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Study sets matching "immunology serology"

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Study sets matching "immunology serology"

57 terms
Serology/ Immunology
What is active immunity?
What is Passive immunity?
What is natural active immunity?
What is artificial active immunity?
You body makes the antibodies
The antibodies come from somewhere else
Host is exposed to foreign immunogen
Vaccine is what exposes you to immunogen
What is active immunity?
You body makes the antibodies
What is Passive immunity?
The antibodies come from somewhere else
13 terms
Immunology & Serology
Neutrophils
Lymphocytes
Monocytes
Eosinophil
Most abundant... Multiple lobes... red granules... Destroy bacteria by…
2nd In abundance... Large nucleus... Specific Immunity... Natural kill…
3rd in abundance... Kidney shaped nucleus... Macrophages; ingest an…
4th in abundance... Bi-lobed nucleus... red granules... Phagocytic wit…
Neutrophils
Most abundant... Multiple lobes... red granules... Destroy bacteria by…
Lymphocytes
2nd In abundance... Large nucleus... Specific Immunity... Natural kill…
119 terms
immunology/serology
precipitation rxn
radial immunodiffusion
radial immunodiffusion rxn
agglutination rxn
rxn btwn soluble ag and soluble ab; max precip occurs when th…
allows gel technique (which usually only identifies ag and ab…
specific ab added to buffered agarose medium; Ag is added to…
cross linking of particulate or insoluble ag w/ corresponding…
precipitation rxn
rxn btwn soluble ag and soluble ab; max precip occurs when th…
radial immunodiffusion
allows gel technique (which usually only identifies ag and ab…
69 terms
Immunology and Serology
Active immunity
Passive immunity
Natrual innate
Adaptive acquired
Individual produces antibody, follows immunization or infecti…
Antibody transfered to individual, no memory... ex: neonatal syp…
Non-specific, no memory, ex: skin, stomach acid, natural kill…
Specific, memory, examples: T-cells (cytokines) B cells (anit…
Active immunity
Individual produces antibody, follows immunization or infecti…
Passive immunity
Antibody transfered to individual, no memory... ex: neonatal syp…
119 terms
immunology/serology
precipitation rxn
radial immunodiffusion
radial immunodiffusion rxn
agglutination rxn
rxn btwn soluble ag and soluble ab; max precip occurs when th…
allows gel technique (which usually only identifies ag and ab…
specific ab added to buffered agarose medium; Ag is added to…
cross linking of particulate or insoluble ag w/ corresponding…
precipitation rxn
rxn btwn soluble ag and soluble ab; max precip occurs when th…
radial immunodiffusion
allows gel technique (which usually only identifies ag and ab…
Immunology and serology
Antigen
Humoral immunity
Cellular immunity
Immune system
Foreign substance that induces such an immune response in a h…
Antibodies, B cells
Cell to cell interaction, T cells
To detect self vs nonself... Protect against foreign ... Natural an…
Antigen
Foreign substance that induces such an immune response in a h…
Humoral immunity
Antibodies, B cells
62 terms
Immunology/Serology
Precipitation
Precipitin
Lattice
Equivalence Zone
The interaction between SOLUBLE antigen and antibody when the…
An antibody in the serum that causes precipitation.
The structure that is believed to form best when antibody is…
The zone where optimum ratio of both antigen and antibody are…
Precipitation
The interaction between SOLUBLE antigen and antibody when the…
Precipitin
An antibody in the serum that causes precipitation.
