Study sets matching "immunity mucosal"

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Study sets matching "immunity mucosal"

62 terms
Mucosal Immunity
What are 3 examples of mucosal surface…
What is the "challenge" faced by host…
What are 5 examples of benefits derive…
What is an example of non-antigen spec…
1. respiratory tract... 2. intestinal tract... 3. urogenital tract…
to protect the body and clear infection without damaging the…
1. synthesis of essential metabolites (Vit K)... 2. break down p…
stomach acid/low pH/vagina acidity/commensals
What are 3 examples of mucosal surface…
1. respiratory tract... 2. intestinal tract... 3. urogenital tract…
What is the "challenge" faced by host…
to protect the body and clear infection without damaging the…
Mucosal Immunity
Tolerance in Gut maintained by
Immunity in Gut
Type I mucosal surfaces
Type II mucosal surfaces
When only receive Bacterial PAMPs signal.... TH3: TGF-beta, IL-1…
When receive both Bacterial PAMPs sig and inflammatory cytoki…
MALT (mucosal associated lymphoid tissue). Simple tissue. Not…
stratified epithelium, no MALT, drainage directly to lymphnod…
Tolerance in Gut maintained by
When only receive Bacterial PAMPs signal.... TH3: TGF-beta, IL-1…
Immunity in Gut
When receive both Bacterial PAMPs sig and inflammatory cytoki…
31 terms
Mucosal Immunity
Immune Function of Turbinates
Respiratory Epithelial Function
Respiratory Epithelial Secretions
B-Defensin
create vortex and stick particles to mucosa
differentiate pathogen vs commensal, secrete cytokines, trans…
B-defensins, cathelicidins, surfactant protein A and D, and l…
bacterial lysis, chemotactic, promote phagocytosis
Immune Function of Turbinates
create vortex and stick particles to mucosa
Respiratory Epithelial Function
differentiate pathogen vs commensal, secrete cytokines, trans…
11 terms
Mucosal Immunity
Gut
Villi
Peyer's Patches
M cell
First point of contact with microbes
Finger-like protrusions whose primary role is absorption of n…
Thin-layered mucus, dome-like lymphoid structures in the smal…
Specialized phagocytic cells whose primary function is to tra…
Gut
First point of contact with microbes
Villi
Finger-like protrusions whose primary role is absorption of n…
12 terms
Mucosal Immunity
Which of the following is a true state…
What do M cells do?
what is present in the dome region of…
What occurs after intestinal dendritic…
B.They are located in the dome area of Peyer's patches.
Take up antigen from the gut lumen - move it to the basal mem…
Rich in dendritic cells, T cells, B cells and is overlaid wit…
dendritic cells travel to mesenteric lymph node to activate a…
Which of the following is a true state…
B.They are located in the dome area of Peyer's patches.
What do M cells do?
Take up antigen from the gut lumen - move it to the basal mem…
34 terms
Mucosal Immunity
Mucosal surfaces
Mucosal surfaces contain?
what are the 3 types of MALT?
Mucins
have continuous contact woth pathogens and commensal organisms
mucins, defensins, antimicrobial peptides
NALT, GALT, BALT
first barrier... large glycoproteins
Mucosal surfaces
have continuous contact woth pathogens and commensal organisms
Mucosal surfaces contain?
