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Study sets matching "immunology chapter 8"

154 terms
Immunology Chapter 8
Chapter 8
T Cell-Mediated Immunity
Activation of naïve T cells on encount…
Process of T-cell activation
T Cell-Mediated Immunity
what happens?
Chapter 8
T Cell-Mediated Immunity
T Cell-Mediated Immunity
34 terms
Chapter 8 - Immunology
AIDS
Acquired immunity
Active immunity
Allergic responses
Acquired Immune Deficiency Syndrome
Formation of antibodies and lymphocytes after exposure to an…
A resistance of the body to infection in which the host produ…
typical allergic responses from pollen, chemicals initiating…
AIDS
Acquired Immune Deficiency Syndrome
Acquired immunity
Formation of antibodies and lymphocytes after exposure to an…
36 terms
Chapter 8 Immunology Flashcards
Most important antibodies for compleme…
Primary antibody for defense against h…
Antibody that provides mucosal immunity
Antibody that crosses the placenta to…
IgM, IgG
IgE
Secretory IgA >>>IgG
IgG
Most important antibodies for compleme…
IgM, IgG
Primary antibody for defense against h…
IgE
71 terms
Chapter 8 (Immunology)
T Cell-Mediated Immunity
Process of T-cell activation
Activation of naïve T cells on encount…
Dendritic cells carry antigens from si…
1.Activation of naïve T cells on encounter with antigen... *Wha…
-T-cell activation or T-cell priming... 1. First stage of a prim…
-Upon infection, the immune system quickly recruits the small…
-The immune system does not initiate the adaptive immune resp…
T Cell-Mediated Immunity
1.Activation of naïve T cells on encounter with antigen... *Wha…
Process of T-cell activation
-T-cell activation or T-cell priming... 1. First stage of a prim…
96 terms
Immunology Chapter 8
Defenses that antibodies mediate
Vaccines
Defects in antibody production
Properties of Antibodies
-block binding of microbes to host cell... -block binding of tox…
Most work through stimulation of protective antibodies.... Stim…
Increases susceptibility to many pathogens ... (bacteria, viruse…
-throughout the body... -differentiate into plasma cells that ca…
Defenses that antibodies mediate
-block binding of microbes to host cell... -block binding of tox…
Vaccines
Most work through stimulation of protective antibodies.... Stim…
Immunology- Chapter 8
lymph
lymphatics
dendritic cells
foreign antigen
the extracellular fluid surrounding tissues forms ______.
lymph is drained by the ______ to the secondary lymphoid tiss…
circulate in tissues
what activates dendritic cells
lymph
the extracellular fluid surrounding tissues forms ______.
lymphatics
lymph is drained by the ______ to the secondary lymphoid tiss…
51 terms
Immunology Chapter 8
Ab May Act Far From Site of Production
Various Levels of Ab Can Be Produced
Antibodies use their Fab regions to...
Antibodies use their Fc regions to...
stimulated B cells initially produce Ab in peripheral lymphoi…
higher levels of production during subsequent responses than…
bind to and block harmful effects of microbes and toxins
activate mechanisms that eliminate microbes and toxins (e.g.…
Ab May Act Far From Site of Production
stimulated B cells initially produce Ab in peripheral lymphoi…
Various Levels of Ab Can Be Produced
higher levels of production during subsequent responses than…
128 terms
chapter 8 immunology
T-cell activation is also called
when a naive T cell first encounters i…
What is the function of an effector CD…
What is the function of effector CD4 T…
T-cell priming
T-cell activation
kills infected cells
secrete cytokines, which activate other cells in the immune s…
T-cell activation is also called
T-cell priming
when a naive T cell first encounters i…
T-cell activation
93 terms
Immunology Chapter 8
What is MHC?
What type of immunity is MHC?
MHC is recognized by what?
To be recognized by T cells, what must…
Discrimination between self & non self
Humoral and cell mediated
T cells
Ag-MHC complex on APC
What is MHC?
Discrimination between self & non self
What type of immunity is MHC?
Humoral and cell mediated
72 terms
Immunology Chapter 8
what cells are the main route to activ…
site of activation of Naive T cells
dendritic cells job
What is the result of TLRs initiating…
dendritic cells
1. skin and most tissue - draining lymph node... 2. respiratory…
-dendritic cells take up bacterial antigens in the skin and t…
-increase efficiency of antigen capture... -increase in receptor…
what cells are the main route to activ…
dendritic cells
site of activation of Naive T cells
1. skin and most tissue - draining lymph node... 2. respiratory…
33 terms
Immunology Chapter 8
Define cytokine
What is autocrine action with cytokines?
