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Study sets matching "homeostasis bone mineral"

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Study sets matching "homeostasis bone mineral"

11 terms
Bone Mineral Homeostasis
Action: ... - Regulate gene transcription…
- used for management of sec. hyperpar…
used for management of sec. hyperparat…
- Analog of Calcitriol for management…
Vit. D analog... Cholecalciferol and Ergocalciferol
Calcitriol... Calcipotriene
Doxercalciferol (1-hydroxyvitamin D3)
Paricalcitol
Action: ... - Regulate gene transcription…
Vit. D analog... Cholecalciferol and Ergocalciferol
- used for management of sec. hyperpar…
Calcitriol... Calcipotriene
58 terms
Bone Physio & Mineral Homeostasis
Bone:... Ion Reservoir
Bone:... Structure
Types of bones
Bone Cells
Stores calcium, phosphorous, & magnesium... - Not primary sour…
90+% of protein matrix is made of collagen type 1... Minerals…
Compact or cortical bone... - Long bones have thicker cortical…
Osteoblasts... Osteocytes... Osteoclasts
Bone:... Ion Reservoir
Stores calcium, phosphorous, & magnesium... - Not primary sour…
Bone:... Structure
90+% of protein matrix is made of collagen type 1... Minerals…
23 terms
Bone Mineral Homeostasis
Increases the reabsorption of calcium…
A moderate decline in magnesium levels…
Sunlight stimulates the conversion of…
1. Causes increased phosphate and calc…
What is the effect of PTH on phosphate and calcium reabsorpti…
How do magnesium levels affect the secretion of PTH?... Name so…
Describe the process by which 7-dehydrocholesterol is convert…
What affect does activated vitamin D have on phosphate and ca…
Increases the reabsorption of calcium…
What is the effect of PTH on phosphate and calcium reabsorpti…
A moderate decline in magnesium levels…
How do magnesium levels affect the secretion of PTH?... Name so…
19 terms
231- Bone Mineral Homeostasis
PTH ___ serum calcium and _____ phosph…
Vitamin D ____ serum calcium and _____…
Calcitonin ____ serum calcium and ____…
_________ directly inhibits the produc…
a.
c.
d.
a.
PTH ___ serum calcium and _____ phosph…
a.
Vitamin D ____ serum calcium and _____…
c.
18 terms
Bone Mineral Homeostasis
Teriparatide
Cinacalcet... (Sina-kal-set)
Paricalcitrol
Denosumab
PTH analog ... must be used low, intermittent doses (OB action)…
treat 2nd HyperPTJH in pts with chronic kidney disease (decre…
Vitamin D analog , ... treats for 2nd hyperPTH in pts with chron…
human monoclonal antibody that binds with high affinity to RA…
Teriparatide
PTH analog ... must be used low, intermittent doses (OB action)…
Cinacalcet... (Sina-kal-set)
treat 2nd HyperPTJH in pts with chronic kidney disease (decre…
30 terms
bone mineral homeostasis
Hypo parathyroidism
Hyper parathyroidism
Rickets (osteomalacia)
Paget's Disease of the bone
Hypo-calcemia and hyper-phosphatemia
Hypercalcemia
Vitamin D deficiency, soft bones, failure to grow, abnormal b…
Localized, hyperactive osteoclast activity, excessive remodel…
Hypo parathyroidism
Hypo-calcemia and hyper-phosphatemia
Hyper parathyroidism
Hypercalcemia
32 terms
Bone mineral homeostasis
Vitamin D metabolites and analogs
Bisphosphonates
Teriparatide/calcitonin
Raloxifine
regulate gene transcription via the vitamin D receptor
Suppress the activity of osteoclasts in part via inhibition o…
act via cognate G protein coupled receptors
interacts selectively with estrogen receptors
