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Study sets matching "immunology type"

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Study sets matching "immunology type"

17 terms
Immunology Cell Type Pics
neutrophil
neutrophil
basophil
mast cell
neutrophil
neutrophil
25 terms
Immunology Type 1 diabetes
Lean adipose vs obesity
adipose in the Obese
Type 1 diabetes: insulinitis
is T1D increasing or Decreasing in the…
-lean adipose contains mostly M2 macrophages and t reg cells…
-high amounts of fat stored in adipose tissue can undergo apo…
-the onset of T1D is associated with infiltration of the Isle…
-increaseing... -about 3% per year... -this rate is higher than we…
Lean adipose vs obesity
-lean adipose contains mostly M2 macrophages and t reg cells…
adipose in the Obese
-high amounts of fat stored in adipose tissue can undergo apo…
9 terms
Immunology: Hypersensitivity Type III
type 3 is characterized by
definition of type 3
immune complexes facilitate
heavy or persistent loads of immune co…
immune complex mediated hypersensitivity
the inability to clear large numbers or complexes of antigen-…
the phagocytic removal of an antigen
damage to surrounding tissues (causes the type III hypersensi…
type 3 is characterized by
immune complex mediated hypersensitivity
definition of type 3
the inability to clear large numbers or complexes of antigen-…
30 terms
Immunology: Hypersensitivity Type II
(Type 2) is defined as
(Type 2) 3 mechanism of antibody-depen…
2 examples of Type II hypersensitivity
ABO blood groups differ by
undesired non-IgE antibody mediated cell destruction
A) complement activation and MAC formation (protein directed…
- blood transfusion reaction... - Rh+ factor fetus rejection
a single sugar residue
(Type 2) is defined as
undesired non-IgE antibody mediated cell destruction
(Type 2) 3 mechanism of antibody-depen…
A) complement activation and MAC formation (protein directed…
19 terms
Immunology: Hypersensitivity Type IV
type 4 hypersensitivity is
definition of type 4
delayed-type hypersensitivity antigens…
hallmark features of delayed-type hype…
delayed type hypersensitivity
antigen-specificed, T cell directed recruitment of macrophage
intracellular bacteria, fungi, parasites, viruses, and contac…
- initiation by T-cells against antibodies... - delayed developm…
type 4 hypersensitivity is
delayed type hypersensitivity
definition of type 4
antigen-specificed, T cell directed recruitment of macrophage
67 terms
Immunology: Hypersensitivity TYPE I
examples of hypersensitivity
ex of chronic inflammation
ex of auto immunity
ex. of immuno deficiencies
allergies, asthma
cancer
arthritis
AIDS, cancer
examples of hypersensitivity
allergies, asthma
ex of chronic inflammation
cancer
23 terms
Immunology-Type III Hypersensitivity
What are the three immune players?
What is the main cause of Type III?
How fast do Type III hypersensitivitie…
How does Type III compare to Type I in…
1. IgM... 2. IgG... 3. Neutrophils
Excessive formation of immune complexes (antigen+antibody)
See reaction in 1-6 hours after exposure, slower response
Type I reaction can happen within minutes
What are the three immune players?
1. IgM... 2. IgG... 3. Neutrophils
What is the main cause of Type III?
Excessive formation of immune complexes (antigen+antibody)
31 terms
Immunology-Type IV Hypersensitivity
Type 4 is induced by _________ cells i…
This reaction is the slowest of all th…
Why is the reaction slower?
Quick review... Reaction times for:... Type…
T cells
48-72 hours later
T cells do not move as quickly as antibodies do (delayer hype…
Type 1: a few minutes... Type 2: a few minutes... Type 3: a few hou…
Type 4 is induced by _________ cells i…
T cells
This reaction is the slowest of all th…
48-72 hours later
36 terms
Immunology-Type II Hypersensitivity
What are the two players in type 2?
In this type, immune responses destroy…
Why are blood transfusions susceptible…
What do we call these RBC surface prot…
IgM... IgG
normal cells
Red blood cells have a variety of surface proteins on the cel…
Blood group antigens or erythrocyte antigens
What are the two players in type 2?
IgM... IgG
In this type, immune responses destroy…
normal cells
11 terms
Immunology (Type IV Hypersensitivity)
Type IV's are also...
