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Study sets matching "immunolgoy"

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Study sets matching "immunolgoy"

13 terms
immunolgoy
RAG-1/2
RSS
VJ/VDJ recombination
TdT
lymphoid specific complex of two proteins that catalyze DNA s…
Recombination Signal Sequences - sites on Ig gene recongintio…
recombination of light chain/ heavy chain
protein that adds N region nucleotides to heavy chain
RAG-1/2
lymphoid specific complex of two proteins that catalyze DNA s…
RSS
Recombination Signal Sequences - sites on Ig gene recongintio…
22 terms
1x46 UWorld Immunolgoy
Ty pe I interferons (alpha and beta)
Anti-phospholipid antibody Syndrome
Leukocyte adhesion deficiency (LAD)
Wiskott-Aldrich syndrome
. Synthesized by most human cells in response to viral infect…
. presence of antiphospholipid ab (ex: anticardiolipin) which…
. aut. recessive disorder characterized by absence of CD18 ag…
. X-linked --> defect in cytoskeleton rearrangement... . triad:…
Ty pe I interferons (alpha and beta)
. Synthesized by most human cells in response to viral infect…
Anti-phospholipid antibody Syndrome
. presence of antiphospholipid ab (ex: anticardiolipin) which…
27 terms
Cell Types for Immunolgoy
granulocytic
neutrophils/PMN
basophil
eosinophil
cells that contain granules... -neutrophils/PMNs ... -basophils ... -e…
-most abundant Leukocyte (50-70%) ... -1st to arrive at the scen…
-have only been found in the blood ... -unknown function ... -relea…
-deal with parasitic infections and allergic reactions and ki…
granulocytic
cells that contain granules... -neutrophils/PMNs ... -basophils ... -e…
neutrophils/PMN
-most abundant Leukocyte (50-70%) ... -1st to arrive at the scen…
27 terms
Cell Types for Immunolgoy
granulocytic
neutrophils/PMN
basophil
eosinophil
cells that contain granules... -neutrophils/PMNs ... -basophils ... -e…
-most abundant Leukocyte (50-70%) ... -1st to arrive at the scen…
-have only been found in the blood ... -unknown function ... -relea…
-deal with parasitic infections and allergic reactions and ki…
granulocytic
cells that contain granules... -neutrophils/PMNs ... -basophils ... -e…
neutrophils/PMN
-most abundant Leukocyte (50-70%) ... -1st to arrive at the scen…
9 terms
Seminarie 6
1. Vad är monoklonala antikroppar? Vi…
2. Varför kan det vara problematiskt…
3. Vilka särskilda egenskaper har pro…
4. Vilken slags sjukdomar behandlas fr…
Monoklonala antikroppar är antikroppar med ursprung från en e…
Antikropp från mus är ett främmande protein för människa och…
Lm som monoklonala antikroppar är mer strukturellt med komple…
TNF = tumör necrosis factor är ett proinflammatoriskt cytokin…
1. Vad är monoklonala antikroppar? Vi…
Monoklonala antikroppar är antikroppar med ursprung från en e…
2. Varför kan det vara problematiskt…
Antikropp från mus är ett främmande protein för människa och…
11 terms
Lecture 15 - Immuno
Chronic inflammation can cause localiz…
Through what mechanisms can chronic in…
What does the hygiene hypothesis state?
What did the regulation of experimenta…
- IBD... - IBS Celiacs... - GI cancer... - Diabetes... - Obesity... - Ather…
- chronic infiltration and accumulation of macrophages and ly…
- due to reduced microbial exposure during infancy, the immun…
- bacterial antigen-specific T cell clones can both induce an…
Chronic inflammation can cause localiz…
- IBD... - IBS Celiacs... - GI cancer... - Diabetes... - Obesity... - Ather…
Through what mechanisms can chronic in…
- chronic infiltration and accumulation of macrophages and ly…
44 terms
Lecture - 13
Which antibody mediate allergy?
IgE antibodies are responsible for?
Allergies are initiated when?
What is IgE really for?
- IgE
type 1 - hypersensitivity
an interaction between an IgE antibody and a multivalent anti…
healthy individuals make IgE only in response to parasites... -…
Which antibody mediate allergy?
- IgE
IgE antibodies are responsible for?
type 1 - hypersensitivity
43 terms
Lecture- 14
CD4 subsets are responsible for?
Th1 cells (IFN-y) provide host defence…
Th2 cells (IL-4, IL-5) provide host de…
Th17 cells (IL-17) provide host defenc…
- generation and function
- many microbes systemic and organ-specific autoimmune diseases
- helminths ... - allergic diseases
- fungi... - bacteria... - organ-specific autoimmune diseases
CD4 subsets are responsible for?
