How can we help?

You can also find more resources in our Help Center.

Study sets matching "immunity patho"

Study sets
Classes
Users

Study sets matching "immunity patho"

32 terms
Pathology - Immunity
antigens
Lymphocytes
B Lymphocytes
plasma cells
any Foreign Substance against which the immune system defends…
primary WBC involved in immune response... 2 main types ... B Lymph…
Develop from bone marrow:... mature/reside in lymphoid tissue... tw…
produce proteins called antibodies or immunoglobulins (Ig)
antigens
any Foreign Substance against which the immune system defends…
Lymphocytes
primary WBC involved in immune response... 2 main types ... B Lymph…
55 terms
Pathology: Immunity
immunity
eosinophil... neutrophil... basophil
eosinophil... neutrophil... basophil... monocyt…
adaptive immunity
the ability of the body to defend itself from invading microo…
name granulocytes
name phagocytic cells
what kind of immunity do monocyte/macrophages help with?
immunity
the ability of the body to defend itself from invading microo…
eosinophil... neutrophil... basophil
name granulocytes
36 terms
Pathology Immunity
Acquired Immune Response
Antigens
B cells
Memory and plasma
Defends body against injury, can remember more quickly the se…
Foreign substances or human cells that have been transformed…
Mature, reside in lymphoid tissue, travel to injury when stim…
What are the two types of B cells?
Acquired Immune Response
Defends body against injury, can remember more quickly the se…
Antigens
Foreign substances or human cells that have been transformed…
26 terms
Immunity - Pathology
Primary Lymph Tissues
Bursa of Fabricius
Red Marrow
Yellow Marrow
Locations where immature lymphocytes are processed into matur…
Found in birds, processes B lymphocytes
Major player in hematopoesis
Mostly fat, can change to make more blood cells
Primary Lymph Tissues
Locations where immature lymphocytes are processed into matur…
Bursa of Fabricius
Found in birds, processes B lymphocytes
34 terms
Pathology Immunity
The Immune response phases are:
An antigen is a
The body defend itself by:
Effector cells are:
1.Recognition, 2.Activation & 3.Effector phase
ANTIbody GENerator... Protein/Saccharide(Bacteria,virus or other…
1.Natural Barriers... 2.Innate immunity... 3.Adaptive immunity
Macrophages... PMN(neutrophils)... NK
The Immune response phases are:
1.Recognition, 2.Activation & 3.Effector phase
An antigen is a
ANTIbody GENerator... Protein/Saccharide(Bacteria,virus or other…
23 terms
Pathology - Immunity
Role of NF-kb
NF-kb is activated by these molecules
In innate immunity, these pathways are…
In adaptive immunity this pathway is u…
Stimulates production of cytokines and several proteins respo…
TLRs
Alternate, lectin
Classical
Role of NF-kb
Stimulates production of cytokines and several proteins respo…
NF-kb is activated by these molecules
TLRs
23 terms
Immune - Pathology
DIGEORGE SYNDROME
SEVERE COMBINED IMMUNODEFICIENCY (SCID)
SEVERE COMBINED IMMUNODEFICIENCY (SCID…
X-LINKED AGAMMAGLOBULINEMIA
Developmental failure of the third and fourth pharyngeal pouc…
Defective cell-mediated and humoral immunity. Pcx: Susceptibi…
Cytokine receptor defects. Adenosine deaminase (ADA) . MHC cl…
Complete lack of immunoglobulin due to disordered B-cell matu…
DIGEORGE SYNDROME
Developmental failure of the third and fourth pharyngeal pouc…
SEVERE COMBINED IMMUNODEFICIENCY (SCID)
Defective cell-mediated and humoral immunity. Pcx: Susceptibi…
40 terms
Immunity Pathology
What type of antibody is involved in T…
What mediators are involved in the Typ…
Name the secondary mediators of the Ty…
Why is it postulated that atopic aller…
Immunoglobulin E (IgE). They bind to the Fc epsilonRI (FceRI)…
Histamines, TNF-alpha, and chemokines. These are stored in th…
Arachidonic acids metabolites (Prostoglandins, thromboxanes,…
There's a genetic component to atopic allergy such that if bo…
What type of antibody is involved in T…
Immunoglobulin E (IgE). They bind to the Fc epsilonRI (FceRI)…
What mediators are involved in the Typ…
Histamines, TNF-alpha, and chemokines. These are stored in th…
7 terms
Pathology- Immunity
Immunity
Nonspecific Resistance
Innate Immunity
Acquired Immunity
more functional than structural
-first line of defense... -responses defends against foreign or…
-second line of defense... -preformed and fully active... -acts imm…