Type IV peak response is __-__ hours a…
Type IV's are a ___ ____ hypersensivit…
What is the immune mechanism for Type…
Delayed type hypersensitivity rxn
24-72
Cell-mediated; T-cells; macrophages; Abs
Sensitization: APC processes Ag and presents it to T helper c…
Type IV's are also...
Delayed type hypersensitivity rxn
Type IV peak response is __-__ hours a…
24-72
20 terms
Immunology Hypersensitivity Type 3
Type 3 hypersensitivity
Antigen antibody complex
What determines where a type 3 reactio…
What is an example of type 3 reaction…
Antigen-antibody complexes deposite in basement membrane... Circ…
Complexes build up in vessel walls cause inflammation tissue…
Antigen:antibody ratio... (phagocytic cells or binding to phagoc…
Immune mediated glomerulonephritis
Type 3 hypersensitivity
Antigen-antibody complexes deposite in basement membrane... Circ…
Antigen antibody complex
Complexes build up in vessel walls cause inflammation tissue…
16 terms
Type 1 DM Immunology
What kind of cells dominate in the Typ…
What immune response is associated wit…
What HLA genes are high risk ?
Which HLA genes are protective?
CD8+... T cell mediated
TH1
DQ2/DQ8... DR3/4 (Kids)
DR2/DQ6
What kind of cells dominate in the Typ…
CD8+... T cell mediated
What immune response is associated wit…
TH1
6 terms
Immunology Cell Types
neutrophils
Monocytes/macrophages
NK cells
antigen specific receptors
Small, short-lived cells with mulitlobed nucleus, predominant…
Large, long-lived cells with dimpled nucleus, renamed when re…
large granular lymphocytes, found in blood and spleen, kill t…
What do T cells have that NK cells don't?
neutrophils
Small, short-lived cells with mulitlobed nucleus, predominant…
Monocytes/macrophages
Large, long-lived cells with dimpled nucleus, renamed when re…
22 terms
Immunology cell types (Innate)
white blood cells
b, t, and nk cells
(innate) inactive precursor in blood
(innate) active in tissue
leukocytes
lymphocytes
monophage
macrophage
white blood cells
leukocytes
b, t, and nk cells
lymphocytes
52 terms
Immunology of blood typing
________ is the only antigen in the H…
The H antigen locus is on chromosome _…
H antigen is closely linked with the _…
H and h alleles are ________
H antigen
19
Se (secretor)
codominant
________ is the only antigen in the H…
H antigen
The H antigen locus is on chromosome _…
19
20 terms
Immunology - Cell Types
2 Phagocytic Cell Types
2 Cell Types that Protect Mucosal Body…
Myeloid Cells Differentiate into:
Lymphoid Cells Differentiate into:
-neutrophils... -macrophages
-mast cells... -basophils
-monocytes... -granulocytes
-T cells... -B cells... -NK cells
2 Phagocytic Cell Types
-neutrophils... -macrophages
2 Cell Types that Protect Mucosal Body…
-mast cells... -basophils
9 terms
Immunology: CD Cell Type Markers
CD3
CD4
CD5
CD8
Pan T Cell marker
T helper/inducer cell
Immature T cells, Tcell-ALL; CLL/SLL;Mantle Cell Lymphoma
T suppressor/ Cytotoxic Cell
CD3
Pan T Cell marker
CD4
T helper/inducer cell
126 terms
Immunology Cell Types
Anucleated
multinucleated
Circulating Phagocyte
rarest circulating granulocyte
Erythrocytes
Megakaryocyte
Neutrophil
basophil
Anucleated
Erythrocytes
multinucleated
Megakaryocyte
72 terms
immunology lab - blood typing
your blood type is ____ from your pare…
what are the four blood types?
you are either ____ for Rh factor
does you blood type change?
inherited
A, B, O, AB
positive or negative
no
your blood type is ____ from your pare…
inherited
what are the four blood types?
