Study sets matching "hiv"

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Study sets matching "hiv"

31 terms
HIV
Worldwide
Statistics in U.S.
Info to know about HIV
Basics of HIV
> 34 million have HIV/AIDS... 2011→... (new HIV infected pts. = 2.5…
Living w/HIV→ >1 million & >13 yrs./old⇒ 20% of them are unaw…
HIV-1→... HIV-2→... Related viruses⇒... SIV→ "simian immunodeficiency…
This Retrovirus Has 2 types⇒... 1. HIV-1→ leads to AIDS... 2. HIV-2…
Worldwide
> 34 million have HIV/AIDS... 2011→... (new HIV infected pts. = 2.5…
Statistics in U.S.
Living w/HIV→ >1 million & >13 yrs./old⇒ 20% of them are unaw…
55 terms
HIV
Recommended INSTI- based regimen for t…
Recommended PI- based regimen for the…
Recommended regimens for HIV-1 infecte…
Abacavir
1.) Dolutegravir/Abacavir/Lamivudine (Triumeq)... 2.)Dolutegravi…
Darunavir + ritonavir + emtricitabine/tenofovir (Prezista & N…
2 NRTIs... - abacavir/lamivudine (Epzicom) OR... - tenofovir/emtric…
Ziagen
Recommended INSTI- based regimen for t…
1.) Dolutegravir/Abacavir/Lamivudine (Triumeq)... 2.)Dolutegravi…
Recommended PI- based regimen for the…
Darunavir + ritonavir + emtricitabine/tenofovir (Prezista & N…
HIV
HIV stands for
AIDS stands for
______________ are diseases which the…
HIV
Human Immunodeficiency Virus
Acquired immunodeficiency syndrome
opportunistic infections
can be transmitted when there is contact with infected fluids…
HIV stands for
Human Immunodeficiency Virus
AIDS stands for
Acquired immunodeficiency syndrome
46 terms
HIV
AIDs... profound immunosuppression... -cau…
retrovirus ... -process of infection... - m…
what do aids patients usually die from…
types of HIV
-oppotunistic infections... -malignacies... -wasting... -CNS degen.
long term latent infection... integrate genome into host DNA or…
opportunistic pathogens or tumors
-HIV 1= US... -HIV 2= west africa... HIV 1 more common
AIDs... profound immunosuppression... -cau…
-oppotunistic infections... -malignacies... -wasting... -CNS degen.
retrovirus ... -process of infection... - m…
long term latent infection... integrate genome into host DNA or…
HIV
What does the primary infection of HIV…
What family of viruses does HIV belong…
the flu like syndrome that people get…
What immune cells does HIV tend to inf…
acute-flu like syndrome
retroviruses
acute retroviral syndrome
CD4+ T helper cells and monocytes/macrophages
What does the primary infection of HIV…
acute-flu like syndrome
What family of viruses does HIV belong…
retroviruses
67 terms
HIV
What is the most common CMV released i…
What are the three structural proteins…
Which HIV regulatory genes are require…
What is important about gag gene?
Retinitis (chorioretinitis)
Gag... Pol... Env
Tat (transcription)... Rev
iT HAS P24 PROTEIN, ANTIGEN IDENTIFIED IN serology test
What is the most common CMV released i…
Retinitis (chorioretinitis)
What are the three structural proteins…
Gag... Pol... Env
32 terms
HIV
What is AIDS, how is HIV spread, what'…
what's the current state of treatments?
how is it usually transmitted in the U…
HIV-1 vs. HIV-2
• HIV-1: Most common human retrovirus... • HIV-2: Not as virulen…
What is AIDS, how is HIV spread, what'…
what's the current state of treatments?
98 terms
HIV
What family and genus does the HIV vir…
What kind of virus is HIV?
Which HIV virus is responsible for mos…
Which group of HIV-1 is divided in sub…
Retrovirus family; Lentivirus genus
enveloped RNA virus
HIV-1
Group M
What family and genus does the HIV vir…
Retrovirus family; Lentivirus genus
What kind of virus is HIV?