mucins, defensins, antimicrobial peptides
Mucosal Immunity
Non-specific/Mechanical barriers:
Non-specific immune molecules and cells:
Specific/Immunologic immune molecules…
Epithelial cells have a crucial role i…
- Skin and epithelial barriers, tight junctions, mucus, and t…
- Lysozyme, lactoferrin, defensins... • in milk, tears, mucus... -…
- Tc... - B cells... - sIgA antibodies... • Milk... • Mucosal linings
MAMPs
Non-specific/Mechanical barriers:
- Skin and epithelial barriers, tight junctions, mucus, and t…
Non-specific immune molecules and cells:
- Lysozyme, lactoferrin, defensins... • in milk, tears, mucus... -…
52 terms
Mucosal Immunity
What are 3 examples of mucosal surface…
What is the "challenge" faced by host…
What are 5 examples of benefits derive…
What is an example of non-antigen spec…
1. respiratory tract... 2. intestinal tract... 3. urogenital tract…
to protect the body and clear infection without damaging the…
1. synthesis of essential metabolites (Vit K)... 2. break down f…
stomach acid/low pH
What are 3 examples of mucosal surface…
1. respiratory tract... 2. intestinal tract... 3. urogenital tract…
What is the "challenge" faced by host…
to protect the body and clear infection without damaging the…
39 terms
Mucosal Immunity
Mucosal Immunity
Mucus Secretions
Mucosal Secretions
Mucus Immunity
Mucosal Immunity
Mucus Secretions
60 terms
Mucosal Immunity
aryl hydrocarbon receptor
autophagosome
CCL9
CCL25
A basic helix-loop-helix transcription factor that is activat…
A double bilayer membrane structure that functions in macroau…
Chemokine made by follicle-associated epithelial cells and bi…
Chemokine made by small intestine epithelial cells that binds…
aryl hydrocarbon receptor
A basic helix-loop-helix transcription factor that is activat…
autophagosome
A double bilayer membrane structure that functions in macroau…
31 terms
mucosal immunity
function of secondary lymphoid tissues
how mucosal membranes act as physical…
MALT
areas of organized mucosal lymphoid ti…
- concentrate Ag and enable interaction with Ag-specific lymp…
- mucus prevents microbe attachment... - serves as a trap for mi…
mucosa-associated lymphoid tissue... GALT: gut-... NALT: nasopharyn…
peyer's patches... appendix... mesenteric lymph nodes... tonsils... adeno…
function of secondary lymphoid tissues
- concentrate Ag and enable interaction with Ag-specific lymp…
how mucosal membranes act as physical…
- mucus prevents microbe attachment... - serves as a trap for mi…
Mucosal Immunity
Innate Immunity on Body Surfaces
Humoral Immunity
Mechanisms of IgA deposition on mucosa…
Mucus
Lysozyme, Lactoferrin, Defensins... - Milk, tears, mucus... Phagoc…
sIgA... - milk, mucosal lining
Transcytosis of IgA from lamina propria to mucosal surface... Ig…
hinders pathogen adherence, capture Ags... glycosylation - charg…
Innate Immunity on Body Surfaces
Lysozyme, Lactoferrin, Defensins... - Milk, tears, mucus... Phagoc…
Humoral Immunity
sIgA... - milk, mucosal lining
41 terms
Mucosal Immunity
Functions of the mucosal immune system
distinct features of mucosal immunity
Components of mucosal immune system
-line of defense against microbial pathogens.... -Tolerance: Pre…
1) intimate association with epithelial cells; ... 2) defined (I…
Integrated network of anatomic sites, immune cells and tissue…
Functions of the mucosal immune system
-line of defense against microbial pathogens.... -Tolerance: Pre…
distinct features of mucosal immunity
1) intimate association with epithelial cells; ... 2) defined (I…
33 terms
mucosal immunity
mucociliary escalator
alveolar macrophges
vomiting and diarrhea
commensal organisms
upper respiratory tract
lower respiratory tract
GIT
ex lactobacilli... colonize intestines... protect by competition fo…
mucociliary escalator
upper respiratory tract
alveolar macrophges
lower respiratory tract
39 terms
Mucosal Immunity
Mucosal Area's
Mucosal tissues of human body
Mucin
Commensal Bacteria in tissues
Small intestine = 400m2 of area... 2/3 lymphocytes serve muco…
- Respiratory tract (sinus, trachea, lungs)... - Gastrointestin…
Mucosal surface protected by the tight junction of epithelial…
Stomach: 1000 bacteria/ml content... Small intestine: 10^5-10^8…
Mucosal Area's
Small intestine = 400m2 of area... 2/3 lymphocytes serve muco…
Mucosal tissues of human body
- Respiratory tract (sinus, trachea, lungs)... - Gastrointestin…
27 terms
mucosal immunity
Epithelial cells produce
IL-10 and TGF-B
TNF-a