A, B, O, AB
72 terms
Immunology - Type I hypersensitivity reactions
List the 4 HSR types
type I hypersensitivity
type IV hypersensitivity
type I:... Immune reactant: ... effector m…
Type I hypersensitivity - IgE-mediated or Immediate... Type II…
immediate or IgE mediated
T lymphocyte mediated or delayed
type I: IgE... Immune reactant: soluble antigen ... effector mech…
List the 4 HSR types
Type I hypersensitivity - IgE-mediated or Immediate... Type II…
type I hypersensitivity
immediate or IgE mediated
18 terms
Test Types Immunology
where do you find the antigen and anti…
what is the RID test type?
what is an example of a false positive…
what is an example of a false negative…
antigen- standard and patient unknown serum... antibody- augar
single diffusion
overfilling the wells
under filling the wells
where do you find the antigen and anti…
antigen- standard and patient unknown serum... antibody- augar
what is the RID test type?
single diffusion
12 terms
Human immunology cell types
Small lymphocyte
Dendritic Cells
Plasma cell
Mast Cell
Production of Antibodies( Bcells) or cytotoxic and helper fun…
Activation of T cells and the Adaptive immune response
fully differentiated B cell that secretes soluble immunoglobu…
expulsion of parasites from the body through release of granu…
Small lymphocyte
Production of Antibodies( Bcells) or cytotoxic and helper fun…
Dendritic Cells
Activation of T cells and the Adaptive immune response
37 terms
Immunology cell types- step
MHC I and II
MHC1
MHC II
A3... HLA subtype and associated disease
encoded by HLA gene, Presents antigen fragments to T cells an…
loci: HLA A, B and C... binding: TCR and CD8... expression: expre…
loci: HLA- DP, DQ, DR... binding: TCR and CD4 +... expression: AP…
hemochromatosis
MHC I and II
encoded by HLA gene, Presents antigen fragments to T cells an…
MHC1
loci: HLA A, B and C... binding: TCR and CD8... expression: expre…
37 terms
Immunology cell types- step
MHC I and II
MHC1
MHC II
A3... HLA subtype and associated disease
encoded by HLA gene, Presents antigen fragments to T cells an…
loci: HLA A, B and C... binding: TCR and CD8... expression: expre…
loci: HLA- DP, DQ, DR... binding: TCR and CD4 +... expression: AP…
hemochromatosis
MHC I and II
encoded by HLA gene, Presents antigen fragments to T cells an…
MHC1
loci: HLA A, B and C... binding: TCR and CD8... expression: expre…
20 terms
Immunology Stevens - Hypersensitivty Type II
Erythroblastosis fetalis
Anamnestic response
Hemolytic disease of the newborn
Exchange transfusion
Severe HDN
Second and later children have an increased risk of contracti…
Appears in infants whose mothers have been exposed to blood-g…
Treatment (procedure) done for HDN
Erythroblastosis fetalis
Severe HDN
Anamnestic response
Second and later children have an increased risk of contracti…
35 terms
Immunology- Types of Cells
What type of response does the innate…
When does the innate immune response a…
What are the two lines of defense with…
What is the main mechanism for recogni…
Non-specific
immediately upon infection
1) physical, chemical and genetic barriers... 2)inflammatory res…
phagocytosis
What type of response does the innate…
Non-specific
When does the innate immune response a…
immediately upon infection
15 terms
Immunology cell types (adaptive)
b/t effector and memory cells produced
long, few
short, many
pathogens, dendritic cells
primary immune response
b/t memory cells live... as ____ are produced
b/t effector cells live... as ____ are produced
b cells are activated by ________ and t cells are by ________
b/t effector and memory cells produced
primary immune response
long, few
b/t memory cells live... as ____ are produced
12 terms
Immunology - Type I hypersensitivity reactions
Type I - General
Type I - Mechanics of the reaction
Type I - How it manifests (complex)
Type I - Receptors
IgE mediated hypersensitivity. Involves some kind of allergen…
Plasma cells secrete IgE, which binds to the Fc receptor on m…
The triggering of a mast cell REQUIRES two separate IgE molec…
Receptor differences between eosinophils, mast cells, basophi…
Type I - General
IgE mediated hypersensitivity. Involves some kind of allergen…
Type I - Mechanics of the reaction
Plasma cells secrete IgE, which binds to the Fc receptor on m…
15 terms
Immunology cell types
Granuloyctes
Neutrophils (G)
Basophil (G)
Eosinophils (G)
-front lines of innate immune system.... -neutrophiles, basophil…
-respond to cytokines generated by other innate cells... -phagoc…
-nonphagocytic granulocytes... -contain histamines in their gran…