enveloped RNA virus
24 terms
HIV
List risk factors for HIV infection
Which demographic group has the greate…
Which demographic group has the greate…
Rank the following activities from hig…
Sex... Needle sharing... Other needle or iatrogenic exposures... Trans…
Men who have sex with men
Heterosexual men and women
Anal sex... Vaginal sex... Oral sex
List risk factors for HIV infection
Sex... Needle sharing... Other needle or iatrogenic exposures... Trans…
Which demographic group has the greate…
Men who have sex with men
32 terms
HIV
stages in HIV
primary HIV infection symptoms (from m…
Neuro, primary HIV complications
which OI appear above 200 CD4
1. transmission ... 2. primary HIV infection ... 3. clinical latent…
1. fever ... 2. adenopathy ... 3. pharyngitis ... 4. rash ... 5. ulcerati…
- meningoencephalitis ... - peripheral neuropathy ... - VII nerve p…
herpes zoster/shingles>TB>oral candidasis
stages in HIV
1. transmission ... 2. primary HIV infection ... 3. clinical latent…
primary HIV infection symptoms (from m…
1. fever ... 2. adenopathy ... 3. pharyngitis ... 4. rash ... 5. ulcerati…
18 terms
HIV
Generic name of Truvada?
Brand name of abacavir?
Generic name of Descov?
Generic name of Combivir?
Tenofovir DF and emtricitabine
Ziagen
Tenofovir alafenamide and emtricitabine
Zidovudine and Lamuvidine
Generic name of Truvada?
Tenofovir DF and emtricitabine
Brand name of abacavir?
Ziagen
HIV
retroviruses
RNA, DNA, reverse transcription
HIV-1
HIV-2
HIV is in this category of viruses
HIV virus is packaged as _____ and converted to ______ via __…
Two serotypes of HIV exist... _______ accounts for the majority…
this serogype has Very, very low incidence in the USA
retroviruses
HIV is in this category of viruses
RNA, DNA, reverse transcription
HIV virus is packaged as _____ and converted to ______ via __…
5 terms
HIV
HIV
AIDs
Treatment Goal
Principle of Tx
- Human Immunodeficiency Virus... - Retrovirus destroys the imm…
- Acquired Immunodeficiency Syndrome... - CD4 count less than 2…
Suppress the load to undetectable levels within 4-6 months
- Most regimens contain:... - 2 NRTIs and either 1 PI or NNRTI…
HIV
- Human Immunodeficiency Virus... - Retrovirus destroys the imm…
AIDs
- Acquired Immunodeficiency Syndrome... - CD4 count less than 2…
17 terms
HIV
Raltegravir (Issentress)
Maraviroc (Selzentry)
Enfuvirtide (Fuzeon)
Lopinavir/RTV (Kaletra)
Integrase Inhibitors... SE: Increase CK levels, risk for myositi…
Entry Inhibitors ... SE: Hepatotoxicity, rash, eosinophilia, inc…
Fusion Inhibitors ... Twice a day SC injection that requires pt…
Protease Inhibitors... Contains 42% alcohol, be careful with Ant…
Raltegravir (Issentress)
Integrase Inhibitors... SE: Increase CK levels, risk for myositi…
Maraviroc (Selzentry)
Entry Inhibitors ... SE: Hepatotoxicity, rash, eosinophilia, inc…
HIV
Nelfinavir
Saquinavir
Ritonavir
Indinavir
Viracept
Invirase
Norvir
Crixivan
Nelfinavir
Viracept
Saquinavir
Invirase
27 terms
HIV
Zidovudine
Didanosine
Stavudine
Lamivudine
Retrovir
Videx EC
Zerit
Epivir
Zidovudine
Retrovir
Didanosine
Videx EC
HIV
Handout 1:... Antenatal Care
Antiretroviral prophylaxis
Antiretroviral therapy
APGAR score ... A - appearance ... P - pulse…
Care of a pregnant woman and her unborn child or fetus before…
Short term use of antiretroviral drugs after possible exposur…
Long-term use of a combination of three or more ARV drugs to…
Developed by Dr. Virginia Apgar as a rapid scoring system to…
Handout 1:... Antenatal Care
Care of a pregnant woman and her unborn child or fetus before…
Antiretroviral prophylaxis
Short term use of antiretroviral drugs after possible exposur…
25 terms
Hiv
Combivir
Trizivir
Epzicom
Truvada
Zidovudine+lamdivudine
zidovudine ... lamdivudine... abacavir
Abacavir +lamdivudine
Tenorfovir+emtricitabine
Combivir
Zidovudine+lamdivudine
Trizivir
zidovudine ... lamdivudine... abacavir
63 terms
HIV
Ziagen generic and class
ABC generic and class
Videx generic and class
DDI generic and class
Abacavir... NRTI
Abacavir... NRTI
Didanosine... NRTI
Didanosine... NRTI
Ziagen generic and class
Abacavir... NRTI
ABC generic and class
Abacavir... NRTI
111 terms
HIV
attacks invaders outside the cells
attacks invaders inside the cells
antibody response... cannot penetrate oth…
Types of T-cells
B-cells
T-cells
B-lymphocytes
effector t-cells- helper (CD4+ and Cytotoxic (killer))... regul…
attacks invaders outside the cells
B-cells
attacks invaders inside the cells
T-cells
39 terms
HIV
adenine
guanine
cytosine
thymine
adenine
guanine
HIV
History
Significance
Transmission
Non Transmission activities
Came of significance in the 80's.
over million people living with it. 21% of people don't know…
Sexual Intercourse. Blood. Parentatal. ... Viral Load: number of…
needle stick most common way for health care workers to acqui…
History
Came of significance in the 80's.
