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Study sets matching "lung cancer"

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Study sets matching "lung cancer"

118 terms
lung cancer
what is the number one cause of cancer…
AA population (more/ less) @ risk for…
average age at diagnosis for mm and lu…
survival rate at 5 yrs for lung cancer
lung CA... (and second most common)
more @ risk
70
1
what is the number one cause of cancer…
lung CA... (and second most common)
AA population (more/ less) @ risk for…
more @ risk
10 terms
Lung Cancer
Lung Cancer
Lung Cancer Etiology
oncogenes
tumor suppressor genes
Highly malignant form developing from a constant irritation o…
Smoking... Asbestos exposure... Radon Exposure... Halogen ether exposu…
Cancer-causing genes that are formed due to mutations
A gene whose protein product inhibits cell division, thereby…
Lung Cancer
Highly malignant form developing from a constant irritation o…
Lung Cancer Etiology
Smoking... Asbestos exposure... Radon Exposure... Halogen ether exposu…
51 terms
Lung Cancer
Lung Cancer risk factors
Lung Cancer Clinical Presentation
SCLC staging
Limited disease
Age... Asbestos... Radiation... Heavy Metals... Coal... Genetics
Cough... dyspnea... hemoptysis... recurrect infections... chest pain
Limited disease... Extensive disease
Disease confined to one side of the chest and the regional ly…
Lung Cancer risk factors
Age... Asbestos... Radiation... Heavy Metals... Coal... Genetics
Lung Cancer Clinical Presentation
Cough... dyspnea... hemoptysis... recurrect infections... chest pain
20 terms
Lung Cancer
squamous cell
small cell lung cancer
single pulmonary nodule
85%
most common type of lung cancer
This lung cancer spreads easily and is often disseminated at…
SPN
percentage of metabolically active SPN which are malignant
squamous cell
most common type of lung cancer
small cell lung cancer
This lung cancer spreads easily and is often disseminated at…
125 terms
Lung Cancer
Risk Factors
What is the number one RF for lung can…
List four environmental RF's
NOTE: Radiation Therapy RF's... •Treatm…
...
Smoking (~90% of all lung cancers).
•Second hand smoke... •Asbestos... •Radon... •Metals
...
Risk Factors
...
What is the number one RF for lung can…
Smoking (~90% of all lung cancers).
22 terms
Lung Cancer
Lung cancer ________ than any other ma…
Lung cancer is the most _____ form of…
Two major types of lung cancers: ... -- E…
______ is the biggest risk factor for…
kills more patients
preventable... Tobacco use
1. NSCLC: Non-small cell lung cancer (87%).... 2. SCLC: Small c…
Cigarette smoking... tobacco... Intensity
Lung cancer ________ than any other ma…
kills more patients
Lung cancer is the most _____ form of…
preventable... Tobacco use
9 terms
Lung Cancer
Why is the survival rate for lung canc…
List the types of lung cancer.
Define neoplasm
What characteristics do benign tumors…
It is difficult to diagnose in the early stages. Some tumors…
Small-cell, squamous cell, Adenocarcinoma, large-cell cancer
A tumor comprised of an abnormal new growth characterized by…
Grow slowly, have distinct borders, are non-invasive, and not…
Why is the survival rate for lung canc…
It is difficult to diagnose in the early stages. Some tumors…
List the types of lung cancer.