-phagocytic cells... -mulitcellular parasitic organisms... -release…
Granuloyctes
-front lines of innate immune system.... -neutrophiles, basophil…
Neutrophils (G)
-respond to cytokines generated by other innate cells... -phagoc…
36 terms
immunology cell types
3 types of proteins in respiratory sys…
cells involved in innate immunity
what is the composition of PMN
PAMPs
1. complement proteins... 2. antimicrobial defensins... 3. iron seq…
1. phagocytic cells... 2. PMNs... 3. macrophages... 4. NK cells
lysosomes and pus
help phagocytes detect what to remove
3 types of proteins in respiratory sys…
1. complement proteins... 2. antimicrobial defensins... 3. iron seq…
cells involved in innate immunity
1. phagocytic cells... 2. PMNs... 3. macrophages... 4. NK cells
8 terms
Immunology: Types of Mice
RAG2 knockout mice (RAG -/-)
MyD88 knockout mice
Wild-Type
BALB/c mice
mice have no recombination activating gene 2, thus no enzymes…
innate immune cells are unable to make any cytokines
control group
falsely driven toward Th2 response
RAG2 knockout mice (RAG -/-)
mice have no recombination activating gene 2, thus no enzymes…
MyD88 knockout mice
innate immune cells are unable to make any cytokines
46 terms
Immunology T cell Types
kill host cells. Since they kill host…
Only activated _____________ cells are…
Another way to activate cytotoxic T ce…
_____________is permanent inactivation…
Cytotoxic T cells
dendritic
TH1
Host Cell Induced Anergy
kill host cells. Since they kill host…
Cytotoxic T cells
Only activated _____________ cells are…
dendritic
34 terms
Types of Responses (immunology)
Responses can be...
Type I Response... Category:... Involves (ce…
Type II Response:... Category:... Involves (…
Type III Response... Category:... Involves (…
broken up into categories of Autoimmunity or or hypersensitivy
Hypersensitive ONLY... Mast cell, basophil, eosinophil response…
Autoimmune or hypersensitive... B-Cells... Binds to Surface
Autoimmune or hypersensitive... B-Cells... Soluble
Responses can be...
broken up into categories of Autoimmunity or or hypersensitivy
Type I Response... Category:... Involves (ce…
Hypersensitive ONLY... Mast cell, basophil, eosinophil response…
11 terms
Immunology: Antibodies and Blood Typing
IgM
IgG
IgA
IgD
monomer- BCR... pentamer- serum... main Ab that activates complemen…
always monomeric... high [serum], long half-life... passive immunit…
monomer- serum (IgA1)... dimeric- secretory/mucosal (IgA2)... secre…
BCR: marker for mature B-cell... low [serum]
IgM
monomer- BCR... pentamer- serum... main Ab that activates complemen…
IgG
always monomeric... high [serum], long half-life... passive immunit…
9 terms
Immunology Cell Types
Platelets
Basophils
Mast Cells
Eosinophils
Clotting... Inflammation
Circulating Granulocyte... Allergic response... Inflammation
Tissue-Based Granulocyte... Allergic response... Inflammation
Circulating Granulocyte... Allergic response... Asthma... Parasite def…
Platelets
Clotting... Inflammation
Basophils
Circulating Granulocyte... Allergic response... Inflammation
38 terms
Immunology Stevens - Hypersensitivty Type I
Type I hypersensitivity
Atopy
Th2 cells
IL-4, IL-13
Short time lag
Inherited tendency to respond to naturally occurring inhaled…
These cells respond to microorganisms and allergens instead o…
Cytokines responsible for the final differentiation in B cells
Type I hypersensitivity
Short time lag
Atopy
Inherited tendency to respond to naturally occurring inhaled…
10 terms
Cell Types (MSSM- Immunology)
Myeloid Cells
Lymphoid Cells
Neutrophil
Eosinophil
Neutrophil, eosinophil, basophil, monocyte, mast cell
B cell, T cell, NK cell
Phagocytic cell that targets bacteria and fungi. Releases cyt…
Phagocytic cell that targets parasites. Releases cytotoxins a…
Myeloid Cells
Neutrophil, eosinophil, basophil, monocyte, mast cell
Lymphoid Cells
B cell, T cell, NK cell
21 terms
Immunology Stevens - Hypersensitivty Type III and Type IV
Type III hypersensitivity
Complement levels measurement
Systemic lupus erythematosus
Kidney (glomerular basement membrane)
Soluble antigen combines with antibody, complexes are formed…
General method of determining immune complex diseases
Antibodies are directed against constituents such as DNA and…
Organ most damaged in SLE
Type III hypersensitivity
Soluble antigen combines with antibody, complexes are formed…
Complement levels measurement
General method of determining immune complex diseases
51 terms
Immunology: Type I Hypersensitivity Reactions
What is the immunologic mechanism of T…
What are some examples of Type I rxns?