CXCL1
Il10, tgf-b,tnf-a, cxcl1, ccl2, cxcl10
Immunisuppressive
Direct th1differentiation
For neutrophils
Epithelial cells produce
Il10, tgf-b,tnf-a, cxcl1, ccl2, cxcl10
IL-10 and TGF-B
Immunisuppressive
Mucosal Immunity
mucous
nasal cavity
pro inflammatory cytokines
anti inflammatory cytokines
-composed of mucins which are glycoproteins... -contain antibodi…
-hairs filter out large particles... -nasal turbinate's create v…
IL-1... IL-6... IL-15... TNF-alpha
IL-10... TGF-betta
mucous
-composed of mucins which are glycoproteins... -contain antibodi…
nasal cavity
-hairs filter out large particles... -nasal turbinate's create v…
Mucosal Immunity
Mucins are ______
Secretory _____ are used to bind micro…
Mucins can be ______ or ______
As food passed through the GI tract, i…
glycoproteins
IgAs... defensins
membrane bound... secreted
increasing
Mucins are ______
glycoproteins
Secretory _____ are used to bind micro…
IgAs... defensins
34 terms
Mucosal Immunity
The Peyer's Patch is located in this l…
This layer of tissue overlies the Peye…
___ cells are only in the follicle-ass…
Process of the tolerogenic dendritic c…
lamina propria
Follicle Associated Epithelium
M cell
Vitamin A taken up by gut epithelial cells -> Vitamin A binds…
The Peyer's Patch is located in this l…
lamina propria
This layer of tissue overlies the Peye…
Follicle Associated Epithelium
37 terms
Mucosal Immunity
Mucous membrane
Mucosal surface innate immunity mechan…
Mucociliary escalator
Alveolar macrophages
Susceptible to infection as they are thin walled to allow for…
1. Mucociliary escalator ... 2. Alveolar macrophages... 3. Commensa…
1. Located in the URT... 2. Prevents particulate material from r…
1. Located in the lungs... 2. Phagocytoses any persistant partic…
Mucous membrane
Susceptible to infection as they are thin walled to allow for…
Mucosal surface innate immunity mechan…
1. Mucociliary escalator ... 2. Alveolar macrophages... 3. Commensa…
42 terms
Mucosal Immunity
Key points
Anatomy of MALT (Mucosal- Associated L…
O-MALT
-BALT
-Anatomically and functional dieting compartments... -Compartmen…
Two types ... -O-MALT -organized ... -D-MALT -diffused
-organized, has lymphoid follicle and germinal center but not…
bronchial associated (lower respiratory tract) less developed…
Key points
-Anatomically and functional dieting compartments... -Compartmen…
Anatomy of MALT (Mucosal- Associated L…
Two types ... -O-MALT -organized ... -D-MALT -diffused
Mucosal Immunity
M; minimal; antigen uptake
effector compartment; mesenteric node;…
dendritic; commensal organisms; IgA; i…
weak; regulatory; strong; effector TH
Peyer's patches and lymphoid follicles are covered in special…
the induction phase occurs in the ___; from here, ag-specific…
___ cells in subepithelial lymphoid tissue present ____ to Ag…
in the absence of Ags with inflammatory patterns, DCs give __…
M; minimal; antigen uptake
Peyer's patches and lymphoid follicles are covered in special…
effector compartment; mesenteric node;…
the induction phase occurs in the ___; from here, ag-specific…
Mucosal Immunity
Two functionally distinct compartments…
Location of plasma cells, effector T c…
Mucosal tissue located at back of the…
Secondary lymphoid tissues of small in…
Inductive and effector
Lamina propria
Palatine tonsils, adenoids, and lingual tonsils
Peyer's patch
Two functionally distinct compartments…
Inductive and effector
Location of plasma cells, effector T c…
Lamina propria
16 terms
Mucosal immunity
Mucin... function... origin
a-defensins... function... origin
Peyer's patch... composition
M cells... function... location
Form mucosal layer... Goblet cells
Antimicrobial molecules... Paneth cells
Lymph node with M cell layer
Transport Ag to DC... Peyer's patch
Mucin... function... origin
Form mucosal layer... Goblet cells
a-defensins... function... origin
Antimicrobial molecules... Paneth cells
Mucosal Immunity
Chronic Exercise - During a football s…
Moderate Exercise - increase SIga
Chronic Stress - Carers for spouses wi…
Academic Stress - During chronic acade…
Fahlman and Engels 2005
Akimoto 2001
Gallagher 2008
Bosch 2002
Chronic Exercise - During a football s…
Fahlman and Engels 2005
Moderate Exercise - increase SIga
Akimoto 2001
21 terms
Mucosal Immunity
Mucoscal Immunity: Chemokine
T cells activated in the gut express t…
Chemokine receptors activate
Commensal bacteria
A cytokine that stimulates the migration of cells to inflamed…
to CCL25 on gut epithelium.