81 terms
Immunology and Serology
innate
adaptive
innate, adaptive
physical defense, inflammation
type of immunity which refers to non-specific defense mechani…
type of immunity which is specific to a foreign antigen or in…
two major categories of immunity, both of which involve cellu…
two components of innate immunity
innate
type of immunity which refers to non-specific defense mechani…
adaptive
type of immunity which is specific to a foreign antigen or in…
213 terms
Immunology and serology
Immunity
Type of immunity
Innate
First line of defense
Is the processes that occur to defend the body against foreig…
Innate (non specific or natural), adaptive (specific or acqui…
Born with it; do not need prior exposure
Desinged to keep microorganisms out (acidic pH of skin surfac…
Immunity
Is the processes that occur to defend the body against foreig…
Type of immunity
Innate (non specific or natural), adaptive (specific or acqui…
167 terms
Immunology and Serology
Characteristics of Immunogens (antigen…
Molecular weight of at least 10 KDa
Simple repeating units do not make goo…
Protein and polysaccharides are better…
Large molecule... High complexity... Chemical composition... Foreigness
Large molecule
High complexity
Chemical composition
Characteristics of Immunogens (antigen…
Large molecule... High complexity... Chemical composition... Foreigness
Molecular weight of at least 10 KDa
Large molecule
262 terms
Immunology and Serology
Accumulation of immune complexesin you…
Jenner
Jenner
Pasteur
Hallmark of autoimmunity
Founder of immunology
Discovered cross immunity in 1798
Fater of Immunology
Accumulation of immune complexesin you…
Hallmark of autoimmunity
Jenner
Founder of immunology
80 terms
Serology-Immunology
Immunology
Immunology
Serology
Antigens
Study of all aspects of the immune system, including its stru…
Branch of biomedical science that deals with the response of…
A division of immunology that specializes in the laboratory d…
A substance that is capable of stimulating an immune response
Immunology
Study of all aspects of the immune system, including its stru…
Immunology
Branch of biomedical science that deals with the response of…
9 terms
Immunology: Serology
serology
precipitation
agglutination
viral haemagglutination
Observation of antibody-antigen reactions in vitro.
Antibodies and antigens in optimal portions bind together, fo…
Formation of visible clumps when cross-linked particles preci…
Agglutination involving red blood cells. In positive reaction…
serology
Observation of antibody-antigen reactions in vitro.
precipitation
Antibodies and antigens in optimal portions bind together, fo…
9 terms
Serology & Immunology
ANA- Antinuclear antibody
ASO Titer
CMV IgG/IgM
EBV Panel/heterophile agglutination test
Used to detect lupus or any autoimmune disease
Strep throat infection
diagnose cytomegalovirus
mono test
ANA- Antinuclear antibody
Used to detect lupus or any autoimmune disease
ASO Titer
Strep throat infection
24 terms
immunology/serology
immunology
innate aka
acquired aka
complement system fx
study of body's mechanisms that discriminate between self/non…
passive, non specific
specific, adaptive
alarm system activating acquired/innate immune system, helps…
immunology
study of body's mechanisms that discriminate between self/non…
innate aka
passive, non specific
77 terms
Immunology/Serology
Innate response... Phagocytosis... Adaptive…
Humoral
Cell-mediated (cellular)
Plasma... 1. Neutralize bacterial toxins…
1st line of defense of immune system: __... 2nd line of defense:…
B lymphocytes, antibodies, and complement are associated with…
T lymphocytes and cytokines are associated with the __ immune…
In humoral immunity, a B-lymphocyte is activated and it matur…
Innate response... Phagocytosis... Adaptive…
1st line of defense of immune system: __... 2nd line of defense:…
Humoral
B lymphocytes, antibodies, and complement are associated with…
106 terms
immunology/serology
immunology
complement system
increased blood and fluid accumulation
antibody
mechanism to discriminate between self/non, eliminate non self
alarm system that activates both immune systems, helps abilit…
inflammation
protein that responds to antigens, defends, 5 classes
immunology
mechanism to discriminate between self/non, eliminate non self
complement system
alarm system that activates both immune systems, helps abilit…
Serology & Immunology
ANA
FTA-ABS
RPR
Anti-HIV
Antinuclear Antibody - Positive results indicate autoimmune d…
Fluorescent treponemal antibody absorption test, confirms for…
Rapid Plasma Reagin - Positive screen indicates syphilis, pos…
Screening for human immunodeficiency virus
ANA
Antinuclear Antibody - Positive results indicate autoimmune d…
FTA-ABS
Fluorescent treponemal antibody absorption test, confirms for…
Immunology & Serology
immunology
antigen
antibody
serology
the study of the body's mechanisms that discriminate between…
foreign substance, stimulates antibody production
(AKA: immunoglobulin) proteins generated by the immune system…
a branch of science dealing with the measurement and characte…
immunology
the study of the body's mechanisms that discriminate between…
antigen
foreign substance, stimulates antibody production
27 terms
Immunology/Serology
Immunology
Antigen
Antibody (immunoglobulin)
Immune response depends on what factors?
