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Study sets matching "human T cell leukemia virus 1"

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Study sets matching "human T cell leukemia virus 1"

19 terms
Human T Cell Leukemia Virus: HTLV
_______: first isolated from a lesion…
_____: isolated from the blood of a pa…
_____: Isolated from the blood of a pa…
_____: Isolated from blood of healthy…
HTLV-1
HTLV-2
HTLV-3/LAV
STLV-3/HIV-2
_______: first isolated from a lesion…
HTLV-1
_____: isolated from the blood of a pa…
HTLV-2
Human T cell lymphotropic virus (HTLV1)
What nonstructural proteins are essent…
Where do you find HTLV-1? (2)
How is HTLV-1 transmitted? (3)
Are cell free HTLV-1 viruses infectious?
- Tax= for replication... - HBZ
- Caribbean basin... - SW Japan
- STD... - mother to child... - blood... - aka: cell-cell contact
no, need cell-to-cell contact
What nonstructural proteins are essent…
- Tax= for replication... - HBZ
Where do you find HTLV-1? (2)
- Caribbean basin... - SW Japan
44 terms
Human T Cell Lymphotrophic Virus
How many people are infected worldwide…
HTLV is transmitted through what?
T/F: HTLV-1 is situated in third-world…
Can HTLV be transmitted through transp…
20 million
sexual contact, ... breastfeeding, ... blood transfusions, ... IV drug…
True
It is very rare!
How many people are infected worldwide…
20 million
HTLV is transmitted through what?
sexual contact, ... breastfeeding, ... blood transfusions, ... IV drug…
15 terms
Retrovirus: Human T cell Lymphotropic Virus
What are the forms of Human T cell Lym…
What strain of HTLV is associated with…
What strain of HTLV is associated with…
What is the HTLV 1 oncogenic transform…
1. HTLV 1 --> causative agent of Adult T cell Leukemia (ATL,…
HTLV 1
HTLV 1
1. HTLV 1 encodes TAX gene; a trans activator of transcriptio…
What are the forms of Human T cell Lym…
1. HTLV 1 --> causative agent of Adult T cell Leukemia (ATL,…
What strain of HTLV is associated with…
HTLV 1
15 terms
Retrovirus: Human T cell Lymphotropic Virus
What are the forms of Human T cell Lym…
What strain of HTLV is associated with…
What strain of HTLV is associated with…
What is the HTLV 1 oncogenic transform…
1. HTLV 1 --> causative agent of Adult T cell Leukemia (ATL,…
HTLV 1
HTLV 1
1. HTLV 1 encodes TAX gene; a trans activator of transcriptio…
What are the forms of Human T cell Lym…
1. HTLV 1 --> causative agent of Adult T cell Leukemia (ATL,…
What strain of HTLV is associated with…
HTLV 1
Human Blood Cells and Leukemia (Lesson 1)
the liquid part of your blood is appro…
(research) what are some nutrients tha…
how would you define "nutrient"?
The 3 main types of blood cells are:
90
iron, oxygen, minerals, water, zinc, fats, proteins
A substance that provides nourishment essential for growth an…
1. red blood cells... 2. white blood cells... 3. platelets
the liquid part of your blood is appro…
90
(research) what are some nutrients tha…
iron, oxygen, minerals, water, zinc, fats, proteins
21 terms
human blood cells and leukemia (lesson 1)
the liquid part of your blood is appro…
(research) what are some nutrients tha…
how would you define "nutrient"?