integrins, leading to firm adhesion and transmigration into t…
Symbiotic bacteria that permanently reside on mucosal surface…
Mucoscal Immunity: Chemokine
A cytokine that stimulates the migration of cells to inflamed…
T cells activated in the gut express t…
to CCL25 on gut epithelium.
Mucosal Immunity
IELs
Goblet cells
Paneth cells
4 Functions of TLRs
Immune cells in mucosal epithelium and lamina propria... CD8+ T…
Secrete mucins that hold commensal bacteria, AMPs, IgA
Secrete AMPs
1. Production of epithelial repair and motility factors... 2. B…
IELs
Immune cells in mucosal epithelium and lamina propria... CD8+ T…
Goblet cells
Secrete mucins that hold commensal bacteria, AMPs, IgA
Mucosal Immunity
Inflammatory diseases of the GI tract…
Inflammatory diseases of the GI tract…
commensals =
food antigens =
Crohn's Disease
Celiac Disease
Crohn's disease
celiac disease
Inflammatory diseases of the GI tract…
Crohn's Disease
Inflammatory diseases of the GI tract…
Celiac Disease
20 terms
Mucosal Immunity
Respiratory system
B-defensins
Cathelicidins
Surfactant A & D
This is the most exposed of all the mucosal surfaces, and acu…
This antimicrobial peptide, secreted by respiratory endotheli…
This antimicrobial peptide, secreted by respiratory endotheli…
These antimicrobial peptides are produced by type II alveolar…
Respiratory system
This is the most exposed of all the mucosal surfaces, and acu…
B-defensins
This antimicrobial peptide, secreted by respiratory endotheli…
13 terms
Mucosal Immunity
CD103+ DC
α4:β7
MadCAM-1
αE:β7
detect food; oral tolerance; secrete IL-10 to signal Ag speci…
integrin on T cell important for crossing blood vessel to lam…
on lamina propria blood vessel; binds α4:β7 on T-cell; expres…
integrin on T cell important for epithelial interaction; bind…
CD103+ DC
detect food; oral tolerance; secrete IL-10 to signal Ag speci…
α4:β7
integrin on T cell important for crossing blood vessel to lam…
30 terms
Mucosal immunity
goblet cells
epithelial cells
Paneth cells
M cells
secrete mucus: barrier function and antibacterial
barrier and antibacterial
anti-bacterial-secreting cells
antigen sampling
goblet cells
secrete mucus: barrier function and antibacterial
epithelial cells
barrier and antibacterial
16 terms
Mucosal Immunity
Oral tolerance
Tolerogenic DC
MALT/GALT
Tonsils
The immune's system default to NOT respond to antigens encoun…
mediate oral tolerance, CD103 + DCs
specialized mucosal secondary lymphoid organs.... consists of t…
Secondary Lymphoid tissue. Strong producers of IgA. ... People…
Oral tolerance
The immune's system default to NOT respond to antigens encoun…
Tolerogenic DC
mediate oral tolerance, CD103 + DCs
Mucosal immunity
B defensins
Catelicidins
Surfactant protein A andD
Lysosomes
Bacterial lyse via pore formation, chemotactic for many leuko…
Antimicrobial a city against Mandy organismfincluding gram po…
Type II alveolar cells. Promote phagocytosis and directly bac…
Secretion and is able to cleave cell wall of gram positive ba…
B defensins
Bacterial lyse via pore formation, chemotactic for many leuko…
Catelicidins
Antimicrobial a city against Mandy organismfincluding gram po…
28 terms
Mucosal immunity
Mucus contains
Mucosal immunity does what?
Mucosal physiological functions include
3/4 of body's lymphocytes and plasma c…
Glycoproteins ... Proteoglycans ... Peptides... Enzymes
Prevents infection and protects the epithelium
Gas exchange... Food absorption ... Sensory activity ... Reproduction
In secondary lymphoid tissue
Mucus contains
Glycoproteins ... Proteoglycans ... Peptides... Enzymes
Mucosal immunity does what?