The study of the immune system & it's ability to fight off vi…
Substance capable of stimulating an immune response
Glycoproteins released in response to an antigen
- Amt of antigen introduced... - Location antigen is introduced…
Immunology
The study of the immune system & it's ability to fight off vi…
Antigen
Substance capable of stimulating an immune response
12 terms
Immunology/Serology
Immunology
Two systems
Physiological/anatomical
Immune response
Defense against foreign invaders
Physiological/anatomical and inflammatory response
Skin and mucous membrane
Antibodies produced that can be distinguished from self and n…
Immunology
Defense against foreign invaders
Two systems
Physiological/anatomical and inflammatory response
60 terms
Immunology : Serology
To detect an antigen we take sample fr…
To detect antibodies we take sample fr…
Why should amount of Ab be known?
To diagnose i mist detect Ag or Ab?
Site of infection
Blood (Ig)
Differentiate recent infection from past infection, vaccinati…
Ag
To detect an antigen we take sample fr…
Site of infection
To detect antibodies we take sample fr…
Blood (Ig)
23 terms
Immunology & Serology
Leukocytosis
Leukopenia
Eosinophilia
Neutrophil abundance
higher than normal WBC count
lower than normal WBC count
elevated eosinophil count
55-65%
Leukocytosis
higher than normal WBC count
Leukopenia
lower than normal WBC count
Immunology/Serology
Who is credited with creating the disc…
Define immunology:
How did using a starfish demonstrate t…
List the 3 steps of how immunology wor…
Elie Metchnikoff
the study of immunity
Elie pierced the larva of a starfish with a thorn. the next m…
self vs. non-self... eliminate non-self... Altered self
Who is credited with creating the disc…
Elie Metchnikoff
Define immunology:
the study of immunity
27 terms
Immunology/Serology
Immunology
Antigen
Antibody (immunoglobulin)
Immune response depends on what factors?
The study of the immune system & it's ability to fight off vi…
Substance capable of stimulating an immune response
Glycoproteins released in response to an antigen
- Amt of antigen introduced... - Location antigen is introduced…
Immunology
The study of the immune system & it's ability to fight off vi…
Antigen
Substance capable of stimulating an immune response
52 terms
Immunology and serology
Immunology
Innate
Acquired
Lymphatic system
Study of the bodys mechanism that discriminstes between self…
Non specific immunity
Specific immunity
Tissues and organs that produce, store, and carry wbcs and ot…
Immunology
Study of the bodys mechanism that discriminstes between self…
Innate
Non specific immunity
211 terms
Immunology and Serology
Immunology
Edward Jenner
Louis Pasteur
Louis Pasteur
Study of the molecules, cells, organs and the systems respons…
Demonstrated the protection for smallpox using cowpox lesion
Discovered Live attenuated vaccine for rabies
Discovered vaccine for anthrax
Immunology
Study of the molecules, cells, organs and the systems respons…
Edward Jenner
Demonstrated the protection for smallpox using cowpox lesion
112 terms
Immunology and Serology
Transient Hypogammaglobulinemia of Inf…
Bruton's Agammaglobulinemia
Patients of Bruton's Agammaglobulinemia
Patients with Bruton's Agammaglobuline…
Low level of IgG after the transplacental IgG begins to disap…
Effects almost exclusively males, patients have no plasma cel…
develop recurrent bacterial infections beginning in infancy,…
circulating mature CD19 positive B cells and exhibit a defici…
Transient Hypogammaglobulinemia of Inf…
Low level of IgG after the transplacental IgG begins to disap…
Bruton's Agammaglobulinemia
Effects almost exclusively males, patients have no plasma cel…
15 terms
Immunology and Serology Cytokines
4 cytokines general functions:
autocrine signaling
juxtacrine signaling
paracrine signaling
1. regulate hematopoiesis... 2. coordinate innate response... 3. ad…
cytokines affect same cell that produced them
membrane bound cytokine affects activity of a bound cell
cytokines affect activity of nearby cells
4 cytokines general functions:
1. regulate hematopoiesis... 2. coordinate innate response... 3. ad…
autocrine signaling
cytokines affect same cell that produced them
93 terms
immunology and serology
immunology
Inate and acquired categories work ver…
2 main categories of immunology
inate aka
the study of the bodies mechanisms that discriminate between…
activate and regulate
innate and acquired
nonspecific or passive
immunology
the study of the bodies mechanisms that discriminate between…
Inate and acquired categories work ver…
activate and regulate
23 terms
Immunology and serology
IgM
IgG
IgE
IgA
Activates initial attack on antigens. Their antibodies are ve…
Most abundant. stimulates phagocytic cells. Can cross placent…
Least common. Binds to histamine producing cells(Basophils an…
Stimulated in IN Vx. 20% of circulationg antibodies. Involved…
IgM
Activates initial attack on antigens. Their antibodies are ve…
IgG
Most abundant. stimulates phagocytic cells. Can cross placent…
27 terms
Immunology and Serology
Define Immunology
Define Serology
Describe the first line of defense
Describe the components and function o…
-study of molecules, cells, organs and systems responsible fo…
Specializes in lab detection and measurement of specific anti…
-skin... -secretions... -phagocytes... -natural biochemicals
ABO systems
Define Immunology
-study of molecules, cells, organs and systems responsible fo…
Define Serology
Specializes in lab detection and measurement of specific anti…
63 terms
Immunology and Serology
Is ADCC cellular or humoral defense?