Significance
over million people living with it. 21% of people don't know…
150 terms
HIV
HIV virology
HIV transmission
Baseline Evaluation
CD4 count - Frequency
RNA virus ... Primary target: CD4 T-cells (requires CXCR4 or…
Most common cause is male-to-male sexual contact.... Majority…
HIV antibody testing (AI)... CD4 T-cell count (AI)... *Plasma H…
At ART initiation or Modification and every 3-6 months init…
HIV virology
RNA virus ... Primary target: CD4 T-cells (requires CXCR4 or…
HIV transmission
Most common cause is male-to-male sexual contact.... Majority…
17 terms
HIV
Normal t helper cell count
Highly sensitive 1st screening test done
Confirmatory test after first test
When is hiv trt initiated
Adults : 800 - 1200... Newborn: can be upto 1500
ELISA. But has high false positive. If this test is -ve but h…
Western blot. Confirm positive elisa with this test
When cd4 drops below 350 ( consider if less than 500) or high…
Normal t helper cell count
Adults : 800 - 1200... Newborn: can be upto 1500
Highly sensitive 1st screening test done
ELISA. But has high false positive. If this test is -ve but h…
65 terms
HIV
Acquisition of HIV-2
Lentivirus
1st pathogenic human retrovirus
TAX
sooty mangabey
HIV1-2... -associated with neurologic & immunosuppressive diseas…
HTLV-1 (Human T Cell Leukemia Virus)
HTLV-1
Acquisition of HIV-2
sooty mangabey
Lentivirus
HIV1-2... -associated with neurologic & immunosuppressive diseas…
80 terms
HIV
Diagnostic testing
When do HIV antibodies typically devel…
When is AIDS diagnosed?
What drug can be used to treat lipoatr…
-ELISA... -Western blot (confirmatory test)... -viral load (RNA PCR…
Within 4-6 weeks following transmission
When CD4 count falls below 200 cells/mm^3
Radiesse
Diagnostic testing
-ELISA... -Western blot (confirmatory test)... -viral load (RNA PCR…
When do HIV antibodies typically devel…
Within 4-6 weeks following transmission
25 terms
HIV
Abacavir (ABC)
Didanosine (ddI)
Emtracitabine (FTC)
Lamivudine (3TC)
Ziagen... (NRTI)
Videx... (NRTI)
Emtriva... (NRTI)
Epivir... (NRTI)
Abacavir (ABC)
Ziagen... (NRTI)
Didanosine (ddI)
Videx... (NRTI)
138 terms
HIV
Other than HIV which two viruses shoul…
Which causes more long term conditions…
Why does the presence of STI's increas…
What percentage of people infected wit…
HBV... CMV
CMV
Stimulates the body's immune system to increase the number of…
21%... Creates a huge problem for transmission
Other than HIV which two viruses shoul…
HBV... CMV
Which causes more long term conditions…
CMV
60 terms
HIV
viral load in
large amounts of virus
most risky form of sexual intercourse
life span of infected CD4 cells with HIV
blood, semen, vaginal secretions, breast milk
during the first 2 to 6 months after infection and again duri…
unprotected anal intercourse
2 days
viral load in
blood, semen, vaginal secretions, breast milk
large amounts of virus
during the first 2 to 6 months after infection and again duri…
83 terms
hiv
CD4+ count
HIV-1 RNA
HIV transmission
positive HIV Ab test
indicator of immune function
viral load... indicator of response to antiretroviral therapy
blood, semen, vaginal secretions
usually becomes positive 4-8 weeks after contracting the dise…
CD4+ count
indicator of immune function
HIV-1 RNA
viral load... indicator of response to antiretroviral therapy
HIV Acute Infection
Chronic Asymptomatic HIV
HIV Symptomatic Infection
AIDS
Flu-like syndrome; antiretroviral... fever, lymphadenopathy, ras…
8-10 years; few if any symptoms... Lymphadenopathy; steady leve…
