Study sets matching "immunopharmacology"

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Study sets matching "immunopharmacology"

8 terms
Immunopharmacology
Cyclosporine and tacrolimus can bind t…
____ is DOC for organ or tissue transp…
____ can inhibit the de novo synthesis…
Both of cyclosporine and tacrolimus ca…
cyclophilin, FK-binding protein;... calcineurin钙调磷酸酶; T-cell t…
Cyclosporine环孢素
Mycophenolate霉酚酸
nephrotoxicity
Cyclosporine and tacrolimus can bind t…
cyclophilin, FK-binding protein;... calcineurin钙调磷酸酶; T-cell t…
____ is DOC for organ or tissue transp…
Cyclosporine环孢素
17 terms
Immunopharmacology
Etanercept
Abatacept
Denileukin diftitox
Rituximab
Soluble TNF receptor/Fc fusion protein.... Binds to TNF, thurs…
MOA: CTLA4-Ig, ... Competitive inhibitor of CD28. Binds to and…
MOA: Il2r (CD25)... Used: for cutaneous T cell lymphoma; CLL (l…
Target: CD20... Used: for CLL; B cell lymphoma (NHL), RA
Etanercept
Soluble TNF receptor/Fc fusion protein.... Binds to TNF, thurs…
Abatacept
MOA: CTLA4-Ig, ... Competitive inhibitor of CD28. Binds to and…
18 terms
Immunopharmacology
Sirolimus (Rapamycin)
Sirolimus Eluting Stents
TNF-alpha effects
Etanerept
Lymphocyte-signaling inhibitor, blocks IL-2 T-cell proliferat…
Stents that release sirolimus. Inhibits coronary artery smoot…
Produced by macrophages, mast cells and activated Th (esp. Th…
Anti-cytokine agent... TNF-alpha blocker (inactivates molecule…
Sirolimus (Rapamycin)
Lymphocyte-signaling inhibitor, blocks IL-2 T-cell proliferat…
Sirolimus Eluting Stents
Stents that release sirolimus. Inhibits coronary artery smoot…
66 terms
Immunopharmacology
GLucocorticoids: Anti inflmmatory MOA
Glucocorticoids: AE
Glucocorticoid: Uses
Name the Calcineurin inhibitors
GLucocorticoids: Anti inflmmatory MOA
Glucocorticoids: AE
Immunopharmacology
aspirin
Cyclosporine
Etanercept
Ibuprofen
Mechanism: COX inhibitor, causes covalent inactivation of COX…
Mechanism: binds and inhibits calcineurin and NFAT activation…
Mechanism: decoy receptor for TNFalpha (works like a mAB)... Ad…
Mechanism: non-specific COX inhibitor... Adverse Fx: nephrotoxi…
aspirin
Mechanism: COX inhibitor, causes covalent inactivation of COX…
Cyclosporine
Mechanism: binds and inhibits calcineurin and NFAT activation…
Immunopharmacology
Glucocorticoids
Cyclosporine
Tacrolimus
Sirolimus
immunosuppressants ... • bind to cytosolic glucocorticoid recept…
calcineurin inhibitor, immunosuppressive drug... -phosphatase ne…
calcineurin inhibitor, immunosuppressive drug... -binds to FK-bi…
proliferation signal inhibitor, immunosuppressant... • Sirolimus…
Glucocorticoids
immunosuppressants ... • bind to cytosolic glucocorticoid recept…
Cyclosporine
calcineurin inhibitor, immunosuppressive drug... -phosphatase ne…
30 terms
Immunopharmacology
Glucocorticoids
Cyclosporine
Tacrolimus
Sirolimus
immunosuppressants ... • bind to cytosolic glucocorticoid recept…
calcineurin inhibitor, immunosuppressive drug... -phosphatase ne…
calcineurin inhibitor, immunosuppressive drug... -binds to FK-bi…
proliferation signal inhibitor, immunosuppressant... • Sirolimus…
Glucocorticoids
immunosuppressants ... • bind to cytosolic glucocorticoid recept…
Cyclosporine
calcineurin inhibitor, immunosuppressive drug... -phosphatase ne…
23 terms
Immunopharmacology
APCs present antigen to CD4 positive T…
1. Binds to an intracellular protein c…
1. Macrolide antibiotic that is 100 ti…
Inhibition of calcineurin... Tacrolimus…
Describe the cellular mechanism of the immune response involv…
Cyclosporine... 1. Mechanism of action... 2. Use... 3. Adverse effect…
Tacrolimus... 1. Mechanism of action... 2. Use
Both cyclosporine and tacrolimus have a mechanism of action t…