The 3 main types of blood cells are:
90
iron, oxygen, minerals, water, zinc, fats, proteins
A substance that provides nourishment essential for growth an…
1. red blood cells... 2. white blood cells... 3. platelets
the liquid part of your blood is appro…
90
(research) what are some nutrients tha…
iron, oxygen, minerals, water, zinc, fats, proteins
18 terms
4.1 Human T-Lymphotropic Virus type 1
Learning objectives
HTLV-1: common diseases
Adult T cell leukemia-lymphoma (ATL) c…
HTLV-1-associated myelopathy (HAM)* pa…
Describe disease manifestations, transmission, basic epidemio…
Adult T cell leukemia-lymphoma (ATL)... HTLV-1-associated myelop…
A generalized eruption of small, confluent violaceous papules…
history of spastic paraparesis showing brain white matter abn…
Learning objectives
Describe disease manifestations, transmission, basic epidemio…
HTLV-1: common diseases
Adult T cell leukemia-lymphoma (ATL)... HTLV-1-associated myelop…
17 terms
Chronic leukemia (path)
Chronic leukemia is a proliferation of…
Classic picture of chronic leukemia
Chronic lymphocytic leukemia - cell ty…
Peripheral smear in chronic lymphocyti…
Mature lymphocytes... Neoplastic proliferation of circulating ma…
Insidious onset... Older adults... -can live a very long time w/ th…
Naive B-cells... CD 5 & CD 20... -CD 5 normally only on T cells,…
Increased lymphocytes & smudge cells
Chronic leukemia is a proliferation of…
Mature lymphocytes... Neoplastic proliferation of circulating ma…
Classic picture of chronic leukemia
Insidious onset... Older adults... -can live a very long time w/ th…
13 terms
Virus
Virus
Pathogen/Antigen
Lytic Cycle
Glycoprotein
Nonliving, requires a host to reproduce and survive
Any type of harmful agent that can cause illness
Viral Replication process which ends in cell destruction
Structures that aid in attachment of virus to healthy cells
Virus
Nonliving, requires a host to reproduce and survive
Pathogen/Antigen
Any type of harmful agent that can cause illness
82 terms
FA/B&W: HUMAN IMMUNODEFICIENCY VIRUS (HIV)
A retrovirus that targets and destroys…
How is the CD4+ count used in AIDS Tx?
How is the viral load used in AIDS Tx?
What is used to indicate whether tx is…
HIV
1. Indicates the degree of immunosuppression, ... 2. Guides ther…
1. Indicates rate of disease progression ... 2. *Indications f…
The viral load
A retrovirus that targets and destroys…
HIV
How is the CD4+ count used in AIDS Tx?
1. Indicates the degree of immunosuppression, ... 2. Guides ther…
125 terms
Leukemia
Lymphoma
Leukemia
Plasma cell neoplasms
Genetic causes of Lymphoid neoplasms
-Malignant tumor of lymphoid tissue with discrete mass
-Malignant neoplasm of hematopoietic stem cells in BM... -Accumu…
-Tumors of terminally differentiated B-cells
-Chromosomal translocations that activate oncogenes... -Blooms,…
Lymphoma
-Malignant tumor of lymphoid tissue with discrete mass
Leukemia
-Malignant neoplasm of hematopoietic stem cells in BM... -Accumu…
8 terms
Viruses and Human Cancers Extra Credit
Human T cell Leukemia Virus Type 1
Epstein-Barr virus
Epstein-Barr virus
Human herpesvirus 8
Adult T-cell leukemia
Burkett's lymphoma
nasophayngeal carcinoma
Kaposi's sarcoma
Human T cell Leukemia Virus Type 1
Adult T-cell leukemia
Epstein-Barr virus
Burkett's lymphoma
8 terms
Extra Credit
Human T cell Leukemia Virus Type 1
Epstein-Barr Virus
Epstein-Barr Virus
Human herpesvirus 8
Adult T cell leukemia
Burkett's lymphoma
Nasopharyngeal carcinoma
Kaposi's sarcoma
Human T cell Leukemia Virus Type 1
Adult T cell leukemia
Epstein-Barr Virus
Burkett's lymphoma
82 terms
Leukemia
What is leukemia?
What age groups are affected by leukem…
Why does leukemia occur?
If leukemia is untreated what occurs?
General term to describe a group of malignant disorders affec…
All age groups
It results in an accumulation of dysfunctional cells because…
Death
What is leukemia?