Vitamin D metabolites and analogs
regulate gene transcription via the vitamin D receptor
Bisphosphonates
Suppress the activity of osteoclasts in part via inhibition o…
46 terms
Bone Mineral Homeostasis
PTH has indirect affect on calcium abs…
PTH affect on kidney
PTH affect on bone
FGF23
increasing the active form of Vit D
decreased calcium excretion... increased phosphate excretion
Calcium and phosphate resorption byhigh doses and bone format…
Decreased Calicum and Phospate absorption
PTH has indirect affect on calcium abs…
increasing the active form of Vit D
PTH affect on kidney
decreased calcium excretion... increased phosphate excretion
45 terms
Bone Mineral Homeostasis
Calcitonin
Parathyroid Hormone
Role of Magnesium in PTH Secretion
Vitamin D
- Released by the thyroid gland in response to rising blood C…
- Released by the parathyroid gland in response to falling bl…
- Moderate decline in Mg --> Incr. PTH Secretion... - *Severe de…
- Pro hormone ... - Gets converted to active form, Calcitriol (1…
Calcitonin
- Released by the thyroid gland in response to rising blood C…
Parathyroid Hormone
- Released by the parathyroid gland in response to falling bl…
14 terms
Agents Bone Mineral Homeostasis
Bone Modeling
Bone Remodeling
Vitamin D
Calcitonin
Formation (deposition) of a new bone... Osteoblasts
Turnover (breakdown and renewal) of pre-existing bone... -Osteo…
Active metabolites of liver, kidney, and skin (some influence…
Horomone made in the C cells of the thyroid. Inhibits bone re…
Bone Modeling
Formation (deposition) of a new bone... Osteoblasts
Bone Remodeling
Turnover (breakdown and renewal) of pre-existing bone... -Osteo…
Bone Mineral Homeostasis
FGF-23
PTH
Teriparatide
Denosumab
produced by osteoblasts and osteoclasts... - inhibits calcitriol…
- increase osteoclasts and osteoblasts activity in bone via l…
recombinant PTH analog... - pulsatile SC administration stimulat…
RANKL inhibitor preventing osteoclast differentiation and fun…
FGF-23
produced by osteoblasts and osteoclasts... - inhibits calcitriol…
PTH
- increase osteoclasts and osteoblasts activity in bone via l…
32 terms
Bone mineral homeostasis drugs
minerals
hormones
vit D, metabolites, and analogs
selective estrogen receptor modulators…
calcium... phosphate
calcitonin... teriparatide
calcipotriene... calcitriol... cholecalciferol (vit D3) (natura…
raloxifene
minerals
calcium... phosphate
hormones
calcitonin... teriparatide
42 terms
6. Bone mineral Homeostasis
Classes
Hormonal vs non-hormonal classes
1. Recombinant PTH
Teripratide MOA
1. Recombinant PTH ... 2. RANKL monoclonal Ab ... 3. Vitamin D... 4. A…
Hromonal : ... -PTH... -Vit. D... -Calcitonin ... -Estrogen (HRT and SERM…
-Teripratide
-increases osteoblast and osteoclast activity via RANKL (TNF)…
Classes
1. Recombinant PTH ... 2. RANKL monoclonal Ab ... 3. Vitamin D... 4. A…
Hormonal vs non-hormonal classes
Hromonal : ... -PTH... -Vit. D... -Calcitonin ... -Estrogen (HRT and SERM…
12 terms
Bone Mineral Homeostasis
Pools of Calcium in serum
Parathyroid hormone
Vitamin D
Calcitonin
40% is protein bound... 10% is complexed... 50% is ionized... Ionized…
Produced from the parathyroid gland when there is low serum c…
Vitamin D... -prohormone produced in skin & UV light... - Everythin…
Calcitonin... -principal action is to lower serum calcium and ph…
Pools of Calcium in serum
