Study sets matching "immunology chapter 8"

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Study sets matching "immunology chapter 8"

Chapter 8 (Immunology)
T Cell-Mediated Immunity
Process of T-cell activation
Activation of naïve T cells on encount…
Dendritic cells carry antigens from si…
1.Activation of naïve T cells on encounter with antigen... *Wha…
-T-cell activation or T-cell priming... 1. First stage of a prim…
-Upon infection, the immune system quickly recruits the small…
-The immune system does not initiate the adaptive immune resp…
T Cell-Mediated Immunity
1.Activation of naïve T cells on encounter with antigen... *Wha…
Process of T-cell activation
-T-cell activation or T-cell priming... 1. First stage of a prim…
34 terms
Chapter 8 - Immunology
AIDS
Acquired immunity
Active immunity
Allergic responses
Acquired Immune Deficiency Syndrome
Formation of antibodies and lymphocytes after exposure to an…
A resistance of the body to infection in which the host produ…
typical allergic responses from pollen, chemicals initiating…
AIDS
Acquired Immune Deficiency Syndrome
Acquired immunity
Formation of antibodies and lymphocytes after exposure to an…
Immunology- Chapter 8
lymph
lymphatics
dendritic cells
foreign antigen
the extracellular fluid surrounding tissues forms ______.
lymph is drained by the ______ to the secondary lymphoid tiss…
circulate in tissues
what activates dendritic cells
lymph
the extracellular fluid surrounding tissues forms ______.
lymphatics
lymph is drained by the ______ to the secondary lymphoid tiss…
Immunology Chapter 8
Ab May Act Far From Site of Production
Various Levels of Ab Can Be Produced
Antibodies use their Fab regions to...
Antibodies use their Fc regions to...
stimulated B cells initially produce Ab in peripheral lymphoi…
higher levels of production during subsequent responses than…
bind to and block harmful effects of microbes and toxins
activate mechanisms that eliminate microbes and toxins (e.g.…
Ab May Act Far From Site of Production
stimulated B cells initially produce Ab in peripheral lymphoi…
Various Levels of Ab Can Be Produced
higher levels of production during subsequent responses than…
128 terms
chapter 8 immunology
T-cell activation is also called
when a naive T cell first encounters i…
What is the function of an effector CD…
What is the function of effector CD4 T…
T-cell priming
T-cell activation
kills infected cells
secrete cytokines, which activate other cells in the immune s…
T-cell activation is also called
T-cell priming
when a naive T cell first encounters i…
T-cell activation
93 terms
Immunology Chapter 8
What is MHC?
What type of immunity is MHC?
MHC is recognized by what?
To be recognized by T cells, what must…
Discrimination between self & non self
Humoral and cell mediated
T cells
Ag-MHC complex on APC
What is MHC?
Discrimination between self & non self
What type of immunity is MHC?
Humoral and cell mediated
Immunology Chapter 8
what cells are the main route to activ…
site of activation of Naive T cells
dendritic cells job
What is the result of TLRs initiating…
dendritic cells
1. skin and most tissue - draining lymph node... 2. respiratory…
-dendritic cells take up bacterial antigens in the skin and t…
-increase efficiency of antigen capture... -increase in receptor…
what cells are the main route to activ…
dendritic cells
site of activation of Naive T cells
1. skin and most tissue - draining lymph node... 2. respiratory…
33 terms
Immunology Chapter 8
Define cytokine
What is autocrine action with cytokines?
What is paracrine action with cytokines?
What is endocrine action with cytokines?
A secreted protein that bind to specific receptors on target…
Within the same cell
Affecting a cell in close proximity
Cells that are a great distance away (circulation)
Define cytokine
A secreted protein that bind to specific receptors on target…
What is autocrine action with cytokines?