APCs present antigen to CD4 positive T…
Describe the cellular mechanism of the immune response involv…
1. Binds to an intracellular protein c…
Cyclosporine... 1. Mechanism of action... 2. Use... 3. Adverse effect…
153 terms
Immunopharmacology
Reasons for Autoimmunity... 3
Autoimmune diseases... 4
T1 DM... Cell mediated attack on Bet…
Immunodeficiency diseases... - X agamm…
1. Self protein never seen before is exposed to immune syst…
1. RA... 2. Lupus... 3. MS... 4. T1DM
...
...
Reasons for Autoimmunity... 3
1. Self protein never seen before is exposed to immune syst…
Autoimmune diseases... 4
1. RA... 2. Lupus... 3. MS... 4. T1DM
35 terms
Immunopharmacology
What is the purpose of immunosuppressa…
What are 4 types of immunosuppressants?
What is the first line of treatment fo…
What are 2 examples of corticosteroids?
inhibit normal or overactive immune response (work best to pr…
1. Corticosteroids... 2. Cytotoxic drugs... 3. Cyclosporine... 4. Tacr…
corticosteroids (shock dosage or pulse treatment)
1. Prednisone... 2. Prednisolone
What is the purpose of immunosuppressa…
inhibit normal or overactive immune response (work best to pr…
What are 4 types of immunosuppressants?
1. Corticosteroids... 2. Cytotoxic drugs... 3. Cyclosporine... 4. Tacr…
75 terms
Immunopharmacology
Which of these belong to the innate im…
True or False... Adaptive immunity takes…
B cells originate from myeloid progeni…
Which of these are antigen presenting…
True
b. false... they originate from lymphoid progenitor cells
e.
Which of these belong to the innate im…
True or False... Adaptive immunity takes…
True
8 terms
Immunopharmacology
Prenisolone
Azathioprine
Cyclophosphamide
Methotrexate
Prenisolone
Azathioprine
Immunopharmacology
Rho ( D) Immune globulin ... Rhogam
RiTUximab
basILiximab
Abatacept
Mechanism ... Primary antibody response blocked if specific anti…
chimeric mouse/human monoclonal Ab to CD20 protein on B lymph…
Mechanism ... IL-2 receptor antagonist-- recombinant monoclonal…
Mechanism ... fusion of human cytotoxic T-Lymphocyte-associated…
Rho ( D) Immune globulin ... Rhogam
Mechanism ... Primary antibody response blocked if specific anti…
RiTUximab
chimeric mouse/human monoclonal Ab to CD20 protein on B lymph…
11 terms
Immunopharmacology
Immunomodulating agents
Corticosteroids
Methotrexate (antimetabolite)
Infliximab (TNFalpha inhibitor)
-major goal is to interfere with or enhance the cell-to-cell…
-used to suppress a wide range of undesired immunological rea…
-a substance that interferes with the normal metabolic proces…
-prototype monoclonal antibody ... -crohn disease, IBS, RA... -used…
Immunomodulating agents
-major goal is to interfere with or enhance the cell-to-cell…
Corticosteroids
-used to suppress a wide range of undesired immunological rea…
Immunopharmacology
glucocorticoids
cyclosporin
tacrolimus (FK-506)
Proliferation Signal Inhibitors (PSIs)
decrease size & lymphoid content of lymph node & spleen... toxi…
calcineurin inhibitor... - required for *activation of T cell…
immunosuppressive macrolide Abx ... *binds to immunophilin FK b…
bind to circulating immunophilin FK506 binding protein 12
glucocorticoids
decrease size & lymphoid content of lymph node & spleen... toxi…
cyclosporin
calcineurin inhibitor... - required for *activation of T cell…
Immunopharmacology
Prednisolone
Azathioprine
Cyclophosphamide
Methotrexate
Reduces access of lymphocytes and monocytes to target tissue.…
Orally bioavailable. Activated to 6-mercaptopurine. Inhibits…
Alkylating Agent. Cross links DNA to kill replicating and non…
Inhibits dihydrofolate reductase to inhibit DNA synthesis. Tx…
Prednisolone
