Study sets matching "manganese"

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Study sets matching "manganese"

Manganese
Manganese Chemistry
Manganese Distribution
Manganese and Iron and Cobalt
Metabolic Functions of Manganese (2)
-Mn2+ most common form... -Mn3+ (1-manganese superoxide dismutas…
-Bone, liver, pancreas, retina, kidney... -mostly in mitochondria
-competes for the same binding sites (competitive inhibition)…
-metalloenzyme... - of other enzymes (cofactor)
Manganese Chemistry
-Mn2+ most common form... -Mn3+ (1-manganese superoxide dismutas…
Manganese Distribution
-Bone, liver, pancreas, retina, kidney... -mostly in mitochondria
23 terms
Manganese
manganese salts... hydrogen gas
rhodochrosite... franklinite... psilomelane…
pyrolusite
ferruginous manganese ores
When placed in dilute inorganic acids, manganese... dissolves an…
Manganese can be found in combination with other chemical ele…
The principal ore of manganese is
Ores that have from 10 - 35% manganese are called
manganese salts... hydrogen gas
When placed in dilute inorganic acids, manganese... dissolves an…
rhodochrosite... franklinite... psilomelane…
Manganese can be found in combination with other chemical ele…
42 terms
Manganese
Mn2+... Mn3+
Mn2+
Mn3+
2.3
What are the valence state of Mn?
reduced form
oxidized form
RDA for males... ___mg/day
Mn2+... Mn3+
What are the valence state of Mn?
Mn2+
reduced form
13 terms
Manganese
Absorption
Transport
Storage
Function
SI, active transport mechanism most likely, quickly saturable…
Free in blood as Mn2+ or bound to various proteins, may be ox…
Rapidly cleared from blood, accumulates in mitochondria of ti…
Antioxidant (mitochondria), metabolism (gluconeogenesis), arg…
Absorption
SI, active transport mechanism most likely, quickly saturable…
Transport
Free in blood as Mn2+ or bound to various proteins, may be ox…
13 terms
Manganese
Symbol
State
Uses
Year
Mn
Solid
Colours amethyst and used in vitamin B
1774
Symbol
Mn
State
Solid
59 terms
Manganese
Valence states
RDA males
RDA females
UL
Mn+2... Mn+3
2.3 mg/d
1.8 mg/d
11 mg/d
Valence states
Mn+2... Mn+3
RDA males
2.3 mg/d
manganese
exists as __ and __ in the body
found at __ in body
AI
food souces
Mn2+, Mn3+
trace levels (10-20mg)
male: 2.3 mg... female: 1.8mg
whole grain cereals, dried fruits, nuts, and veggies
exists as __ and __ in the body
Mn2+, Mn3+
found at __ in body
trace levels (10-20mg)
11 terms
Manganese
total body content of Mn (mg)
body distribution: bone
body distribution: liver
body distribution: pancreas
10-20 mg (1/500 tsp)
3.3 μ/g
2 μ/g
1.4 μ/g
total body content of Mn (mg)
10-20 mg (1/500 tsp)
body distribution: bone
3.3 μ/g
Manganese
white flour
Saturable
Active
High
Manganese Sources:... -Whole grain cereals... -Dried fruits... -Nuts... -…
Manganese mechanism of absorption is unknown... -Absorption occu…
Manganese Absorption... -High-affinity _____ transport mechanism…
______ intakes lead to lower absorption to protect against to…
white flour
Manganese Sources:... -Whole grain cereals... -Dried fruits... -Nuts... -…
Saturable
Manganese mechanism of absorption is unknown... -Absorption occu…
Manganese
Mn is present in ...
Mn in the soil
Mn uptake and translocation
Relatively [ ] in the plant
various primary rocks -> released by weathering to form secon…
Mn2+ is adsorbed to clay minerals and organic matter -> Mn2+…
active uptake and rate is low -> lower rate than Ca2+ and Mg2…
immobile; with only small amts of Mn2+ translocated in the ph…
Mn is present in ...
various primary rocks -> released by weathering to form secon…
Mn in the soil
Mn2+ is adsorbed to clay minerals and organic matter -> Mn2+…
23 terms
Manganese
Was manganese defiicency found in anim…
What is the most stable form and only…
What form do we mostly find in our blo…
how much manganese is found in our body?
animals
Mn 2+
Mn 3+
10-20 mg
Was manganese defiicency found in anim…
animals
What is the most stable form and only…
Mn 2+
Manganese
What are the valence of Manganese? Whi…
What is a good source of Manganese?