-third line of defense... -highly specific... -responds specificall…
Immunity
more functional than structural
Nonspecific Resistance
-first line of defense... -responses defends against foreign or…
27 terms
Immune Pathology
Immune privileged sites
Breaking tolerance for autoimmunity
Genes linked to autoimmunity
IPEX: Immune dysreg, polyendocrinopath…
Lyphocytes don't usually enter tissues (eyes, testes, placent…
Genes--defects in self-tolerance pw... Environment lead to activ…
Dominant factors for autoimmunity... HLA genes : MHC I/II... Unclea…
rare genetic disease; mut of foxP3 gnee-transcription factor…
Immune privileged sites
Lyphocytes don't usually enter tissues (eyes, testes, placent…
Breaking tolerance for autoimmunity
Genes--defects in self-tolerance pw... Environment lead to activ…
70 terms
Pathology: Immunity
what do class I & II HLA genes encode?
what do class II HLA genes encode?
where are Class I HLA antigens express…
what encodes Class I HLA antigens (3)?
cell surface glycoproteins
components of complement system
all nucleated cells and platelets
HLA-A, HLA-B, HLA-C
what do class I & II HLA genes encode?
cell surface glycoproteins
what do class II HLA genes encode?
components of complement system
30 terms
Immune pathology
Type I HS
Type II HS
Good pasture syndrome (Anti-GBM)
Type III HS
IgE mediated
- Anti-body mediated... Eg:... - Good pasture syndrome (Anti-GBM)... -…
- Type 2 HS... - alpha 3 chain of type 4 (target)
- IgM/IgG... Target Sites... - Glomerulonephritis... - Arthritis... - Car…
Type I HS
IgE mediated
Type II HS
- Anti-body mediated... Eg:... - Good pasture syndrome (Anti-GBM)... -…
16 terms
Immune Pathology
Innate Immunity
Natural Barriers
Inflammatory Response
Passive Immunity
-aka natural immunity... -immunity that is immediately available…
skin, epithelium of GI/GU/Resp., coughing, sneezing, cilia, v…
-rapid and nonspecific ... -vasodilation: red, warm, swollen, pa…
-produced by transfer of antibodies from another person... -indu…
Innate Immunity
-aka natural immunity... -immunity that is immediately available…
Natural Barriers
skin, epithelium of GI/GU/Resp., coughing, sneezing, cilia, v…
22 terms
Immune Pathology
X-linked (Bruton) agammaglobulinemia
Selective IgA deficiency
Common variable immunodeficiency
Thymic aplasia (DiGeorge syndrome)
Defect in BTK, a tyrosine kinase gene --> no B-cell maturatio…
Most common primary immunodeficiency... Presentation: Majority a…
Defect in B-cell differentiation... Presentation: Can be acquire…
22q11 deletion; failure to develop 3rd and 4th pharyngeal pou…
X-linked (Bruton) agammaglobulinemia
Defect in BTK, a tyrosine kinase gene --> no B-cell maturatio…
Selective IgA deficiency
Most common primary immunodeficiency... Presentation: Majority a…
27 terms
Immune Pathology
resistance to pathogens, exterior defe…
thymic hormone production, t cell func…
strenuous
immunodeficiency disease
innate immune system function declines:
acquired immune system function declines:
type of exercise impairing immune system
absent or depressed immune response
resistance to pathogens, exterior defe…
innate immune system function declines:
thymic hormone production, t cell func…
acquired immune system function declines:
44 terms
immune pathology
Multiple sceloris
Rheumatoid artheritis
Crohn's disease
vitiligo
is a progressive autoimmune disorder characterized by inflamm…
chronic autoimmune disorder in which the joints and some orga…
chronic autoimmune disorder that can occur anywhere in the di…
melanin pigment. due to destruction of melanocytes due to a u…
Multiple sceloris
is a progressive autoimmune disorder characterized by inflamm…
Rheumatoid artheritis
chronic autoimmune disorder in which the joints and some orga…
49 terms
Pathology-Immune
T Cell Activation Signal 2
B cell Activation Signal 2
Th1
Th2
Binding of CD28 on the surface of T cells with CD80/86 on the…
CD40 on B cell interact with CD40L on T cell
produce IFN-Y, activate macrophage and ab production by B cell
produce IL-4->stimulate B cells undergo ab class switching->I…
T Cell Activation Signal 2
Binding of CD28 on the surface of T cells with CD80/86 on the…
B cell Activation Signal 2
CD40 on B cell interact with CD40L on T cell
35 terms
Pathology Immune
B cells account for approximately how…
T cells account for approximately how…
Where do T cells populate?