Reduces access of lymphocytes and monocytes to target tissue.…
Azathioprine
Orally bioavailable. Activated to 6-mercaptopurine. Inhibits…
16 terms
Immunopharmacology
Glucocorticoids
Glucocorticoids
Cyclosporine
Cyclosporine
- Inhibit NF-kB and suppresses B/T cell function
- HTN, hyperglycemia, dyslipidemia, osteoporosis
- Calcineurin inhibitor that binds to Cyclophilin, blocks IL-…
- Nephrotoxicity, HTN, dyslipidemia, Hirsutism, Gum hyperplas…
Glucocorticoids
- Inhibit NF-kB and suppresses B/T cell function
Glucocorticoids
- HTN, hyperglycemia, dyslipidemia, osteoporosis
39 terms
Immunopharmacology
Immunogenicity (definition)
Inhibitors of gene expression
Anti-metabolites (examples)
lymphocyte-signaling inhibitors (examp…
Mostly means the immune system may recognize a cell or molecu…
corticosteroids
Azathioprine... Mycophenolate mofetil... Methotrexate
Cyclosporine, Tacrolimus, Sirolimus
Immunogenicity (definition)
Mostly means the immune system may recognize a cell or molecu…
Inhibitors of gene expression
corticosteroids
49 terms
Immunopharmacology
innate immunity
acquired response
are non-aspirin meds like acetominophe…
inflammatory challenges
inflammation
cell mediated & humoral
yes to treat symptoms. But not the cause of inflamm
trigger response formation of mediators
innate immunity
inflammation
acquired response
cell mediated & humoral
36 terms
Immunopharmacology
MOA corticosteroids
Uses of corticosteroids
Prototype immunophilin inhibitors
Uses of cyclosporine
inhibits phospholipase A2, inhibits T cell proliferation, inc…
transplant and hematologic cancers
cyclosporine, tacrolimus, sirolimus
transplant and autoimmune diseases
MOA corticosteroids
inhibits phospholipase A2, inhibits T cell proliferation, inc…
Uses of corticosteroids
transplant and hematologic cancers
28 terms
Immunopharmacology
antibodies mediate many of the effects…
inflammatory challenges
antibodies mediate many of the effects…
cyclooygenases
no, they are part of acquired immunity
trigger response formation of inflammatory mediators, symptom…
no
exist as isozymes... ~COX-1 has a broad tissue distribution whil…
antibodies mediate many of the effects…
no, they are part of acquired immunity
inflammatory challenges
trigger response formation of inflammatory mediators, symptom…
23 terms
Immunopharmacology
APCs present antigen to CD4 positive T…
1. Binds to an intracellular protein c…
1. Macrolide antibiotic that is 100 ti…
Inhibition of calcineurin... Tacrolimus…
Describe the cellular mechanism of the immune response involv…
Cyclosporine... 1. Mechanism of action... 2. Use... 3. Adverse effect…
Tacrolimus... 1. Mechanism of action... 2. Use
Both cyclosporine and tacrolimus have a mechanism of action t…
APCs present antigen to CD4 positive T…
Describe the cellular mechanism of the immune response involv…
1. Binds to an intracellular protein c…
Cyclosporine... 1. Mechanism of action... 2. Use... 3. Adverse effect…
24 terms
Immunopharmacology
Glucocorticoids
Cyclosporine
Tacrolimus
Toxicity of cyclosporine and tacrolumus
decrease size and lympoid content of node and spleen... toxic to…
Calciineurin inhibitor... typically used for organ transplantati…
immunosupressive macrolide... binds to FK binding protein causin…
cyclo - nerphrotoxicity, HTN, hyperglycemia, liver dysfunct…
Glucocorticoids
decrease size and lympoid content of node and spleen... toxic to…
Cyclosporine
Calciineurin inhibitor... typically used for organ transplantati…
24 terms
Immunopharmacology
Immunosuppressive clinical uses
Innate immune system
Inhibition of gene expression
Mechanisms for modulating immune syste…
Solid organ and bone marrow .... Autoimmune disorders.