Small-cell, squamous cell, Adenocarcinoma, large-cell cancer
5 terms
Lung Cancer
Formula: Number of pack years
Lung cancer: Define
Lung Cancer: Dx
Lung cancer: Sx
Non Small Cell Lung Cancer ... - hypercalcemia (due to increase…
Diagnostic tests ... - Chest x-ray ... - Biopsy (bronchoscopy, nee…
Cough... Wheezing, dyspnea... Hoarseness... Hemoptysis, blood-tinge…
Formula: Number of pack years
Lung cancer: Define
Non Small Cell Lung Cancer ... - hypercalcemia (due to increase…
20 terms
Lung Cancer
Prevention Lung Cancer
Screening
Diagnosis
Small Cell Lung Cancer Paraneoplastic…
-Abstinence from smoking... -Retinol (vitamin A), B-carotene, N-…
USPSTF recommends low dose CT to screen for early stage lung…
Be alert for symptoms of hemoptysis, fever, weight loss, pulm…
-Acromegaly-growth hormone releasing hormone... -Cushing syndrom…
Prevention Lung Cancer
-Abstinence from smoking... -Retinol (vitamin A), B-carotene, N-…
Screening
USPSTF recommends low dose CT to screen for early stage lung…
78 terms
Lung Cancer
Lung cancer Demographics
Lifetime risk by age 85
Estimated number of new cases diagno…
Estimated number of deaths in 2016
5th most common cancer type... leading cause of cancer related d…
1:13 (men)... 1:22 (women)
12,203... 7,130 males... 5,073 females
8,839... 5,122 males... 3,716 females
Lung cancer Demographics
5th most common cancer type... leading cause of cancer related d…
Lifetime risk by age 85
1:13 (men)... 1:22 (women)
53 terms
Lung cancer
non-small cell and neuroendocrine carc…
adenocarcinoma and squamous cell carci…
well differentiated (carcinoid) and po…
squamous cell, adeno, small cell and o…
what are the 2 categories of lung cancer?
what are the 2 types of non-small cell carcinoma?
what are the 2 categories of neuroendocrine tumor?
what 4 categories of tumor are called bronchogenic carcinomas?
non-small cell and neuroendocrine carc…
what are the 2 categories of lung cancer?
adenocarcinoma and squamous cell carci…
what are the 2 types of non-small cell carcinoma?
20 terms
Lung Cancer
Lung cancer: Risk and define
Lung cancer: risk
Lung cancer: Local sx
Lung cancer: SX Local metastasis
• #1 cause of cancer death for male and female ... • #1 risk fac…
•Age... • Cigarette smoking ... - Pack Years=cigarettes/20/day, th…
- cough... - dyspnea-late prognosis... - hemoptysis-late prognosis…
- Esophageal compression -> dysphagia ... - Laryngeal nerve para…
Lung cancer: Risk and define
• #1 cause of cancer death for male and female ... • #1 risk fac…
Lung cancer: risk
•Age... • Cigarette smoking ... - Pack Years=cigarettes/20/day, th…
28 terms
Lung Cancer
How is lung function most commonly det…
Lobar Anatomy
Lobar anatomy on the CXR
Mediastinal lymph nodes
PFT... DLCO
N1 Nodes: Double Digit... ... N2 Nodes: Single Digit
How is lung function most commonly det…
PFT... DLCO
Lobar Anatomy
64 terms
Lung cancer
Biggest cause of cancer deaths
Lung cancer risk is proportional to
Hoarse voice or weight loss >10% =
Hoarse voice suggests
Lung cancer
Pack years
Very poor prognostic markers
Invasion of recurrent laryngeal nerve
Biggest cause of cancer deaths
Lung cancer
Lung cancer risk is proportional to
Pack years
36 terms
Lung Cancer
Leading cause of cancer death in women
More likely to develop adenocarcinoma;…
Driver mutations of lung cancer
Immunotherapy for non-small cell lung…
lung
women
kras... egfr... eml4-alk
immune checkpoint inhibitors - used by cancer cells to avoid…
Leading cause of cancer death in women
lung
More likely to develop adenocarcinoma;…
women
20 terms
Lung Cancer
Risk factors for lung cancer
Presentation of lung cancer
Benign lung cancer lesions that have c…
Law of "S" in lung cancer
polycyclic aromatic hydrocarbons found in cigarette smoke... ra…
coin lesion on x ray (pic). Compare to previous x ray. If coi…
coin lesions can be granulomas due to TB/fungus, especially h…
if it starts with letter "S" the cancer is in Smokers, Centra…
Risk factors for lung cancer
polycyclic aromatic hydrocarbons found in cigarette smoke... ra…
Presentation of lung cancer
coin lesion on x ray (pic). Compare to previous x ray. If coi…
123 terms
Lung Cancer
What is the leading cause of lung canc…
10 years after smoking cessation what…
What are some risk factors for lung ca…
What are the three genetic factors tha…
smoking
1/2
- smoking... - radon... *homes, buikdings, schools... *colorless, od…
1. Activation of dominant oncogenes... -K-ras, myc (proto-oncog…
What is the leading cause of lung canc…
smoking
10 years after smoking cessation what…
1/2
78 terms
LUNG CANCER
leading cancer diagnoses
leading cancer deaths
true or false: more Americans die each…
true or false: lung cancer is one of t…
1 prostate (men); breast (women)... 2 lung (both)... 3 colorectal (…
1 lung (both)... 2 prostate (men); breast (women)... 3 colorectal (…
TRUE... and ~50% more women will die of lung cancer than breast…
TRUE... 90% of cases are attributed to smoking and USPSTF recomm…
leading cancer diagnoses
1 prostate (men); breast (women)... 2 lung (both)... 3 colorectal (…
leading cancer deaths
1 lung (both)... 2 prostate (men); breast (women)... 3 colorectal (…
125 terms
Lung Cancer
Risk Factors
What is the number one RF for lung can…
List four environmental RF's
NOTE: Radiation Therapy RF's... •Treatm…
...
