How can we help?

You can also find more resources in our Help Center.

Study sets matching "immunohematology"

Study sets
Classes
Users

Study sets matching "immunohematology"

452 terms
IMMUNOHEMATOLOGY
PRIMARY VS. SECONDARY RESPONSE
Stimulus... -Primary=... Secondary=
Lag phase... -Primary= how long is respon…
Type of antibody... -Types of antibodies…
...
Primary= First exposure to antigen.... Secondary= Subsequent exp…
Primary= Days to months... Secondary= Hours
Primary= IgM at first, May switch to IgG after *2-3 weeks…
PRIMARY VS. SECONDARY RESPONSE
...
Stimulus... -Primary=... Secondary=
Primary= First exposure to antigen.... Secondary= Subsequent exp…
293 terms
IMMUNOHEMATOLOGY
PRIMARY VS. SECONDARY RESPONSE
Stimulus... -Stages (2)- how they response
Lag phase... Stages- how long
Type of antibody... -Types of antibodies…
...
Primary= First exposure to antigen.... Secondary= Subsequent exp…
Primary= Days to months... Secondary= Hours
Primary= IgM at first, May switch to IgG after *2-3 weeks…
PRIMARY VS. SECONDARY RESPONSE
...
Stimulus... -Stages (2)- how they response
Primary= First exposure to antigen.... Secondary= Subsequent exp…
337 terms
IMMUNOHEMATOLOGY
PRIMARY VS. SECONDARY RESPONSE
Stimulus... -Primary=... Secondary=
Lag phase... -Primary= how long is respon…
Type of antibody... -Types of antibodies…
...
Primary= First exposure to antigen.... Secondary= Subsequent exp…
Primary= Days to months... Secondary= Hours
Primary= IgM at first, May switch to IgG after *2-3 weeks…
PRIMARY VS. SECONDARY RESPONSE
...
Stimulus... -Primary=... Secondary=
Primary= First exposure to antigen.... Secondary= Subsequent exp…
121 terms
Immunohematology
Maximum Collection
Minimum Donor Age
Donor Temperature
Donor Blood Pressure
No more than 10.5 mL of whole blood/kilogram of body weight.
16 (no max)
Less than or equal to 37.5°C (99.5°F)
Less than or equal to 180(systolic)... Less than or equal to 100…
Maximum Collection
No more than 10.5 mL of whole blood/kilogram of body weight.
Minimum Donor Age
16 (no max)
98 terms
Immunohematology
Immune Response
Primary Immune Response
Secondary Immune Response
Immune System
Physiological mechanism to fight disease to clear foreign sub…
First to be exposed to the foreign agent. IgM is the predomin…
Subsequent exposure to the same antigen. Rapid response where…
Provides protection non-self and abnormal self. One part is d…
Immune Response
Physiological mechanism to fight disease to clear foreign sub…
Primary Immune Response
First to be exposed to the foreign agent. IgM is the predomin…
123 terms
Immunohematology
A sugar
B sugar
H sugar
Most common blood group mutation
N-acetyl-D-galactosamine
D-galactose
L-fucose
Missense
A sugar
N-acetyl-D-galactosamine
B sugar
D-galactose
30 terms
Immunohematology
explain the significance of the red bl…
what does forward type detect?
what does reverse type detect?
what blood type is the universal donor?
the H antigen is really the base to determine if pt is type A…
detects antigens present on RBC
detects antibodys present in serum
O negative
explain the significance of the red bl…
the H antigen is really the base to determine if pt is type A…
what does forward type detect?
detects antigens present on RBC
130 terms
immunohematology
Collection of donor blood
Maximum collection
Medications evaluated by MD
criteria for donor selection
- Follows registration, medical history, and physical examina…
No more than 10.5 mL of whole blood per kilogram of body
Platelets from donors who have taken medication within 48hrs…
-Age: >16 yrs minimum or conform to state law, no max... -Temp:…
Collection of donor blood
- Follows registration, medical history, and physical examina…
Maximum collection
No more than 10.5 mL of whole blood per kilogram of body
30 terms
Immunohematology
ABO Blood Genes location
Group O RBCs
Group A, B, AB RBCs
Group A Antigens
On chromosome 9
Contain precursor glycolipid on cell surface... - H antigen/subs…
A and B antigens are formed by the addition of sugars to the…
Addition of N-acetyl galactosamine to H antigen
ABO Blood Genes location
On chromosome 9
Group O RBCs
Contain precursor glycolipid on cell surface... - H antigen/subs…
274 terms
Immunohematology
Collection of donor blood
Maximum collection
Medications evaluated by MD
criteria for donor selection
- Follows registration, medical history, and physical examina…
No more than 10.5 mL of whole blood per kilogram of body
Platelets from donors who have taken medication within 48hrs…
-Age: >16 yrs minimum or conform to state law, no max... -Temp:…
Collection of donor blood
- Follows registration, medical history, and physical examina…
Maximum collection
No more than 10.5 mL of whole blood per kilogram of body
25 terms
Immunohematology
Type A Blood has...