Within the same cell
62 terms
Immunology Chapter 8
T cell priming
TH1 ... TH2... TFH (follicular helper)... Treg…
secrete cytokines in order to activate…
inactivation of T cells
Another name for T cell activation
Name the 5 types of CD4 T cells
The general function of CD4 T cells
Interaction of a naïve T cell with antigen presented by cells…
T cell priming
Another name for T cell activation
TH1 ... TH2... TFH (follicular helper)... Treg…
Name the 5 types of CD4 T cells
118 terms
Immunology Chapter 8
B cells develop in the _____ and move…
in the secondary lymphoid tissue B cel…
negative selection take place in
activated B cells give rise to
bone marrow and move to the secondary lymphoid tissue
antigens
the bone marrow
memory B cells and plasma cells
B cells develop in the _____ and move…
bone marrow and move to the secondary lymphoid tissue
in the secondary lymphoid tissue B cel…
antigens
38 terms
Immunology Exam III Chapter 8
Positive selection of T cells
Negative selection of T cells
Effector function of T cells
Goal of T-cell activation
prove ability to bind peptide:MHC complex, commit to either C…
prove it will not attack self
perform cytotoxic fcn (CD8) or activate/suppress other immune…
produce expanded effector T-cell population w/ ability to fig…
Positive selection of T cells
prove ability to bind peptide:MHC complex, commit to either C…
Negative selection of T cells
prove it will not attack self
8 terms
Immunology chapter 8
Where do naive T-cells encounter antig…
Function of dendritic cells
What happens to viruses that cant infe…
Dendritic cells all have TLRs except?
in Secondary Lymphoid Tissue
-activates naive t cells by MHC II molecules... -when infected p…
can be cross penetrated to activate CD8+ t cells
TLR9
Where do naive T-cells encounter antig…
in Secondary Lymphoid Tissue
Function of dendritic cells
-activates naive t cells by MHC II molecules... -when infected p…
154 terms
Immunology Chapter 8
Chapter 8
T Cell-Mediated Immunity
Activation of naïve T cells on encount…
Process of T-cell activation
T Cell-Mediated Immunity
what happens?
Chapter 8
T Cell-Mediated Immunity
T Cell-Mediated Immunity
Immunology Chapter 8
What is the process by which thymic an…
What is the collection of antigen rece…
T-cell progenitors develop in the ____…
Where does positive and negative selec…
lymphocyte maturation
lymphocyte repertoire
bone marrow; thymus
the thymus
What is the process by which thymic an…
lymphocyte maturation
What is the collection of antigen rece…
lymphocyte repertoire
96 terms
Immunology Chapter 8
Defenses that antibodies mediate
Vaccines
Defects in antibody production
Properties of Antibodies
-block binding of microbes to host cell... -block binding of tox…
Most work through stimulation of protective antibodies.... Stim…
Increases susceptibility to many pathogens ... (bacteria, viruse…
-throughout the body... -differentiate into plasma cells that ca…
Defenses that antibodies mediate
-block binding of microbes to host cell... -block binding of tox…
Vaccines
Most work through stimulation of protective antibodies.... Stim…
47 terms
Chapter 8: Immunology Vocabulary
Peristalsis
Wandering phagocyte
Lymphokine
Invaginate
The involuntary rhythmic movement of smooth muscle tissue tha…
A mobile phagocyte (as opposed to a stationary or fixed one)…
A type of cytokine; a soluble protein released by sensitized…
Indentation of the phagocytic membrane when ingesting foreign…
Peristalsis
The involuntary rhythmic movement of smooth muscle tissue tha…
Wandering phagocyte
A mobile phagocyte (as opposed to a stationary or fixed one)…
51 terms
immunology - chapter 8
most common APC cell to activate naive…
interaction of naive T cell with a non…
take up antigen and bring it to lymph…
immature dendritic cells bring in anti…
dendritic cell
leads to inactivation
Langerhan's Cells (immature dendritics)
DEC205 receptors
most common APC cell to activate naive…
dendritic cell
interaction of naive T cell with a non…
leads to inactivation
Immunology Chapter 8
Homing
Vascular addressin
High endothelial venule
Sphingosine 1 phosphate (S1P)
the movement of cells from the circulation to a tissue. For e…
...