Smoking (~90% of all lung cancers).
•Second hand smoke... •Asbestos... •Radon... •Metals
...
Risk Factors
...
What is the number one RF for lung can…
Smoking (~90% of all lung cancers).
9 terms
Lung Cancer
Why is the survival rate for lung canc…
List the types of lung cancer.
Define neoplasm
What characteristics do benign tumours…
It is difficult to diagnose in the early stages. Some tumors…
Small-cell, squamous cell, Adenocarcinoma, large-cell cancer
A tumour comprised of an abnormal new growth characterized by…
Grow slowly, have distinct borders, are non-invasive, and not…
Why is the survival rate for lung canc…
It is difficult to diagnose in the early stages. Some tumors…
List the types of lung cancer.
Small-cell, squamous cell, Adenocarcinoma, large-cell cancer
20 terms
Lung cancer
Most common malignant tumour & third m…
Aetiological factors
Non small cell carcinomas
Carcinomas by frequency (most common f…
Bronchial carcinoma
-Smoking... -Environmental (asbestos, arsenic, chromium, nickel,…
Squamous cell... Adenocarcinoma... Large cell
Squamous... Adenocarcinoma... Small cell... Large cell... Alveolar cell (…
Most common malignant tumour & third m…
Bronchial carcinoma
Aetiological factors
-Smoking... -Environmental (asbestos, arsenic, chromium, nickel,…
42 terms
Lung Cancer
Why is it bad to smoke after being dia…
Possible Causes of Lung Cancer
Two Main Types of Lung Cancer
Subtypes of Non-Small Cell Lung Cancer
• chemo/radiation is less effective in smokers... • side effects…
smoking... • asbestos... • beryllium... • radon... • genetics
• small cell lung cancer (SCLC)... • non small cell lung cancer…
• squamous cell... • adenocarcinoma... • large cell carcinoma... • car…
Why is it bad to smoke after being dia…
• chemo/radiation is less effective in smokers... • side effects…
Possible Causes of Lung Cancer
smoking... • asbestos... • beryllium... • radon... • genetics
23 terms
Lung Cancer
Adenocarcinoma
Squamous Cell Carcinoma
Large Cell (endocrine) Carcinoma
In situ Pulmonary Adenocarcinoma... (prev…
-Grows along and lines alveoli... -Appears like pneumonia on CXR
Adenocarcinoma
Squamous Cell Carcinoma
54 terms
Lung Cancer
lung cancer risk factors
what is the lifetime risk of lung canc…
what is the number 2 cause of lung can…
your lung cancer risk is much much hig…
-gender... -smoking... -older age... -airflow obstruction... -genetic pre…
20%
radon... -ionizing radiation and asbestos... -uranium miner
an asbestos worker
lung cancer risk factors
-gender... -smoking... -older age... -airflow obstruction... -genetic pre…
what is the lifetime risk of lung canc…
20%
54 terms
Lung Cancer
lung cancer risk factors
what is the lifetime risk of lung canc…
what is the number 2 cause of lung can…
your lung cancer risk is much much hig…
-gender... -smoking... -older age... -airflow obstruction... -genetic pre…
20%
radon... -ionizing radiation and asbestos... -uranium miner
an asbestos worker
lung cancer risk factors
-gender... -smoking... -older age... -airflow obstruction... -genetic pre…
what is the lifetime risk of lung canc…
20%
51 terms
Lung Cancer
Gross image of lung cancer
Lung Cancer Epidemic : 1915-1996
epidemiology
Etiology of smoking
-normal tan/brown parenchyma on gross exam... -abnormal portion:…
-incidence in males rolse steeply: but after 1990 went down a…
-still struggle with low survival rate... -problems in late diag…
*smoking accounts for 80-85 % of bronchogenic cancer... -risk re…
Gross image of lung cancer
-normal tan/brown parenchyma on gross exam... -abnormal portion:…
Lung Cancer Epidemic : 1915-1996
-incidence in males rolse steeply: but after 1990 went down a…
81 terms
Lung Cancer
Lung Cancer
Lung tumors that arise from metastases…
The lung is the most common site of me…
Although there are multiple types of l…
*Number one cause of cancer mortality in the world... *Incidence…
T
T... (According to Robbin)
Small Cell and Non Small Cell
Lung Cancer
*Number one cause of cancer mortality in the world... *Incidence…
Lung tumors that arise from metastases…
T
28 terms
Lung Cancer
SIADH
What stage would bone metastasis occur?
