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Study sets matching "hiv"

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Study sets matching "hiv"

31 terms
HIV
Worldwide
Statistics in U.S.
Info to know about HIV
Basics of HIV
> 34 million have HIV/AIDS... 2011→... (new HIV infected pts. = 2.5…
Living w/HIV→ >1 million & >13 yrs./old⇒ 20% of them are unaw…
HIV-1→... HIV-2→... Related viruses⇒... SIV→ "simian immunodeficiency…
This Retrovirus Has 2 types⇒... 1. HIV-1→ leads to AIDS... 2. HIV-2…
Worldwide
> 34 million have HIV/AIDS... 2011→... (new HIV infected pts. = 2.5…
Statistics in U.S.
Living w/HIV→ >1 million & >13 yrs./old⇒ 20% of them are unaw…
55 terms
HIV
Recommended INSTI- based regimen for t…
Recommended PI- based regimen for the…
Recommended regimens for HIV-1 infecte…
Abacavir
1.) Dolutegravir/Abacavir/Lamivudine (Triumeq)... 2.)Dolutegravi…
Darunavir + ritonavir + emtricitabine/tenofovir (Prezista & N…
2 NRTIs... - abacavir/lamivudine (Epzicom) OR... - tenofovir/emtric…
Ziagen
Recommended INSTI- based regimen for t…
1.) Dolutegravir/Abacavir/Lamivudine (Triumeq)... 2.)Dolutegravi…
Recommended PI- based regimen for the…
Darunavir + ritonavir + emtricitabine/tenofovir (Prezista & N…
39 terms
HIV
adenine
guanine
cytosine
thymine
adenine
guanine
82 terms
HIV
how is HIV transmitted
how to reduce transmission
high risk for HIV transmission
s/sx's of primary HIV infxn (list from…
blood ... semen ... vaginal secretion... breast milk... sex... needles ... birth
limit partners... get tested ... latex condoms (*polyurethane/polyi…
very high risk - pre-exposure prophylaxis... gays... discordant c…
non-specific... fever... lethargy... myalgias... rash... headache... pharyngi…
how is HIV transmitted
blood ... semen ... vaginal secretion... breast milk... sex... needles ... birth
how to reduce transmission
limit partners... get tested ... latex condoms (*polyurethane/polyi…
65 terms
HIV
What does the primary infection of HIV…
What family of viruses does HIV belong…
the flu like syndrome that people get…
What immune cells does HIV tend to inf…
acute-flu like syndrome
retroviruses
acute retroviral syndrome
CD4+ T helper cells and monocytes/macrophages
What does the primary infection of HIV…
acute-flu like syndrome
What family of viruses does HIV belong…
retroviruses
13 terms
HIV
HIV stands for
AIDS stands for
______________ are diseases which the…
HIV
Human Immunodeficiency Virus
Acquired immunodeficiency syndrome
opportunistic infections
can be transmitted when there is contact with infected fluids…
HIV stands for
Human Immunodeficiency Virus
AIDS stands for
Acquired immunodeficiency syndrome
46 terms
HIV
AIDs... profound immunosuppression... -cau…
retrovirus ... -process of infection... - m…
what do aids patients usually die from…
types of HIV
-oppotunistic infections... -malignacies... -wasting... -CNS degen.
long term latent infection... integrate genome into host DNA or…
opportunistic pathogens or tumors
-HIV 1= US... -HIV 2= west africa... HIV 1 more common
AIDs... profound immunosuppression... -cau…
-oppotunistic infections... -malignacies... -wasting... -CNS degen.
retrovirus ... -process of infection... - m…
long term latent infection... integrate genome into host DNA or…
67 terms
HIV
What is the most common CMV released i…
What are the three structural proteins…
Which HIV regulatory genes are require…
What is important about gag gene?
Retinitis (chorioretinitis)
Gag... Pol... Env
Tat (transcription)... Rev
iT HAS P24 PROTEIN, ANTIGEN IDENTIFIED IN serology test
What is the most common CMV released i…
Retinitis (chorioretinitis)
What are the three structural proteins…
Gag... Pol... Env
32 terms
HIV
What is AIDS, how is HIV spread, what'…
what's the current state of treatments?
how is it usually transmitted in the U…
HIV-1 vs. HIV-2
• HIV-1: Most common human retrovirus... • HIV-2: Not as virulen…
What is AIDS, how is HIV spread, what'…
what's the current state of treatments?