What is paracrine action with cytokines?
What is endocrine action with cytokines?
A secreted protein that bind to specific receptors on target…
Within the same cell
Affecting a cell in close proximity
Cells that are a great distance away (circulation)
Define cytokine
A secreted protein that bind to specific receptors on target…
What is autocrine action with cytokines?
Within the same cell
62 terms
Immunology Chapter 8
T cell priming
TH1 ... TH2... TFH (follicular helper)... Treg…
secrete cytokines in order to activate…
inactivation of T cells
Another name for T cell activation
Name the 5 types of CD4 T cells
The general function of CD4 T cells
Interaction of a naïve T cell with antigen presented by cells…
T cell priming
Another name for T cell activation
TH1 ... TH2... TFH (follicular helper)... Treg…
Name the 5 types of CD4 T cells
180 terms
Immunology Chapter 8
What do TH1's activate?
What do TH2's activate?
What do TH17's do?
TFH
Macrophages to suppress intracellular infections
B cells to make IgE isotypes (parasitic infections)
Secrete an IL-17 cytokine which recruits neutrophils
Found in the follicle, activates B cells for other isoptypes
What do TH1's activate?
Macrophages to suppress intracellular infections
What do TH2's activate?
B cells to make IgE isotypes (parasitic infections)
118 terms
Immunology Chapter 8
B cells develop in the _____ and move…
in the secondary lymphoid tissue B cel…
negative selection take place in
activated B cells give rise to
bone marrow and move to the secondary lymphoid tissue
antigens
the bone marrow
memory B cells and plasma cells
B cells develop in the _____ and move…
bone marrow and move to the secondary lymphoid tissue
in the secondary lymphoid tissue B cel…
antigens
8 terms
Immunology chapter 8
Where do naive T-cells encounter antig…
Function of dendritic cells
What happens to viruses that cant infe…
Dendritic cells all have TLRs except?
in Secondary Lymphoid Tissue
-activates naive t cells by MHC II molecules... -when infected p…
can be cross penetrated to activate CD8+ t cells
TLR9
Where do naive T-cells encounter antig…
in Secondary Lymphoid Tissue
Function of dendritic cells
-activates naive t cells by MHC II molecules... -when infected p…
38 terms
Immunology Exam III Chapter 8
Positive selection of T cells
Negative selection of T cells
Effector function of T cells
Goal of T-cell activation
prove ability to bind peptide:MHC complex, commit to either C…
prove it will not attack self
perform cytotoxic fcn (CD8) or activate/suppress other immune…
produce expanded effector T-cell population w/ ability to fig…
Positive selection of T cells
prove ability to bind peptide:MHC complex, commit to either C…
Negative selection of T cells
prove it will not attack self
25 terms
Chapter 8 Hematology and Immunology
Coagul/o
Thromb/o
Splen/o
Thym/o
Root meaning coagulation. Coagulo refers to the blood's abili…
Root meaning clot.
Root meaning spleen. Which is an organ located on the left up…
Root meaning thymus. Which is n organ found in the base of th…
Coagul/o
Root meaning coagulation. Coagulo refers to the blood's abili…
Thromb/o
Root meaning clot.
46 terms
Immunology Chapter 8
What is the process by which thymic an…
What is the collection of antigen rece…
T-cell progenitors develop in the ____…
Where does positive and negative selec…
lymphocyte maturation
lymphocyte repertoire
bone marrow; thymus
the thymus
What is the process by which thymic an…
lymphocyte maturation
What is the collection of antigen rece…
lymphocyte repertoire
Immunology Chapter 8
Immature dendritic cells located in
Mature dendritic cells located in
Dendrites interact with
Dendritic cells are confined to
The skin and other peripheral tissures
The lymph node
T cells in cortex of lymph node
Outerpart of cortex where naive T cells congregate
Immature dendritic cells located in
The skin and other peripheral tissures
Mature dendritic cells located in
The lymph node
32 terms
immunology chapter 8
Major histocompatibility complex
MHC II
MHC I
general organization of the MHC genes
TCR recognizes a short peptide carried in the groove of MHC
TH recognizes MHC class II... - 33 kDa a chain... - 28 kDa B chain…
-TC recognizes in context of MHC class I... - larger 45 kDa glyc…
- high resolution gene mapping and DNA sequencing indicates t…
Major histocompatibility complex
TCR recognizes a short peptide carried in the groove of MHC
MHC II
TH recognizes MHC class II... - 33 kDa a chain... - 28 kDa B chain…
40 terms
Immunology Chapter 8 Review
__________ binding to antigen ________…
Binding of antibody to toxins ________…
any _____________ of antibody has the…
any part of a pathogen's life cycle th…
F(ab), sterically, tissues, host cells
inactivates, binding, clearance
isotype
stick, invade, antibody
__________ binding to antigen ________…
F(ab), sterically, tissues, host cells
Binding of antibody to toxins ________…
inactivates, binding, clearance
29 terms
Kaplan Immunology Chapter 8-10
What does Cell Mediated immunity prote…
What cytokines enhances killing in CMI?