CD4+ counts drop to 200-500... oral hairy leukoplakia, candida,…
CD4 count below 200 OR AIDS defining illness... CD4 to CD8 rati…
HIV Acute Infection
Flu-like syndrome; antiretroviral... fever, lymphadenopathy, ras…
Chronic Asymptomatic HIV
8-10 years; few if any symptoms... Lymphadenopathy; steady leve…
13 terms
HIV
Gag Gene
Pol Gene
Env Gene
T-Tropic
codes for proteins that are (group specific antigen/core) par…
codes for proteins (polymerases) that are crucial to the life…
codes for the envelope glycoproteins that are critical for in…
- X4 Strains... - HIV viruses that preferentially infect T cells…
Gag Gene
codes for proteins that are (group specific antigen/core) par…
Pol Gene
codes for proteins (polymerases) that are crucial to the life…
69 terms
HIV
NRTI
NRTI
NRTI
NRTI
emtricitabine
lamivudine
zidovudine
tenofovir
NRTI
emtricitabine
NRTI
lamivudine
61 terms
HIV
AIDS defined
opportunistic infection
normal CD4 cell concentration
difference betwen HIV and AIDS
having 1 or more opportunistic infection. cd4 count of less t…
any infection by a microorganism caused by a microorganism th…
900-1200/cubic mm
HIV is the virus, AIDS is the syndrome
AIDS defined
having 1 or more opportunistic infection. cd4 count of less t…
opportunistic infection
any infection by a microorganism caused by a microorganism th…
8 terms
HIV
Zidovudine
Didanosine
Stavudine
Zalcitabine
AZT (old: ZVD; Thymine)
ddI (Inosine/Adenosine)
d4T (Thymine)
DDC (Cytosine)
Zidovudine
AZT (old: ZVD; Thymine)
Didanosine
ddI (Inosine/Adenosine)
HIV
HIV
types of HIV
AIDS
OIs: opportunistic infections
-human immunodeficiency virus... -retro virus: RNA only... -obligat…
type 1: most virulent. world wide... type 2: non-progressing. ar…
end stage HIV... CD4 T helper cell count < 200 ... Wasting... without…
Life threatening illness caused by nonpathogenic organisms in…
HIV
-human immunodeficiency virus... -retro virus: RNA only... -obligat…
types of HIV
type 1: most virulent. world wide... type 2: non-progressing. ar…
82 terms
HIV
cause of HIV
structure of HIV virus
what does the HIV infect
process of infection of HIV
enveloped retroviruses HIV-1 (most virulent) or HIV-2
enveloped and contains ssRNA and 2 proteins - reverse transcr…
t cells
gp120 on virus binds to CD4 on t cells, then CCR5 or CXCR4 on…
cause of HIV
enveloped retroviruses HIV-1 (most virulent) or HIV-2
structure of HIV virus
enveloped and contains ssRNA and 2 proteins - reverse transcr…
64 terms
HIV
Difference between HIV-1 and HIV 2. Wh…
What is ACTG 076?
HLA-B5701
Coreceptor Tropism Assay (Trofile)
HIV-1: Predominant throughout the world (major cause of AIDS)…
AIDS CLINICAL TRIALS GROUP: Antiretrovirals reduce mother to…
Panel recommended screening for hypersensitivity to ABC (abac…
Identifies the tropism of patients with HIV. If you have R5 v…
Difference between HIV-1 and HIV 2. Wh…
HIV-1: Predominant throughout the world (major cause of AIDS)…
What is ACTG 076?
AIDS CLINICAL TRIALS GROUP: Antiretrovirals reduce mother to…
HIV
High risk demographics of HIV in NC
What is HIV?
What is AIDS?
6 fluids that HIV can be transmitted t…
-70% of cases are men... -men under age 30, women over age 50... -n…
-human immunodeficiency virus... -retrovirus that infects immune…
-acquired immune deficiency syndrome... -when CD4+ cell count <…
1. pre-seminal fluid... 2. semen... 3. anal mucus... 4. vaginal fluid…
High risk demographics of HIV in NC
-70% of cases are men... -men under age 30, women over age 50... -n…
What is HIV?
