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Study sets matching "immunoglobulins"

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Study sets matching "immunoglobulins"

107 terms
Immunoglobulins
Immunoglobulins (Igs)
Immunoglobulins
Immunoglobulins
Immunoglobulins
Also known as antibodies (Ab)
Produced in response to foreign substances entering the body
Bind to the antigens - Ag-Ab complexes - elimination of the A…
Synthesized by the B lymphocytes
Immunoglobulins (Igs)
Also known as antibodies (Ab)
Immunoglobulins
Produced in response to foreign substances entering the body
13 terms
Immunoglobulins
What are the subtypes of Immunoglobuli…
What is the main immunoglobulin?
IgG
What are the 2 immunoglobulins that ca…
IgM... IgA... IgD... IgE... IgG
IgG- has all the functions
Delayed response, indicates a more chronic infection... =seconda…
IgG and IgM
What are the subtypes of Immunoglobuli…
IgM... IgA... IgD... IgE... IgG
What is the main immunoglobulin?
IgG- has all the functions
25 terms
Immunoglobulins
OVERVIEW
What is immunoglobulin
understand the significance of multipl…
9 IMPORTANT Ab PARTS - LIST
immunoglobulin = antibody... Ig = immunoglobulin - usually gener…
One of the initial ways to identify Igs was through gel elect…
OVERVIEW
What is immunoglobulin
immunoglobulin = antibody... Ig = immunoglobulin - usually gener…
23 terms
Immunoglobulins
______ divides Igs into a F(ab')2 and…
Isotypes of Igs are determined by what?
What do allotypic differences in Igs u…
Idiotypic differences in Igs involve w…
Pepsin; Papain
Heavy chains (μ, γ, δ, α, ε).
Allotypic differences usually involve changes in one or more…
They're involved with the variability in the regions of the h…
______ divides Igs into a F(ab')2 and…
Pepsin; Papain
Isotypes of Igs are determined by what?
Heavy chains (μ, γ, δ, α, ε).
22 terms
Immunoglobulins
Describe features of innate immune sys…
Describe features of adaptive immune s…
Antibodies are an example of what type…
Immunoglobulins bind to what and how s…
1. non-specific, no memory... 2. first line = physical and chemi…
1. specific and acquire memory... 2. antibody response... 3. T cell…
Adaptive
Antigens... very strongly = dissociation constant Kd 10-7
Describe features of innate immune sys…
1. non-specific, no memory... 2. first line = physical and chemi…
Describe features of adaptive immune s…
1. specific and acquire memory... 2. antibody response... 3. T cell…
53 terms
Immunoglobulins
Roles for antibodies
IgG Subclasses
IgA Subclasses
Immunoglobulin domains
Immune response... Specific antisera... Monoclonal Antibodies... Diagn…
1,2,3,4
1,2,slgA
Constant... Variable
Roles for antibodies
Immune response... Specific antisera... Monoclonal Antibodies... Diagn…
IgG Subclasses
1,2,3,4
10 terms
Immunoglobulins
IgG1
IgG2
IgG3
IgG4
Heavy chain g1, MW = 146 kDa... 9 mg/ml in serum, 21 day half-li…
Heavy chain g2, MW = 146 kDa... 1 mg/ml in serum, 7 day half-lif…
Heavy chain g3, MW = 170 kDa... 3 mg/ml in serum, 20 day half-li…
Heavy chain g4, MW = 146 kDa... 0.5 mg/ml in serum, 21 day half-…
IgG1
Heavy chain g1, MW = 146 kDa... 9 mg/ml in serum, 21 day half-li…
IgG2
Heavy chain g2, MW = 146 kDa... 1 mg/ml in serum, 7 day half-lif…
54 terms
Immunoglobulins
Roles for antibodies
IgG Subclasses
IgA Subclasses
Immunoglobulin domains
Immune response... Specific antisera... Monoclonal Antibodies... Diagn…
1,2,3,4
1,2,slgA
Constant... Variable
Roles for antibodies
Immune response... Specific antisera... Monoclonal Antibodies... Diagn…
IgG Subclasses
1,2,3,4
17 terms
Immunoglobulins
Structure of an Immunoglobulin
Fab region of Ig
Fc region of Ig
Papain
- Fragment, antigen binding... - determines idiotype: unique ant…
- Constant... - Carboxy Terminal... - Complement Binding... - Carbohyd…
- 2 Fab's and I Fc... - Fab binds to the antigent and is monoval…
Structure of an Immunoglobulin
Fab region of Ig
- Fragment, antigen binding... - determines idiotype: unique ant…
29 terms
Immunoglobulins
Albumin
Antigen
Immunogen
Antigenic determinant, epitope
Most abundant plasma protein. Maintinas osmotic pressure, imp…
Any foreign molecule that is bound selectively by antibodies
The molecule that induces antibody production. May be a prote…
Small region of a larger molecule that elicits the production…
Albumin
Most abundant plasma protein. Maintinas osmotic pressure, imp…
Antigen
Any foreign molecule that is bound selectively by antibodies
60 terms
Immunoglobulins
immunoglobulins is another word for
THEME of antibody role
Four chains of immunoglobulins
What links light and heavy chains
Antibodies
bind to toxins/antigens and enhance immune response which is…
2 Heavy and 2 light
Disulfide bridges; strong covalent bonds
immunoglobulins is another word for
Antibodies
THEME of antibody role
bind to toxins/antigens and enhance immune response which is…
80 terms
Immunoglobulins
Immunoglobulins:
Immunoglobulins are the product of?