What does the Delayed Type Hyersensiti…
What is the difference between CTL, NK…
1. CMI protects against intracellular pathogens... 2. TH1 cells…
1. IFN-y... 2. TNF alpha... 3. TNF- Beta
TH1 function
Macrophages kill intracellularly
What does Cell Mediated immunity prote…
1. CMI protects against intracellular pathogens... 2. TH1 cells…
What cytokines enhances killing in CMI?
1. IFN-y... 2. TNF alpha... 3. TNF- Beta
47 terms
Chapter 8: Immunology Vocabulary
Peristalsis
Wandering phagocyte
Lymphokine
Invaginate
The involuntary rhythmic movement of smooth muscle tissue tha…
A mobile phagocyte (as opposed to a stationary or fixed one)…
A type of cytokine; a soluble protein released by sensitized…
Indentation of the phagocytic membrane when ingesting foreign…
Peristalsis
The involuntary rhythmic movement of smooth muscle tissue tha…
Wandering phagocyte
A mobile phagocyte (as opposed to a stationary or fixed one)…
51 terms
immunology - chapter 8
most common APC cell to activate naive…
interaction of naive T cell with a non…
take up antigen and bring it to lymph…
immature dendritic cells bring in anti…
dendritic cell
leads to inactivation
Langerhan's Cells (immature dendritics)
DEC205 receptors
most common APC cell to activate naive…
dendritic cell
interaction of naive T cell with a non…
leads to inactivation
36 terms
Immunology Flashcards Chapter 8
Most important antibodies for compleme…
Primary antibody for defense against h…
Antibody that provides mucosal immunity
Antibody that crosses the placenta to…
IgM, IgG
IgE
Secretory IgA >>>IgG
IgG
Most important antibodies for compleme…
IgM, IgG
Primary antibody for defense against h…
IgE
36 terms
Immunology flashcards - Chapter 8
Most important antibodies for compleme…
Primary antibody for defense against h…
Antibody that provides mucosal immunity
Antibody that crosses the placenta to…
IgM, IgG
IgE
Secretory IgA >>>IgG
IgG
Most important antibodies for compleme…
IgM, IgG
Primary antibody for defense against h…
IgE
18 terms
Immunology Chapter 8
Homing
Vascular addressin
High endothelial venule
Sphingosine 1 phosphate (S1P)
the movement of cells from the circulation to a tissue. For e…
...
...
a chemotactic lipid that binds to a receptor on naive T cells…
Homing
the movement of cells from the circulation to a tissue. For e…
Vascular addressin
...
27 terms
Chapter 8 - Immunology
Non-specific defences (in general)
Specific defences (in general)
Plant active defences
Role of lymphatic system
Physical barriers found in all organisms. Innate, not produce…
Acquired, develops as a result of contact with particular pat…
Invoked after pathogen has been recognised and contributes to…
Returns proteins that leak from blood and continuously sweeps…
Non-specific defences (in general)
Physical barriers found in all organisms. Innate, not produce…
Specific defences (in general)
Acquired, develops as a result of contact with particular pat…
154 terms
Immunology Chapter 8
dendritic cells
immature DCs
periphery
highly phagocytic... express low levels o…
transport Ag from site of infection
encounter pathogens in the periphery
where do immature DCs encounter pathgens
2 characteristics of immature DCS
dendritic cells
transport Ag from site of infection
immature DCs
encounter pathogens in the periphery
38 terms
Immunology Chapter 8
Receptor mediated endocytosis
Macropinocytosis
Cross presentation
Immature DCs (Langerhans)
used to capture bacteria and virus particles from the extrace…
Mechanism of internalization that involves the nonspecific in…
used to stimulate a CD8 T cell response
DC in skin and other peripheral tissues that are active in th…
Receptor mediated endocytosis
used to capture bacteria and virus particles from the extrace…
Macropinocytosis
Mechanism of internalization that involves the nonspecific in…
62 terms
immunology chapter 8
central lymphoid tissues
peripheral lymphoid tissue
mucosal associated lymphoid tissue
CD45R
the bone marrow and thymus are what classification of tissue?