Prevents infection and protects the epithelium
mucosal immunity
B cells at mucosal surfaces primarily…
chemical mucosal protection conferred by
lysozyme
defensins
IgA
pH, specialized proteins, and broad-spectrum antimicrobials
breaks down peptidoglycan membrane of gram-positive bacteria…
disrupt bacterial membranes in the small intestine
B cells at mucosal surfaces primarily…
IgA
chemical mucosal protection conferred by
pH, specialized proteins, and broad-spectrum antimicrobials
Mucosal immunity
what is the first line of defense agai…
M cells stands for what? what types of…
4 APC
APC prime what?
mucosal immune system
microfold cells... APC surrounding Peyer's Patches
1. Dendrites... 2. Macrophages... 3. B cell... 4. Microfold cell
naive B and T-cells to become effector cells
what is the first line of defense agai…
mucosal immune system
M cells stands for what? what types of…
microfold cells... APC surrounding Peyer's Patches
24 terms
Mucosal immunity
What type of immunity does mucosa pose…
Mucosal surfaces that have large areas…
2 catagories of mucosal lymphoid tissue
Inductive sites
both aquired and inate
1. respitory... 2. urogenital... 3. Gastrointestinal... *Has large am…
1. inductive sites ... 2. Effector sites
Sites where Antigen is encountered, processed, and an Imm…
What type of immunity does mucosa pose…
both aquired and inate
Mucosal surfaces that have large areas…
1. respitory... 2. urogenital... 3. Gastrointestinal... *Has large am…
64 terms
Mucosal Immunity
The site of primary immune responses i…
GALT organization
The largest lymph nodes in the body th…
____ are dome like aggregates of lymph…
Peyer's patches
Peyer's patches... single lymphoid follicles... appendix... Mesenteric…
Mesenteric lymph nodes
Peyer's Patches
The site of primary immune responses i…
Peyer's patches
GALT organization
Peyer's patches... single lymphoid follicles... appendix... Mesenteric…
29 terms
Mucosal Immunity
mucosal immunity
non-specific immune molecules and cells
Specific/Immunologic
organized peripheral lymphoid tisses l…
equiped with unique innate and acquired defense mechanisms. F…
-lysozyme, lactoferrin, defensins (milk, tears, mucus)... -phago…
-Tc... -B cells... -sIgA antibodies (milk, mucosal linings)
MALT. NALT in nasopharynx and GALT in gut
mucosal immunity
equiped with unique innate and acquired defense mechanisms. F…
non-specific immune molecules and cells
-lysozyme, lactoferrin, defensins (milk, tears, mucus)... -phago…
Mucosal Immunity
Mucosae
Mucosal tissues of the human body
Mucosal Defenses
Mucus
Mediate most biological interactions with the environement su…
1. Lachrymal gland... 2. Salivary gland... 3. Mammary gland... 4. Kidn…
1. Mucus... 2. Soluble mediators... 3. Non-inflammatory macrophages…
glycoproteins and proteoglycans that bind/absorb pathogens... -p…
Mucosae
Mediate most biological interactions with the environement su…
Mucosal tissues of the human body
1. Lachrymal gland... 2. Salivary gland... 3. Mammary gland... 4. Kidn…
32 terms
Mucosal Immunity
The gut has a constant state of low le…
What are the two distinct areas of GALT?
GALT is in the form of ____ and tends…
What isotype switching is going to be…
inflammation
T cell rich... B cell rich
peyer patches; mucosal layer; M cells
IgA
The gut has a constant state of low le…
inflammation
What are the two distinct areas of GALT?