...
a chemotactic lipid that binds to a receptor on naive T cells…
Homing
the movement of cells from the circulation to a tissue. For e…
Vascular addressin
...
154 terms
Immunology Chapter 8
dendritic cells
immature DCs
periphery
highly phagocytic... express low levels o…
transport Ag from site of infection
encounter pathogens in the periphery
where do immature DCs encounter pathgens
2 characteristics of immature DCS
dendritic cells
transport Ag from site of infection
immature DCs
encounter pathogens in the periphery
38 terms
Immunology Chapter 8
Receptor mediated endocytosis
Macropinocytosis
Cross presentation
Immature DCs (Langerhans)
used to capture bacteria and virus particles from the extrace…
Mechanism of internalization that involves the nonspecific in…
used to stimulate a CD8 T cell response
DC in skin and other peripheral tissues that are active in th…
Receptor mediated endocytosis
used to capture bacteria and virus particles from the extrace…
Macropinocytosis
Mechanism of internalization that involves the nonspecific in…
64 terms
Immunology Vocab: Chapter 8
T-Cell Activation (T Cell Priming)
Helper T Cells:
Immature Dendritic Cells
Mature Dendritic Cells (activated)
The activation of mature naive T cells by antigen presented t…
General name for effector CD4 T cells that function to help o…
Dendritic cell present in tissues, which takes up antigen but…
Dendritic cell in secondary lymphoid tissues that... expresses c…
T-Cell Activation (T Cell Priming)
The activation of mature naive T cells by antigen presented t…
Helper T Cells:
General name for effector CD4 T cells that function to help o…
64 terms
Immunology Chapter 8
T cell activation/ T cell priming
Helper T cell
Immature dendritic cells
Mature dendritic cells/ activated dend…
Naive T cell encountere its specific antigen and is instructe…
Effector CD4 T cell, help other cells acquire and exert their…
Dendritic cells present in tissues, which takes up antigen bu…
Dendritic cell in secondary lymphoid tissues that expresses c…
T cell activation/ T cell priming
Naive T cell encountere its specific antigen and is instructe…
Helper T cell
Effector CD4 T cell, help other cells acquire and exert their…
48 terms
CHAPTER 8: IMMUNOLOGY
1st Line of Defense
Peristalsis
Yeast Infection
2nd Line of Defense
Skin, mucous membranes and secretions
Involuntary rhythmic movement of smooth muscle that pushes fo…
Caused by candida albicans
Circulatory system (phagocytes, complement, proteins, interfe…
1st Line of Defense
Skin, mucous membranes and secretions
Peristalsis
Involuntary rhythmic movement of smooth muscle that pushes fo…
Chapter 8 Immunology
Major Events of B Lymphocyte Developme…
Major Events of B Lymphocyte Developme…
Major Events of B Lymphocyte Developme…
Major Events of B Lymphocyte Developme…
Develop from hematopoeitic stem cells in bone marrow
Immature B cells rearrange Ig genes and express a cell surfac…
Negative selection in bone marrow removes B cells that recogn…
Immature B cells migrate to peripheral lymphoid organs
Major Events of B Lymphocyte Developme…
Develop from hematopoeitic stem cells in bone marrow
Major Events of B Lymphocyte Developme…
Immature B cells rearrange Ig genes and express a cell surfac…
48 terms
Immunology Chapter 8
Receptor mediated endocytosis
Macropinocytosis
Cross presentation
Immature DCs (Langerhans)
1 of 2 mechanisms of antigen capture by dendritic cells... -TLRs…
1 of 2 mechanisms of antigen capture by dendritic cells... non-s…
aka antigen transfer- the capture of antigen by a professiona…
in peripheral tissue, before antigen capture ... -MHC is in endo…
Receptor mediated endocytosis
1 of 2 mechanisms of antigen capture by dendritic cells... -TLRs…
Macropinocytosis
1 of 2 mechanisms of antigen capture by dendritic cells... non-s…
55 terms
Immunology Chapter 8
T-cell activation
Dendritic cells
antigen destinations
immature DCs
the activation of mature naive T cells by antigens present to…
capture antigens at site of infection, transport them to the…
1. Skin and peripheral tissue -> Draining lymph node... 2. Blood…
dendritic cell present in tissues, which takes up antigen but…
T-cell activation
the activation of mature naive T cells by antigens present to…
Dendritic cells
capture antigens at site of infection, transport them to the…
Immunology Chapter 8
T cell activation
T cell priming
immature dendritic cells
mature dendritic cells
the stimulation of mature naive T cells by antigen presented…
The activation of mature naive T cells by antigen presented t…
dendritic cell present in tissues, which takes up antigen but…
dendritic cell in secondary lymphoid tissues that express co…
T cell activation
the stimulation of mature naive T cells by antigen presented…
T cell priming
The activation of mature naive T cells by antigen presented t…
30 terms
Immunology Chapter 8 SQ
True or False: In regards to T-cell pr…
True or False: In regards to T-cell pr…
True or False: In regards to T-cell pr…
True or False: In regards to T-cell pr…
False.