- generation and function
Th1 cells (IFN-y) provide host defence…
- many microbes systemic and organ-specific autoimmune diseases
61 terms
Lecture 12 - Immu
Cells capable of cytotoxicity express?
The Ab binds to the target cell, while…
Antibody provides?
What are the cells capable of antibody…
FcR
Fc portion of the Ab
specificity
- Macrophages... - Natural Killer (NK)... - Neutrophils... - eosinophils
Cells capable of cytotoxicity express?
FcR
The Ab binds to the target cell, while…
Fc portion of the Ab
19 terms
IMmuni- lect 19
Cell that have lost control of the cel…
Benign tumor?
Malignant tumor?
DNA alteration can induce malignant tr…
- a tumor/ neoplams
- unable to invade healthy surrounding tissue incapable of in…
- becomes progressively more invasive... - may metastasize - inv…
- chemical substances... - physical agents... - ionizing radiation…
Cell that have lost control of the cel…
- a tumor/ neoplams
Benign tumor?
- unable to invade healthy surrounding tissue incapable of in…
212 terms
Exam 1
Microbiology
Prions
Prions
Viroids
study of organims too small to be seen clearly with the unaid…
Proteinaceous infectious particles. Devoid of nucleic acid. S…
Cause slow infections (month-years-decades). Dementia > spasm…
"virus like," 10x smaller than smallest plant virus. Linear o…
Microbiology
study of organims too small to be seen clearly with the unaid…
Prions
Proteinaceous infectious particles. Devoid of nucleic acid. S…
36 terms
Immunology - Lecture 8
Secreted by multiple clones of antigen…
Produced as the product of a single st…
In monoclonal antibodies the binding s…
What principle are immunoprecipitation…
Polyclonal antibodies
Monoclonal antibodies
binding sites retained,... change the Fc region... - Fc region repl…
- the ability of antibodies to bind to more than one antigeni…
Secreted by multiple clones of antigen…
Polyclonal antibodies
Produced as the product of a single st…
Monoclonal antibodies
47 terms
Lecture - 17 immuno
Defense to pathogens is mediated by bo…
The immune response capable of respond…
Cells for Virus and intracellular bact…
Cells for extracellular bacteria?
- innate and adaptive immunity
- distinct and specialized ways to different pathogens in ord…
CD8+ T cells
CD4+ Th1 cells, ... CD4+ Th17 cells
Defense to pathogens is mediated by bo…
- innate and adaptive immunity
The immune response capable of respond…
- distinct and specialized ways to different pathogens in ord…
61 terms
Immunology - Lecture 4
Innate immunity is evolutionarily " ol…
Innate receptors are found in virtuall…
Only ____ have adaptive immunity?
Host defense mediated by Ab and other…
adaptive
all plants and animals
vertebrates
Humoral Immunity
Innate immunity is evolutionarily " ol…
adaptive
Innate receptors are found in virtuall…
all plants and animals
71 terms
Immunology - Lecture 2
Coordination of physiological function…
Key roles of the receptor (R) is?
A molecule that binds the receptor (R)…
R-L results in?
- the ability of cells to sense and then respons
- to sense the enviornment
- Ligand (L)
Transduction of signal to the interior of the cell
Coordination of physiological function…
- the ability of cells to sense and then respons
Key roles of the receptor (R) is?
- to sense the enviornment
59 terms
Immunology - Lecture 9
The site that selects for maturation o…
What is the Thymus?
Transient cells are derived from?
Most of the thymocytes (immature T cel…
Thymus
- a large bag consisting of both stationary cells, such as ep…
hematopoietic stem cells and include thymocytes and antigen-p…
die there and only 2% survive and leave the thymus as mature…
The site that selects for maturation o…
Thymus
What is the Thymus?
- a large bag consisting of both stationary cells, such as ep…
44 terms
Immunology - Lecture 5
Antibodies alone are not very effectiv…
What is the complement system?
Complement in combination with antibod…
The complement operates as a ?
- Ab can bind to the surface of bacteria and viruses and may…
- a complex group of over 30 different proteins that work tog…
- Bacteria, viruses, and other pathogens
- Cascade mechanism... - sequential activation: components inact…
Antibodies alone are not very effectiv…
- Ab can bind to the surface of bacteria and viruses and may…
What is the complement system?
- a complex group of over 30 different proteins that work tog…
38 terms
Lecture 10 imuno
T-cell activation require?