91 terms
HIV
# of adults and children living with A…
# of new infection of HIV
# of deaths from HIV in 2010
Why is AIDS mortality declining & more…
34 million (majority in sub-saharan Africa)
2.7 million
1.8 million
introduction of highly active antiretroviral therapy
# of adults and children living with A…
34 million (majority in sub-saharan Africa)
# of new infection of HIV
2.7 million
98 terms
HIV
What family and genus does the HIV vir…
What kind of virus is HIV?
Which HIV virus is responsible for mos…
Which group of HIV-1 is divided in sub…
Retrovirus family; Lentivirus genus
enveloped RNA virus
HIV-1
Group M
What family and genus does the HIV vir…
Retrovirus family; Lentivirus genus
What kind of virus is HIV?
enveloped RNA virus
24 terms
HIV
List risk factors for HIV infection
Which demographic group has the greate…
Which demographic group has the greate…
Rank the following activities from hig…
Sex... Needle sharing... Other needle or iatrogenic exposures... Trans…
Men who have sex with men
Heterosexual men and women
Anal sex... Vaginal sex... Oral sex
List risk factors for HIV infection
Sex... Needle sharing... Other needle or iatrogenic exposures... Trans…
Which demographic group has the greate…
Men who have sex with men
32 terms
HIV
stages in HIV
primary HIV infection symptoms (from m…
Neuro, primary HIV complications
which OI appear above 200 CD4
1. transmission ... 2. primary HIV infection ... 3. clinical latent…
1. fever ... 2. adenopathy ... 3. pharyngitis ... 4. rash ... 5. ulcerati…
- meningoencephalitis ... - peripheral neuropathy ... - VII nerve p…
herpes zoster/shingles>TB>oral candidasis
stages in HIV
1. transmission ... 2. primary HIV infection ... 3. clinical latent…
primary HIV infection symptoms (from m…
1. fever ... 2. adenopathy ... 3. pharyngitis ... 4. rash ... 5. ulcerati…
18 terms
HIV
Generic name of Truvada?
Brand name of abacavir?
Generic name of Descov?
Generic name of Combivir?
Tenofovir DF and emtricitabine
Ziagen
Tenofovir alafenamide and emtricitabine
Zidovudine and Lamuvidine
Generic name of Truvada?
Tenofovir DF and emtricitabine
Brand name of abacavir?
Ziagen
26 terms
HIV
HIV
types of HIV
AIDS
OIs: opportunistic infections
-human immunodeficiency virus... -retro virus: RNA only... -obligat…
type 1: most virulent. world wide... type 2: non-progressing. ar…
end stage HIV... CD4 T helper cell count < 200 ... Wasting... without…
Life threatening illness caused by nonpathogenic organisms in…
HIV
-human immunodeficiency virus... -retro virus: RNA only... -obligat…
types of HIV
type 1: most virulent. world wide... type 2: non-progressing. ar…
15 terms
HIV
viral load
t-cells
HIV window period
blood
quantitative amount of a virus in blood (could measure other…
type of lymphocyte in immune response, the CD4 cells are targ…
the time between infection with HIV and measurable level of H…
bodily fluid capable of transmitting HIV with the highest con…
viral load
quantitative amount of a virus in blood (could measure other…
t-cells
type of lymphocyte in immune response, the CD4 cells are targ…
44 terms
HIV
Describe the HIV particle
gag gene results in 6 products
pol gene results in enzymes
env gene results in 2 viral enveloped…
Lentivirus and retrovirus. 2 single copies of RNA. Reverse tr…
encodes for a gag protein that is cleaved into different prod…
encodes for a protein that, when cleaved into different produ…
encodes for an env protein, which, when cleaved, results in t…
Describe the HIV particle
Lentivirus and retrovirus. 2 single copies of RNA. Reverse tr…
gag gene results in 6 products
encodes for a gag protein that is cleaved into different prod…
30 terms
HIV
Countries with highest HIV
Populations with highest incidence in…
Statistics 2015
HIV: Virus enters what type of lymph t…
#1 Africa; #2 USSR/South Asia; #3 South America (less treatme…
MSM and African American
36 million live w/HIV. 17 mil ppl treatment. 70% of mom recie…
Helper T cell (lymphs) through the CD4 receptor
Countries with highest HIV
#1 Africa; #2 USSR/South Asia; #3 South America (less treatme…
Populations with highest incidence in…
MSM and African American
14 terms
HIV
Entry inhibitor
Reverse transcriptase inhibitors: nucl…
CCR5 receptor antagonist
integrase inhibitors
enfuvirtide
AZT... 3TC... 4DT... DDI... DDC... last letter indicates ... ones with D are *…
...