Approx how many T CD4+?
15%
70%
paracortical and deep medullary areas of lymph nodes and peri…
60%
B cells account for approximately how…
15%
T cells account for approximately how…
70%
22 terms
Immune Pathology
Allergies
Allergies (causes)
Allergies (symptoms)
Allergies (treatments)
The body's immune system response to foreign substances which…
Exposure to substances that trigger the immune system to prod…
Can very from mild to severely life-threatening and include:…
Avoiding allergens, medications to reduce symptoms and for se…
Allergies
The body's immune system response to foreign substances which…
Allergies (causes)
Exposure to substances that trigger the immune system to prod…
22 terms
Immune Pathology
1st Line of defense
2nd line of defense
3rd line of defense
3 functions of the immune system
Skin/ barriers
cardiovascular system/lympathic
non-specific attack, specific defense
wall off foreign invaders, systematically destroy invader, cl…
1st Line of defense
Skin/ barriers
2nd line of defense
cardiovascular system/lympathic
33 terms
Immune Pathologies
Hypersensitivity reactions
Steps/mechanisms of Hypersensitivity r…
Example of a Hypersensitivity 1 reaction
Other examples of Hypersensitivity 1 r…
1. Anaphylaxis ... 2. Cytotoxic ... 3. Immune complex mediated (fir…
Steps/mechanisms of Hypersensitivity reaction_____... 1. Activat…
Example of a hypersensitivity __________ reaction... Allergic Rh…
Other examples of hypersensitivity ___________ reactions ... - E…
Hypersensitivity reactions
1. Anaphylaxis ... 2. Cytotoxic ... 3. Immune complex mediated (fir…
Steps/mechanisms of Hypersensitivity r…
Steps/mechanisms of Hypersensitivity reaction_____... 1. Activat…
107 terms
The Immune System and Immune Pathology
Immunology is the study of ____ that a…
Is the immune system always helpful or…
what are the 3 types of immunity?
Innate Immunity is immunity you are __…
physiologic mechanisms, foreign
no too much of a good thing is bad
innate, acquired/adaptive immunity, autoimmunity
born with, prevent, neutralize
Immunology is the study of ____ that a…
physiologic mechanisms, foreign
Is the immune system always helpful or…
no too much of a good thing is bad
75 terms
The immune system and immune pathology
Immunology
Types of immunity
Innate immunity
Innate immunity... 1st and 2nd line of de…
Definition: Study of physiologic mechanisms that allow the bo…
Innate Immunity... - Immunity you are born with... - Designed to pr…
1St line of defense against pathological invasion... Non-specifi…
1st line of defense... - Skin... - Mucosal barriers (mouth, nose, a…
Immunology
Definition: Study of physiologic mechanisms that allow the bo…
Types of immunity
Innate Immunity... - Immunity you are born with... - Designed to pr…
31 terms
Pathology and Microbiology - innate immunity
Define an allergy?
Define immunopathology?