Mn overload is _______ and is associat…
Is digestion needed for absorption?
Mn+2: reduced form... Mn+3: Oxidized form
Pineapple
toxic; Parkinson's disease
it's unclear
What are the valence of Manganese? Whi…
Mn+2: reduced form... Mn+3: Oxidized form
What is a good source of Manganese?
Pineapple
Manganese
Valence states
Mn2+
Mn3+
RDA for males
Mn2+... Mn3+
reduced form
oxidized form
2.3 mg/day
Valence states
Mn2+... Mn3+
Mn2+
reduced form
Manganese
Valence States of Manganese
Good source of manganese
Similar to _____ Mn overload is toxic…
(T/F) Absorption is grater in females…
Mn+2: reduced form... Mn+3: Oxidized form
Pineapple (2.3mg per cup)
Iron... Parkinson's
True
Valence States of Manganese
Mn+2: reduced form... Mn+3: Oxidized form
Good source of manganese
Pineapple (2.3mg per cup)
5 terms
Manganese
Function
Deficiency
Requirement
Toxic
Cofactor/activator of enzyme systems... Oxidative phosphorylatio…
Poultry: pyrosis (slipped tendon)... CNS: degeneration (ataxia)…
2 - 40 ppm... Poorly absorbed so requirement for available Mn is…
1000 ppm... Tolerance ratio: greater than 20:1
Function
Cofactor/activator of enzyme systems... Oxidative phosphorylatio…
Deficiency
Poultry: pyrosis (slipped tendon)... CNS: degeneration (ataxia)…
37 terms
Manganese
What is the reduced form of Mn?
What is the oxidized form of Mn?
What is the RDA for Mn?
What is the UL for Mn?
Mn+2
Mn+3
Males: 2.3 mg/day... Females: 1.8 mg/day
11 mg/day
What is the reduced form of Mn?
Mn+2
What is the oxidized form of Mn?
Mn+3
7 terms
manganese
chemical forms of Mn
functions of Mn
absorption of Mn
transport of Mn
2+, 3+, 7+ states... catalytic roles in redox reactions
bone growth... -enhances osteogenesis at growth plates... -regulate…
Mn+2 enters cytosol via DMT1
bound to globin in portal vein... bound to transferrin in rest o…
chemical forms of Mn
2+, 3+, 7+ states... catalytic roles in redox reactions
functions of Mn
bone growth... -enhances osteogenesis at growth plates... -regulate…
8 terms
Manganese
Food sources
Functions
Helps body form
Role in
Whole grains... Dried fruits... Nuts... Leafy vegetables... Tea... Grains
1. Enzymes... 2. Modulator of second messenger pathways
1. Connective tissues and bones... 2. Blood clotting factors... 3.…
1. Fat and carbohydrate metabolism... 2. Calcium absorption... 3. B…
Food sources
Whole grains... Dried fruits... Nuts... Leafy vegetables... Tea... Grains
Functions
1. Enzymes... 2. Modulator of second messenger pathways
Manganese
Absorption
Bioavailability
Concerns in infants:
Chelation:
not well regulated - 3-4% absorbed
decresaed with: large amount Ca, P... Mg, Fe, Zn, Cu, Soy
absorption/retention high - mothers milk low in Fe
ascorbic acid, tannins, oxalic acid
Absorption
not well regulated - 3-4% absorbed
Bioavailability
decresaed with: large amount Ca, P... Mg, Fe, Zn, Cu, Soy
Manganese
Forms
Mn role in enzymatic reactions?
Mn key funtions
How does Mn function as an antioxidant?