raltegravir, elvitegravir
Entry inhibitor
enfuvirtide
Reverse transcriptase inhibitors: nucl…
AZT... 3TC... 4DT... DDI... DDC... last letter indicates ... ones with D are *…
12 terms
HIV
transmittable HIV strain
HIV receptor
HIV coreceptor
ccr5 deletion
R5 strain
CD4
CCR5 or CXCR4 (chemokine receptors that induce chemotaxis of…
confers HIV resistance (or immunity for homozygotes)
transmittable HIV strain
R5 strain
HIV receptor
CD4
10 terms
HIV
CD4+ Tcell
AZT
Protease Inhibitor
Integrase Inhibitor
The target of HIV
Reverse Transcriptase inhibitor
inhibit enzymes that assemble the new protein coats for newly…
Blocks viral enzymes required to insert viral DNA into host DNA
CD4+ Tcell
The target of HIV
AZT
Reverse Transcriptase inhibitor
82 terms
HIV
how is HIV transmitted
how to reduce transmission
high risk for HIV transmission
s/sx's of primary HIV infxn (list from…
blood ... semen ... vaginal secretion... breast milk... sex... needles ... birth
limit partners... get tested ... latex condoms (*polyurethane/polyi…
very high risk - pre-exposure prophylaxis... gays... discordant c…
non-specific... fever... lethargy... myalgias... rash... headache... pharyngi…
how is HIV transmitted
blood ... semen ... vaginal secretion... breast milk... sex... needles ... birth
how to reduce transmission
limit partners... get tested ... latex condoms (*polyurethane/polyi…
17 terms
HIV
exposure to smth
to cause AIDS
to be susceptible to smth
to weaken the immune system
to be revealed to smth
to provoke AIDS
to be vulnerable to smth
to undermine the immunity
exposure to smth
to be revealed to smth
to cause AIDS
to provoke AIDS
11 terms
HIV
CDC classification of HIV
Symptomatic HIV dz
AIDS defining illness
CD4 < 100
asymp HIV... Symp HIV without AIDS... AIDS
Mod-to-severe cervical dysplasia (CIN II, CIN III or CIS)... bac…
CD4+ < 200 or ... Candidiasis of the esophagus, lungs, or trache…
Toxoplasmosis PROPHYLAXIS: ... -First Line: TMP-SMX ... -Second lin…
CDC classification of HIV
asymp HIV... Symp HIV without AIDS... AIDS
Symptomatic HIV dz
Mod-to-severe cervical dysplasia (CIN II, CIN III or CIS)... bac…
59 terms
HIV
Monitoring Parameters (prior to ART/ m…
Treatment-Naive ART Regimens
IRIS Mgmt
Drug Resistance Testing Criteria
-Viral load, ... -CD4+ count, ... -blood chemsitry, ... -CBC... -LFTs ... (2…
2NRTIs +... -nNRTI ... -PI (w/ ritonavir) ... -INSTI
-Start/continue therapy for underlying pathogen... -Continue ART…
-ALL pregnant women prior to therapy... -Those entering pregnanc…
Monitoring Parameters (prior to ART/ m…
-Viral load, ... -CD4+ count, ... -blood chemsitry, ... -CBC... -LFTs ... (2…
Treatment-Naive ART Regimens
2NRTIs +... -nNRTI ... -PI (w/ ritonavir) ... -INSTI
55 terms
HIV
Recommended INSTI- based regimen for t…
Recommended PI- based regimen for the…
Recommended regimens for HIV-1 infecte…
Abacavir
1.) Dolutegravir/Abacavir/Lamivudine (Triumeq)... 2.)Dolutegravi…
Darunavir + ritonavir + emtricitabine/tenofovir (Prezista & N…
2 NRTIs... - abacavir/lamivudine (Epzicom) OR... - tenofovir/emtric…
Ziagen
Recommended INSTI- based regimen for t…
1.) Dolutegravir/Abacavir/Lamivudine (Triumeq)... 2.)Dolutegravi…
Recommended PI- based regimen for the…
Darunavir + ritonavir + emtricitabine/tenofovir (Prezista & N…
37 terms
HIV
Immunodeficiency Diseases
HIV Type I
HIV Type II
Seroconversion
-Lack of one or more components of the immune system results…
responsible for most HIV infections worldwide
endemic in many countries in West Africa; rare is other parts…
the development of evidence of antibody response to a disease…
Immunodeficiency Diseases
-Lack of one or more components of the immune system results…
HIV Type I
responsible for most HIV infections worldwide
25 terms
HIV
HIV is a RNA
