs
uncommon
49 terms
HIV Pharmacology
What suffix do protease inhibitors have?
What suffix do INSTIs have?
Name primary NRTIs
Name primary NNRTIs
-navir
-gravir
Abacavir... Didanosine... Lamivudine... Zidovudine... Stavudine... Emtricita…
Nevirapine... Delavirdine... Efavirenz... Etravirine... Rilpivirine
What suffix do protease inhibitors have?
-navir
What suffix do INSTIs have?
-gravir
43 terms
HIV Pharmacology
classes of drugs
3 main viral processes targeted in dru…
NRTIs- drugs
NNRTIs- drugs
-NRTIs (nucleos/tide reverse transcriptase inhibitors)... -NNRTI…
-HIV reverse transcriptase... -HIV integrase... -HIV protease
FIRST LINE (AELTZ)... -abacavir... -emtricitabine... -lamivudine... -teno…
FIRST LINE... -efavirenz (avoid in pregnancy)... ALTERATIVE... -Nevira…
classes of drugs
-NRTIs (nucleos/tide reverse transcriptase inhibitors)... -NNRTI…
3 main viral processes targeted in dru…
-HIV reverse transcriptase... -HIV integrase... -HIV protease
25 terms
HIV Pharmacology
Entry inhibitors attach themselves to…
fusion inhibitor ... -Targets gp41 prote…
entry inhibitor ... -Targets the CCR5 co…
2 Forms:... -Nucleoside analog reverse-tr…
Entry and Fusion Inhibitors
Enfuvirtide
Maraviroc
Nucleoside & Nucleotide Reverse Transcriptase Inhibitors (NRT…
Entry inhibitors attach themselves to…
Entry and Fusion Inhibitors
fusion inhibitor ... -Targets gp41 prote…
Enfuvirtide
22 terms
Pharm Block 3 HIV
cART
Enfurtivide
Maraviroc
Raltegravir
2 NRTI + NNRTI or PI
Entry Inhibitor (gp41 subunit)
Entry Inhibitor (CCR5 coreceptor)... Salvage therapy
Integrase Inhibitor
cART
2 NRTI + NNRTI or PI
Enfurtivide
Entry Inhibitor (gp41 subunit)
48 terms
Pharm Block 3 HIV
cART
Enfuvirtide
Maraviroc
Raltegravir
2 NRTI + NNRTI or PI
Entry Inhibitor - FUSION INHIBITOR (gp41 subunit)... metabolized…
Entry Inhibitor (CCR5 coreceptor) ... Salvage therapy... Must be co…
Integrase Inhibitor
cART
2 NRTI + NNRTI or PI
Enfuvirtide
Entry Inhibitor - FUSION INHIBITOR (gp41 subunit)... metabolized…
39 terms
HIV Drugs structures (pharmacology)
acyclovir
adefovir
guanine
adenine
acyclovir
adefovir
11 terms
HIV Pharmacology with Pictures
Class? - Darunavir
Class? - Ritonavir
Class? - Atazanavir
Class? - Emtricitabine+Tenofovir
Protease inhibitor, brand name Prezista
Protease inhibitor, brand name Norvir
Protease inhibitor, brand name Reyataz
Two nucleoside reverse transcriptase inhibitors. Truvada, com…
Class? - Darunavir
Protease inhibitor, brand name Prezista
Class? - Ritonavir
Protease inhibitor, brand name Norvir
40 terms
Pharmacology Antiviral/HIV Drugs
antiviral/HIV drugs... drugs for respira…
antiviral/HIV drugs... which drugs are a…
antiviral/HIV drugs... which drugs are a…
antiviral/HIV drugs... which drugs are a…
amantadine NA... rimantadine NA... oseltamivir... zanamivir... ribavirin
oseltamivir... zanamivir
ribavirin ... acyclovir... gancyclovir
vidarabine
antiviral/HIV drugs... drugs for respira…
amantadine NA... rimantadine NA... oseltamivir... zanamivir... ribavirin
antiviral/HIV drugs... which drugs are a…
oseltamivir... zanamivir
25 terms
Pharmacology HIV/AIDS Medications
Zidovudine
Tenofovir
Efavirenz
Atazanavir
Nucleoside Reverse Transcriptase Inhibitor... Trade name: ZDV, A…
Nucleotide Reverse Transcriptase Inhibitor... Trade name: Viread…
Nonnucleoside Reverse Transcriptase Inhibitor... Trade Name: Sus…
Protease Inhibitor... Trade Name: Reyataz... Uses:... Treatment of HI…
Zidovudine
Nucleoside Reverse Transcriptase Inhibitor... Trade name: ZDV, A…
Tenofovir
Nucleotide Reverse Transcriptase Inhibitor... Trade name: Viread…
47 terms
Pharmacology Anti-HIV Drugs
Abacavir Class
Abacavir Mechanism of Action
Abacavir Mechanism of Resistance
Abacavir Phys/Pharm Effects
NRTI (Guanosine analog)
Activated by cellular phosphorylation to triphosphate (nucleo…
Resistance is slow.... Mutations in viral reverse transcriptase…
Inhibition of mitochondrial function leads to a build up of t…
Abacavir Class
NRTI (Guanosine analog)
Abacavir Mechanism of Action
Activated by cellular phosphorylation to triphosphate (nucleo…
54 terms
Pharmacology Non-HIV Antivirals
Antiviral characteristics
Herpesvirus group
Prototype of medication for herpes tre…
Agent of choice for HSV or VZV infecti…
- able to enter the cells infected with virus... - interfere wit…
- Herpes simplex virus (HSV) - causes infection of the genita…
Acyclovir (Zovirax)
Acyclovir (Zovirax)
Antiviral characteristics
- able to enter the cells infected with virus... - interfere wit…
Herpesvirus group
- Herpes simplex virus (HSV) - causes infection of the genita…
42 terms
Pharmacology Antivirals (Non-HIV)
Nucleoside
Nucleotide
Acyclovir Class
Acyclovir Mechanism of Action
Base + Sugar
Phosphorylated Nucleoside
Acyclic Guanosine Derivative
- Requires three phosphorylation steps for activation. First…
Nucleoside
Base + Sugar
Nucleotide
Phosphorylated Nucleoside
108 terms
HIV Drugs block7
This drug class is similar to nucleoti…
Do NRTIs have drug interactions? What…
What needs to be monitored in NRTIs? H…
How are NRTIs excreted?