Physical, biochemical, cellular components.
Mechanism for modulating immune system function.... Glucocortic…
1. Inhibition of gene expression.... 2. Selective cytostatic/cyt…
Immunosuppressive clinical uses
Solid organ and bone marrow .... Autoimmune disorders.
Innate immune system
Physical, biochemical, cellular components.
13 terms
Immunopharmacology
Sirolimus
Etanercept
Infliximab
Adalimumab
specific lymphocyte-signaling inhibitor... Mechanism: binds FKB…
TNF-alpha inhibitor... Structure: dimer with TNF binding domain…
TNF-alpha inhibitor... Structure: monoclonal antibody with mous…
TNF-alpha inhibitor... Structure: fully human IgG anti-TNF anti…
Sirolimus
specific lymphocyte-signaling inhibitor... Mechanism: binds FKB…
Etanercept
TNF-alpha inhibitor... Structure: dimer with TNF binding domain…
27 terms
Immunopharmacology
prednisone mechanism of action
therapeutic use of corticosteroids
Prednisone affect cell-mediated immuni…
Therapeutic effects of prednisone
affects pro-inflammatory cell gene expression... decrease synthe…
suppress undesired immune responses like transplantation, hem…
increases concentration of neutrophils... increase flux from bo…
max effects = given before antigen exposure, peak effects at…
prednisone mechanism of action
affects pro-inflammatory cell gene expression... decrease synthe…
therapeutic use of corticosteroids
suppress undesired immune responses like transplantation, hem…
35 terms
Immunopharmacology
Glucocorticoids
Calcineurin inhibitors
Cyclosporine
Calcineurin
decrease size and lymphoid content ... modify cellular function…
cyclosporine
forms complex cyclophilin which inhibits cytoplasmic phosphat…
required for activation of T cell NF-AT... NF-AT synthesizes IL-
Glucocorticoids
decrease size and lymphoid content ... modify cellular function…
Calcineurin inhibitors
cyclosporine
Immunopharmacology
Is primary or secondary immune respons…
"Once memory cell are established, wha…
What is the toxicity effect of immunos…
What is the gold standard drug for hyp…
Primary
Low effectiveness
Increased risk of infection and lymphomas
Prednisone
Is primary or secondary immune respons…
Primary
"Once memory cell are established, wha…
Low effectiveness
22 terms
Immunopharmacology
Hypofunction of immune system?
Hyperfunction of immune system?
Hypersensitivity does not happen on?
Type 1 Hypersensitivity?
Cancer... Infection
Allergy... Asthma... Autoimmune disease
First exposure... Antibodies are formed during sensitizing expo…
Example Anaphylaxis ... Mediated by IgE attached to mast cells
Hypofunction of immune system?
Cancer... Infection
Hyperfunction of immune system?