Once T cells are activated they?
Successful T cell-APC interactions org…
Co-stimulatory signals are required for?
- antigen presentation as a first signal... - other molecular in…
differentiate into their effector forms... - CD8+ T cells go on…
an immunological synapse... - TCR/MHC peptide complexes and co-…
- optimal T cell activation and proliferation
T-cell activation require?
- antigen presentation as a first signal... - other molecular in…
Once T cells are activated they?
differentiate into their effector forms... - CD8+ T cells go on…
30 terms
Lecture 18 immuni
What are primary immunodeficiencies (P…
What are immunodeficiencies?
Primary immunodeficiency?
Acquired (secondary immunodeficiency)
- helped immunologists understand the role of particular gene…
- failure of immune system to protect host from disease-causi…
- genetic - develops before birth... - relatively rare
- Caused by infection, cancer, or immunosuppressive drugs... - m…
What are primary immunodeficiencies (P…
- helped immunologists understand the role of particular gene…
What are immunodeficiencies?
- failure of immune system to protect host from disease-causi…
38 terms
Immuni - lecture 16
The act of transferring cells, tissues…
Can be a problem due to?
Rejection of transplantation caused du…
What is transplantation immunology?
transplantation
- the immune system having elaborate and effective mechanisms…
- immunological reactions against foreign Ags on grafted tiss…
- seeks means of reducing immune-system activation and promot…
The act of transferring cells, tissues…
transplantation
Can be a problem due to?
- the immune system having elaborate and effective mechanisms…
167 terms
Medical Immunology Test 4
Is vaccination adaptive or innate immu…
procedure by which adaptive immune sys…
immunological memory is induced by what?
immunological memory is utilized durin…
adaptive
vaccination
primary adaptive immune response
secondary adaptive immune response
Is vaccination adaptive or innate immu…
adaptive
procedure by which adaptive immune sys…
vaccination
65 terms
Immunology - lecture 7
TCR recognize?
Th recognize in context of?
Tc recognize in context of?
T cells respond to antigen only if?
a short peptide carried in the groove of the major histocompa…
MHC class 2
MHC class 1
the antigen is "presented" to them
TCR recognize?
a short peptide carried in the groove of the major histocompa…
Th recognize in context of?
MHC class 2
66 terms
Immunolgy - Lecture 1
Any substance (usually foreign) that b…
A substance capable of eliciting an im…
Y-shaped proteins used by the adaptive…
Infiltration of leuokocytes (white blo…
Antigen
Immunogen (all immunogens are antigens but some antigens are…
Antibodies
Inflammation (to set on fire)... (initial response to harmful st…
Any substance (usually foreign) that b…
Antigen
A substance capable of eliciting an im…
Immunogen (all immunogens are antigens but some antigens are…
159 terms
med immuno final
The generic name for a therapeutic ant…
T/F: Fab fragments have 2 variable dom…
If an Ig molecule does not have a flex…
Approximately how many amino acids are…
mab
true
IgM or IgE
200 (100 per domain)
The generic name for a therapeutic ant…
mab
T/F: Fab fragments have 2 variable dom…
true
21 terms
Seminarie 4
1. Vad är det för skillnader och lik…
2. Vad innebär det att B-cellens anti…
3. Vad är BCR-komplexet, och vilken r…
4. A. Hur initieras antigendriven sign…
BCR hos en naiv B-cell utgörs av membranbundna IgM och IgD-an…
BCR binder direkt till en struktur på en mikroorganism så som…
BCR-komplexet består av BCR och dess accessoriska proteiner:…
A) För signal 1 via BCR-komplexet krävs korsbinding: alltså d…
1. Vad är det för skillnader och lik…
BCR hos en naiv B-cell utgörs av membranbundna IgM och IgD-an…
2. Vad innebär det att B-cellens anti…
BCR binder direkt till en struktur på en mikroorganism så som…
17 terms
Seminarie 2
1. Vad binder T-cellsreceptorn (TCRαβ)…
2. Vilka signaler driver aktivering av…
3. Varför har alla kärnförsedda cel…
4. A. Vad innebär det att MHC-generna…
Komplex av MHC-molekyl och peptid
TLR-ligander (PAMPs) och proinflammatoriska cytokiner aktiver…
Alla friska kärnförsedda celler presenterar "själv"-peptider…