the spleen, lymph nodes, and MALT are what classification of…
MALT
surface marker on CLP (common lymphoid progenitor) in bone ma…
central lymphoid tissues
the bone marrow and thymus are what classification of tissue?
peripheral lymphoid tissue
the spleen, lymph nodes, and MALT are what classification of…
36 terms
Immunology Flashcards Chapter 8
Most important antibodies for compleme…
Primary antibody for defense against h…
Antibody that provides mucosal immunity
Antibody that crosses the placenta to…
IgM, IgG
IgE
Secretory IgA >>>IgG
IgG
Most important antibodies for compleme…
IgM, IgG
Primary antibody for defense against h…
IgE
48 terms
CHAPTER 8: IMMUNOLOGY
1st Line of Defense
Peristalsis
Yeast Infection
2nd Line of Defense
Skin, mucous membranes and secretions
Involuntary rhythmic movement of smooth muscle that pushes fo…
Caused by candida albicans
Circulatory system (phagocytes, complement, proteins, interfe…
1st Line of Defense
Skin, mucous membranes and secretions
Peristalsis
Involuntary rhythmic movement of smooth muscle that pushes fo…
64 terms
Immunology Vocab: Chapter 8
T-Cell Activation (T Cell Priming)
Helper T Cells:
Immature Dendritic Cells
Mature Dendritic Cells (activated)
The activation of mature naive T cells by antigen presented t…
General name for effector CD4 T cells that function to help o…
Dendritic cell present in tissues, which takes up antigen but…
Dendritic cell in secondary lymphoid tissues that... expresses c…
T-Cell Activation (T Cell Priming)
The activation of mature naive T cells by antigen presented t…
Helper T Cells:
General name for effector CD4 T cells that function to help o…
Chapter 8 Immunology
Major Events of B Lymphocyte Developme…
Major Events of B Lymphocyte Developme…
Major Events of B Lymphocyte Developme…
Major Events of B Lymphocyte Developme…
Develop from hematopoeitic stem cells in bone marrow
Immature B cells rearrange Ig genes and express a cell surfac…
Negative selection in bone marrow removes B cells that recogn…
Immature B cells migrate to peripheral lymphoid organs
Major Events of B Lymphocyte Developme…
Develop from hematopoeitic stem cells in bone marrow
Major Events of B Lymphocyte Developme…
Immature B cells rearrange Ig genes and express a cell surfac…
36 terms
Immunology Flashcards Chapter 8
Most important antibodies for compleme…
Primary antibody for defense against h…
Antibody that provides mucosal immunity
Antibody that crosses the placenta to…
IgM, IgG
IgE
Secretory IgA >>>IgG
IgG
Most important antibodies for compleme…
IgM, IgG
Primary antibody for defense against h…
IgE
36 terms
Immunology Flashcards Chapter 8
Most important antibodies for compleme…
Primary antibody for defense against h…
Antibody that provides mucosal immunity
Antibody that crosses the placenta to…
IgM, IgG
IgE
Secretory IgA >>>IgG
IgG
Most important antibodies for compleme…
IgM, IgG
Primary antibody for defense against h…
IgE
36 terms
Immunology Flashcards Chapter 8
Most important antibodies for compleme…
Primary antibody for defense against h…
Antibody that provides mucosal immunity
Antibody that crosses the placenta to…
IgM, IgG
IgE
Secretory IgA >>>IgG
IgG
Most important antibodies for compleme…
IgM, IgG
Primary antibody for defense against h…
IgE
55 terms
Immunology Chapter 8
T-cell activation
Dendritic cells
antigen destinations
immature DCs
the activation of mature naive T cells by antigens present to…
capture antigens at site of infection, transport them to the…
1. Skin and peripheral tissue -> Draining lymph node... 2. Blood…
dendritic cell present in tissues, which takes up antigen but…
T-cell activation
the activation of mature naive T cells by antigens present to…
Dendritic cells
capture antigens at site of infection, transport them to the…
64 terms
Immunology Chapter 8
T cell activation/ T cell priming
Helper T cell
Immature dendritic cells
Mature dendritic cells/ activated dend…
Naive T cell encountere its specific antigen and is instructe…
Effector CD4 T cell, help other cells acquire and exert their…
Dendritic cells present in tissues, which takes up antigen bu…
Dendritic cell in secondary lymphoid tissues that expresses c…
T cell activation/ T cell priming
Naive T cell encountere its specific antigen and is instructe…
Helper T cell
Effector CD4 T cell, help other cells acquire and exert their…
36 terms