General term to describe a group of malignant disorders affec…
What age groups are affected by leukem…
All age groups
Cells
Cell
Cell membrane
Cell walls
Cytoplasm
The smallest part of anything living
Surrounds a cell holding the parts of the cell together. Allo…
Surround the cell membrane stiff give plant extra support and…
All the material of the cell between the cell membrane and th…
Cell
The smallest part of anything living
Cell membrane
Surrounds a cell holding the parts of the cell together. Allo…
14 terms
1: T-Cell Neoplasms
Peripheral T-cell Lymphoma- Not Otherw…
Angioimmunoblastic T-Cell Lymphoma (AI…
Hepatosplenic T Cell Lymphoma
Enteropathy Associated T-Cell Lymphoma
Clinical: Lymphadenopathy, Fevers, night sweats, weight loss.…
Clinical: subtype of PTCL with similiar characteristics, caus…
Clinical: occurs in young males, massive hepatosplenomegaly,…
Clinical: strongly associated with Celiacs, ulcerative masses…
Peripheral T-cell Lymphoma- Not Otherw…
Clinical: Lymphadenopathy, Fevers, night sweats, weight loss.…
Angioimmunoblastic T-Cell Lymphoma (AI…
Clinical: subtype of PTCL with similiar characteristics, caus…
122 terms
leukemia
myeoloid stem cells become
myeloid progenitor leukemias
how does a bone marrow stem cell becom…
what will you see on smear of an acute…
RBC... granulocytes
acute myeloid leukemias... myeloproliferative neoplasms... myelodys…
-there is an early hematopoietic precursor event... -fails to di…
blasts on smear
myeoloid stem cells become
RBC... granulocytes
myeloid progenitor leukemias
acute myeloid leukemias... myeloproliferative neoplasms... myelodys…
20 terms
Cells
osmosis
hypertonic
hypotonic
isotonic
Diffusion of water across a membrane
Having greater concentration of solute than another solution
Having a lower concentration of solute than another solution
Having the same solute concentration as another solution.
osmosis
Diffusion of water across a membrane
hypertonic
Having greater concentration of solute than another solution
119 terms
Leukemia
What are the myeloid neoplasms?
What do lymphoid neoplasms develop into?
Types of leukemias?
Pathopys of leukemia?
Acute myeloid leukemias (AML)... Myeloproliferative neoplasms (M…
Precursors normally develop into T or B lymphocytes
ALL - acute lymphocytic leukemia... AML - acute myelogenous leuk…
1. Early hematopoietic precursor event... 2. Failure to differen…
What are the myeloid neoplasms?
Acute myeloid leukemias (AML)... Myeloproliferative neoplasms (M…
What do lymphoid neoplasms develop into?
Precursors normally develop into T or B lymphocytes
16 terms
C&T: Plasma (Cell) Membranes
What does a cell look like?
Can you point out the different organe…
What do all cells have in common?
What is a plasma membrane?
Function determines appearance
They all have a plasma membrane.
Controls passage of material into and out of cell.... It acts a…
What does a cell look like?
Function determines appearance
Can you point out the different organe…
26 terms
leukemia 1
how do you diagnose lymphoma
how do you diagnose leukemia
plasma cell neoplasmas
causes of lymphoid neoplasms
via biopsy
via bone marrow biopsy
mutliple myeloma... tumors of terminally differentiated B cells…
genetic... - chromosome translocations and oncogenes ... - inherite…
how do you diagnose lymphoma
via biopsy
how do you diagnose leukemia
via bone marrow biopsy
41 terms
Leukemia
Acute leukemia
20%
Chronic leukemia
11q23 (MLL)
Blasts cannot mature... -*20% of nucleated cells in blood/marrow…
Percentage of blasts needed to diagnose as acute leukemia
Survival for years... -gradual onset... Cells reach full maturation
Chromosomal abnormality with poor prognosis... Histone modifying…
Acute leukemia
Blasts cannot mature... -*20% of nucleated cells in blood/marrow…
20%
Percentage of blasts needed to diagnose as acute leukemia
42 terms
Human Anatomy Chapter 18 Blood
Blood
Plasma
Albumin
Fibrinogen
-Has red/white blood cells and platelets. Suspended in plasma…
Dissolved solute with 3 types of proteins: Albumin, Fibrinoge…
Aids in maintaining osmotic pressure. Most common solute in p…
Needed for clot formation. Least common in plasma.