Is delayed hypersensitivity cellular o…
What is the primary defense against in…
What is the primary defense against ex…
humoral
cellular
cellular
humoral
Is ADCC cellular or humoral defense?
humoral
Is delayed hypersensitivity cellular o…
cellular
36 terms
Immunology and Serology
Antigen
Factors that influence antigenicity are?
Antigenicity
What antigens stimulate an immune resp…
Any substance which is capable of getting a response from the…
Size, complexity, foreignness, route of administration, amoun…
Degree to which an antigen stimulate an immune response
Viruses, Bacteria, Parasites and anything which is foreign to…
Antigen
Any substance which is capable of getting a response from the…
Factors that influence antigenicity are?
Size, complexity, foreignness, route of administration, amoun…
51 terms
Clinical Immunology & Serology Methodologies
Immunoassay
Manual serology tests are called
serology
Antibody is composed of
common name for test with Ab & Ag. Term often associated with…
rapid tests (pregnancy test is an ex.)
the scientific study or diagnostic examination of blood serum…
variable region (Fab) and constant region (Fc). 2 Heavy chain…
Immunoassay
common name for test with Ab & Ag. Term often associated with…
Manual serology tests are called
rapid tests (pregnancy test is an ex.)
64 terms
Immunology & Serology Chapter 1
immunology
Antigen
Immunity
Two types of immunity
The study of a host's reaction when foreign substances are in…
A foreign substance that induces an immune response. ... AKA imm…
A condition of being resistant to an infection
natural and acquired
immunology
The study of a host's reaction when foreign substances are in…
Antigen
A foreign substance that induces an immune response. ... AKA imm…
31 terms
Immunology-Serology
Innate immunity
First line defense
Second line defense
Adaptive immunity
Nonspecific or natural
Physical barriers and chemical secretions
Phagocytosis, inflammation and complement system
Specific or acquired
Innate immunity
Nonspecific or natural
First line defense
Physical barriers and chemical secretions
115 terms
immunology/serology
precipitation rxn
radial immunodiffusion
radial immunodiffusion rxn
agglutination rxn
rxn btwn soluble ag and soluble ab; max precip occurs when th…
allows gel technique (which usually only identifies ag and ab…
specific ab added to buffered agarose medium; Ag is added to…
cross linking of particulate or insoluble ag w/ corresponding…
precipitation rxn
rxn btwn soluble ag and soluble ab; max precip occurs when th…
radial immunodiffusion
allows gel technique (which usually only identifies ag and ab…
22 terms
Unit 5C-Serology/Immunology
humoral immunity
cell-mediated immunity
antigen
immunoglobulins
type of immunity that uses B Lymphocytes to produce antibodie…
type of immunity that uses T Lymphocytes agaist viruses, fung…
considered a forgien substance in the body that stimulates an…
another name for antibodies
humoral immunity
type of immunity that uses B Lymphocytes to produce antibodie…
cell-mediated immunity
type of immunity that uses T Lymphocytes agaist viruses, fung…
11 terms
Antinuclear Antibodies: Immunology/Serology
Homogenous pattern ... (image)
Homogenoous pattern primary disease st…
Homogenous pattern antibodies
Speckled pattern... (image)
SLE
anti-ds-DNA... anti-Histone... anti-DNP
Homogenous pattern ... (image)
Homogenoous pattern primary disease st…
SLE
41 terms
Immunology/Serology Testing Methods
ZOE (Zone of Equivalence)
Prozone
Postzone
Four-Fold (2 Tube)
-when optimum reaction occurs... -"B"
-when you have excess Ab... -will cause false negatives... -"A"
-when you have excess Ag... -will cause false negatives... -"C"
-change in titer that indicates a recent/current infection
ZOE (Zone of Equivalence)
-when optimum reaction occurs... -"B"
Prozone
-when you have excess Ab... -will cause false negatives... -"A"
16 terms
Immunology and Serology: Project 1
Antigen
Antibody
Immunogen
Affinity
A foreign material that is not intended to be within the huma…
A substance dispatched by the body to help fight foreign subs…