How quickly do Type I reactions occur?
What happens to the body when histamin…
Allergen cross-links IgE-sensitized mast cells and basophils…
- hay fever ... - asthma ... - anaphylaxis ... - atopic dermatitis ... -…
- symptoms present seconds to minutes after allergen contact
- smooth muscle contraction (bronchial constriction and GI pe…
What is the immunologic mechanism of T…
Allergen cross-links IgE-sensitized mast cells and basophils…
What are some examples of Type I rxns?
- hay fever ... - asthma ... - anaphylaxis ... - atopic dermatitis ... -…
36 terms
Immunology-General Hypersensitivity and Type I
What is a hypersensitivity?
Can you be hypersensitive to an antige…
Hypersensitivites 1-3 are carried out…
A Type 1 hypersensitivity is often a l…
A normal immunological reaction that has been exaggerated
No
Antibodies... T cells and mediators
allergies
What is a hypersensitivity?
A normal immunological reaction that has been exaggerated
Can you be hypersensitive to an antige…
No
16 terms
Immunology- Type II and III Hypersensitivity
What is another name for a Type II hyp…
What 2 components are the initiators o…
What is the mechanism of a Type II rea…
What are the 2 main effectors of a Typ…
Cytotoxic hypersensitivity, either complement or ADCC mediated
1) IgG antibodies- predominant... 2) IgM antibodies- minor
IgG binds an antigen, with the immune complex formation trigg…
IgG mainly activates complement and NK cells, but neutrophils…
What is another name for a Type II hyp…
Cytotoxic hypersensitivity, either complement or ADCC mediated
What 2 components are the initiators o…
1) IgG antibodies- predominant... 2) IgM antibodies- minor
42 terms
Immunology- Type I and IV Hypersensitivity
What are the 4 types of reaction?
What is the most common form of an all…
What 5 cells/products are involved in…
What is the basic sequence of events i…
Type 1- Anaphylactic/immediate... Type 2- Cytotoxic... Type 3- Immu…
Type I hypersensitivity
1) Th2 (CD4) cells... 2) IgE antibodies... 3) Mast cells... 4) Eosinop…
First exposure to allergen activates Th2 cells and stimulates…
What are the 4 types of reaction?
Type 1- Anaphylactic/immediate... Type 2- Cytotoxic... Type 3- Immu…
What is the most common form of an all…
Type I hypersensitivity
33 terms
Immunology -> Hypersensitivity type III-IV
Type III reaction:
During a Type III reaction:
3 types of Type III reactions
Arthus reaction
-Mediated by immune complexes, usu. IgG... •(antigen-antibody co…
-immune complexes in blood are deposited in joints, kidney, b…
-Arthus reaction... -Serum sickness... -Other immune complexes
-4-8 hours... -Reaction to injected antigen if there are high le…
Type III reaction:
-Mediated by immune complexes, usu. IgG... •(antigen-antibody co…
During a Type III reaction:
-immune complexes in blood are deposited in joints, kidney, b…
18 terms
Immunology: Type III Hypersensitivity Reactions
Describe the immunologic mechanism of…
What are some examples of Type III rea…
What do immune complexes contain?
What is the cause of tissue damage?
- antibodies (IgG, IgM and IgA) form immune complexes against…
- SLE ... - glomerulonephritis ... - Arthrus rxm ... - serum sickness
- IgM/IgG, antigen and complement
complement... neutrophils activated by immune complexes
Describe the immunologic mechanism of…
- antibodies (IgG, IgM and IgA) form immune complexes against…
What are some examples of Type III rea…
- SLE ... - glomerulonephritis ... - Arthrus rxm ... - serum sickness
51 terms
Immunology: Type I Hypersensitivity Reactions
What is the immunologic mechanism of T…
What are some examples of Type I rxns?