NRTIs
no; Didanosine & Tenofovir
CBC, LFTs, Serum Creatine, BUN; ... baseline; after modification…
renally
This drug class is similar to nucleoti…
NRTIs
Do NRTIs have drug interactions? What…
no; Didanosine & Tenofovir
210 terms
Pharmacology Block 1
component of a cell or organism that i…
quantitative relationship
dose or concentration
pharmacological effect
receptor
Receptors largely determine the (?) between dose or concentra…
Receptors largely determine the quantitative relationship bet…
Receptors largely determine the quantitative relationship bet…
component of a cell or organism that i…
receptor
quantitative relationship
Receptors largely determine the (?) between dose or concentra…
42 terms
HIV Antiviral Pharmacology
Nucleoside Reverse Transcriptase Inhib…
Non-Nucleoside Reverse Transcriptase I…
HIV Protease Inhibitors (PIs; List)
HIV Integrase Strand Transfer Inhibito…
1st Line: Abacavir, Emtracitabine, Lamivudine, Tenofovir, Zid…
1st Line: Efavirenz (AVOID IN PREGNANCY)... 1st Line Alternative…
1st line: Atazanavir, Darunavir... Alternate: Lopinavir, Tiprana…
Raltegravir
Nucleoside Reverse Transcriptase Inhib…
1st Line: Abacavir, Emtracitabine, Lamivudine, Tenofovir, Zid…
Non-Nucleoside Reverse Transcriptase I…
1st Line: Efavirenz (AVOID IN PREGNANCY)... 1st Line Alternative…
19 terms
Pharmacology: AntiCancer & HIV
MOA: Gleevec
MOA cyclophosphamide
MOA: methotrexate
MOA: paclitaxel (Taxol)
inhibits cancer-specific tyrosine kinase (reduces SE of tradi…
bivalent cross-link of DNA (leads to cytotoxicity)
inhibits dihydrofolate reductase, inhibits synthesis of thymi…
binds to tubulin dimers adn antagonizes microtubule disassemb…
MOA: Gleevec
inhibits cancer-specific tyrosine kinase (reduces SE of tradi…
MOA cyclophosphamide
bivalent cross-link of DNA (leads to cytotoxicity)
58 terms
Pharmacology (anti-HIV)
To discuss / differentiate the pharmac…
HIV is what type of virus?
Gp41 and GP120 are glyco-proteins that…
HIV requires _____________ to bind to…
...
Retrovirus
Allow the HIV to anchor onto CD4 T- helper cells.
Co-receptor (CCR5 or CXCR4)
To discuss / differentiate the pharmac…
...
HIV is what type of virus?
Retrovirus
33 terms
Pharmacology Antiviral agent (HIV)
Viral attach and infusion
HIV1 vs. HIV2
Zidovudine AZT
Zidovudine AZT ADR
- HIV viral has gp120 and gp41complex on the viral surface.…
NNRTIs are effective on HIV1 but not HIV2
NRTI ... - active form = AZT triphosphate... conversion require thy…
- non-selective activation => accumulate all dividing cell, n…
Viral attach and infusion
- HIV viral has gp120 and gp41complex on the viral surface.…
HIV1 vs. HIV2
NNRTIs are effective on HIV1 but not HIV2
37 terms
Pharm1 - Block3 - HIV/AIDS
Converts HIV RNA genome to DNA
Inserts HIV DNA copy in host genome
Cleaves HIV proteins to use in making…
Virus uses ? to enter host cells
Reverse Transcriptase
Integrase
Protease
CD4 molecules and chemokine receptors
Converts HIV RNA genome to DNA
Reverse Transcriptase
Inserts HIV DNA copy in host genome
Integrase
27 terms
Pharmacology - HIV antivirals
What is HIV?
What does HIV infect?
What do CD4+ helper T cells do?