40% is protein bound... 10% is complexed... 50% is ionized... Ionized…
Parathyroid hormone
Produced from the parathyroid gland when there is low serum c…
47 terms
57 Bone Mineral Homeostasis
PTH
Calcitonin
PTH and kidneys
Calcitonin and kidneys
Inc plasma Ca... Dec plasma P
Dec plasma Ca... Dec plasma P
Inc Ca reabsorption... Dec Ca excretion
Dec Ca reabsorption... Inc Ca excretion
PTH
Inc plasma Ca... Dec plasma P
Calcitonin
Dec plasma Ca... Dec plasma P
11 terms
Bone Mineral Homeostasis, Drugs
Calcitriol
Alendronate
Risedronate
Ibandronate
-Vit. D analog... -Reg. gene transcription via vit. D rec. to in…
-Biphosphonate... -Suppresses the activity of osteoclasts and in…
-Biphosphonate... -Suppresses the activity of osteoclasts and in…
-Biphosphonate... -Suppresses the activity of osteoclasts and in…
Calcitriol
-Vit. D analog... -Reg. gene transcription via vit. D rec. to in…
Alendronate
-Biphosphonate... -Suppresses the activity of osteoclasts and in…
60 terms
Bone Mineral Homeostasis
What is the active form of Vitamin D
Bone Homeostasis can be viewed as a dy…
What cells are responsible for anaboli…
What cells are responsible for catabol…
Calcitriol... Calcium absorption can be increased to as much as…
Anabolic (bone formation) and Catabolic (bone reabsorption) p…
Osteoblasts
Osteoclasts
What is the active form of Vitamin D
Calcitriol... Calcium absorption can be increased to as much as…
Bone Homeostasis can be viewed as a dy…
Anabolic (bone formation) and Catabolic (bone reabsorption) p…
40 terms
drugs for bone mineral homeostasis
bone, GI, kidney
calbindin
duodenum
low bioavailability
3 major sites of calcium homeostasis
inside cells binds free calcium
where calcium is absorbed in the gut
why only 10% of ingested calcium is absorbed
bone, GI, kidney
3 major sites of calcium homeostasis
calbindin
inside cells binds free calcium
16 terms
Pharm - Bone Mineral Homeostasis
LOW mg vs VERY LOW MG and pth... and... high…
Fibroblast growth factor 23... whats it do
teriparatide... drug type... use... ae
denosumab... drug type... use... ae
low mg -- inc pth... very low mg -- DEC PTH... high dose pth -- con…
inhibits calcitriol and phosphate reabsorption
pth analoge... use: pulsatile --> bone formation in osteoporosis…
rankL inhibitor antibody... use: osteoporosis... ae: infections
LOW mg vs VERY LOW MG and pth... and... high…
low mg -- inc pth... very low mg -- DEC PTH... high dose pth -- con…
Fibroblast growth factor 23... whats it do
inhibits calcitriol and phosphate reabsorption
14 terms
Bone Mineral Homeostasis
Alendronate
Raloxifene
Risedronate
Vitamin D
t-Fosamax
t-Evista
t-Actonel
t-Caltrate
Alendronate
t-Fosamax
Raloxifene
t-Evista
44 terms
Pharmacology of bone mineral homeostasis
Calcium uptake is achieved through
Calcium excretion in the urine is regu…
Calcium turnover
Phosphate turnover
Facilitated diffusion throughout the intestine ... Active transp…
PTH- parathyroid hormone ... It is influenced by filtered sodium…
The efficiency of intestinal calcium absorption is inversely…
More than 80% of total body of total body phosphorus is found…
Calcium uptake is achieved through
Facilitated diffusion throughout the intestine ... Active transp…
Calcium excretion in the urine is regu…
PTH- parathyroid hormone ... It is influenced by filtered sodium…
11 terms
Bone Mineral Homeostasis
Bone Physiology
Glucocorticoid-induced Osteoporosis