Allergy... Asthma... Autoimmune disease
7 terms
Immunopharmacology
Azathioprine
Cycophosphamide
Methotrexate
Mycophenolate mofetil
--> 6-mercaptopurine, inhibits purine de novo and salvage pat…
alkylating agent that crosslinks DNA, autoimmune diseases
dihydrofolate reductase inhibitor; autoimmune diseases
IMP dehydrogenase inhibitor; autoimmune diseases (RA and refr…
Azathioprine
--> 6-mercaptopurine, inhibits purine de novo and salvage pat…
Cycophosphamide
alkylating agent that crosslinks DNA, autoimmune diseases
Immunopharmacology
Prednisone
MMF
Azathioprine
Leflunomide
Glucocorticoid... inhibition of gene expression... Reduce function…
Inhibits T and B lymphocyte response by inhibiting type II IM…
forms a purine analog that interferes with purine nucleic aci…
prodrug of an inhibitor of pyrimidine synthesis... inhibition of…
Prednisone
Glucocorticoid... inhibition of gene expression... Reduce function…
MMF
Inhibits T and B lymphocyte response by inhibiting type II IM…
Immunopharmacology
Calcineurin Inhibitors SEs
m-TOR pathway inhibitors SEs
Nucleotide Synthesis Inhibitors SEs
Antibodies SEs
Nephrotoxicity... HTN
Thromobytopenia ... DLD
Myelosuppression... hemorrhagic cystitis (specific to cyclophosp…
flu like illness
Calcineurin Inhibitors SEs
Nephrotoxicity... HTN
m-TOR pathway inhibitors SEs
Thromobytopenia ... DLD
45 terms
Immunopharmacology
Immunopharmacology
Physiology of Immune System
Abnormal Immune Responses
Autoimmunity
-Agents that suppress the immune system play an important rol…
-Part of body that attacks and rids the body of foreign invad…
-The immune system has evolved to protect the host from invad…
-Arises when the body mounts an immune response against itsel…
Immunopharmacology
-Agents that suppress the immune system play an important rol…
Physiology of Immune System
-Part of body that attacks and rids the body of foreign invad…
Immunopharmacology
Aspirin
Cyclosporine (tacrolimus)
Etanercept (Adalimumab, Infliximab)
Ibuprofen
Non-specific COX inhibitor, causes covalent inactivation of C…
Binds cyclophillin and inhibits calcineurin and NFAT activati…
Decoy receptor for TNF-alpha (works like mAB)(SE: injection s…
Non-specific COX inhibitor (SE: nephrotoxicity, some GI toxic…
Aspirin
Non-specific COX inhibitor, causes covalent inactivation of C…
Cyclosporine (tacrolimus)
Binds cyclophillin and inhibits calcineurin and NFAT activati…
16 terms
Immunopharmacology
4 major classes of immunosuppressive t…
5 considerations in organ transplant
Induction therapy is
Maintenance therapy is
Glucocorticoids... Calcineurin Inhibitors (Cyclosporine, Tacrol…
1. matching ... 2. multiple immunosuppressive drugs @ differ tar…
Used: Prophylactically to prevent rejection... Goal: delay use…
Used: maintain immunosuppressive state... Goal: multiple drugs @…
4 major classes of immunosuppressive t…
Glucocorticoids... Calcineurin Inhibitors (Cyclosporine, Tacrol…
5 considerations in organ transplant
1. matching ... 2. multiple immunosuppressive drugs @ differ tar…
15 terms
Immunopharmacology
Cyclosporin
nephrotoxicity, HTN
Tacrolimus
Sirolimus
Binds to cyclophilin to inhibit calcineurin (needed for IL-2)
SE of Cyclosporin
Binds to specific immunophilins (FKBP12) in cytoplasm to inhi…
Aka Rapamycin, suppresses IL-2, IL-4. Blocks cytokine signal…
Cyclosporin
Binds to cyclophilin to inhibit calcineurin (needed for IL-2)
nephrotoxicity, HTN
SE of Cyclosporin
102 terms