HIV transmission
HIV transmission risk of contracting is
HIV viral load is
retorvirus
Blood, semen, breast milk, saliva, Sexual, parenteral, vertic…
dependent on Viral load, Integrity of the exposed site, Type…
anywhere from 5,000 to 10,000 copies/mL
HIV is a RNA
retorvirus
HIV transmission
Blood, semen, breast milk, saliva, Sexual, parenteral, vertic…
HIV
HIV Genome
HIV Structural Genes
Reverse Transcriptase
Viral Binding to Host
+ssRNA, diploid, linear... enveloped... icosahedral capsid
gp120 (Env) = attachment to CD4 host... gp41 (Env) = fusion and…
synthesizes dsDNA from genomic RNA... dsDNA then integrates into…
Virus binds CD4 and a coreceptor... Macrophage = early infection…
HIV Genome
+ssRNA, diploid, linear... enveloped... icosahedral capsid
HIV Structural Genes
gp120 (Env) = attachment to CD4 host... gp41 (Env) = fusion and…
42 terms
HIV
retroviruses
RNA, DNA, reverse transcription
HIV-1
HIV-2
HIV is in this category of viruses
HIV virus is packaged as _____ and converted to ______ via __…
Two serotypes of HIV exist... _______ accounts for the majority…
this serogype has Very, very low incidence in the USA
retroviruses
HIV is in this category of viruses
RNA, DNA, reverse transcription
HIV virus is packaged as _____ and converted to ______ via __…
189 terms
HIV
how many people in the us have HIV
highest population affected by HIV
natural immunity
Macrophage
>1.2 million
men who have sex with men
AKA: innate... responds quickly... leads to infection
eats foreign microbe with antigens and brings it to the T cell
how many people in the us have HIV
>1.2 million
highest population affected by HIV
men who have sex with men
36 terms
HIV
life cycle of HIV virus
Mediation act on each step
t-20 fusion inhibirotr
entry inhibitor
1. surface protein interact and attach virus to T helper cell…
1. surface protein interact and attach virus to T helper cell…
prevents protein form interaction so virus does not attach to…
prevents CCR5 TROPIC virus from entering t helper cell (step2)
life cycle of HIV virus
1. surface protein interact and attach virus to T helper cell…
Mediation act on each step
1. surface protein interact and attach virus to T helper cell…
23 terms
HIV
Describe the history of HIV
Describe the Human Immunodeficiency Vi…
Describe the Viral origins of HIV
Describe the various HIV types
• 1981- Reports of opportunistic infections in MSM / IVDU, US…
• ssRNA Baltimore Classification 6 - RNA with DNA intermediat…
• Zoonotic infections from primates to humans... • Single initia…
• HIV-1... - Dominant virus world-wide... - Transmissions from chim…
Describe the history of HIV
• 1981- Reports of opportunistic infections in MSM / IVDU, US…
Describe the Human Immunodeficiency Vi…
• ssRNA Baltimore Classification 6 - RNA with DNA intermediat…
76 terms
HIV
Human Immunodeficiency Virus
Three main mechanisms for lowered CD4+…
Life expectancy is ________ for HIV pa…
Rank the following Countries from high…
- Infects human immune cells... --- Helper T cells (CD4+ cells)…
1. Direct viral killing of infected cells... 2. Increased rate o…
A. increasing ... Due to effectiveness of ART in treatment of HI…
1. Sub-Saharan Africa (23.5 million, Most in the world)... 2. So…
Human Immunodeficiency Virus
- Infects human immune cells... --- Helper T cells (CD4+ cells)…
Three main mechanisms for lowered CD4+…
1. Direct viral killing of infected cells... 2. Increased rate o…
21 terms
HIV
Steps in HIV Replication (7)
gp120
gp41
Lipid membrane
1) Attach to host cell surface using host cell receptor... 2) Pe…
Docking glycoprotein
Transmembrane Glycoprotein
lipid bilayer
Steps in HIV Replication (7)
1) Attach to host cell surface using host cell receptor... 2) Pe…
gp120
Docking glycoprotein
78 terms
HIV
...