True.
True.
True.
True or False: In regards to T-cell pr…
False.
True or False: In regards to T-cell pr…
True.
23 terms
Immunology Chapter 8
Steps of Homing
LFA-1
CCL19 and CCL21
CCR7
1. Rolling mediated by selectins.... 2.Activation of integrins b…
-Must be activated by chemokines.... -Binds to ICAM-1 resulting…
-Chemokines that upregulate integrins.... -Bind to CCR7.
-Expressed on many lymphocytes.... -Only binds to CCL19 and CCL21.
Steps of Homing
1. Rolling mediated by selectins.... 2.Activation of integrins b…
LFA-1
-Must be activated by chemokines.... -Binds to ICAM-1 resulting…
Immunology SQ Chapter 8
True or False?... A monoclonal antibody s…
True or False?... APC's express both clas…
True or False?... Class III MHC genes enc…
True or False?... In out-bred populations…
True.
True.
False. They are soluble proteins that do not function in anti…
False. The offspring of heterozygous parents inherit one MHC…
True or False?... A monoclonal antibody s…
True.
True or False?... APC's express both clas…
True.
103 terms
Chapter 8 Immunology
Antigen is brought in from?
Antigen encounters t cells brought from
If there is interaction of a naive t c…
he immune system captures the pathogen…
Lymph
blood
T cell becomes inactivated
secondary lymphoid tissues.
Antigen is brought in from?
Lymph
Antigen encounters t cells brought from
blood
Immunology (Chapter 8 and 10)
In most cases, if the testing cannot b…
What are the majority of immunology te…
Complement in body fluids can be inact…
What is the formulat for "Fianl Concen…
72; -20
Serum
56 degrees C for 30 mins
C1 V2 = C2 V2
In most cases, if the testing cannot b…
72; -20
What are the majority of immunology te…
Serum
Immunology Chapter 8
What do TH1's activate?
What do TH2's activate?
What do TH17's do?
TFH
Macrophages to suppress intracellular infections
B cells to make IgE isotypes (parasitic infections)
Secrete an IL-17 cytokine which recruits neutrophils
Found in the follicle, activates B cells for other isoptypes
What do TH1's activate?
Macrophages to suppress intracellular infections
What do TH2's activate?
B cells to make IgE isotypes (parasitic infections)
104 terms
Chapter 8 - Immunology
Activation of T cells requires it to e…
What happens when a naïve T cell encou…
The process that a naive T cell underg…
The specific antigen of an effector T…
Antigen
It is stimulated to differentiate into an effector cell.
T-cell activation - AKA T-cell priming.
Antigen Presenting Cells. However, only DENDRITIC cells can a…
Activation of T cells requires it to e…
Antigen
What happens when a naïve T cell encou…
It is stimulated to differentiate into an effector cell.