Immunoglobulins are the proteins mostl…
Each monomeric units contains?
glycoproteins present on B cells as antigen receptors and fre…
humoral immune response
the gamma region of serum protein electrophoresis... --> basical…
2 identical heavy chains and 2 identical light chains
Immunoglobulins:
glycoproteins present on B cells as antigen receptors and fre…
Immunoglobulins are the product of?
humoral immune response
64 terms
Immunoglobulins
What are the two types of immunoglobul…
Run me from BCR to secrted Ab
How many antigens can an Ab bind to?
How many kDA is a antibody?
BCR... secreted Ab
1. Expressed on mature B cells in a membrane-bound form that…
Just one
150 kDa
What are the two types of immunoglobul…
BCR... secreted Ab
Run me from BCR to secrted Ab
1. Expressed on mature B cells in a membrane-bound form that…
18 terms
Immunoglobulins
First expressed on cell surface and fi…
Most abundant on cell surface and seco…
Mononomer on cell surface but pentamer…
Activates complement (>IgG) ... Opsonizat…
IgM
IgM
IgM
IgM
First expressed on cell surface and fi…
IgM
Most abundant on cell surface and seco…
IgM
9 terms
immunoglobulins
IgG
IgM
IgA
IgD
(Memory strategy goo goo...babies say goo goo) Comes from pla…
(memory strategy got to move it move it.) First responder to…
(memory strategy Amylase aims to protects mucous membrane) Fo…
(memory strategy easy to reverse letters when learning to wri…
IgG
(Memory strategy goo goo...babies say goo goo) Comes from pla…
IgM
(memory strategy got to move it move it.) First responder to…
80 terms
Immunoglobulins
Antibodies
Three Types of Globulins
Antibodies are ___ globulins.
Polyclonal Antibodies
Antigen specific proteins produced by plasma cells that belon…
1.) Alpha ... 2.) Beta... 3.) Gamma
gamma
Secreted by different B-cell lineages within the body. (Heter…
Antibodies
Antigen specific proteins produced by plasma cells that belon…
Three Types of Globulins
1.) Alpha ... 2.) Beta... 3.) Gamma
32 terms
Immunoglobulins
Immunity forms
Antibody structure
Light chain regions
heavy chain regions
Cellular (phagocytosis and cytotoxicity)... Humoral (Uses solub…
*2 identical heavy and light chains... (both contribute to antig…
Kappa and lambda... (functionally identical
Alpha, gamma, delta, epsilon, mu... (Distinct functions)
Immunity forms
Cellular (phagocytosis and cytotoxicity)... Humoral (Uses solub…
Antibody structure
*2 identical heavy and light chains... (both contribute to antig…
16 terms
Immunoglobulins
Heavy chain
amino
hypervariable or CDR
covalent disulfide
this structural component of an Ig determines its isotype... com…
this terminal end is where the variable region is contained
found within the variable region of an Ig. This portion recog…
the type of bond that holds the four polypeptide chains of an…
Heavy chain
this structural component of an Ig determines its isotype... com…
amino
this terminal end is where the variable region is contained
24 terms
Immunoglobulins
IgG
IgM
IgA
IgD
- MW: 150,000... - 7S... - Valence: 2... - Half life: 23... - Crosses pla…
- MW: 900,000... - "macroglobulins"... - 19S... - Valence: 10 (5 reali…
- MW: serum - 160,000... secretory - 380,000... - serum: 7S... secreto…
- MW: 180,000... - 7S... - Valence: 2... - Half life: 2.8... - Complement…
IgG
- MW: 150,000... - 7S... - Valence: 2... - Half life: 23... - Crosses pla…
IgM
- MW: 900,000... - "macroglobulins"... - 19S... - Valence: 10 (5 reali…
8 terms
Immunoglobulins
Major class of circulation antibody
The pair of heavy chains & light chain…
Constant region
Variable region
IgG (gamma globulins)
Disulfide bridges
Region of IgG at C-terminal region of heavy and light chains…
Where binding of antigen occurs. Region of IgG at the N-termi…
Major class of circulation antibody
IgG (gamma globulins)
The pair of heavy chains & light chain…
Disulfide bridges
24 terms
Immunoglobulins
What is the immune system?