Lung cancer staging I and II
Lung cancer staging III
Stage IV - no cure. Chemotherapy and palliative care. ... Try t…
I solitary nodule no lymph nodes found in the lung.... II hilar…
III a - tymor has spread to the lymph nodes in the tracheal a…
SIADH
What stage would bone metastasis occur?
Stage IV - no cure. Chemotherapy and palliative care. ... Try t…
26 terms
Lung Cancer
What are two key characteristics of be…
What are three characteristics of mali…
Identify 3 pathologic or structural ch…
The most common cause of lung cancer is:
They grow slowly and are usually encapsulated.
1. Invade surrounding tissues.... 2. Cause necrosis. ... 3. may b…
1. excessive mucous production. ... 2. Inflammation of the airwa…
Smoking
What are two key characteristics of be…
They grow slowly and are usually encapsulated.
What are three characteristics of mali…
1. Invade surrounding tissues.... 2. Cause necrosis. ... 3. may b…
28 terms
Lung Cancer
How is lung function most commonly det…
Lobar Anatomy
Lobar anatomy on the CXR
Mediastinal lymph nodes
PFT... DLCO
N1 Nodes: Double Digit... ... N2 Nodes: Single Digit
How is lung function most commonly det…
PFT... DLCO
Lobar Anatomy
25 terms
Lung Cancer
NSCLC
NSCLC treatment: surgery
Radiation
NSCLC Adjuvant chemotherapy
-slower growth than SCLC... -moderately sensitive to radiation... -…
treatment of choice for resectable cancers... For patients with…
-Treatment of choice with chemotherapy for unresectable tumor…
used in stage II, III ... cisplatin based therapy (standard for…
NSCLC
-slower growth than SCLC... -moderately sensitive to radiation... -…
NSCLC treatment: surgery
treatment of choice for resectable cancers... For patients with…
9 terms
Lung Cancer
Lung Cancer death rank
Lung Cancer s/s
Lung Cancer risk factors
Lung Cancer screening
#1 in cancer related deaths
late-stage disease when pts become symptomatic ... fatigue, ano…
smokers 55-75 with at least 30 pack year
CT scan but high false positives, patient axiety, radiation e…
Lung Cancer death rank
#1 in cancer related deaths
Lung Cancer s/s
late-stage disease when pts become symptomatic ... fatigue, ano…
25 terms
Lung Cancer
Adenocarcinoma in situ
Squamous Cell
What increases risk of lung cancer
By how much does LDCT reduce lung canc…
-solid nodule... -not invasive, grows over lining of lung... -lipit…
-proximal airways... -form keratin pearls and intercellular brid…
HIV, pulm fibrosis, enviornmental toxins, and radiation therapy
20% screen 340 ppl to save 1
Adenocarcinoma in situ
-solid nodule... -not invasive, grows over lining of lung... -lipit…
Squamous Cell
-proximal airways... -form keratin pearls and intercellular brid…
52 terms
Lung Cancer
Lung cancer
lung cancer
NSCLC
SCLC
leading cause of cancer related death... Is preventable ... 5 yr su…
Median age of diagnosis is 71 yrs ... 45-85 yo (if younger or ol…
Adenocarcinoma (38.5%)... Squamous cell carcinoma (20%)... Large ce…
60% at stage 4 when diagnosed
Lung cancer
leading cause of cancer related death... Is preventable ... 5 yr su…
lung cancer
Median age of diagnosis is 71 yrs ... 45-85 yo (if younger or ol…
30 terms
Lung Cancer
Persistent cough/chronic cough
Low dose heliac CT scan for persons 55…
Majority are adenocarcinomas, found in…
Early
Which clinical finding is most associated with lung cancer sy…
The current screening guidelines for lung cancer in primary c…
Which of the following is a correct statement about lung canc…
Lung cancer is curable when caught in the ........ stages?