-human immunodeficiency virus... -retrovirus that infects immune…
119 terms
HIV
epitopes of HIV
steps of PEP
disadvantages of PEP
exposure to Hep C
GP120, GP41
Step 1—treat exposure site... Step 2—Report and document... Step 3—…
o People return to unsafe behaviors... o Resistant strain of HIV…
HCV—1.8%; no treatment; follow up includes testing for HCV an…
epitopes of HIV
GP120, GP41
steps of PEP
Step 1—treat exposure site... Step 2—Report and document... Step 3—…
HIV
HIV
Transmission fluids
Transmission activities
Prevention
Human Immodeficiency Virus, the virus that causes AIDS
HIV infected Semen... Vaginal Secrations... infected blood... blood fr…
Sexual contact with HIV infected persons... sharing drug needles…
To be knowledgable of what constitutes risky behaviors and ho…
HIV
Human Immodeficiency Virus, the virus that causes AIDS
Transmission fluids
HIV infected Semen... Vaginal Secrations... infected blood... blood fr…
29 terms
HIV
env
gag
pol
gp120
Structural gene encodes for gp120 and gp41 (cleaved from gp160)
Structural gene encodes for p24
Structural gene encodes for:... • reverse transcriptase... • aspart…
attachment to host CD4+ T cell
env
Structural gene encodes for gp120 and gp41 (cleaved from gp160)
gag
Structural gene encodes for p24
54 terms
HIV
The nurse reviews a plan of care for a…
During an assessment, the nurse finds…
The nurse provides education to a pati…
The nurse is caring for a patient newl…
...
...
...
...
The nurse reviews a plan of care for a…
...
During an assessment, the nurse finds…
...
18 terms
HIV
Enfuvirtide
Maraviroc
Nucleoside RT inhibitors... Non-nucleosid…
Raltegravir
Attachment and fusion
Chemokine and CD4 receptors
Reverse transcription
Integrase ... -transport double stranded unintegrated DNA into t…
Enfuvirtide
Attachment and fusion
Maraviroc
Chemokine and CD4 receptors
58 terms
HIV
HIV
HIV: Modes of transmission
HIV: Most common mode of transmission
Routes that do NOT transmit HIV
a ribonucleic acid (RNA) virus, or retrovirus, which means it…
Sexual intercourse with an infected partner (semen & vaginal…
Sexual contact with an HIV-infected partner
hugging, DRY kissing, shaking hands, sharing eating utensils,…
HIV
a ribonucleic acid (RNA) virus, or retrovirus, which means it…
HIV: Modes of transmission
Sexual intercourse with an infected partner (semen & vaginal…
44 terms
HIV
Describe the HIV particle
gag gene results in 6 products
pol gene results in enzymes
env gene results in 2 viral enveloped…
Lentivirus and retrovirus. 2 single copies of RNA. Reverse tr…
encodes for a gag protein that is cleaved into different prod…
encodes for a protein that, when cleaved into different produ…
encodes for an env protein, which, when cleaved, results in t…
Describe the HIV particle
Lentivirus and retrovirus. 2 single copies of RNA. Reverse tr…
gag gene results in 6 products
encodes for a gag protein that is cleaved into different prod…
HIV
how is HIV transmitted
how to reduce transmission
high risk for HIV transmission
s/sx's of primary HIV infxn (list from…
blood ... semen ... vaginal secretion... breast milk... sex... needles ... birth
limit partners... get tested ... latex condoms (*polyurethane/polyi…
very high risk - pre-exposure prophylaxis... gays... discordant c…
non-specific... fever... lethargy... myalgias... rash... headache... pharyngi…
how is HIV transmitted
blood ... semen ... vaginal secretion... breast milk... sex... needles ... birth
how to reduce transmission
limit partners... get tested ... latex condoms (*polyurethane/polyi…
30 terms
HIV
Countries with highest HIV
Populations with highest incidence in…
Statistics 2015
HIV: Virus enters what type of lymph t…
#1 Africa; #2 USSR/South Asia; #3 South America (less treatme…
MSM and African American
36 million live w/HIV. 17 mil ppl treatment. 70% of mom recie…
Helper T cell (lymphs) through the CD4 receptor
Countries with highest HIV
#1 Africa; #2 USSR/South Asia; #3 South America (less treatme…
Populations with highest incidence in…
MSM and African American
HIV
CD4+ Tcell
AZT
Protease Inhibitor
Integrase Inhibitor
The target of HIV
Reverse Transcriptase inhibitor
inhibit enzymes that assemble the new protein coats for newly…
Blocks viral enzymes required to insert viral DNA into host DNA
CD4+ Tcell
The target of HIV
AZT
Reverse Transcriptase inhibitor
65 terms
HIV
Brand name: Zidovudine... a. Combivir... b.…
Brand name: Didanosine... a. Combivir... b.…
Brand name: Lamivudine... a. Combivir... b.…
Brand name: Stavudine... a. Combivir... b. E…
e
g
c
i
Brand name: Zidovudine... a. Combivir... b.…
e
Brand name: Didanosine... a. Combivir... b.…
g
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