Type B Blood has...
Type AB Blood has...
Type O Blood has...
A antigens and B antibodies
B antigens and A antibodies
A and B antigens and no antibodies
No antigens but A and B antibodies
Type A Blood has...
A antigens and B antibodies
Type B Blood has...
B antigens and A antibodies
10 terms
Immunohematology
ABO chromosome
ABO addition mechanism
ABO ... antibodies... Ab occurrence... Ig type
Bombay phenotype
Chromosome 9
A antigen to H... B antigen to H... H antigen alone
A: B-... B: A-... AB: none... O: A-, B-... All naturally present... A- and B…
Lack of H antigen; O blood phenotype... Double recessive hh alle…
ABO chromosome
Chromosome 9
ABO addition mechanism
A antigen to H... B antigen to H... H antigen alone
21 terms
immunohematology
ABO antibodies present in everyone exc…
most common naturally occuring Abs are…
the ABO group is the most concerning a…
"bombay" is
1. infants (take a while to produce) 2. the elderly
ABO Abs
the universality and the hemolytic effect
a person with hh genotype who does not have "H substance" wil…
ABO antibodies present in everyone exc…
1. infants (take a while to produce) 2. the elderly
most common naturally occuring Abs are…
ABO Abs
88 terms
Immunohematology
Indirect ELISA
Sandwich ELISA
Competitive ELISA
ELISA (Enzyme-linked Immunosorbent Ass…
ELISA technique used to determine the presence or quantity of…
ELISA technique used to determine the presence or quantity of…
ELISA technique used to determine the presence or quantity of…
____________________ is used to detect the presence of small…
Indirect ELISA
ELISA technique used to determine the presence or quantity of…
Sandwich ELISA
ELISA technique used to determine the presence or quantity of…
Immunohematology
Febrile Non-Hemolytic Reaction
Allergic Reactions to transfused produ…
Urticarial Allergic Reactions
Hemolytic Reactions
MC transfusion complication.... HA, Fever, Chills, Mild Dyspnea.…
IgG antibodies recognize IgA in the infused blood product, ca…
Triggered by the presence of an allergen in the donated blood…
Preformed IgM antibodies against donor RBCs fix complement, i…
Febrile Non-Hemolytic Reaction
MC transfusion complication.... HA, Fever, Chills, Mild Dyspnea.…
Allergic Reactions to transfused produ…
IgG antibodies recognize IgA in the infused blood product, ca…
20 terms
Immunohematology
Big four Rh distributions
Anti-G
Weak Du
Partial D vs Weak D
Whites: R1 > r > R2 > R0... Blacks: R0 > r > R1 > R2... Asians: R1…
Red cell that has C or D antigen also has the G antigen.... Can…
RHCe on opposite chromosome to RHD, C in trans. eg: Dce/dCe,…
Partial D makes anti-D whereas weak D does not.