Mn2+ and Mn3+
either as activator or part of metalloenzyme
- antioxidant (manganese superoxide dismutase - MnSOD) ... - wou…
- main antioxidant enzyme in mitochondria ... - superoxide produ…
Forms
Mn2+ and Mn3+
Mn role in enzymatic reactions?
either as activator or part of metalloenzyme
17 terms
manganese
deficiency
symptoms of deficiency
other signs seen
AI for adult males
for americans, generally consume above AI
-nausea, vomiting, dermatitis... -decreased growth of hair and n…
Ataxia, cell structure abnormalities, compromised reproductiv…
2.3mg/d
deficiency
for americans, generally consume above AI
symptoms of deficiency
-nausea, vomiting, dermatitis... -decreased growth of hair and n…
Manganese
Mn+2: reduced form... Mn+3: Oxidized form
Pineapple (2.3mg per cup)
Iron... Parkinson's
True
Valence States of Manganese
Good source of manganese
Similar to _____ Mn overload is toxic and is associated with…
(T/F) Absorption is grater in females than males
Mn+2: reduced form... Mn+3: Oxidized form
Valence States of Manganese
Pineapple (2.3mg per cup)
Good source of manganese
Manganese
Form
Soil Status
Role in Plants
Deficiency
Mn 2+
Defiance aggravated by low pH
Cofactor - respiratory carbon cycle ... Oxygen-evolving complex…
Interveinal chlorosis ... Necrotic spots ... Gray speck ... Purple lus…
Form
Mn 2+
Soil Status
Defiance aggravated by low pH
12 terms
Manganese
Pineapple
DCT1
ZIP14
Gallbladder
One of the best plant sources of manganese
Primary brush border transporter
Suggested secondary brush border transporter
Structure in which manganese is primarily concentrated
Pineapple
One of the best plant sources of manganese
DCT1
Primary brush border transporter
75 terms
Manganese
Mn+2
Mn+3
Males: 2.3 mg/day... Females: 1.8 mg/day
Parkinson's disease
reduced form
oxidized form
RDA
Similar to iron Mn overload is toxic and is associated with w…
Mn+2
reduced form
Mn+3
oxidized form
5 terms
Manganese
function
Zinc and Cu
deficiency
toxicity
carbohydrate metabolism... gluconeogenesis... collagen formation... an…
shares functional similarites
very rare... nausea ... vomiting... poor growth... skeletal abnormalities…
neurological impairment... parkinsons-like symptoms
function
carbohydrate metabolism... gluconeogenesis... collagen formation... an…
Zinc and Cu
shares functional similarites
Manganese
Mn+2
Mn+3
RDA
UL
reduced form
oxidized form
Males 19-30 2.3 mg/day... Females 19-30 1.8 mg/day
11 mg/day
Mn+2
reduced form
Mn+3
oxidized form
9 terms
Manganese
Manganese Tranport
Excretory Pathway
Mn-dependent enzymes: Biochemical Func…
Glycosyl Transferases
Remains Free in Portal Blood or is bound to alpha-2-Macrogl…
- Mainly Biliary via BILE (like Cu2+)... - *Secretory Pathway Ca…
...
- Requires Mn as Cofactor... - family of enzymes that catalyze…
Manganese Tranport
Remains Free in Portal Blood or is bound to alpha-2-Macrogl…
Excretory Pathway
- Mainly Biliary via BILE (like Cu2+)... - *Secretory Pathway Ca…
68 terms
Manganese (Mn)
Manganese's reduced form is __________…
Mn2+ is the ____________ form
Mn3+ is the _________ form
Sources of Manganese
Mn2+ (reduced)... Mn3+ (oxidized)
reduced
oxidized
Nuts, green vegetables, pinneapple, blueberries, and tea
Manganese's reduced form is __________…
Mn2+ (reduced)... Mn3+ (oxidized)
Mn2+ is the ____________ form
reduced
25 terms
manganese - zirconium
manganese
mercury
neon
nickel
Mn
Hg
Ne
Ni
manganese
Mn
mercury
Hg
Minerals - Manganese
Maharashtra
Madhya Pradesh
Andhra Pradesh
Telangana
Nagpur, Bhandara
Chhindwara, Balaghat
Vishakhapatnam, Srikakulam
Adilabad
Maharashtra
Nagpur, Bhandara
Madhya Pradesh
Chhindwara, Balaghat
Manganese Notes
Absorption of manganese
Biological function of manganese
Sources of manganese
Dietary reference value of manganese
Mn is taken up by divalent metal transporter (DMT1) and trans…
•It has a role in bone formation - cofactor in enzyme glycosy…
50% comes from tea... Leafy vegetables, wheat-germ, water
Safe intake = 2-5mg/day... (Reflects requirements and toxicity)
Absorption of manganese
Mn is taken up by divalent metal transporter (DMT1) and trans…
Biological function of manganese
•It has a role in bone formation - cofactor in enzyme glycosy…
21 terms
Manganese & Molybdenum
What is the AI for manganese?