Calcium
Phosphate
• Osteoblasts - responsible for anabolic activity... • Osteoclas…
• Inhibit osteoblast activity... • Stimulate osteoclast prolifer…
○ Necessary for bone formation... ○ Important for physiologic pr…
Changes in phosphate levels affect plasma calcium levels... • Pa…
Bone Physiology
• Osteoblasts - responsible for anabolic activity... • Osteoclas…
Glucocorticoid-induced Osteoporosis
• Inhibit osteoblast activity... • Stimulate osteoclast prolifer…
60 terms
Bone Mineral Homeostasis
What is the active form of Vitamin D
Bone Homeostasis can be viewed as a dy…
What cells are responsible for anaboli…
What cells are responsible for catabol…
Calcitriol... Calcium absorption can be increased to as much as…
Anabolic (bone formation) and Catabolic (bone reabsorption) p…
Osteoblasts
Osteoclasts
What is the active form of Vitamin D
Calcitriol... Calcium absorption can be increased to as much as…
Bone Homeostasis can be viewed as a dy…
Anabolic (bone formation) and Catabolic (bone reabsorption) p…
35 terms
Bone Mineral Homeostasis Pharmacology
Osteoporosis
Calcium must be maintained within the…
functions of calcium
parathyroid hormone
loss of normal bone structure and increased fracture suscepti…
8.5 to 10.4 mg/dL
normal conduction of electrical current along nerves, muscle…
acts synergistically with vitamin D
Osteoporosis
loss of normal bone structure and increased fracture suscepti…
Calcium must be maintained within the…
8.5 to 10.4 mg/dL
29 terms
Bone Mineral Homeostasis
Magnesium
Fibroblast Growth Factor-23
Parathyroid Hormone (PTH)
Teriparatide... PTH
Magnesium... -Moderate Decline in Mg-> Enhances PTH secretion... -…
Fibroblast Growth Factor -23... -Produced by Osteoblast and Oste…
Parathyroid Hormone (PTH) ... Parathyroid Hormone (PTH) mech:... -…
Teriparatide... -PTH Recombinant ... Teriparatide Clinical Use:... -P…
Magnesium
Magnesium... -Moderate Decline in Mg-> Enhances PTH secretion... -…
Fibroblast Growth Factor-23
Fibroblast Growth Factor -23... -Produced by Osteoblast and Oste…
22 terms
Bone Mineral Homeostasis Drugs
Raloxifene
Alendronate
Ibandronate
Pamidronate
- SERM used in treatment and prevention of osteoporosis... -Decr…
- Bisphosphonate used to treat osteoporosis and Paget's... - Onc…
- Bisposphonate used to treat osteoporosis and Paget's ... - Onc…
-Bisphosphonate... -Treats hypercalcemia of malignancy ... - Given…
Raloxifene
- SERM used in treatment and prevention of osteoporosis... -Decr…
Alendronate
- Bisphosphonate used to treat osteoporosis and Paget's... - Onc…
59 terms
Pharm Bone Mineral Homeostasis
**Q: 62 y/o postmenopausal woman has s…
normal plasma range of calcium
hormone responsible for activation of…
cell type that synthesizes bone matrix…
prednisone
9-11 mg/dL
PTH
osteoblasts... osteoclasts
**Q: 62 y/o postmenopausal woman has s…
prednisone
normal plasma range of calcium
9-11 mg/dL
44 terms
Bone Mineral Homeostasis
Magnesium and PTH
reasons for Magnesium decrease
PTH MOA
PTH bone effects
moderate decline--enhance PTH secretion... Severe decline--decre…
chronic diarrhea, diuretic alcohol abuse, ... chronic PPI and am…
increases osteoclast and blast activity via ligand RANKL (TNF…
continuous high levels--subperiosteal bone resorption... low dos…
Magnesium and PTH
moderate decline--enhance PTH secretion... Severe decline--decre…
reasons for Magnesium decrease