Big four Rh distributions
Whites: R1 > r > R2 > R0... Blacks: R0 > r > R1 > R2... Asians: R1…
Anti-G
Red cell that has C or D antigen also has the G antigen.... Can…
Immunohematology
Agglutinogen
Hemolysin
Isoantibodies
Autoantibodies
Antigen on RBC surface... Agglutinin-antibody that attacks an ag…
antibody that attacks an RBC antigen and causes hemolysis
antibodies that are formed against antigens from outside the…
antibodies that are formed against one or more tissues within…
Agglutinogen
Antigen on RBC surface... Agglutinin-antibody that attacks an ag…
Hemolysin
antibody that attacks an RBC antigen and causes hemolysis
5 terms
Immunohematology
direct Coombs
indirect Coombs
Type II hypersensitivity
Forward testing
Detects antibody that have adhered to patient's RBCs.... - autoi…
Detects serum antibodies that are freely floating, but can po…
This type of hypersensitivity is cytotoxic killing of antigen…
Reactant antibodies (anti-A, anti-B) + patient cells
direct Coombs
Detects antibody that have adhered to patient's RBCs.... - autoi…
indirect Coombs
Detects serum antibodies that are freely floating, but can po…
20 terms
Immunohematology
any substance capable of eliciting an…
An immunoglobulin molecule produced in…
he degree to which an antigen is capab…
portion of the antigen molecule in whi…
antigen
antibody
Immunogenicity
antigenic determinant
any substance capable of eliciting an…
antigen
An immunoglobulin molecule produced in…
antibody
123 terms
Immunohematology
A sugar
B sugar
H sugar
Most common blood group mutation
N-acetyl-D-galactosamine
D-galactose
L-fucose
Missense
A sugar
N-acetyl-D-galactosamine
B sugar
D-galactose
14 terms
immunohematology
Washed RBC
CRYO
IHTR
DHTR
90% of wbc, platelets and plasma removed
contains fibrinogen, Factor 8, Von Willebrand factor, and Fac…
pain at infusion site, chest/back pain, renal failure w/ olig…
Malaise, Jaundice, unexplained fall in hemoglobin level
Washed RBC
90% of wbc, platelets and plasma removed
CRYO
contains fibrinogen, Factor 8, Von Willebrand factor, and Fac…
157 terms
immunohematology
phenotype O in white population
phenotype O in black population
phenotype O in asian population
phenotype A in white population
45%
49
40
40
phenotype O in white population
45%
phenotype O in black population
49
130 terms
immunohematology
Collection of donor blood
Maximum collection
Medications evaluated by MD
criteria for donor selection
- Follows registration, medical history, and physical examina…
No more than 10.5 mL of whole blood per kilogram of body
Platelets from donors who have taken medication within 48hrs…
-Age: >16 yrs minimum or conform to state law, no max... -Temp:…
Collection of donor blood
- Follows registration, medical history, and physical examina…
Maximum collection
No more than 10.5 mL of whole blood per kilogram of body
17 terms
Immunohematology
ABO Blood group system
O blood type
Why is O blood the universal donor?
A blood type
most important blood group system in human-blood transfusion…
Express neither A nor B antigen ... - Universal donor ... - Plasma…
They lack antigens so if a person receives the blood they wil…
Have A antigen on red blood cell surface and anti-B antibodie…
ABO Blood group system
most important blood group system in human-blood transfusion…
O blood type
Express neither A nor B antigen ... - Universal donor ... - Plasma…
98 terms
Immunohematology
What defines the Bombay phenotype?
What is the significance of the Bombay…
What are the RBC antigens (forward typ…
What are the RBC antigens (forward typ…
lacks H antigens
have anti-A, B, and H antibodies; type as an 'O' but will cro…
H, Rh (D)
H
What defines the Bombay phenotype?
lacks H antigens
What is the significance of the Bombay…
have anti-A, B, and H antibodies; type as an 'O' but will cro…
37 terms
Immunohematology
Blood Bank, studies antigen antibody R…
most common blood type, OO, does not h…
second most common blood type, AA or A…
third most common blood type, BB or BO…
Immunohematology
Blood Type O
Blood Type A
Blood Type B
Blood Bank, studies antigen antibody R…
Immunohematology
most common blood type, OO, does not h…
Blood Type O
56 terms
Immunohematology
The lowest hematocrit for an autologou…
A person can donate a unit of whole bl…
a person can not donate blood for 12 m…
a positive HBsAG test will cause a vol…
33%
8 weeks
have a virus
to be permenantly deferred
The lowest hematocrit for an autologou…
33%
A person can donate a unit of whole bl…
8 weeks
18 terms
Immunohematology
Immunohematology
Blood banking
Major tests include
ABO
Study of immunological response to blood cells.
Collecting, storing, process, and distribution, of blood and…
ABO, Reverse typing, RH, and Cross matching
Antigens on cell surface
Immunohematology
Study of immunological response to blood cells.
Blood banking
Collecting, storing, process, and distribution, of blood and…
82 terms
Immunohematology
Immune System Roles
Self
Non-self
First line of response
1) Defense against foreign, external organisms and objects... 2)…
Anything within the organism that derives from the host genom…
Anything physically outside the host and introduced into the…
physical barriers, biochemical effectors (tears, mucus)
Immune System Roles
1) Defense against foreign, external organisms and objects... 2)…
Self
Anything within the organism that derives from the host genom…
10 terms
Immunohematology
immunohematology
three elements that make up RBC
what type of antigens produce the best…
immune response
antigen-antibody reactions related to blood disorders and the…
50% protein, 40% lipids, 10% carbs
protein and protein carb. complexes more than lipid and nucle…
responsible for determining self from non self and then defen…
immunohematology
antigen-antibody reactions related to blood disorders and the…
three elements that make up RBC
50% protein, 40% lipids, 10% carbs
45 terms
Immunohematology
Polyagglutination
weak or missing ABO antigens, antibodi…
weak or missing ABO antigens or antibo…
acquired B phenotype
...