What is the UL for manganese?
What are food sources of manganese?
Is manganese deficiency common?
-infants = 0.003... -7-12 mo = 0.6... -19-50y males= 2.3... -19-50y fe…
11
oats, brown rice, garbanzo beans, spinach
no
What is the AI for manganese?
-infants = 0.003... -7-12 mo = 0.6... -19-50y males= 2.3... -19-50y fe…
What is the UL for manganese?
11
Manganese & Molybdenum
What does Mn fxn as?
Does Mn defeciency cause problems?
What 5 enzymes would be effected by a…
What enzymes are a ligase/lyase in glu…
1. Enzyme activator... 2. Metalloenzyme
Rarely...can be replaced by other divalent ions (ex: Mg2+, Cu…
1. Glycosyl Transferase... -responsible for glycoprotein & pro…
Pyruvate Carboxylase= Ligase... PEPCK= Lyase
What does Mn fxn as?
1. Enzyme activator... 2. Metalloenzyme
Does Mn defeciency cause problems?
Rarely...can be replaced by other divalent ions (ex: Mg2+, Cu…
20 terms
Manganese-> Zinc
Manganese
Mercury
Neon
Nickel
Mn
Hg
Ne
Ni
Manganese
Mn
Mercury
Hg
30 terms
Manganese and Molybdenum
Mn2+
Mn3+
Similar to Iron,
Digestion of Mn
reduced form
oxidized form
Mn overload is toxic and associated with PD
unclear if digestion of food is needed for Mn abs, abs as Mn2…
Mn2+
reduced form
Mn3+
oxidized form
17 terms
Manganese and Copper
Soil factors that influence Mn availab…
Mn is less available in what soil pH?
Manganese essential functions in plants?
manganese is required for what photosy…
-soil pH... -SOM levels
alkaline soils
-photosynthesis... -enzyme activation... -auxin breakdown
water splitting reaction resulting in O2 evolution
Soil factors that influence Mn availab…
-soil pH... -SOM levels
Mn is less available in what soil pH?
alkaline soils
30 terms
Manganese and Molybdenum
Mn2+
Mn3+
Similar to Iron,
Digestion of Mn
reduced form - Mn
oxidized form-Mn
Mn overload is toxic and associated with PD
unclear if digestion of food is needed for Mn abs, abs as Mn2…
Mn2+
reduced form - Mn
Mn3+
oxidized form-Mn
Manganese Complexes
Mn2+/[Mn(H2O)6]2+
Mn(OH)2
Mn2O3.xH2O
[MnCl4]2-
pale pink
off white/white ppt
brown ppt
green-yellow
Mn2+/[Mn(H2O)6]2+
pale pink
Mn(OH)2
off white/white ppt
48 terms
Chromium and Manganese
What are the forms in which Chromium e…
What forms of Chromium are important t…
Cr3+
Cr6+
2- to 6+
3+ and 6+
is the form found in food, utilized in the body, form that is…
carcinogen, dangerous to humans, is very oxidized and this pu…
What are the forms in which Chromium e…
2- to 6+
What forms of Chromium are important t…
3+ and 6+
Manganese & Molybdenum
What does Mn fxn as?
Does Mn defeciency cause problems?