chronic diarrhea, diuretic alcohol abuse, ... chronic PPI and am…
31 terms
Bone Mineral Homeostasis
Bone Mineral Homeostasis Basics
Parathyroid Hormone Function
Vitamin D Function
Calcitonin Function
involves multiple systems and cells types:... GI Tract for abs…
promotes release of Ca2+ and PO4 into extracellular fluid... sti…
increases GI absorption of Ca2+ and PO4... augments bone mineral…
released in response to hypercalcemia state... inhibits osteocla…
Bone Mineral Homeostasis Basics
involves multiple systems and cells types:... GI Tract for abs…
Parathyroid Hormone Function
promotes release of Ca2+ and PO4 into extracellular fluid... sti…
Bone Mineral Homeostasis
What is the effect of a moderate decli…
What is the effect of severe decrease…
What are some common causes of lowered…
What is the reaction in the liver that…
Increase PTH secretion
Decrease PTH secretion
- Chronic diarrhea... - Diuretics... - Alcohol abuse ... - Chronic PPI…
Cholecalciferol (Vit. D3) to 25-hydroxyvitamin D3, via 25 hyd…
What is the effect of a moderate decli…
Increase PTH secretion
What is the effect of severe decrease…
Decrease PTH secretion
13 terms
Pharm: Bone Mineral Homeostasis
for emergency use in severe muscle spa…
emergency vitamin D to treat low calcium
PTH (three letters, 6 actions)
vitamin D (two primary, one secondary)
calcium salts -->
calcitrol
1) increases Ca and Phosphate reabsorption in kidneys 2) calc…
primary: increases calcium reabsorption from gut, decreases e…
for emergency use in severe muscle spa…
calcium salts -->
emergency vitamin D to treat low calcium
calcitrol
42 terms
Bone Mineral Homeostasis (Fandy)
FGF23
OsteoCYTEs
OsteoBLASTs
OsteoCLASTs
-Produced/secreted by osteoBLASTs... *stimulated by CALCITRIOL…
"Inactive" cells... -small + isolated
Bone "building" cells... -small/cuboidal
Bone "catabolizing" cells... -large cells with multiple nuclei
FGF23
-Produced/secreted by osteoBLASTs... *stimulated by CALCITRIOL…
OsteoCYTEs
"Inactive" cells... -small + isolated
Bone Mineral Homeostasis
Adverse effects if have hypocalcemia
Adverse effects if have hypercalcemia
What is diffusible calcium?
What are the three pools of Ca in serum?
tetany ... paraesthesias... muscle cramps... osteoporosis... convulsions…
muscle weakness... CNS depression... coma ... calcium nephrolithiasis
transfer between serum and cell membrane
protein bound... complexed... ionized
Adverse effects if have hypocalcemia
tetany ... paraesthesias... muscle cramps... osteoporosis... convulsions…
Adverse effects if have hypercalcemia
muscle weakness... CNS depression... coma ... calcium nephrolithiasis
13 terms
bone mineral homeostasis
PTH-GI tract
PTH-Kidney
PTH-Bone
Vitamin D-GI tract
↑ Ca2+ absorption via vitamin D action,↑ [Ca2+] ↓ [Pi]
↑ Ca2+ reabsorption; ↓ Pi reabsorption, ↑ [Ca2+] ↓ [Pi]
↑ Osteoclast activity (continuous PTH)(↓ Bone mass),... ↑ Osteob…
↑ Ca2+ and Pi absorption, ↑ [Ca2+] ↑ [Pi]
PTH-GI tract
↑ Ca2+ absorption via vitamin D action,↑ [Ca2+] ↓ [Pi]
PTH-Kidney
↑ Ca2+ reabsorption; ↓ Pi reabsorption, ↑ [Ca2+] ↓ [Pi]
40 terms
Bone Mineral Homeostasis - Ooi
what is Rickets caused by?
what treatment is used for Rickets
what enzyme coverts Vitamin D3 to the…
What controls the expression of CYP27B1?
Vitamin D deficiency
UV exposure -- synthesizes vitamin D
CYP27B1 ... kidney ... calcitriol = 1,25(OH)2D3
parathyroid hormone (PTH)
what is Rickets caused by?