Define autoimmunity?
what is the relationship between infla…
mounting an immune response to environmental material
tissue damaged caused by excessive immune response
the failure to distinguish self from non-self
the inflammatory process mobilizes the determinants of the in…
Define an allergy?
mounting an immune response to environmental material
Define immunopathology?
tissue damaged caused by excessive immune response
17 terms
immune pathologies
allergies
allergies causes
allergies symptoms
allergies treatments
the body's immune system response to foreign substances which…
exposure to substances that trigger the immune system to crea…
congestion, itchy nose, itchy/ watery eyes, hives, wheezing,…
avoiding allergens, medications to reduce symptoms, immunothe…
allergies
the body's immune system response to foreign substances which…
allergies causes
exposure to substances that trigger the immune system to crea…
58 terms
Pathology Introduction + Innate Immunity
Disease
Aetiology
Pathogenesis
Epidemiology
Disturbance of homeostasis, abnormal conditions, disorder, ca…
cause of disease
development of disease
study of diseases in the population
Disease
Disturbance of homeostasis, abnormal conditions, disorder, ca…
Aetiology
cause of disease
75 terms
The immune system and immune pathology
Immunology
Types of immunity
Innate immunity
Innate immunity... 1st and 2nd line of de…
Definition: Study of physiologic mechanisms that allow the bo…
Innate Immunity... - Immunity you are born with... - Designed to pr…
1St line of defense against pathological invasion... Non-specifi…
1st line of defense... - Skin... - Mucosal barriers (mouth, nose, a…
Immunology
Definition: Study of physiologic mechanisms that allow the bo…
Types of immunity
Innate Immunity... - Immunity you are born with... - Designed to pr…
107 terms
Pathology - Chapter 3 - Immunity
Acquired immune response
This response occurs AFTER inflammatio…
Immune response
Antigens
This is similar to the inflammatory response in that this pro…
Acquired immune response
This type of response remembers the past
These are the foreign substances against which the immune sys…
Acquired immune response
This is similar to the inflammatory response in that this pro…
This response occurs AFTER inflammatio…
Acquired immune response
75 terms
The immune system and immune pathology
Immunology
Types of immunity
Innate immunity
Innate immunity... 1st and 2nd line of de…
Definition: Study of physiologic mechanisms that allow the bo…
Innate Immunity... - Immunity you are born with... - Designed to pr…
1St line of defense against pathological invasion... Non-specifi…
1st line of defense... - Skin... - Mucosal barriers (mouth, nose, a…
Immunology
Definition: Study of physiologic mechanisms that allow the bo…
Types of immunity
Innate Immunity... - Immunity you are born with... - Designed to pr…
20 terms
Immune Deficiencies & Immune Pathology
x-linked agammaglobulinemia
x-linked agammaglobulinemia
x-linked severe combined immunodeficie…
x-linked severe combined immunodeficie…
-Rare congential immune disease... -male infants present history…
Due to block in B cell differentiation from stem cells. Defec…
-Involves defect in common gamma chain of receptor IL-2 & oth…
Due to defective expression of cytokine RECEPTORS. deficiency…
x-linked agammaglobulinemia
-Rare congential immune disease... -male infants present history…
x-linked agammaglobulinemia
Due to block in B cell differentiation from stem cells. Defec…
35 terms
Immune Pathologies
When were immunodeficiency... diseases re…
What are two inherited phagocyte defec…
What protein does leukocyte adhesion d…
What does chronic granulomatous diseas…
-Recognized in the 1950s when use of antibiotics reduced chil…
-Leukocyte adhesion deficiency (LAD)... -Chronic granulomatous d…
-Lack of functional integrins on leukocytes so there is a def…
-Mutations in subunits of the NADPH oxidase so phagocytes do…
When were immunodeficiency... diseases re…
-Recognized in the 1950s when use of antibiotics reduced chil…
What are two inherited phagocyte defec…
-Leukocyte adhesion deficiency (LAD)... -Chronic granulomatous d…
195 terms
Oral Pathology Ch. 3: Immunity
The immune response defends the body a…
The immune response differs from the _…
The immune response may result in an i…
The immune response involves what type…
injury... microorganisms.
Inflammatory... memory... more quickly
injury to body... The tooth (periodontitis)
lymphocyte (specific white blood cells)
The immune response defends the body a…
injury... microorganisms.