Immunopharmacology
divisions of innate/nonspecific immune…
divisions of adaptive immune system
name the myeloid cells
name the lymphoid cells
cellular (granulocytes, macrophages, NK cells) and humoral (c…
cellular (T cells) and humoral (B cells and Abs)
granulocytes (-phils), monocytes (macrophages and dendritic c…
T, B, NK cells
divisions of innate/nonspecific immune…
cellular (granulocytes, macrophages, NK cells) and humoral (c…
divisions of adaptive immune system
cellular (T cells) and humoral (B cells and Abs)
23 terms
Immunopharmacology
immunosuppressive drugs
major uses
major problems
Azathioprine
dampen immune response
preventing/treat transplant rejection... treat autoimmune diseases
lack of specificity but high toxicity (use combos in lower do…
prophylaxis of renal transplant rejection (co-administered w/…
immunosuppressive drugs
dampen immune response
major uses
preventing/treat transplant rejection... treat autoimmune diseases
18 terms
Immunopharmacology
3 abnormal immune responses
Autoimmunity
Hypersensitivity
Immunodeficiency
Autoimmunity, hypersensitivity, immunodeficiency
Body mounts an immune response against self, failure to disti…
Over reacting to an antigen
Decreased or inadequate response from one or more components…
3 abnormal immune responses
Autoimmunity, hypersensitivity, immunodeficiency
Autoimmunity
Body mounts an immune response against self, failure to disti…
12 terms
Immunopharmacology
Interferon-γ
Interleukin-2
BCG
Cyclosporine
↓T cell fxn, ↑cell-mediated immune, ↑NK activity... ↑↑phagocyte…
⊕Th cells, ⊕cytotoxic T cells, ⊕NK toxicity (LAK too)... - for:…
??? - ⊕local inflammatory rx @ bladder... - for: 1º and relapse…
⊕cyclophilins = ⊖calcineurin = ↓IL-2 = ↓T-cells... - for: transp…
Interferon-γ
↓T cell fxn, ↑cell-mediated immune, ↑NK activity... ↑↑phagocyte…
Interleukin-2
⊕Th cells, ⊕cytotoxic T cells, ⊕NK toxicity (LAK too)... - for:…
Immunopharmacology
Glucocorticoids
Glucocorticoids MOA
Glucocorticoids Side Effects
Cyclosporine MOA
1. Prednisone... 2. Methylprednisolone... Dexamethasone
Inhibit NF-kB... - Suppress B and T cell function... - Blocks trans…
1. Hypertension... 2 Hyperglycemia... 3. Dyslipidemia... 4. Osteoporosis
Calcineurin inhibitor (binds to cyclophilin)... - Downregulate I…
Glucocorticoids
1. Prednisone... 2. Methylprednisolone... Dexamethasone
Glucocorticoids MOA
Inhibit NF-kB... - Suppress B and T cell function... - Blocks trans…
22 terms
Immunopharmacology
corticosteroids
T-cell supressants
cyclosporine
cyclosporine
what is given to treat... Systemic: oral erythema multiforme, pe…
Calcineurin inhibitors... -Cyclosporine... -Tacrolimus... Sirolimus…
inhibits calcineurin / T-cell activation... decreases formation…
Phenobarbital, phenytoin, rifampin: induce CYP3A, decrease cy…
corticosteroids
what is given to treat... Systemic: oral erythema multiforme, pe…
T-cell supressants
Calcineurin inhibitors... -Cyclosporine... -Tacrolimus... Sirolimus…
Immunopharmacology
prednisone (Imuran)... methylprednisolone…
prednisone RxK... methylprednisolone (Med…
azathioprine (Imuran)
azathioprine RxK
corticosteroid
acts on cell proliferation... peripheral leukocytes and macropha…
cytotoxic and anti proliferative agents (T and B)
antimetabolite... acts on cell proliferation... derivative of 6-mer…
prednisone (Imuran)... methylprednisolone…
corticosteroid
prednisone RxK... methylprednisolone (Med…
acts on cell proliferation... peripheral leukocytes and macropha…