What serves as a receptor for HIV and…
RNA retrovirus carrying its genetic material in RNA rather…
a limited number of cell types in the body including destroyi…
They are necessary for normal immune function and orchestrate…
CD4+ antigen
What is HIV?
RNA retrovirus carrying its genetic material in RNA rather…
What does HIV infect?
a limited number of cell types in the body including destroyi…
516 terms
Pharmacology Block 2
Does the the somatic nervous system co…
where do neurons of the somatic nervou…
what are the neurotransmitter(s) at th…
What kind of tissues do neurons of the…
voluntary AND involuntary activity
motor neurons originate in the spinal cord and directly inner…
Acetylcholine is the neurotransmitter at neuromuscular junction
smooth muscle, cardiac muscle, and exocrine glands (basically…
Does the the somatic nervous system co…
voluntary AND involuntary activity
where do neurons of the somatic nervou…
motor neurons originate in the spinal cord and directly inner…
58 terms
Block 10 - Oncology, HIV-AIDS
Molecular Pathogenesis of Colorectal C…
Role of APC and β-catenin in Oncogenes…
Macro and Microscopic Appearance of Co…
Familial Adenomatous Polyposis (FAP):
Microsatellite instability pathway (15%): DNA mismatch repair…
APC and β-catenin are components of the Wnt signaling pathway…
Macroscopic Appearance: Pedunculated, Sessile, Flat, Depresse…
Autosomal-dominant mutation of APC gene on chromosome 5q. ... M…
Molecular Pathogenesis of Colorectal C…
Microsatellite instability pathway (15%): DNA mismatch repair…
Role of APC and β-catenin in Oncogenes…
APC and β-catenin are components of the Wnt signaling pathway…
39 terms
HIV/AIDS Pharmacology
CD4 count
PCP prophylaxis
toxoplasmosis gondii encephalitis prop…
mycobacterium avium complex prophylaxis
less than 200 is associated w/ AIDS and opportunistic infecti…
BACTRIM DS ... - drug of choice for prophylaxis and treatment…
Bactrim DS daily
need 2 agents... - macrolides preferred (azithromycin, clarith…
CD4 count
less than 200 is associated w/ AIDS and opportunistic infecti…
PCP prophylaxis
BACTRIM DS ... - drug of choice for prophylaxis and treatment…
11 terms
Pharmacologic Agents for HIV/AIDS
Drug list
3 drug regimen: general classes
3 drug regimen: example combinations
Nucleoside/Nucleotide Reverse Transcri…
-Nucleoside/Nucleotide Reverse Transcriptase Inhibitors (NRTI…
-2 nucleoside reverse transcriptase inhibitors (NRTIs)... -1 Int…
-INSTI + 2 NRTIs: Dolutegravir/abacavir/lamivudine (must be H…
-inhibit reverse transcriptase; cause premature chain termina…
Drug list
-Nucleoside/Nucleotide Reverse Transcriptase Inhibitors (NRTI…
3 drug regimen: general classes
-2 nucleoside reverse transcriptase inhibitors (NRTIs)... -1 Int…
51 terms
HIV Pharmacology I [Sandoval]
What are the 7 NRTIs?
What is the general MOA of NRTIs?
What is the difference between NRTIs a…
What are the 4 genes that are mutated…
Abacavir, Didanosine, Emtricitabine, Lamivudine, Stavudine, T…
Competitive inhibition of HIV reverse transcriptase.
NRITs are incorporated into the amino acid chain and cause in…
M184v, L74V,D67N and M41L
What are the 7 NRTIs?
Abacavir, Didanosine, Emtricitabine, Lamivudine, Stavudine, T…
What is the general MOA of NRTIs?
Competitive inhibition of HIV reverse transcriptase.
12 terms
CH 37? pharmacology HIV
Drugs to treat HIV/AIDS
Reverse Transcriptase Inhibitors
Protease Inhibitors
Nucleosides
Reverse Transcriptase Inhibitors... Protease Inhibitors... Nucleosi…
*Action - Bind directly to HIV reverse transcriptase blocking…
*Action - Block protease activity within the HIV virus... *Pharm…
*Action - Interfere with HIV replication by inhibiting cell p…
Drugs to treat HIV/AIDS
Reverse Transcriptase Inhibitors... Protease Inhibitors... Nucleosi…
Reverse Transcriptase Inhibitors
*Action - Bind directly to HIV reverse transcriptase blocking…
14 terms
HIV Pharmacology (FA192)
Nomenclature: -ivir
-avir
-navir
-ovir
generally influenza drugs
HIV drugs
protease inhibitors
other viruses (could be HIV or others)
Nomenclature: -ivir
generally influenza drugs
-avir
HIV drugs
20 terms
HIV / Immune pharmacology
Interferon Alpha-2b therapeutic
Interferon Alpha-2b pharmacologic
Aldesleukin therapeutic
Aldesleukin pharmacologic
Immunostimulant
Interferon, biologic response modifier
immunostimulant
Interleukin, biologic response modifier
Interferon Alpha-2b therapeutic
Immunostimulant
Interferon Alpha-2b pharmacologic
Interferon, biologic response modifier
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