An antigen that can trigger the production of an immune respo…
When a force or attraction between multiple chemicals or part…
Antigen
A foreign material that is not intended to be within the huma…
Antibody
A substance dispatched by the body to help fight foreign subs…
30 terms
Unit 3 Immunology/Serology
Double diffusion
Radial Immunodiffusion
Countercurrent Immunoelectrophoresis
Immunoelectrophoresis
2 Ag in gel with one Pt. Ab. No electric current. Looking for…
Monospecific antiserum is in gel. Ag added to cut out wells i…
Gel is cooled onto plate with Ag in one well, Ab in the other…
Gel method to ID proteins, semi-quantitative. Pt. Ab in anti-…
Double diffusion
2 Ag in gel with one Pt. Ab. No electric current. Looking for…
Radial Immunodiffusion
Monospecific antiserum is in gel. Ag added to cut out wells i…
56 terms
Immunology & Serology Chapter 2
Lymphocyte
Primary lymphoid organs
Differentiation happens in one of two…
Bone Marrow
is a key cell in immune response... *lymphs are a large part of…
unique because they arise from hematopoietic stem cell then f…
Bone marrow and Thymus
*Main source of hematopoiesis stem cells... *All cell line have…
Lymphocyte
is a key cell in immune response... *lymphs are a large part of…
Primary lymphoid organs
unique because they arise from hematopoietic stem cell then f…
101 terms
Immunology/Serology Exam 3
Factors that influence the development…
Lysozymes and phagocytosis
Possibly the activation of complement
Interferon
Sole presence of the agent or microorganism
Bacteria
Yeast
Viruses
Factors that influence the development…
Sole presence of the agent or microorganism
Lysozymes and phagocytosis
Bacteria
270 terms
Immunology & Serology chap 4
What is the confirmatory serological t…
What bands must appear for a HIV Weste…
Genetic probes can detect __________ _…
What is the purpose of reverse transcr…
Western Blot Assay
p24, gp41, or gp120-160
replicating viruses.
To detect nucleic acid gene sequences in HIV-1 & HIV-2
What is the confirmatory serological t…
Western Blot Assay
What bands must appear for a HIV Weste…
p24, gp41, or gp120-160
29 terms
Immunology (Immunologic and Serologic Procedures)
Define precipitation.
Define agglutination.
Define flocculation
Define hemagglutination.
Aggregation of soluble test antigen
Aggregation of particulate test antigens
Macroscopic particles produced when soluble test antigen mixe…
Agglutination of erythrocytes in tests for antibody detection.
Define precipitation.
Aggregation of soluble test antigen
Define agglutination.
Aggregation of particulate test antigens
84 terms
Immunology/Serology Exam 1
A specific function of the immune syst…
The first line of defense against infe…
Acquired immunity can result from
An antigen is a substance that
To recognize self from non-self, defend the body against non-…
Unbroken skin and mucous membranes
Vaccination and contracting a disease
Stimulates antibody formation, has the ability to bind to an…
A specific function of the immune syst…
To recognize self from non-self, defend the body against non-…
The first line of defense against infe…
Unbroken skin and mucous membranes
47 terms
immunology/serology Ch.16
humoral immunity
B
-T-cell mediated immunity, viruses, fu…
blood levels of immunoglobulins
Defects in ______ result in pyogenic (pus-producing) bacteria…
Humoral immunity is ___ cells
Defects in ______ immunity results in recurrent infections wi…
When evaluating immunoglobulin deficiency states, ______- cha…
humoral immunity
Defects in ______ result in pyogenic (pus-producing) bacteria…
B
Humoral immunity is ___ cells
35 terms
immunology/serology Ch.17
MHC
-Class I (HLA-A, B, and C) proteins... -C…
-haplotypes
Class I HLA proteins
The classical HLA antigens is also known as:
Classical HLA antigens include:
HLA proteins are inherited as _____ from parental chromosomes…
-expressed on the cell surface on all nucleated cells
MHC
The classical HLA antigens is also known as:
-Class I (HLA-A, B, and C) proteins... -C…
Classical HLA antigens include:
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