Blood
-Has red/white blood cells and platelets. Suspended in plasma…
Plasma
Dissolved solute with 3 types of proteins: Albumin, Fibrinoge…
12 terms
Leukemia
Leukemia
Disease Process
Classifications of leukemia
Acute Leukemia
malignant disorder of blood cells and the lymphatic tissue, m…
Malignant blood cells excessively proliferate in the bone mar…
Acute vs Chronic... Myeloid vs lymphoid
Characterized by excessive proliferation of immature blast ce…
Leukemia
malignant disorder of blood cells and the lymphatic tissue, m…
Disease Process
Malignant blood cells excessively proliferate in the bone mar…
24 terms
Pathology: Leukemia 1
Blast count in bone marrow > 20% is in…
Blast count in bone marrow < 20% is in…
Age Brackets:... 1. Acute Lymphoblastic…
General Features of Leukemia / Bone ma…
Acute Leukemia
Chronic Leukemia
1. New born to 14 yrs... 2.15-39 yrs... 3. 40-60 yrs... 4. >60 yrs
1. Anemia... 2. Fever... 3. Bleeding
Blast count in bone marrow > 20% is in…
Acute Leukemia
Blast count in bone marrow < 20% is in…
Chronic Leukemia
36 terms
Leukemia 1
Leukemia what are signs and symptoms s…
What happens in Leukemia
What will peripheral Blood smear Of Ac…
Acute Leukemia ... what is happening... w…
BM infiltration... Hepatoslpenomegaly... Lymphoma: ... Enlarging mass…
Group of malignant disorders of hematopoietic precursor cells…
Blasts (acute leukemia 2 types AML and ALL). AML is mylogenou…
Malignant cells fail to differentiate into normal mature cell…
Leukemia what are signs and symptoms s…
BM infiltration... Hepatoslpenomegaly... Lymphoma: ... Enlarging mass…
What happens in Leukemia
Group of malignant disorders of hematopoietic precursor cells…
142 terms
leukemia 1
usually a result of decreased numbers…
advanced HIV infection... glucocorticoid…
worrisome
what is leukopenia usually caused by (low neutrophils or low…
what are some common times when leukopenia is observed
neutrophil counts less than 1000 are indicative of ___
usually a result of decreased numbers…
what is leukopenia usually caused by (low neutrophils or low…
advanced HIV infection... glucocorticoid…
what are some common times when leukopenia is observed
17 terms
Cell Model
Cell Membrane
Centrioles
Centresome
Chromatin
Cell Membrane
Centrioles
17 terms
Bio ch 19 virus
Retrovirus
Prion
Protein coat
Spike
A virus that contains RNA as its geneic material
Infectious particle made only of mis folded protein
Surrounds the core of a viral particles
Proteins that stick out of the surface of a viral particle
Retrovirus
A virus that contains RNA as its geneic material
Prion
Infectious particle made only of mis folded protein
61 terms
Leukemia
What is leukemia
Types of leukemia
What mature cells do the lymphoid prog…
What mature cells do the myeloid proge…
This a cancer of haematopoietic cells usually associated with…
Acute lymphoblastic leukemia ... Acute myeloid leukemia ... Chronic…
T cells ... B cells which become plasma cells
Neutrophils... Basophils... Eosinophils... Monocytes... Platelets (megaka…
What is leukemia
This a cancer of haematopoietic cells usually associated with…
Types of leukemia
Acute lymphoblastic leukemia ... Acute myeloid leukemia ... Chronic…
8 terms
Human Immunodeficiency Virus- 1
Retrovirus Groups
Drug Targets
Stages of Infection
Consequences of Rapid Evolution
Mammalian type C - murine leukemia virus... Lentivirus - HIV, SI…
Attachment/Uncoating inhibitors... Fusion Inhibitors... Reverse Tra…
Acute- 2-3 months of flu like symptoms... Chronic - latency, sym…
Drug resistance... Change in receptor from CCR5 of macrophages t…
Retrovirus Groups
Mammalian type C - murine leukemia virus... Lentivirus - HIV, SI…
Drug Targets
Attachment/Uncoating inhibitors... Fusion Inhibitors... Reverse Tra…
28 terms
Hematology-Intro to leukemias
Aleukemic leukemia
Lymphoma
Neoplasm
cancerous
Abnormal cells found in bone marrow and not in peripheral blood
Abnormal proliferation of lymphoid cells within the lymphatic…
growth of abnormal tissue such as a tumor
invasive growth that spreads destructively
Aleukemic leukemia
Abnormal cells found in bone marrow and not in peripheral blood
Lymphoma
Abnormal proliferation of lymphoid cells within the lymphatic…
25 terms
NCD 1 - Leukemia and Lymphoma
Essential Thrombocythemia
Leukocytosis
Lymphopenia
Eosinophilia
60yo patient comes to your office. He complains of headaches,…
Increase in white cells
decrease in lymphocyte
increase in eosinophils
Essential Thrombocythemia
60yo patient comes to your office. He complains of headaches,…
Leukocytosis
Increase in white cells
25 terms
Leukemia
Chronic Myeloproliferative Neoplasms
Chronic Myelogenous Leukemia
Which therapy do you use for CML?