...
HIV 1
...
HIV :... - Family: Retroviridae... - Genus: Lentivirus... Is an…
HIV 1 and HIV 2 are superficially similar, but each contain…
The MCC of HIV disease throughout the world and US is?
Characteristics of HIV 2 infections:... - immunodeficiency pro…
...
HIV :... - Family: Retroviridae... - Genus: Lentivirus... Is an…
...
HIV 1 and HIV 2 are superficially similar, but each contain…
14 terms
HIV
HIV
AIDS case definition
HIV Etiology
Opportunistic Infections
-Retrovirus (changes viral RNA → DNA via reverse transcriptas…
1) Definitive AIDS diagnoses (w/ or w/o laboratory evidence o…
-Like other retroviruses, depends on a unique enzyme, reverse…
HIV
-Retrovirus (changes viral RNA → DNA via reverse transcriptas…
AIDS case definition
1) Definitive AIDS diagnoses (w/ or w/o laboratory evidence o…
18 terms
HIV
Epidemiology
Risk Factors for HIV/AIDS
Screening for HIV
Diagnosis of HIV
The epidemic is still growing but at a lower rate than before…
MSM... IV drug users... Unprotected sex w/ >1 partner ... Unprotected…
Pts in health-care settings unless pt opts-out ... *Pregnant w…
HIV-1 and HIV-2 Immunoassay (4th generation Ag/Ab assay) used…
Epidemiology
The epidemic is still growing but at a lower rate than before…
Risk Factors for HIV/AIDS
MSM... IV drug users... Unprotected sex w/ >1 partner ... Unprotected…
56 terms
HIV
NRTIs
Ziagen
Epzicom
Trizivir
Nucleoside/tide Reverse Transcriptase Inhibitors... D-Z T S-A-L-…
abacavir, ABC... HLA-B*5701 screening... BW: hypersensitivity reac…
abacavir + lamivudine... Take without regards to meals
abacavir + lamividune + zidovudine... Take without regards to m…
NRTIs
Nucleoside/tide Reverse Transcriptase Inhibitors... D-Z T S-A-L-…
Ziagen
abacavir, ABC... HLA-B*5701 screening... BW: hypersensitivity reac…
22 terms
HIV
Sources of Transmission of HIV
CD4 Cells
AIDS CD4 Cell Count
Opportunistic Infection
-Blood products/transfusions before 1985... -Pregnancy, birth, b…
A type of white blood cell that's specifically targeted and d…
Less than 200
Nonpathogenic infection that becomes pathogenic because of a…
Sources of Transmission of HIV
-Blood products/transfusions before 1985... -Pregnancy, birth, b…
CD4 Cells
A type of white blood cell that's specifically targeted and d…
13 terms
HIV
background
diagnosis
initial eval and monitoring
antiretorviral therapy
RNA retrovirus, attacks immune system (CD4 T helper cels) - d…
acute - nonspecific flulike symptoms - self limiting... HIV ab p…
CD4 and viral load... comprehensive metabolic panel (LFTs, SCrr)…
restore and preserve immune system... suppress HIV viral load to…
background
RNA retrovirus, attacks immune system (CD4 T helper cels) - d…
diagnosis
acute - nonspecific flulike symptoms - self limiting... HIV ab p…
37 terms
HIV
Life Cycle
Preferred Regimens
NRTI side effects
Protease Inhibitors side effects
1. HIV attaches to host CD4 receptor and a co-receptor (CCR5…
NNRTI-based regimen... - Efavirenz/tenofovir/emtricitabine (ATR…
Boxed warnings for:... -lactic acidosis... -severe hepatomegaly w/…
-hyperglycemia, insulin resistance... -lipohypertrophy... -hyperlip…
Life Cycle
1. HIV attaches to host CD4 receptor and a co-receptor (CCR5…
Preferred Regimens
NNRTI-based regimen... - Efavirenz/tenofovir/emtricitabine (ATR…
33 terms
HIV
HIV 1