Immunology Flashcards Chapter 8
Most important antibodies for compleme…
Primary antibody for defense against h…
Antibody that provides mucosal immunity
Antibody that crosses the placenta to…
IgM, IgG
IgE
Secretory IgA >>>IgG
IgG
Most important antibodies for compleme…
IgM, IgG
Primary antibody for defense against h…
IgE
48 terms
Immunology Chapter 8
Receptor mediated endocytosis
Macropinocytosis
Cross presentation
Immature DCs (Langerhans)
1 of 2 mechanisms of antigen capture by dendritic cells... -TLRs…
1 of 2 mechanisms of antigen capture by dendritic cells... non-s…
aka antigen transfer- the capture of antigen by a professiona…
in peripheral tissue, before antigen capture ... -MHC is in endo…
Receptor mediated endocytosis
1 of 2 mechanisms of antigen capture by dendritic cells... -TLRs…
Macropinocytosis
1 of 2 mechanisms of antigen capture by dendritic cells... non-s…
63 terms
Immunology Chapter 8
T cell activation
T cell priming
immature dendritic cells
mature dendritic cells
the stimulation of mature naive T cells by antigen presented…
The activation of mature naive T cells by antigen presented t…
dendritic cell present in tissues, which takes up antigen but…
dendritic cell in secondary lymphoid tissues that express co…
T cell activation
the stimulation of mature naive T cells by antigen presented…
T cell priming
The activation of mature naive T cells by antigen presented t…
30 terms
Immunology Chapter 8 SQ
True or False: In regards to T-cell pr…
True or False: In regards to T-cell pr…
True or False: In regards to T-cell pr…
True or False: In regards to T-cell pr…
False.
True.
True.
True.
True or False: In regards to T-cell pr…
False.
True or False: In regards to T-cell pr…
True.
23 terms
Immunology Chapter 8
Steps of Homing
LFA-1
CCL19 and CCL21
CCR7
1. Rolling mediated by selectins.... 2.Activation of integrins b…
-Must be activated by chemokines.... -Binds to ICAM-1 resulting…
-Chemokines that upregulate integrins.... -Bind to CCR7.
-Expressed on many lymphocytes.... -Only binds to CCL19 and CCL21.
Steps of Homing
1. Rolling mediated by selectins.... 2.Activation of integrins b…
LFA-1
-Must be activated by chemokines.... -Binds to ICAM-1 resulting…
30 terms
Chapter 8 immunology
characteristics of a mature DC
DC get to lymph node
Naive T cells get to lymph node
High endothelial venules (HEV)
decrease in pinocytosis/phagocytosis... increase in antigen pres…
with the help of cytokines through afferent lymph node
upstream lymph node or through blood vessel with HEV
loose "rolling" adhesion slows down T cells... Chemokines activa…
characteristics of a mature DC
decrease in pinocytosis/phagocytosis... increase in antigen pres…
DC get to lymph node
with the help of cytokines through afferent lymph node
103 terms
Chapter 8 Immunology
Antigen is brought in from?
Antigen encounters t cells brought from
If there is interaction of a naive t c…
he immune system captures the pathogen…
Lymph
blood
T cell becomes inactivated
secondary lymphoid tissues.
Antigen is brought in from?
Lymph
Antigen encounters t cells brought from
blood
Immunology SQ Chapter 8
True or False?... A monoclonal antibody s…
True or False?... APC's express both clas…
True or False?... Class III MHC genes enc…
True or False?... In out-bred populations…
True.
True.
False. They are soluble proteins that do not function in anti…
False. The offspring of heterozygous parents inherit one MHC…
True or False?... A monoclonal antibody s…
True.
True or False?... APC's express both clas…
True.
Immunology (Chapter 8 and 10)
In most cases, if the testing cannot b…
What are the majority of immunology te…
Complement in body fluids can be inact…
What is the formulat for "Fianl Concen…
72; -20
Serum
56 degrees C for 30 mins
C1 V2 = C2 V2
In most cases, if the testing cannot b…
72; -20
What are the majority of immunology te…
Serum
16 terms
Janeways Immunology - Chapter 8
B cell development (early)
B frumu þroskun byrjar á endurröðun _…
RAG
early pro-B frumur
Communicate with base cells (stromalfrumur)... Vaxtarþættir, boð…
1. þungu
Essential for immunogloblin and T-cell receptor REARRANGEMENT…
D-J rearranging
B cell development (early)
Communicate with base cells (stromalfrumur)... Vaxtarþættir, boð…
B frumu þroskun byrjar á endurröðun _…
1. þungu
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