Vitamin D deficiency
what treatment is used for Rickets
UV exposure -- synthesizes vitamin D
38 terms
Bone Mineral Homeostasis
Magnesium
Fibroblast growth factor 23
PTH
Teriparatide
• moderate decline in Mg: enhances PTH secretion... • severe dec…
• produced by osteoblasts & osteoclasts... • inhibits calcitriol…
• increases both osteoclast and osteoblast activity in bone v…
recombinant PTH analog... • pulsatile doses stimulate bone forma…
Magnesium
• moderate decline in Mg: enhances PTH secretion... • severe dec…
Fibroblast growth factor 23
• produced by osteoblasts & osteoclasts... • inhibits calcitriol…
20 terms
Bone Mineral Homeostasis
Abnormalities in bone mineral homeosta…
Principal Regulators
Parathyroid Hormone
Vitamin D
-tetany... -coma... -muscle weakness... -osteoporosis with fractures... -…
peptide, parathyroid hormone (PTH) and steroid, vitamin D
-regulates calcium and phosphate flux across cell membranes i…
net effect is to increase both serum calcium and phosphate
Abnormalities in bone mineral homeosta…
-tetany... -coma... -muscle weakness... -osteoporosis with fractures... -…
Principal Regulators
peptide, parathyroid hormone (PTH) and steroid, vitamin D
12 terms
Bone Mineral Homeostasis Agents
Parathyroid hormone
calcitriol
calcitonin
estrogens
enhances bone formation and resorption. Net effect is increas…
vitamin D. targets are intestine, bone, and kidney. stimulate…
lowers serum calcium and phosphate by reducing bone resorptio…
inhibit bone-resorbing action of PTH, preventing accelerated…
Parathyroid hormone
enhances bone formation and resorption. Net effect is increas…
calcitriol
vitamin D. targets are intestine, bone, and kidney. stimulate…
31 terms
Pharma - bone mineral homeostasis
Teriparatide
Teriparatide
Sevelamer
Deferoxamine
Recombinant of PTH 1-34
Treatments for osteoporosis by new bone formation
A gel rx for hyperphosphatemia
Chelates iron for the treatment of chronic kidney disease
Teriparatide
Recombinant of PTH 1-34
Teriparatide
Treatments for osteoporosis by new bone formation
38 terms
Bone Mineral Homeostasis
Magnesium
Fibroblast growth factor 3
PTH
Teriparatide
• moderate decline in Mg: enhances PTH secretion... • severe dec…
• produced by osteoblasts & osteoclasts... • inhibits calcitriol…
• increases both osteoclast and osteoblast activity in bone v…
recombinant PTH analog... • pulsatile doses stimulate bone forma…
Magnesium
• moderate decline in Mg: enhances PTH secretion... • severe dec…
Fibroblast growth factor 3
• produced by osteoblasts & osteoclasts... • inhibits calcitriol…
25 terms
Bone Mineral Homeostasis
Calcium sensing membrane on __________…
Parathyroid hormone (PTH) is released…
PTH - Action and Effects 1
PTH - Action and Effects 2
Parathyroid gland
There is a decrease in serum Ca2+
Increases serum Ca2+ and decreases PO4-
Ca2+ transfers from bone to blood increasing absorption in in…
Calcium sensing membrane on __________…
Parathyroid gland
Parathyroid hormone (PTH) is released…
There is a decrease in serum Ca2+
16 terms
Pharm - Bone Mineral Homeostasis
LOW mg vs VERY LOW MG and pth... and... high…
Fibroblast growth factor 23... whats it do
teriparatide... drug type... use... ae
denosumab... drug type... use... ae
low mg -- inc pth... very low mg -- DEC PTH... high dose pth -- con…
inhibits calcitriol and phosphate reabsorption
pth analoge... use: pulsatile --> bone formation in osteoporosis…
rankL inhibitor antibody... use: osteoporosis... ae: infections
LOW mg vs VERY LOW MG and pth... and... high…
low mg -- inc pth... very low mg -- DEC PTH... high dose pth -- con…
Fibroblast growth factor 23... whats it do
inhibits calcitriol and phosphate reabsorption
30 terms
39. Bone mineral homeostasis
Increase Calcium... Decrease Phosphate
Decrease Calcium... Decrease Phosphate
Increase Calcium... Increase Phosphate
RANKL
Effect of PTH
Effect of Calcitonin
Effect of Activated vit. D (1,25-dihydroxycholecalciferol)
PTH increases activity of osteoclasts and osteoblasts via ____?