HIV-2
tat
rev
crossed the species barrier 3 times... 3 subgroups (M, O, N)... Gro…
prevalent in West Africa... less virulent than HIV-1... 7-8 subtype…
transactivates transcription of HIV genes
regulates RNA splicing & promotes export of mRNA to the cytop…
HIV 1
crossed the species barrier 3 times... 3 subgroups (M, O, N)... Gro…
HIV-2
prevalent in West Africa... less virulent than HIV-1... 7-8 subtype…
24 terms
HIV
HIV (retrovirus)
HIV structural proteins
HIV regulatory proteins
HIV Life cycle
(+)ssRNA -(rT)-> DNA, enveloped, diploid. incorporated into h…
Gag-Pol precursor --> ... - gag - includes p24 (capsid protein)…
Tat - viral transcription factor ... Rev - promotes nuclear expo…
1. Tropism: ... - GP120 binds to CD4 and CCR5 --> p41 unfolds --…
HIV (retrovirus)
(+)ssRNA -(rT)-> DNA, enveloped, diploid. incorporated into h…
HIV structural proteins
Gag-Pol precursor --> ... - gag - includes p24 (capsid protein)…
9 terms
HIV
HIV: progression of disease
HIV transmission
Prevention of HIV infections
Retroviridae
Acute infection (2-4 weeks post-infection); Most people will…
Found in blood, semen, vaginal secretions and breast milk of…
HIV screening; Medical care, treatment, and supportive servic…
Icosahedral; Enveloped, spherical to pleomorphic; Medium (80-…
HIV: progression of disease
Acute infection (2-4 weeks post-infection); Most people will…
HIV transmission
Found in blood, semen, vaginal secretions and breast milk of…
26 terms
HIV
zidovudine (AZT)
didanosine (ddI)
stavudine (D4T)
zalcitabine (ddC)
zidovudine (AZT)
didanosine (ddI)
18 terms
HIV
HIV
AIDs
universal precautions
monogamous relationship
A virus that attacks and destroys the human immune system.
A person is considered to have AIDS once their cd4 count is b…
An approach to infection control in which all human blood and…
Where partners are intimate with only each other.
HIV
A virus that attacks and destroys the human immune system.
AIDs
A person is considered to have AIDS once their cd4 count is b…
17 terms
HIV
Raltegravir (Issentress)
Maraviroc (Selzentry)
Enfuvirtide (Fuzeon)
Lopinavir/RTV (Kaletra)
Integrase Inhibitors... SE: Increase CK levels, risk for myositi…
Entry Inhibitors ... SE: Hepatotoxicity, rash, eosinophilia, inc…
Fusion Inhibitors ... Twice a day SC injection that requires pt…
Protease Inhibitors... Contains 42% alcohol, be careful with Ant…
Raltegravir (Issentress)
Integrase Inhibitors... SE: Increase CK levels, risk for myositi…
Maraviroc (Selzentry)
Entry Inhibitors ... SE: Hepatotoxicity, rash, eosinophilia, inc…
20 terms
HIV
HIV - type of virus
AIDS related complex
Minor opporutnistic infection in ARD
AIDS
RNA retrovirus
AIDS prodrome... constitutional symptoms - fever, night sweats,…
oral hairy leukoplakia (EBV)
CD4 <200
HIV - type of virus
RNA retrovirus
AIDS related complex
AIDS prodrome... constitutional symptoms - fever, night sweats,…
24 terms
HIV
time between the infection with human…
Individual is highly contagious during…
symptoms Primary infection
muscle pain
Primary infection HIV
Primary infection HIV
fever, fatigue, rash, myalgias, H/A
myalgia
time between the infection with human…
Primary infection HIV
Individual is highly contagious during…
Primary infection HIV
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