How quickly do Type I reactions occur?
What happens to the body when histamin…
Allergen cross-links IgE-sensitized mast cells and basophils…
- hay fever ... - asthma ... - anaphylaxis ... - atopic dermatitis ... -…
- symptoms present seconds to minutes after allergen contact
- smooth muscle contraction (bronchial constriction and GI pe…
What is the immunologic mechanism of T…
Allergen cross-links IgE-sensitized mast cells and basophils…
What are some examples of Type I rxns?
- hay fever ... - asthma ... - anaphylaxis ... - atopic dermatitis ... -…
19 terms
Immunology: Type II Hypersensitivity Reactions
What is the immunologic mechanism of T…
What are some examples of Type II reac…
Describe how autoantibodies can create…
Describe how autoantibodies can create…
- cytotoxic (IgG and IgM) antibodies formed against cell surf…
- autoimmune hemolytic anemia ... - antibody-dependent cellular…
- myasthenia gravis ... - autoantibodies to AChR inhibits muscle…
- Graves disease ... - autoantibodies stimulate hormone synthesi…
What is the immunologic mechanism of T…
- cytotoxic (IgG and IgM) antibodies formed against cell surf…
What are some examples of Type II reac…
- autoimmune hemolytic anemia ... - antibody-dependent cellular…
34 terms
Immunology: Type IV Hypersensitivity Reactions
What is the immunologic mechanism of T…
What are some examples of Type IV HSR?
How is Type IV HSR initiated?
How can DTH be beneficial?
- delayed type (DTH)... - sensitized Th1 cells stimulate cell-me…
- granulomatous disease (TB, sarcoidosis, Crohn's) ... - contact…
- by inflammatory CD4+ Th1 cells that have been sensitized by…
- resistance to intracellular pathogens, fungi and tumors
What is the immunologic mechanism of T…
- delayed type (DTH)... - sensitized Th1 cells stimulate cell-me…
What are some examples of Type IV HSR?
- granulomatous disease (TB, sarcoidosis, Crohn's) ... - contact…
34 terms
Immunology: Type IV Hypersensitivity Reactions
What is the immunologic mechanism of T…
What are some examples of Type IV HSR?
How is Type IV HSR initiated?
How can DTH be beneficial?
- delayed type (DTH)... - sensitized Th1 cells stimulate cell-me…
- granulomatous disease (TB, sarcoidosis, Crohn's) ... - contact…
- by inflammatory CD4+ Th1 cells that have been sensitized by…
- resistance to intracellular pathogens, fungi and tumors
What is the immunologic mechanism of T…
- delayed type (DTH)... - sensitized Th1 cells stimulate cell-me…
What are some examples of Type IV HSR?
- granulomatous disease (TB, sarcoidosis, Crohn's) ... - contact…
34 terms
Immunology: Type IV Hypersensitivity Reactions
What is the immunologic mechanism of T…
What are some examples of Type IV HSR?
How is Type IV HSR initiated?
How can DTH be beneficial?
- delayed type (DTH)... - sensitized Th1 cells stimulate cell-me…
- granulomatous disease (TB, sarcoidosis, Crohn's) ... - contact…
- by inflammatory CD4+ Th1 cells that have been sensitized by…
- resistance to intracellular pathogens, fungi and tumors
What is the immunologic mechanism of T…
- delayed type (DTH)... - sensitized Th1 cells stimulate cell-me…
What are some examples of Type IV HSR?
- granulomatous disease (TB, sarcoidosis, Crohn's) ... - contact…
18 terms
Immunology: Type III Hypersensitivity Reactions
Describe the immunologic mechanism of…
What are some examples of Type III rea…
What do immune complexes contain?
What is the cause of tissue damage?
- antibodies (IgG, IgM and IgA) form immune complexes against…
- SLE ... - glomerulonephritis ... - Arthrus rxm ... - serum sickness
- IgM/IgG, antigen and complement
complement... neutrophils activated by immune complexes
Describe the immunologic mechanism of…
- antibodies (IgG, IgM and IgA) form immune complexes against…
What are some examples of Type III rea…
- SLE ... - glomerulonephritis ... - Arthrus rxm ... - serum sickness
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