What is the immune system divided into…
Describe the features of the innate im…
Describe the features of the adaptive…
Is a complex network of cells and soluble molecules which int…
The innate & adaptive system
- Non-specific ... - No memory... - First line: physical & chemical…
- Specific ... - Acquisition of memory ... - Antibody response... - T-…
What is the immune system?
Is a complex network of cells and soluble molecules which int…
What is the immune system divided into…
The innate & adaptive system
97 terms
Immunoglobulins
Infliximab
Omalizumab
Primary defense against
Effector mechanisms
Anti-TNF Ab
Anti-IgE Ab... Think: bind to IgE to prevent allergic reaction…
EXTRACELLULAR organisms... Ab bind to microbial Ag, Neutralize,…
promote phagocytosis (opsonin-- IgG C3b)... Inflammatory mediato…
Infliximab
Anti-TNF Ab
Omalizumab
Anti-IgE Ab... Think: bind to IgE to prevent allergic reaction…
9 terms
Immunoglobulins
IgG
IgG
IgA
IgM
Major line of defense
Slowest produced immunoglobulin
Found in exocrine gland secretions, such as tears, breast mil…
First responder, produced quickest
IgG
Major line of defense
IgG
Slowest produced immunoglobulin
26 terms
Immunoglobulins
Antibody... IgG most utilized in IHC
Light chain
Heavy chain
gamma, alpha, mu, delta, epsilon
are made by a class of white blood cells, called B lymphocyte…
Makes up 2 identical outermost chains on the antibody... 2 type…
-2 identical innermost chains... - differ in antigenic and stru…
What are the five heavy chains that make up the different iso…
Antibody... IgG most utilized in IHC
are made by a class of white blood cells, called B lymphocyte…
Light chain
Makes up 2 identical outermost chains on the antibody... 2 type…
48 terms
Immunoglobulins
What is the common origin of all cells…
What is another name for a surface imm…
What is another name for a (free) immu…
Which cells express surface immunoglob…
Hematopoietic stem cell, common lymphoid progenitor
B-cell receptor
Antibody
B cells
What is the common origin of all cells…
Hematopoietic stem cell, common lymphoid progenitor
What is another name for a surface imm…
B-cell receptor
28 terms
Immunoglobulins
What are immunoglobulins?
B cells
Plasma (effector) cells
3 secondary response characteristics f…
The antigen recognition molecules of B cells
> Differentiate into Plasma cells (effector cells)... > Differen…
Secrete antibodies which flag cells to be destroyed by Macrop…
> Produce antibodies which bind with greater affinity to thei…
What are immunoglobulins?
The antigen recognition molecules of B cells
B cells
> Differentiate into Plasma cells (effector cells)... > Differen…
224 terms
Immunoglobulins
Antibody basic structure
Ig domain
Fab region + parts that make it up
Fc region + parts that make it up
-2 identical light chains... -2 identical heavy chains
Type of protein domain (pattern) that consists of a 2-layer s…
Hypervariable region of Ig where antigens bind; VH, VL, CH1, CL
Constant region of Ig that confers the effector function; CH2…
Antibody basic structure
-2 identical light chains... -2 identical heavy chains
Ig domain
Type of protein domain (pattern) that consists of a 2-layer s…
20 terms
Immunoglobulins
Which immunoglobulin treats mainly int…
Which immunoglobulins have a valence o…
Which immunoglobulin is important in b…
Which immunoglobulins have a CH4 domain?