Persistent cough/chronic cough
Which clinical finding is most associated with lung cancer sy…
Low dose heliac CT scan for persons 55…
The current screening guidelines for lung cancer in primary c…
17 terms
Lung Cancer
how to tell if chest tube is working
pneumonectomy
calcium levels
treatment for paraneoplastic syndromeneo
bubbling in the chest tube
removal of the entire lung
8.5-10
high dose steroids, plasma pheresis ... IV IGG
how to tell if chest tube is working
bubbling in the chest tube
pneumonectomy
removal of the entire lung
57 terms
Lung Cancer
(SCLC/NSCLC) is more common and includ…
the #1 cause of lung cancer, leading t…
which is NOT a risk factor for lung ca…
T/F mean age of diagnosis of lung canc…
NSCLC (non small cell, vs small cell which account for less t…
smoking (includes passive smokers and secondhand smoke)
d (not alcohol)
true
(SCLC/NSCLC) is more common and includ…
NSCLC (non small cell, vs small cell which account for less t…
the #1 cause of lung cancer, leading t…
smoking (includes passive smokers and secondhand smoke)
135 terms
Lung Cancer
Who is at higher risk for lung cancer,…
Who is at higher risk for lung cancer,…
What risk factor causes > 90% of lung…
Diseases associated with increased ris…
AAM
Caucasian females
Smoking
1.COPD... 2. Pulmonary fibrosis... 3. Sarcoidosis... 4. HIV
Who is at higher risk for lung cancer,…
AAM
Who is at higher risk for lung cancer,…
Caucasian females
71 terms
Lung Cancer
What is the main cause of lung cancer?
What are occupational and environmenta…
What are the warning signs of lung can…
What cancer has the lowest survival ra…
Cigarette smoking
Benzopyrene, radon particles, asbestos fibers, diesel exhaust…
Persistent cough, hemoptysis (coughing up blood), bloody sput…
Lung
What is the main cause of lung cancer?
Cigarette smoking
What are occupational and environmenta…
Benzopyrene, radon particles, asbestos fibers, diesel exhaust…
58 terms
Lung Cancer
Syndrome resulting from impairment of…
What should you consider whenever hema…
Cells/tissue involved in lung CA
Two major categories of lung cancer
Trauma, post-op, stroke, or anything that causes destruction…
neoplasia
-Epithelioid malignancy arising in the bronchiolar and alveol…
-Small cell lung CA (SCLC - formerly oat cell CA)... -Non small…
Syndrome resulting from impairment of…
Trauma, post-op, stroke, or anything that causes destruction…
What should you consider whenever hema…
neoplasia
60 terms
Lung Cancer
Risk Factors for Lung Cancer
Cardinal (Danger) Symptoms of Lung Can…
Chronic Cough Presentation of Lung Can…
Hemoptysis Presentation of Lung Cancer
Smoking (most important, the more cigarettes and the anger yo…
Weight loss... Chronic cough (>3wks)... Hemoptysis... Chest pain... Hoars…
Presents in 50-75% of pts... Most frequently in small cell and s…
Seen in 25-50% of pts... Should be noted though the most common…
Risk Factors for Lung Cancer
Smoking (most important, the more cigarettes and the anger yo…
Cardinal (Danger) Symptoms of Lung Can…
Weight loss... Chronic cough (>3wks)... Hemoptysis... Chest pain... Hoars…
123 terms
Lung Cancer
What is the leading cause of lung canc…
10 years after smoking cessation what…
What are some risk factors for lung ca…
What are the three genetic factors tha…
smoking
1/2
- smoking... - radon... *homes, buikdings, schools... *colorless, od…
1. Activation of dominant oncogenes... -K-ras, myc (proto-oncog…
What is the leading cause of lung canc…
smoking
10 years after smoking cessation what…
1/2
85 terms
Lung Cancer
What is lung cancer?