Chapter 8 Immunology
Describe an activated dendritic cell u…
T cells failing to encounter specific…
The co-simulatory molecule ___ o profe…
Which of the following is NOT produced…
Bears highly elaborated finger-like processes called dendrites
efferent lymph
B7; CD28
CD40 ligand
Describe an activated dendritic cell u…
Bears highly elaborated finger-like processes called dendrites
T cells failing to encounter specific…
efferent lymph
39 terms
Immunology chapter 8
What two components do TCR interact wi…
MHC restriction
How was MHC originally discovered?
What is MHC?
-Linear peptide fragment of protein antigen... -Major histocompa…
Since antigen must be presented by MHC molecule, T-cell respo…
organ transplantation
-Closely linked genes inherited as a unit... -Human MHC is calle…
What two components do TCR interact wi…
-Linear peptide fragment of protein antigen... -Major histocompa…
MHC restriction
Since antigen must be presented by MHC molecule, T-cell respo…
18 terms
Immunology Chapter 8
How does the Tcell activate the macrop…
In addition to TCR and MHC II in T hel…
What are the 2 indirect effector funct…
Cytokines produced by Lymphocytes are…
By the production of Cytokines IFN-gamma
CD40-ligand on the T-helper cell which binds CD40 recptor on…
1. Cell mediated activation (macrophage activation)... 2. Humora…
Lymphokines
How does the Tcell activate the macrop…
By the production of Cytokines IFN-gamma
In addition to TCR and MHC II in T hel…
CD40-ligand on the T-helper cell which binds CD40 recptor on…
7 terms
Immunology Chapter 8
Antibodies bind to free microbes and i…
How does IgA protect through mucosal i…
IgA is produced by
How do microbes evade antibody recogni…
Neutralizing antibodies
A special transport molecule moves it across mucosal epitheli…
B cells in mucosal tissues
Change their surface molecules
Antibodies bind to free microbes and i…
Neutralizing antibodies
How does IgA protect through mucosal i…
A special transport molecule moves it across mucosal epitheli…
chapter 8 immunology
what does the DC look like in peripher…
what does DC look like in circulation?
What does DC look like at the lymphoid…
How do DCs capture antigen?
immature, MHC is still in endocytic vesicles, antigen capture…
MHC starts to separate away from vesicles
Mature DC (activated) with MHC on the surface
TLR receptor mediated endocytosis; binding of antigen and TLR…
what does the DC look like in peripher…
immature, MHC is still in endocytic vesicles, antigen capture…
what does DC look like in circulation?
MHC starts to separate away from vesicles
119 terms
immunology chapter 8
Which of the following describes an ac…
Activated T cells express _____, which…
T cells failing to encounter specific…
Naive lymphocytes homing to lymphoid t…
C... Bears highly elaborated finger-like processes called dendri…
d... CTLA4; suppression
e... efferent lymph
a... L-selectin
Which of the following describes an ac…
C... Bears highly elaborated finger-like processes called dendri…
Activated T cells express _____, which…
d... CTLA4; suppression
9 terms
Immunology Chapter 8
Exogenous antigens are processed throu…
What do internalized antigens go throu…
Peptides in the endocytic pathway get…
What are the four steps of processing…
the endocytic pathway
compartments with decreasing pH. Early endosome, late endosom…
MHC class II.
1. Invariant chain binds to MHC II molecule when leaving ER t…
Exogenous antigens are processed throu…
the endocytic pathway
What do internalized antigens go throu…
compartments with decreasing pH. Early endosome, late endosom…
Immunology Chapter 8
How do T cell receptors recognize anti…
MHC
MHC Class I
MHC Class II
T cell receptors only recognize antigen if its held in an MHC…
Major histocompatibility complex, actually refers to the gene…
found on all nucleated cells and presents ag from the cytosol…
found only on some cells and presents ag from outside the cel…
How do T cell receptors recognize anti…
T cell receptors only recognize antigen if its held in an MHC…
MHC
Major histocompatibility complex, actually refers to the gene…
Immunology Exam 3 Chapter 8
Differentiate the different types of T…
Predict a T cells fate under given env…
Explain the importance of the innate c…
Explain hoe effector CD4 T cells preve…
...