enhance antigen-antibody binding. Incubate at 4C, use enzyme…
sometimes you need to screen the saliva
retest using different monoclonal and human polyclonal reagents
Polyagglutination
...
weak or missing ABO antigens, antibodi…
enhance antigen-antibody binding. Incubate at 4C, use enzyme…
44 terms
Immunohematology
blood banking immunoglobulins
detected via agglutination or hemolysis
most common blood type in whites + bla…
blood bank tube
IgM, IgA, IgG
antigen-antibody rxns
type O
pink or red top
blood banking immunoglobulins
IgM, IgA, IgG
detected via agglutination or hemolysis
antigen-antibody rxns
105 terms
immunohematology
what is the composition and structure…
proteins that extend from the outer su…
proteins beneath the lipid bilayer, li…
what is the main component of the lipi…
semi permeable, made of lipids.... supported by protein cytoskel…
integral membrane proteins
peripheral proteins
semi permeable phospholipids
what is the composition and structure…
semi permeable, made of lipids.... supported by protein cytoskel…
proteins that extend from the outer su…
integral membrane proteins
33 terms
Immunohematology
how old do you have to be to donate bl…
what does your oral temperature have t…
blood pressure for donating blood is
donating blood your pulse has to be
16
37.5' or 99.5
<180 systolic <100 diastolic
50-100 bpm
how old do you have to be to donate bl…
16
what does your oral temperature have t…
37.5' or 99.5
41 terms
Immunohematology
Structure of RBC membrane
Spectrin
ATP
ATP Decrease & Cell Membrane
Phospholipid bilayer... Integral proteins... Peripheral proteins
Helps maintain the membrane in its desired, flexible form
Helps maintain spectrin levels... Provides energy for sodium pot…
RBC membrane will become rigid... -May happen when RBCs are stored
Structure of RBC membrane
Phospholipid bilayer... Integral proteins... Peripheral proteins
Spectrin
Helps maintain the membrane in its desired, flexible form
98 terms
Immunohematology
what is Immunohematology?
do RBCs or plasma express the antigens?
do RBCs or plasma contain the antibodi…
how are the ABO antigen groups formed?
The study of antigen-antibody reactions as they relate to blo…
RBC
plasma
transferases add specific sugars to the H substance on the me…
what is Immunohematology?
The study of antigen-antibody reactions as they relate to blo…
do RBCs or plasma express the antigens?
RBC
89 terms
Immunohematology
Criteria for donating blood
How long is a person deferred if they…
Deferral for measles, mumps, polio, ty…
Deferral for rubella, chicken pox vacc…
Temp: lower than 99.5... BP: at least 80/50 and no higher than 1…
48 hours
2 weeks
4 weeks
Criteria for donating blood
Temp: lower than 99.5... BP: at least 80/50 and no higher than 1…
How long is a person deferred if they…
48 hours
25 terms
Immunohematology
What is an antigen?
What is an antibody?
What is an agglutinogen?
What is a a hemolysin?
a substance that causes the formation of antibodies
proteins produced by lymphocytes and plasma cells in response…
an antigen on the surface of a red blood cell
An agglutinogen that lyses red blood cells
What is an antigen?
a substance that causes the formation of antibodies
What is an antibody?
proteins produced by lymphocytes and plasma cells in response…
49 terms
IMMUNOHEMATOLOGY
T/F: Blood group antigens are sugar gr…
What is name of type testing when pts…
What is name of type testing when reac…
What testing is only done in newborns?
True
forward grouping
reverse grouping
forward typing
T/F: Blood group antigens are sugar gr…
True
What is name of type testing when pts…
forward grouping
34 terms
Immunohematology
What are you generally transfusing whe…
Why was this pretty easy to deal with?
What about white cells?
What about platelets?
red blood cells
RBCs don't carry MHC antigens and the antigens they have are…
they get destroyed
they have HLA class one and may require HLA typing if someone…
What are you generally transfusing whe…
red blood cells
Why was this pretty easy to deal with?
RBCs don't carry MHC antigens and the antigens they have are…
30 terms
Immunohematology
What is a common characteristic of A,…
What is unique about Bombay phenotypes
What is the universal donor
What is the universal recipient
They are all carbohydrates
They lack H antigen.. For some reason they offer different re…
O neg
AB pos
What is a common characteristic of A,…
They are all carbohydrates
What is unique about Bombay phenotypes
They lack H antigen.. For some reason they offer different re…
70 terms
Immunohematology
Any substance that stimulates antibody…
Immunoglobulin that is produced by B l…
What does monoclonal mean?