From where does lung cancer arise?
How does lung cancer begin?
What's the most common cancer in the US?
Uncontrolled growth of malignant cells in one or both lungs a…
From protective or ciliated cells in the bronchial epithelium
As a result of repeated carcinogenic irritation causing incre…
lung cancer
What is lung cancer?
Uncontrolled growth of malignant cells in one or both lungs a…
From where does lung cancer arise?
From protective or ciliated cells in the bronchial epithelium
37 terms
Lung Cancer
5 year overall survival rate
- Responsible for ~80% of lung cancer…
- Cough... - Dyspnea... - Chest, shoulder pa…
- Rapidly growing... - Surgery has no rol…
15%
Smoking
Presentation
Small-cell
5 year overall survival rate
15%
- Responsible for ~80% of lung cancer…
Smoking
18 terms
Lung Cancer
Surgery is a Tx option for which kind…
What is the 2nd most common cause of l…
Adjuvant chemo timeframe? ; NSCLC
NSCLC→ Limited & Resectable... Treatment:
Non-Small Cell (NSCLC)
Radon
given 6 to 8 weeks after surgery
Surgery & Adjuvant Chemo... Cisplatin + Vinorelbine x 4 cyc…
Surgery is a Tx option for which kind…
Non-Small Cell (NSCLC)
What is the 2nd most common cause of l…
Radon
38 terms
Lung Cancer
What are the risk factors of lung canc…
Parenchyma
What is the pathophysiology (where it'…
Seven general warning signs of cancer:
Tobacco use (all types)... Occupational/Environmental exposure... H…
...
-more than 90% come from lung parenchyma (lung tissue)... -very…
C - change in bowel/bladder habits... A - sore or cut that doesn…
What are the risk factors of lung canc…
Tobacco use (all types)... Occupational/Environmental exposure... H…
Parenchyma
...
18 terms
Lung Cancer
what is the most common benign lung ma…
what is a coin lesion with well define…
what is an early mutation in cancer fo…
what are some late mutations in cancer…
pulmonary hamartoma
pulmonary hamartoma
inactivation of tumor suppressor genes in 3p
TP53 and KRAS
what is the most common benign lung ma…
pulmonary hamartoma
what is a coin lesion with well define…
pulmonary hamartoma
75 terms
Lung Cancer
How many lung cancer's per year are di…
How many lung cancer in men and how ma…
How many deaths in lung cancer per year?
How many deaths of lung cancer in men…
224,000 cases of lung cancer per year
116,000 lung cancer in men and 108,000 cancers in women
150,000 deaths in lung cancer per year
87,000 deaths in men and 72,000 deaths in women
How many lung cancer's per year are di…
224,000 cases of lung cancer per year
How many lung cancer in men and how ma…
116,000 lung cancer in men and 108,000 cancers in women
37 terms
Lung Cancer
CT screening should be done in this po…
Paraneoplastic Syndromes of lung cancer
Most common lung cancer
Stage IA NSCLC: Treatment
55-74 yrs old in good health plus... 30 pack year plus... Still smo…
C.SHADOW... -Cushing's syndrome... -SIADH ... -Hypercalcemia... -*A…
Adenocarcinoma
Surgery -/+ adjuvant chemotherapy
CT screening should be done in this po…
55-74 yrs old in good health plus... 30 pack year plus... Still smo…
Paraneoplastic Syndromes of lung cancer
C.SHADOW... -Cushing's syndrome... -SIADH ... -Hypercalcemia... -*A…
22 terms
Lung Cancer
Lung Cancer S/Sx
Types of Lung Cancer
Cisplatin
Carboplatin
persistent cough, dyspnea, hemoptysis, weight loss, chest pai…
Small Cell Carcinoma (SCLC)... - Epithelial Cell... Non-Small Cell…
- alkylating agent... - Renal dose adjust... - Taxanes must be give…
- alkylating agent... - Renal dose adjust... - Taxanes BEFORE plati…
Lung Cancer S/Sx
persistent cough, dyspnea, hemoptysis, weight loss, chest pai…
Types of Lung Cancer
Small Cell Carcinoma (SCLC)... - Epithelial Cell... Non-Small Cell…
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