The immune response differs from the _…
Inflammatory... memory... more quickly
119 terms
Pathology Immunity Exam
What are the factors in the non-specif…
What are the 2 routes of the specific…
What are the specific types of B & T L…
What cells are called immunomodulators?
1. physical and chemical barriers: tears, skin, mucosa, enzym…
B cells for Humoral & T cells for Cell-Mediated
B/plasma/memory & T/helper/suppressor/memory/cytotoxic
cytokines (B & T cells produce Lymphokines) & monocytes and m…
What are the factors in the non-specif…
1. physical and chemical barriers: tears, skin, mucosa, enzym…
What are the 2 routes of the specific…
B cells for Humoral & T cells for Cell-Mediated
68 terms
Pathology Exam 2 - Immunity
autoimmunity
What breaks down in autoimmunity; what…
self-tolerance
hypersensitivity
immune system recognizes own cells as foreign >> mounts immun…
self-tolerance/self recognition. MHC (major histamine complex…
immune system's ability to recognize it's own cells as self
Normal immune response that is inappropriately triggered... Exce…
autoimmunity
immune system recognizes own cells as foreign >> mounts immun…
What breaks down in autoimmunity; what…
self-tolerance/self recognition. MHC (major histamine complex…
58 terms
Pathology Test 1 Immunity
the agent that triggers an immune resp…
An antigen can be from (7)
LPS is on G+ bacteria. It is on the ce…
Smaller weight substances become antig…
antigen
- Can be chemical (natural or synthetic)... - Food proteins... - Pr…
FT... LPS is on G - bacteria
haptens
the agent that triggers an immune resp…
antigen
An antigen can be from (7)
- Can be chemical (natural or synthetic)... - Food proteins... - Pr…
33 terms
Innate Immunity Pathology
Innate immunity
Adaptive immunity
Redness
Pain
nonspecific response to foreign invaders, occurs naturally in…
cells adapt to certain invaders, acquired when body first enc…
Inflammatory Vascular Response; blood vessel dilation; increa…
Inflammatory Vascular Response; stimulation of nerve endings,…
Innate immunity
nonspecific response to foreign invaders, occurs naturally in…
Adaptive immunity
cells adapt to certain invaders, acquired when body first enc…
30 terms
Pathology L3- Immunity
Immunity
Immunology
What is the relevance of immunology?
Normal immune response
all the physiological mechanisms that allow the body to recog…
study of immunity
vaccinations, organ transplants, pregnancy (rhesis negative b…
-the ability to recognise and react only to foreign materials…
Immunity
all the physiological mechanisms that allow the body to recog…
Immunology
study of immunity
19 terms
Pathology (Immunity and blood)
Immune system split into ________ and…
Innate immunity's characteristics
Acquired immunity's characteristics
Acquired: Humoral
Innate... Aquired
Natural... Native... Physical defence:... Skin, mucous membrane, cilia…
Specific... Cellular immunity... Humoral immunity
Defence against extracellular microbes and their toxins (eg B…
Immune system split into ________ and…
Innate... Aquired
Innate immunity's characteristics
Natural... Native... Physical defence:... Skin, mucous membrane, cilia…
172 terms
T2 Pathology: Immunity
Allergies / hypersensitivity
Auto-immune
Microbe
Antimicrobial substance ... (e.g. lysosom…
Immune response to an invader is excessive.
The immune response when self-tissues are perceived as danger…
Bacteria and viruses are examples of this.
Tends to kill/ damage microbes.
Allergies / hypersensitivity
Immune response to an invader is excessive.
Auto-immune
The immune response when self-tissues are perceived as danger…
172 terms
**T2 Pathology: Immunity
Allergies / hypersensitivity
Auto-immune
Microbe
Antimicrobial substance ... (e.g. lysosom…
Immune response to an invader is excessive.
The immune response when self-tissues are perceived as danger…
Bacteria and viruses are examples of this.
Tends to kill/ damage microbes.
Allergies / hypersensitivity
Immune response to an invader is excessive.
Auto-immune
The immune response when self-tissues are perceived as danger…
172 terms
T2 Pathology: Immunity
Allergies / hypersensitivity happens w…
Auto-immune
Microbe
Antimicrobial substance ... (e.g. lysosom…
Immune response to an invader is excessive.
immune system attacks self
Bacteri, virus, fungi, amoeba... Microscopic organism
Tends to kill/ damage microbes.