IgM
IgG, IgD and IgE
IgM
IgM and IgE
Which immunoglobulin treats mainly int…
IgM
Which immunoglobulins have a valence o…
IgG, IgD and IgE
5 terms
immunoglobulins
IgG
IgA
IgM
IgD
Most abundant, about 80% of all antibodies in blood; found in…
Found mainly in sweat, tears, saliva, mucus, breast milk, and…
About 5-10% of all antibodies in blood; also found in lymph.…
Mainly found on surfaces of B cells as antigen receptors, whe…
IgG
Most abundant, about 80% of all antibodies in blood; found in…
IgA
Found mainly in sweat, tears, saliva, mucus, breast milk, and…
5 terms
Immunoglobulins
IgG
IgA
IgM
IgD
protects against bacteria/virus by enhancibg phagocytosis, ne…
Provides localize protection against bacteria and viruses on…
activates complement and causes agglutination and lysis micro…
Involves in activation of B cells
IgG
protects against bacteria/virus by enhancibg phagocytosis, ne…
IgA
Provides localize protection against bacteria and viruses on…
5 terms
Immunoglobulins
G
M
A
D
human serum... 2nd immune response... protection of newborn... against…
PriMARY Responses... PlasMA MEMbrane of b lymphocytes... new infect…
found in saliva, tears, mucus(resp passage, GI tract)... prevent…
receptor for antigen found mostly on mature B-lymphocytes
G
human serum... 2nd immune response... protection of newborn... against…
M
PriMARY Responses... PlasMA MEMbrane of b lymphocytes... new infect…
Immunoglobulins
IgG
IgM
IgA
IgD
Monomer, located in the blood and lymph... 1. enhances phagocyto…
Pentamer, located in blood, lymph and surface of B cell... 1. fi…
Dimer, located in secretions like tears as well as blood and…
Monomer, located in blood, lymph, B cell surface... 1. initiates…
IgG
Monomer, located in the blood and lymph... 1. enhances phagocyto…
IgM
Pentamer, located in blood, lymph and surface of B cell... 1. fi…
20 terms
immunoglobulins
IgD
IgE
IgG
IgA
No known serum value; 1 of 2 BCR types
Reaginic antibody; Type 1 Hypersensitivity Reactions; Protect…
Immunity for Pathogens; Best immunity antigen; Toxin, Bacteri…
Secretory-Breast milk; J-chain----Serum-Neutralizing and oxid…
IgD
No known serum value; 1 of 2 BCR types
IgE
Reaginic antibody; Type 1 Hypersensitivity Reactions; Protect…
131 terms
Immunoglobulins
Whole blood... Serum... Plasma... CSF... Serous fl…
10-15% lower
30 mins - 1 hr
2hrs
Samples for glucose determination
Whole blood gives approximately _______ glucose levels than s…
A serum specimen is appropriate for glucose analysis if serun…
Maximum of hours specimen should be kept at room temp
Whole blood... Serum... Plasma... CSF... Serous fl…
Samples for glucose determination
10-15% lower
Whole blood gives approximately _______ glucose levels than s…
23 terms
Immunoglobulins
Blood plasma
Major antibody in primary and secondar…
Inactivates antigen
Neutralizes toxins
IgG
IgG
IgG
IgG
Blood plasma
IgG
Major antibody in primary and secondar…
IgG
11 terms
Immunoglobulins
IgG
IgG
IgG
IgG
75-80% of antibodies
most stable with a halflife of >3 weeks
OK complement activator, good opsonizer
can cross placenta
IgG
75-80% of antibodies
IgG
most stable with a halflife of >3 weeks
8 terms
Immunoglobulins
Major effector of SPECIFIC immune resp…
Isotypes of light chains ... No known fun…
'B cell receptor'... Exists as monomer on…
Co-expressed on surface of naive B cel…
General
Kappa/Lambda
IgM
IgD
Major effector of SPECIFIC immune resp…
General
Isotypes of light chains ... No known fun…
Kappa/Lambda
5 terms
Immunoglobulins
IgM
IgA
IgD
IgG
Largest amount, appear at first exposure
Usually within secretions
Basophil binding, smallest amount
Second response to an infection
IgM
Largest amount, appear at first exposure
IgA
Usually within secretions
11 terms
Immunoglobulins
Activation of B cells
Results of Ag-Ab binding
What amino acids compose the hinge reg…
Where is the antigen binding site on a…
MHC... T-dependent antigen... T-independent antigen
agglutination... activation of complement... osponization... Ab depend…
proline and cysteine
Fab fragment
Activation of B cells
MHC... T-dependent antigen... T-independent antigen
Results of Ag-Ab binding
agglutination... activation of complement... osponization... Ab depend…
27 terms
Immunoglobulins
IgA
IgG
IgM
IgD
secreted by plasma cells; transported to gut, lungs, reproduc…