Increase Calcium... Decrease Phosphate
Effect of PTH
Decrease Calcium... Decrease Phosphate
Effect of Calcitonin
30 terms
Mineral bone homeostasis drugs
Biphosphonates MOA
Biphosphonates MOA... Second generation
Biphosphonates Uses
Biphosphonates First generation agents
1. Binds to Ca2+ in bone... OC releases acid which displaces bip…
Block enzyme farnesyl pyrophosphate synthase... Prevents G-prote…
Osteoporosis... Peridontal disease... Malignant hypercalcemia... Paget…
Etidronate
Biphosphonates MOA
1. Binds to Ca2+ in bone... OC releases acid which displaces bip…
Biphosphonates MOA... Second generation
Block enzyme farnesyl pyrophosphate synthase... Prevents G-prote…
10 terms
Bone Mineral Homeostasis
Osteoblasts
Osteoclasts
Osteocytes
Glucocorticoid-induced osteoporosis
Responsible for anabolic activity
Responsible for catabolic activity
Storage of Calcium and bone repair
1) Inhibit osteoblast activity... 2) Stimulate osteoclast prolif…
Osteoblasts
Responsible for anabolic activity
Osteoclasts
Responsible for catabolic activity
47 terms
6 - bone mineral homeostasis
homeostasis vs balance... which one is i…
osteoclast vs osteoblasts
2 major mineral constituents of bone c…
what percent of calcium exists in crys…
homeostatsis (immediate)... .....adjustments required to maintai…
osteoclasts remove/destroy bone matrix... osteoblasts produce/b…
calcium and phosphate
99% (skeleton and teeth)... 1% in free/active form
homeostasis vs balance... which one is i…
homeostatsis (immediate)... .....adjustments required to maintai…
osteoclast vs osteoblasts
osteoclasts remove/destroy bone matrix... osteoblasts produce/b…
90 terms
Adrenocorticoids and Bone/Mineral Homeostasis
Function of Glucocorticoids
Function of Mineralcorticoids
Define Addison's disease
Cushing's Syndrome is caused by an ade…
Effect intermediary metabolism, catabolism, immune responses,…
Regulate sodium and potassium re-absorption in the collecting…
Adrenal Cortical Insufficiency.... Partial or complete loss of a…
Adenoma is in the pituitary that secretes ACTH. This leads to…
Function of Glucocorticoids
Effect intermediary metabolism, catabolism, immune responses,…
Function of Mineralcorticoids
Regulate sodium and potassium re-absorption in the collecting…
Bone Mineral Homeostasis
More than 99% of calcium is stored in…
Calcium is stored as _____.
Extracellular calcium is essential for…
Calcium enters the body mainly though…
Bones and teeth
hydroxyapatite (crystalline form)
blood coagulation and skeleton remodeling
the intestines
More than 99% of calcium is stored in…
Bones and teeth
Calcium is stored as _____.
hydroxyapatite (crystalline form)
40 terms
Bone Mineral Homeostasis
Increases the reabsorption of calcium…
Decreases the reabsorption of calcium…
A moderate decline in magnesium levels…
Chronic diarrhea, diuretics and alcoho…
What is the effect of PTH on phosphate and calcium reabsorpti…
What is the effect of calcitonin on phosphate and calcium rea…
How do magnesium levels affect the secretion of PTH?
Name some conditions that cause a decrease in magnesium levels.
Increases the reabsorption of calcium…
What is the effect of PTH on phosphate and calcium reabsorpti…
Decreases the reabsorption of calcium…
What is the effect of calcitonin on phosphate and calcium rea…
Bone Mineral Homeostasis
What is the active form of Vitamin D
Bone Homeostasis can be viewed as a dy…
What cells are responsible for anaboli…
What cells are responsible for catabol…
Calcitriol... Calcium absorption can be increased to as much as…
Anabolic (bone formation) and Catabolic (bone reabsorption) p…
Osteoblasts
Osteoclasts
What is the active form of Vitamin D
Calcitriol... Calcium absorption can be increased to as much as…
Bone Homeostasis can be viewed as a dy…
Anabolic (bone formation) and Catabolic (bone reabsorption) p…
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