T cell rich... B cell rich
26 terms
Mucosal immunity
Payer's patches
What features allow M cells to take up…
What two strategies of mucosal immunit…
What is proactive mucosal immune respo…
located in the walls of the small intestines and contain B ce…
lack of digestive enzymes, mucus, protective glycocalyx, and…
Proactive mucosal immune response and suppressed inflammatory…
it constantly makes adaptive immune responses against gut mic…
Payer's patches
located in the walls of the small intestines and contain B ce…
What features allow M cells to take up…
lack of digestive enzymes, mucus, protective glycocalyx, and…
14 terms
Mucosal Immunity
IgA
IgM
stratification vs compartmentalization
MALT/GALT
constituent of secondary immune responses ... predominant Ab in…
first antibody produced in primary response ... produced by neo…
stratification - minimizing direct contact between bacteria a…
lamina propria - germ free animals have very few lamina propr…
IgA
constituent of secondary immune responses ... predominant Ab in…
IgM
first antibody produced in primary response ... produced by neo…
52 terms
Mucosal Immunity
What are 3 examples of mucosal surface…
What is the "challenge" faced by host…
What are 5 examples of benefits derive…
What is an example of non-antigen spec…
1. respiratory tract... 2. intestinal tract... 3. urogenital tract…
to protect the body and clear infection without damaging the…
1. synthesis of essential metabolites (Vit K)... 2. break down f…
stomach acid/low pH
What are 3 examples of mucosal surface…
1. respiratory tract... 2. intestinal tract... 3. urogenital tract…
What is the "challenge" faced by host…
to protect the body and clear infection without damaging the…
29 terms
Mucosal Immunity
list effector immune cells at mucosal…
major antibody in mucosal secretions i…
major antibody in mucosal secretions i…
3 major intestinal lymphoid compartments
IgA-secreting plasma cells, macrophages, mast cells, eosinoph…
IgA
IgG1
Peyer's patches, lamina propria, intraepithelial lymphocytes
list effector immune cells at mucosal…
IgA-secreting plasma cells, macrophages, mast cells, eosinoph…
major antibody in mucosal secretions i…
IgA
50 terms
Mucosal Immunity
How many lymphocytes inhabit the mucosa?
The mucosal is what?
What is Mucin?
What are commensal bacteria?
75%
chronic and non inflammatory
polymeric glycoprotein that are secreted and membrane bound,…
bacteria that help out the body
How many lymphocytes inhabit the mucosa?
75%
The mucosal is what?
chronic and non inflammatory
69 terms
Mucosal Immunity
T or F : The mucosa is in full contact…
What kind of epithelia in MALT?
Which layer contains blood vessels, ly…
What kind of immunity is MALT involved…
T... -Gets exposed to a lot of Ag
Columnar
Lamina Propria
Early adaptive... -B,T, DC, macrophages
T or F : The mucosa is in full contact…
T... -Gets exposed to a lot of Ag
What kind of epithelia in MALT?
Columnar
11 terms
Mucosal Immunity
Main 3 functions of mucosal immunity
MALT is present in:
what are peyer's patches? where are th…
importance of the intestinal mucosa an…
1) protect mucus membranes from infection... 2) prevent the upta…
(mucosa associated lymphoid tissue)... >GI (GALT)... > respiratory…
large oval lymph collections in the SI mucosa, forming a stro…
>must be able absorb food protein and not activate an immune…
Main 3 functions of mucosal immunity
1) protect mucus membranes from infection... 2) prevent the upta…
MALT is present in:
(mucosa associated lymphoid tissue)... >GI (GALT)... > respiratory…
44 terms
Mucosal Immunity
What are the 3 components of secretory…
The secretory component of sIgA is res…
Where is monomeric IgA mostly found? W…
Where is secretory mostly found?
1. IgA dimer... 2. J chain... 3. Secretory component... = 11S
Acid
Found in serum, made in bone marrow
Secretions, submucosa
What are the 3 components of secretory…
1. IgA dimer... 2. J chain... 3. Secretory component... = 11S
The secretory component of sIgA is res…
Acid
20 terms
Mucosal Immunity
What makes the mucosal surfaces so vul…
Where are the majority of the body's l…
Where is GI secondary lymphoid tissue…
What is Waldeyer's ring?
(1) Thin, dynamic, permeable... (2) Large surface area... (3) Keep…
Mucosal lymphoid and nonlymphoid tissues
Mouth (palatine tonsils, adenoids, and lingual tonsils), surf…
Adenoids, palatine tonsils, lingual tonsils
What makes the mucosal surfaces so vul…
(1) Thin, dynamic, permeable... (2) Large surface area... (3) Keep…
Where are the majority of the body's l…
Mucosal lymphoid and nonlymphoid tissues
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