What does polyclonal mean?
antigen
antibody
a single class of immunoglobulin derived from a single B-cell…
produced as different classes of immunoglobulin by many B-cel…
Any substance that stimulates antibody…
antigen
Immunoglobulin that is produced by B l…
antibody
Immunohematology
Most Blood group systems are inherited…
The Kell antigen (KI) is:
REsistance to malaria is best associat…
Which of the following constitutes per…
Autosomal codominant
strongly immunogenic
Duffy
confirmed positive test for Hepatitis B surface antigen (HBsA…
Most Blood group systems are inherited…
Autosomal codominant
The Kell antigen (KI) is:
strongly immunogenic
Immunohematology
Ideally, immunohemtology testing shoul…
immunohemtologic testing can look for…
If testing for antibody, the test must…
If testing for antigen, the test must…
immunity from vaccine vs natir
antigen or antibody
antigen
antibody
Ideally, immunohemtology testing shoul…
immunity from vaccine vs natir
immunohemtologic testing can look for…
antigen or antibody
19 terms
Immunohematology
what is present in all individuals exc…
what makes ABO system the most importa…
What is the basis of the ABO system?
what is hh genotype?
ABO anitbodies
universality of AB and hemolytic effect
H substance
bombay syndrome... forms hemolytic anti H
what is present in all individuals exc…
ABO anitbodies
what makes ABO system the most importa…
universality of AB and hemolytic effect
IMMUNOHEMATOLOGY
WHAT IMMUNODOMINAT SUGAR CONFERS A ANT…
WHAT GENOTYPE CONFERS THE BOMBAY BLOOD…
WHAT GENES ENCODE FOR Rh ANTIGENS?
TESTING FOR THE D ANTIGEN WAS CONDUCTE…
N-ACETYLGALACTOSAMINE
hh
RHD AND RHCE
THE TEST IS INVALID BECAUSE THE CONTROL TUBE WAS POSITIVE/
WHAT IMMUNODOMINAT SUGAR CONFERS A ANT…
N-ACETYLGALACTOSAMINE
WHAT GENOTYPE CONFERS THE BOMBAY BLOOD…
hh
28 terms
Immunohematology
Immunohematology is the study of what?
What is immunhematology essential for?
Antigens found on RBCs include?
What are the four blood groups?
Immunology of blood cells, typically RBCs (antigens on RBCs)
Blood incompatibilities during pregnancy & ensure safe blood…
ABH
AA, BB, AB, OO
Immunohematology is the study of what?
Immunology of blood cells, typically RBCs (antigens on RBCs)
What is immunhematology essential for?
Blood incompatibilities during pregnancy & ensure safe blood…
38 terms
Immunohematology
Name the antigens of KIDD.
Does the KIDD blood group show dosage?
Are KIDD antigens detectable throughou…
Name 3 Characteristics of KIDD antibod…
JKa, JKb, JK3
Yes
Yes; they're developed even on fetal red cells
Evanescent... Activate a lot of complement... Associated with sever…
Name the antigens of KIDD.
JKa, JKb, JK3
Does the KIDD blood group show dosage?
Yes
178 terms
Immunohematology Review
What are blood group antigens?
List several blood group antigens of l…
List several high incidence blood grou…
What is the most common pattern of inh…
Most blood group antigens are proteins, glycoproteins, or gly…
V, Kpa, Jsa, Lua, Vw, Di, Wr, Cob. These antigens are found i…
Kpb, k, Jsb, Lub, I, Vel, Coa, and U. These antigens are foun…
Autosomal codominant. The genes are inherited equally by male…
What are blood group antigens?
Most blood group antigens are proteins, glycoproteins, or gly…
List several blood group antigens of l…
V, Kpa, Jsa, Lua, Vw, Di, Wr, Cob. These antigens are found i…
192 terms
Immunohematology Review
What are blood group antigens?
List several blood group antigens of l…
List several high incidence blood grou…
What is the most common pattern of inh…
Most blood group antigens are proteins, glycoproteins, or gly…
C<sup>W</sup>, V, Kp<sup>a</sup>, Js<sup>a</sup>, Lu<sup>a</s…
Kp<sup>b</sup>, k, Js<sup>b</sup>, , Lu<sup>b</sup>, I, Ge, T…
Autosomal codominant. The genes are inherited equally by male…
What are blood group antigens?
Most blood group antigens are proteins, glycoproteins, or gly…
List several blood group antigens of l…
C<sup>W</sup>, V, Kp<sup>a</sup>, Js<sup>a</sup>, Lu<sup>a</s…
1 of 10