Polycythemia Vera
Chronic myelogenous leukemia... polycythemia vera... primary myelof…
decreased LAP score... defined by bcl-abl gene rearrangement; t(…
Imatinib ... - occupies the binding pocket of the Abl Kinase dom…
increase in erythrocytes ... JAK2 mutation... decreased serum EPO... i…
Chronic Myeloproliferative Neoplasms
Chronic myelogenous leukemia... polycythemia vera... primary myelof…
Chronic Myelogenous Leukemia
decreased LAP score... defined by bcl-abl gene rearrangement; t(…
26 terms
Human Immunodeficiency Virus (Retroviruses)
Describe the characteristics and struc…
Name the retroviruses associated with…
HTLV-2: primary clinical manifestation…
HTLV-1 primary clinical manifestations…
Retroviruses are enveloped, single stranded (+) RNA viruses t…
Deltaretrovirus Complex Human T cell Leukemia (HTLV)... Lentivir…
Closely related to HTLV-1 and transmitted by similar manner... A…
Myelopathies "Tropical spastic paraparesis"... Inflammation, spi…
Describe the characteristics and struc…
Retroviruses are enveloped, single stranded (+) RNA viruses t…
Name the retroviruses associated with…
Deltaretrovirus Complex Human T cell Leukemia (HTLV)... Lentivir…
73 terms
Onc 1 Acute Leukemia
leukemia... -what is it
leukemia is caused by
myeloid stem cells differentiate into
lymphoid stem cells differntieate into
-malignant condition affecting the immature blood forming cel…
deffective maturation or differentiation of the two types of…
-white blood cells... -red blood cells... -platelets
two different lymphocytes... -T cells... -B cells
leukemia... -what is it
-malignant condition affecting the immature blood forming cel…
leukemia is caused by
deffective maturation or differentiation of the two types of…
21 terms
Virus
EBV(binding)
HIV binding
Replication
ParvoVirus
EBV binds to C3d receptor (CR2) on human B cells
HIV binds to CD4 & chemokine receptors on CD4+ T cells and ma…
DNA virus replicate in nucleus (HBV has reverse trasncriptase…
TOO small to encode own DNA polymerase; depends on rapidly gr…
EBV(binding)
EBV binds to C3d receptor (CR2) on human B cells
HIV binding
HIV binds to CD4 & chemokine receptors on CD4+ T cells and ma…
17 terms
Chronic Leukemia
Chronic Leukemia
Chronic Lymphocytic Leukemia (CLL) aka…
CLL Histology
CLL Treatment
proliferation of MATURE lymphocytes (as opposed to immature i…
chronic proliferation of immunoINCOMPETENT naive b cells... CD5…
smudge cells are granular amorphic cells.... more lymphocytes t…
usually just observe if its in the early stages... indications…
Chronic Leukemia
proliferation of MATURE lymphocytes (as opposed to immature i…
Chronic Lymphocytic Leukemia (CLL) aka…
chronic proliferation of immunoINCOMPETENT naive b cells... CD5…
105 terms
Acute Leukemia
leukemia
lymphoma
acute in terms of leukemias
why is leukemia bad
progressive malignant disease of blood-FORMING organs... prolife…
neoplastic disorder of the lymphoid tissue
immature... WBCs ar the earlier stages of differentiation
causes an arrest in development of an entire cell lineage. ... p…
leukemia
progressive malignant disease of blood-FORMING organs... prolife…
lymphoma
neoplastic disorder of the lymphoid tissue
41 terms
Human immunodeficiency virus (HIV)
HIV
HIV-1
Group M (major)
Group O (oulier)
Retrovirus family; lentivirus genus... RNA; enveloped... replicat…
responsible for most cases of AIDS in the US... crossed the spe…
-subtypes (clades A-J) -- genomes are >25% unique... -circulatin…
West central Africa; very few cases in US
HIV
Retrovirus family; lentivirus genus... RNA; enveloped... replicat…
HIV-1
responsible for most cases of AIDS in the US... crossed the spe…
84 terms
Patho: Hematologic Dz Part 2