Att MHC-generna är polymorfa innebär att många alleliska vari…
1. Vad binder T-cellsreceptorn (TCRαβ)…
Komplex av MHC-molekyl och peptid
2. Vilka signaler driver aktivering av…
TLR-ligander (PAMPs) och proinflammatoriska cytokiner aktiver…
14 terms
Seminarie 3
1. Vad är det för skillnad mellan TC…
2. Hur och varför bildas immunologisk…
3. ... A Vad har costimulering för funkt…
4. Vilket är sambandet mellan adjuvan…
TCR: receptor som saknar intracellulär domän. För att förmedl…
Immunologisk synaps = då T-cell och en antigenpresenterande c…
A) att bekräfta för T-cellen att antigenet som presenteras är…
Adjuvans är ett hjälpämne som kan tillsättas i vaccinering me…
1. Vad är det för skillnad mellan TC…
TCR: receptor som saknar intracellulär domän. För att förmedl…
2. Hur och varför bildas immunologisk…
Immunologisk synaps = då T-cell och en antigenpresenterande c…
72 terms
Med Immuno Test 3
what do dendritic cells do
malt
why are dendritic cells highly special…
do macrophages leave the site of infec…
they carry antigen to secondary lymphoid tissue
mucosa-associated lymphoid tissue
to activate adaptive immune response
no
what do dendritic cells do
they carry antigen to secondary lymphoid tissue
malt
mucosa-associated lymphoid tissue
17 terms
Seminarie 1
1. a) Vilka är skillnaderna mellan in…
1. b) Vilka är de generella skillnade…
2. Vad är det för skillnad mellan hu…
3. Vad är det för skillnad mellan ak…
INNEBOENDE IMMUNITET... Inre försvar: ... - Är alltid där på plats…
INNEBOENDE IMMUNITET:... Pattern Recognition Receptors (PRRs) =…
Patogener som förekommer extracellulärt kan bekämpas humoralt…
Aktiv immunitet innebär att kroppens immunsystem har aktivera…
1. a) Vilka är skillnaderna mellan in…
INNEBOENDE IMMUNITET... Inre försvar: ... - Är alltid där på plats…
1. b) Vilka är de generella skillnade…
INNEBOENDE IMMUNITET:... Pattern Recognition Receptors (PRRs) =…
175 terms
Microbiology Unit 1
Bacteriology
Virology
Mycology
Parasitology
Study of bacteria
Study of viruses
Study of fungi
Study of parasites (traditionally parasites that are animals…
Bacteriology
Study of bacteria
Virology
Study of viruses
23 terms
Immunology Introduction
Immunity
immunolgoy
Physical barriers
Innate immunity
free from burden
study of host defenses against infectious disease, neoplasm,…
- skin - physically prevents invasion of tissues, pH 5.5, fat…
when physical barriers are breached, like a patrol boat - fir…
Immunity
free from burden
immunolgoy
study of host defenses against infectious disease, neoplasm,…
212 terms
Exam 1 MICRO
Microbiology
Prions
Prions
Viroids
study of organims too small to be seen clearly with the unaid…
Proteinaceous infectious particles. Devoid of nucleic acid. S…
Cause slow infections (month-years-decades). Dementia > spasm…
"virus like," 10x smaller than smallest plant virus. Linear o…
Microbiology
study of organims too small to be seen clearly with the unaid…
Prions
Proteinaceous infectious particles. Devoid of nucleic acid. S…
42 terms
Mod 38: Stress *screams*
Health pysch (behavioral medicine)
Stressor
Appraisal
Stress reaction
Studies impacts of emotions like phases of stress response/ad…
Event we view as threatening, challenging, or overwhelming
Deciding whether to view something as a stressor
Emotional or physical response to stressor
Health pysch (behavioral medicine)
Studies impacts of emotions like phases of stress response/ad…
Stressor
Event we view as threatening, challenging, or overwhelming
90 terms
Immunology Exam 3: Lecture 1 Hepatitis and Viruses and Viral Exanthems
What are the viruses that cause Hepati…
Which Hepatitis virus is a DNA virus?…
What is the family of HAV?... What is th…
What is the family of HCV?... What is th…
Hep A virus... Hep B virus... non A, Non B [NANB] hep viruses:... H…
Hep B virus is a DNA virus... Hep [C,A,D,E] are RNA viruses
HAV family: Picornaviridae... HBV Family: Hepadnaviridae
HCV: Flaviviridae... HDV: unassigned... HEV: Hepeviridae
What are the viruses that cause Hepati…
Hep A virus... Hep B virus... non A, Non B [NANB] hep viruses:... H…
Which Hepatitis virus is a DNA virus?…
Hep B virus is a DNA virus... Hep [C,A,D,E] are RNA viruses
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