Immunopharmacology
Autoimmunity
Some Autoimmune Disorders
Hypersensitivity
Some Hypersensitivity rxn
Arises when the body mounts an immune response against itself…
-Rheumatoid Arthritis ... -Systemic Lupus Erythematous ... -Multipl…
Overacting to an antigen ... -Often to an antigen found in the e…
-Asthma... -Allergic Rhinitis... -Contact Dermatitis
Autoimmunity
Arises when the body mounts an immune response against itself…
Some Autoimmune Disorders
-Rheumatoid Arthritis ... -Systemic Lupus Erythematous ... -Multipl…
36 terms
Immunopharmacology
corticosteroids
cytotoxic and antiproliferative agents…
T-cell suppressants
other antibody suppressives
-prednisone... -prednisolone
-azathioprine... -methotrexate... -cyclophosphamide
-cyclosporine... -mycophenolate... -muromonab-CD3... -lymphocyte immun…
-Rho immune globulin (Rhogam)
corticosteroids
-prednisone... -prednisolone
cytotoxic and antiproliferative agents…
-azathioprine... -methotrexate... -cyclophosphamide
42 terms
Immunopharmacology
Glucocorticoids (corticorticoids) (cor…
Calcineurin Inhibitors
mTOR (mammalian target of rapamycin) I…
Mycophenolate mofetil
Prednisone:... -gold standard... -antibody response reduced... -catabo…
Cyclosporine: binds cyclophilin intracellular protein, blocks…
Sirolimus (rapamycin)... Everolimus... Temsirolimus... -mTOR proteins…
Inhibits T and B lymphocytes
Glucocorticoids (corticorticoids) (cor…
Prednisone:... -gold standard... -antibody response reduced... -catabo…
Calcineurin Inhibitors
Cyclosporine: binds cyclophilin intracellular protein, blocks…
165 terms
Immunopharmacology
annexin1
arachidonic acid and lyso-paf
remodelling pathway
20c
inhibits PLA2
two products forms from action of PLA2
name of primary pathway for PAF production under inflammatory…
how many carbons in prostaglanding
annexin1
inhibits PLA2
arachidonic acid and lyso-paf
two products forms from action of PLA2
24 terms
Immunopharmacology
Drugs Glucocorticoids/Corticosteriods
Glucocorticoids MOA
Drugs that are calcineurin inhibitors
Cyclosporin MOA
Prednisone... Prednisolone ... Dexamethasone... Glucocorticoids - ONE…
Glucocorticoid response element in DNA (regulate gene transcr…
Cyclosporine... Tacrolimus... calcium in cycles and spoils the tac…
Binds to cyclophilin C and inhibits calcineurin (inhibits pho…
Drugs Glucocorticoids/Corticosteriods
Prednisone... Prednisolone ... Dexamethasone... Glucocorticoids - ONE…
Glucocorticoids MOA
Glucocorticoid response element in DNA (regulate gene transcr…
42 terms
Immunopharmacology
Glucocorticoids
prednisone
Calcineurin Inhibitors
Cyclosporin
i. 1st line immunosuppressive therapy... 1. Interrupts cell cycl…
hypersensitivities
Cyclosporin... Tacrolimus... 1. NFATc/NFATn- activates IL-2 gene tr…
1. initially binds cyclophilin... a. Used in organ transplants,…
Glucocorticoids
i. 1st line immunosuppressive therapy... 1. Interrupts cell cycl…
prednisone
hypersensitivities
35 terms
Immunopharmacology
primary immune response
effect on immune responses
inhibition more likely if...
innate immunity
more easily suppressed than secondary
not all immunosuppression is created equal
therapy starts before exposure to immunogen
broad-based, low affinity; no priming, early response
primary immune response
more easily suppressed than secondary
effect on immune responses
not all immunosuppression is created equal
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