Leukemia Acute Diseases
Leukemia Chronic Diseases
Infectious mononucleosis Patho
Infectious mononucleosis Classic Triad
Acute lymphocytic leukemia (ALL)... Acute myelogenous leukemia (…
Chronic lymphocytic leukemia (CLL)... Chronic Myelogenous Leukem…
Acute neoplastic lymphoproliferative syndrome (non-cancerous)…
1. pharyngitis... 2. lymphadenopathy... 3. fever... "flu like s/s"
Leukemia Acute Diseases
Acute lymphocytic leukemia (ALL)... Acute myelogenous leukemia (…
Leukemia Chronic Diseases
Chronic lymphocytic leukemia (CLL)... Chronic Myelogenous Leukem…
42 terms
Path Leukemia,Lymphoma I-Campbell
Malignancy of hematopoietic cells (lym…
Malignancy of hematopoietic cells of l…
Target DNA is unmasked. Complimentary…
associated with ineffective hematopoie…
Leukemia
Lymphoma
FISH
Myelodysplastic syndromes
Malignancy of hematopoietic cells (lym…
Leukemia
Malignancy of hematopoietic cells of l…
Lymphoma
31 terms
Week 1 Thursday: T cell mediated Immunity
Overview
importance of memory
Activation of naive T cells
activated T cells
basis of secondary responses:... accelerated... heightened... occur b…
requires recognition and second signal:... B7-1 and 2 to CD28... i…
once initial activation, T cells no longer need 2nd signal to…
Overview
importance of memory
basis of secondary responses:... accelerated... heightened... occur b…
64 terms
Combo with "Chronic myeloid leukemia" and 9 others
What chromosome is present in chronic…
What happens to basophils in chronic m…
What is a common drug used for treatin…
What happens to eosinophils in chronic…
The Philadelphia chromosome
They are increased
Gleevec
They are increased
What chromosome is present in chronic…
The Philadelphia chromosome
What happens to basophils in chronic m…
They are increased
16 terms
Identif
Cyclophosphamide
Circumcision
Epstein-Barr Virus
Tobacco
Hematologic Malignant Neoplasm
Penile Ca (HPV) Infection
Nasopharyngeal Cancer
Lung Cancer
Cyclophosphamide
Hematologic Malignant Neoplasm
Circumcision
Penile Ca (HPV) Infection
16 terms
Gen Pathology
Cyclophosphamide
Circumcision
Epstein Barr Virus
Tobaco
Hematologic Malignant Neoplasm
Penile CA Infection
Nasopharyngeal Cancer
Lung cancer
Cyclophosphamide
Hematologic Malignant Neoplasm
Circumcision
Penile CA Infection
37 terms
leukemia 1
Lymphoma
Leukemia
plasma cells neoplasm ... fractures and…
etio-pathogenesis of lymphoid neoplasm
- malignant tumors of lymphoid tissue ... - discrete tissue mass…
- malignant neoplasms of hematopoietic stem cells in BM... - tum…
- tumors of terminally differentiated B-cells ... - origin - bm…
- genetic causes - translocation, oncogene ... - viruses - HTLV-…
Lymphoma
- malignant tumors of lymphoid tissue ... - discrete tissue mass…
Leukemia
- malignant neoplasms of hematopoietic stem cells in BM... - tum…
50 terms
Living Env't (Human Bio) Set 1
active transport
amino acids
cell
cell membrane
the process by which cells use energy (ATP) to transport mole…
the building blocks of proteins
the basic unit of structure and function that makes up all or…
the thin boundary between the cell and its environment; made…
active transport
the process by which cells use energy (ATP) to transport mole…
amino acids
the building blocks of proteins
24 terms
Leukemia
Leukemia
Hematological neoplasms
Lymphoblastic
Myeloid
A type of cancer of the blood or bone marrow, characterized b…
Diseases that affect blood, bone marrow, lymph, or lymphatic…
Lymphocytic leukemia
Myelogenous leukemia
Leukemia
A type of cancer of the blood or bone marrow, characterized b…
Hematological neoplasms
Diseases that affect blood, bone marrow, lymph, or lymphatic…
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