What 5 enzymes would be effected by a…
What enzymes are a ligase/lyase in glu…
1. Enzyme activator... 2. Metalloenzyme
Rarely...can be replaced by other divalent ions (ex: Mg2+, Cu…
1. Glycosyl Transferase... -responsible for glycoprotein & pro…
Pyruvate Carboxylase= Ligase... PEPCK= Lyase
What does Mn fxn as?
1. Enzyme activator... 2. Metalloenzyme
Does Mn defeciency cause problems?
Rarely...can be replaced by other divalent ions (ex: Mg2+, Cu…
Alkaline manganese
-Ve
+ve
Electrolyte
Pros
Zinc
Manganese (IV) oxide
KOH
Long shelf life ; gd low-temp performance
-Ve
Zinc
+ve
Manganese (IV) oxide
Manganese (Mn)
dietary sources
manganese in the body
how manganese works in the body
manganese deficiency
whole grains, legumes, and nuts
Mn homeostasis is maintained by regulating both absorption an…
involved in amino acid, carbohydrate, and cholesterol metabol…
naturally occuring defiency has never been reported
dietary sources
whole grains, legumes, and nuts
manganese in the body
Mn homeostasis is maintained by regulating both absorption an…
52 terms
exam 2- manganese
Valence states
Pineapple contains ____ mg manganese p…
similar to iron, Mn overload is toxic…
does Mn require digestion for absorpti…
Mn2+ (reduced)... Mn3+ (oxidized)
2.3
Parkinson's disease
unknown
Valence states
Mn2+ (reduced)... Mn3+ (oxidized)
Pineapple contains ____ mg manganese p…
2.3
Lecture 8 Manganese
Manganese general characteristics?
Is Manganese Politically vulnerable an…
What state is Manganese found in?
Typical Abundances of MN?
Very hard... Good alloy... good high Temp properties
US has no deposits, large majority of world deposits are foun…
analogue of Fe (+2), found in Mn(+2), (+4) state... in solution…
.1% in crust compared to 6% for Fe... 12th most abundant element?
Manganese general characteristics?
Very hard... Good alloy... good high Temp properties
Is Manganese Politically vulnerable an…
US has no deposits, large majority of world deposits are foun…
9 terms
Manganese and Molybdenum
Form bridges between ATP and ADP and e…
Magnesium - both have same function
nuts, legumes, tea, wholegrains
Throughout the SI
What does Manganese do?
What other mineral is related to Manganese?
What are rich sources of Manganese?
Where is Manganese absorbed
Form bridges between ATP and ADP and e…
What does Manganese do?
Magnesium - both have same function
What other mineral is related to Manganese?
21 terms
Exam 3: Manganese (Mn)
The reduced form of Manganese is
The oxidized form of Manganese is
______________ contains 2.3 mg/cup
T/F: Similar to iron, Mn overload is t…
Mn+2
Mn+3
Pineapple
True
The reduced form of Manganese is
Mn+2
The oxidized form of Manganese is
Mn+3
25 Elements After Manganese
Iron
Cobalt
Nickel
Copper
Fe
Co
Ni
Cu
Iron
Fe
Cobalt
Co
17 terms
water II Iron and Manganese
ZEOLITE
SEQUESTRATION
RESINS
ION EXCHANGE
A type of ion exchange material used to soften water.
Prevention of precipitation of the metals.
INSOLUBLE POLYMERS USED IN WATER TREATMENT.
A water treatment process involving the switching of ions bet…
ZEOLITE
A type of ion exchange material used to soften water.
SEQUESTRATION
Prevention of precipitation of the metals.
46 terms
Zinc, Copper and Manganese
Transition Metals and Metalloenzymes…
Lewis Acid
Chemical Basis for Metalloenzyme Complex
Zn as Lewis Acid (Diagram)
- "Transitional elements"... - Zn (technically NOT a transitiona…
Lewis Acid (electron acceptor) + Lewis Base (electron donor)…
Simplest term: Acid + Base -> Complex... Generalized: Electron…
Transition Metals and Metalloenzymes…
- "Transitional elements"... - Zn (technically NOT a transitiona…
Lewis Acid
Lewis Acid (electron acceptor) + Lewis Base (electron donor)…
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