Allergies / hypersensitivity happens w…
Immune response to an invader is excessive.
Auto-immune
immune system attacks self
131 terms
Pathology, Microbiology & Immunity
Acute inflammation
Hyperplasia
Chronic inflammation
Functions of acute inflammation
initial response taking place in the minutes/hours following…
the enlargement of an organ or tissue caused by an increase i…
persistent inflammation taking place alongside attempts at he…
-carriage of proteins, fluid and cells from blood vessels to…
Acute inflammation
initial response taking place in the minutes/hours following…
Hyperplasia
the enlargement of an organ or tissue caused by an increase i…
107 terms
Pathology - Chapter 3 - Immunity
Acquired immune response
This response occurs AFTER inflammatio…
Immune response
Antigens
This is similar to the inflammatory response in that this pro…
Acquired immune response
This type of response remembers the past
These are the foreign substances against which the immune sys…
Acquired immune response
This is similar to the inflammatory response in that this pro…
This response occurs AFTER inflammatio…
Acquired immune response
22 terms
Environmental and Immune Pathology- Premidterm
Signs and Sx of Mercury toxicity
Berylliosis
Alcohol can cause unconsciousness at w…
Metabolism of alcohol
Paresthesia... Tremors... Insomnia... Memory loss... Emotional instability
Chronic fumes or dust causing Type IV HSR... Industrial setting…
300mg/dl
Signs and Sx of Mercury toxicity
Paresthesia... Tremors... Insomnia... Memory loss... Emotional instability
Berylliosis
Chronic fumes or dust causing Type IV HSR... Industrial setting…
129 terms
Pathology T2 Immunity
What happens when a response to an inv…
When self tissues are perceived as dan…
What is a microbe?
What tends to kill/ damage microbes?
Allergies/ hypersensitivity
Autoimmune
Bacteria or a Virus
antimicrobial substance, such as lysosomal enzyme released by…
What happens when a response to an inv…
Allergies/ hypersensitivity
When self tissues are perceived as dan…
Autoimmune
Pathology Immunity, Test 2
This defends the body against injury a…
This works at the same time as the inf…
What are the WBC's involved in the imm…
These are foreign substances which the…
Immune Response
immune response
B lymphocytes... T lymphocytes... Macrophages... eosinophils... mast cell…
antigens
This defends the body against injury a…
Immune Response
This works at the same time as the inf…
immune response
129 terms
Pathology T2 Immunity
What happens when a response to an inv…
When self tissues are perceived as dan…
What is a microbe?
What tends to kill/ damage microbes?
Allergies/ hypersensitivity
Autoimmune
Bacteria or a Virus
antimicrobial substance, such as lysosomal enzyme released by…
What happens when a response to an inv…
Allergies/ hypersensitivity
When self tissues are perceived as dan…
Autoimmune
11 terms
Pathology Immunity lecture
What is an antigen
Antigens can include:
Haptens
Example of Haptens
the agent that triggers an immune response
chemicals, food proteins, products of microbes, microbes them…
smaller weight substances become antigenic when combined w/ l…
metals, poison ivy, medicine (penicillin)
What is an antigen
the agent that triggers an immune response
Antigens can include:
chemicals, food proteins, products of microbes, microbes them…
13 terms
Pathology: Immunity and Disease
What is innate immunity ?
What is adaptive immune respone?
Non-specific defenses are designed to…
Name 2 non-specific defences
Defense mechansims present even before infection or activated…
Cell-mediated immunity... Humoral immunity
Viruses and Bacteria
-Intact Skin... -Mucus and Cilia
What is innate immunity ?
Defense mechansims present even before infection or activated…
What is adaptive immune respone?
Cell-mediated immunity... Humoral immunity
Unit 5 Pathology and Immunity
bacteria
bacteriophage
capsid
conjugation
member of the domain bacteria
virus that infects bacteria
a form of glycocalyx that consists of a gelatinous layer
transfer of genetic material from one cell to another
bacteria
member of the domain bacteria
bacteriophage
virus that infects bacteria
1 of 10