...
...
...
Differentiate the different types of T…
...
Predict a T cells fate under given env…
...
39 terms
Immunology Chapter 8 Notes
How are pathogen antigens brought to t…
How are dendritic cells activated?
What do naive T-cells circulate through?
Following activation, dendritic cells…
By dendritic cells.
Encounter with pathogen.
Blood and lymphatics.
Synthesize the co-stimulatory molecule B7, increase antigen p…
How are pathogen antigens brought to t…
By dendritic cells.
How are dendritic cells activated?
Encounter with pathogen.
Immunology chapter 8
What is inactivation?
Complement and body fluids can be inac…
What type of pipette is used in the lab?
What is the meniscus?
The process that destroys complement activity. Complement is…
56C for 30 minutes
Automatic pipette
The curvature at the top of the liquid
What is inactivation?
The process that destroys complement activity. Complement is…
Complement and body fluids can be inac…
56C for 30 minutes
17 terms
Immunology Chapter 8
How do dendritic cells capture antigen?
What is the connection between Toll-li…
How do T cells get to the lymph node?…
What does it take to stimulate naïve T…
1. Receptor-mediated endocytosis - TLRs can mediate this proc…
Used to help dendritic cells capture antigen... -mediate the pro…
-Naive T cells can enter a draining lymph node by 2 routes:…
-professional APC provide 2 simultaneous signals to activate…
How do dendritic cells capture antigen?
1. Receptor-mediated endocytosis - TLRs can mediate this proc…
What is the connection between Toll-li…
Used to help dendritic cells capture antigen... -mediate the pro…
6 terms
Immunology chapter 8
How are antigens brought from the site…
For any particular antigen arriving in…
How do immature dendritic cells become…
How is it that dendritic cells are not…
Antigens are brought to the lymph node in afferent lymphatics…
Yes, antigen specific T-cells are trapped inside of its lymph…
(2 ways) ... (1) PAMPs binding to dendritic cells PRR's... (2) Inf…
...
How are antigens brought from the site…
Antigens are brought to the lymph node in afferent lymphatics…
For any particular antigen arriving in…
Yes, antigen specific T-cells are trapped inside of its lymph…
Chapter 8 Immunology
in a precipitation reaction, how can t…
precipitation differs from agglutinati…
which of the following statements appl…
which of the following is characterist…
high affinity and high avidity
precipitation involves a soluble antigen, while agglutination…
all of the above
concentration is directly in proportion to the square of the…
in a precipitation reaction, how can t…
high affinity and high avidity
precipitation differs from agglutinati…
precipitation involves a soluble antigen, while agglutination…
38 terms
Immunology Chapter 8
What is the role of dendritic cells?
Naive t cell antigen encounter
What is T cell homing?
What happens during t cell homing
They engulf antigens and present them on the surface of their…
when naive t cells first encounter an antigen, it is presente…
Process of naive t cells leaving the bloodstream and entering…
t cells bing to HEV endothelium through interaction of L-Sele…
What is the role of dendritic cells?
They engulf antigens and present them on the surface of their…
Naive t cell antigen encounter
when naive t cells first encounter an antigen, it is presente…
105 terms
immunology chapter 8 (official)
What are the reasons for the several d…
What are the 4 different types of leuk…
L-selectin
LFA-1
Once an antigen-specific T cell is trapped in the lymph node…
1. Selectins ... 2. vascular addressins ... 3. integrins... 4. immunog…
L-Selectin (on T cells) interact with vascular addressins on…
LFA-1( on T cells) - activated by chemokines it binds to extr…
What are the reasons for the several d…
Once an antigen-specific T cell is trapped in the lymph node…
What are the 4 different types of leuk…
1. Selectins ... 2. vascular addressins ... 3. integrins... 4. immunog…
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