most common isotype of secondary immune responses
first antibody produced in primary immune response, confined…
transmembrane receptor on B cells, no known effector functions
IgA
secreted by plasma cells; transported to gut, lungs, reproduc…
IgG
most common isotype of secondary immune responses
9 terms
Immunoglobulins
IgG
IgG
IgA
IgM
most abundant Ig both in serum and extravascular spaces; long…
fixes complement; acts as an opsonin; has ability to cross th…
found in saliva, tears, colostrum as well as nasal, bronchial…
largest Ig molecule; restricted almost entirely to the intrav…
IgG
most abundant Ig both in serum and extravascular spaces; long…
IgG
fixes complement; acts as an opsonin; has ability to cross th…
39 terms
Immunoglobulins
G1
E
A
M
Highest subtype serum concentration
Lowest serum concentration
Most produced
1st type made by B-cells
G1
Highest subtype serum concentration
E
Lowest serum concentration
8 terms
Immunoglobulins
IgG
IgM
IgA
IgE
Opsonization of antigens for phagocytosis by macrophages and…
Activation of the classical pathway of complement... Antigen rec…
Mucosal immunity: secretion of IgA into the lumens of GI and…
IgE Mast cell degranulation (immediate hypersensitivity react…
IgG
Opsonization of antigens for phagocytosis by macrophages and…
IgM
Activation of the classical pathway of complement... Antigen rec…
8 terms
Immunoglobulins
IgG
IgG
IgA
IgM
only antibody that can be transferred through the placenta
most abundant antibody
predominant antibody in secretions (saliva, tears, milk, mucu…
second most abundant antibody
IgG
only antibody that can be transferred through the placenta
IgG
most abundant antibody
9 terms
Immunoglobulins
IgG
IgM
IgE
IgD
Most abundant, 21 day halftime, dominerende antistof, ... ONLY A…
Uspecifikke, Largest Ig Molecule, first line of defense, 10 d…
main function kill parasites. ative constituents of immunemed…
bit of a puzzle, occur in all species and nearly looks the sa…
IgG
Most abundant, 21 day halftime, dominerende antistof, ... ONLY A…
IgM
Uspecifikke, Largest Ig Molecule, first line of defense, 10 d…
10 terms
Immunoglobulins
IgM
IgA
IgD
IgG
Initial attack. Good at clumping microorganisms for elimination
Secretions and mucosal immunity. Stimulated by IN vaccinations
Abundance on B cell membranes. Low levels in serum. Activate…
Most abundant. Can cross placenta
IgM
Initial attack. Good at clumping microorganisms for elimination
IgA
Secretions and mucosal immunity. Stimulated by IN vaccinations
5 terms
immunoglobulins
IgG 75-85
IgA 5-15
IgM 5-10
IgE 0.5
located in blood plasma-major antibody in primary and seconda…
located in tears saliva, mucus, breast milk, GI pulmonary pro…
First LG to respond to microbial invasion- activates compleme…
mucous membranes and tonsils. binds to mast cells. causes rel…
IgG 75-85
located in blood plasma-major antibody in primary and seconda…
IgA 5-15
located in tears saliva, mucus, breast milk, GI pulmonary pro…
21 terms
Immunoglobulins
igA
igA
igA
igA
combines with protein in mucosa to protect body surfaces from…
2nd largest class of immunoglobins
found in tears, saliva, sweat, mucus membreanes and bile
it is secretes by plama cells in the GI and resp. tracts and…
igA
combines with protein in mucosa to protect body surfaces from…
igA
2nd largest class of immunoglobins
5 terms
Immunoglobulins
IgG
IgA
IgM
IgD
Bactericidal, beast neutralizing antibody, starts complement…
Secretory or serum, virus neutralizing, opsonizing, protects…
least specialized, produced rapidly and early, C' fixing, hig…
Membrane bound, B cell receptor, can activate basophils and m…
IgG
Bactericidal, beast neutralizing antibody, starts complement…
IgA
Secretory or serum, virus neutralizing, opsonizing, protects…
6 terms
Immunoglobulins
IgD
IgE
IgG
IgA
-B cell receptor... -On inactivated B cells ... -Activated basophil…
-Release histamine ... -Protect from parasitic worms... -Reaginic a…
-Excellent toxin, bacterial, and virus-neutralizing antibody…
- found in mucosal areas... -found in saliva, tears, breast milk…
IgD
-B cell receptor... -On inactivated B cells ... -Activated basophil…
IgE
-Release histamine ... -Protect from parasitic worms... -Reaginic a…
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