Study sets matching "medchem"

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Study sets matching "medchem"

Medchem
Nicotine
Varenicline
Muscarine
Metacholine chloride
Has two basic nitrogens, a tertiary N (most basic) & a pyridine
Nicotinic agonist
Muscarinic agonist
Muscarinic agonist: nasal spray to diagnose asthma
Nicotine
Has two basic nitrogens, a tertiary N (most basic) & a pyridine
Varenicline
Nicotinic agonist
180 terms
Medchem
who developed the concept of Drug rece…
T/F: Medicinal chemistry is an interdi…
The first compound discovered to have…
T/F a lead compound has to be from a n…
Erlich
True... studies how chemical structure influences biologic acti…
Lead Compound
FALSE: the lead compound can be either natural or synthetic
who developed the concept of Drug rece…
Erlich
T/F: Medicinal chemistry is an interdi…
True... studies how chemical structure influences biologic acti…
18 terms
medchem
primary amine
secondary amine
tertiary amine
quaternary amine salts
basic
basic
basic
neutral
primary amine
basic
secondary amine
basic
13 terms
medchem
testosterone
finasteride
tamsulosin
sidenafil
testosterone
finasteride
7 terms
MEDCHEM
Sumatriptan (imitrex)
Almotriptan (axert)
Zolmitriptan (zomig)
Rizatriptan (maxalt)
succinate... SQ/PO/nasal... MAO-A... highest potency (injection), ... q…
MAO-A... efficacy like oral sumatriptan, more favourable side‐…
MAO-A... three dose forms, highest consistency in open‐label…
MAO-A... slightly quicker onset of effect than the other availab…
Sumatriptan (imitrex)
succinate... SQ/PO/nasal... MAO-A... highest potency (injection), ... q…
Almotriptan (axert)
MAO-A... efficacy like oral sumatriptan, more favourable side‐…
medchem
cocaine
benzocaine
Procaine (novocaine)
proparocaine (Alcaine, Ophtheltic)
cocaine
benzocaine
122 terms
medchem
Sulfonamide... Block bacterial synthesis…
Acylation, Glucuronidation
Trimethoprim ... Block bacterial synthesi…
Reduces Dihydrofolic acid to Tetrhydro…
General name, MOA
How are sulfonamide drugs metabolized
General name, MOA
Trimethoprim MOA and AE
Sulfonamide... Block bacterial synthesis…
General name, MOA
Acylation, Glucuronidation
How are sulfonamide drugs metabolized
23 terms
Medchem
What is the structure of palmitic acid?
What is the structure of stearic acid?
What is the structure of palmitoleic a…
What is the structure of oleic acid?
What is the structure of palmitic acid?
What is the structure of stearic acid?
Medchem
viruses (can/cannot) develop resistanc…
viruses contain (RNA/DNA)
In the latent period of AIDS, the leve…
Karposi's sarcoma is caused by which v…
can
both
CD4 positive T lymphocytes
HHV-8
viruses (can/cannot) develop resistanc…
can
viruses contain (RNA/DNA)
both
medchem
Ras
CAAX motif
lead compound
pharmacophore
intracellular protein with lipid anchor on end that link to b…
c=cys a=allphatic amino acid X=ala, met, ser ... is protein that…
prototype molecule having the desired activate, but also unde…
3 dimensional representation of key function groups needed fo…
Ras
intracellular protein with lipid anchor on end that link to b…
CAAX motif
c=cys a=allphatic amino acid X=ala, met, ser ... is protein that…
20 terms
medchem...
metolazone: quinazolinone... ketone inste…
chlorthalidone... phthalindone interconve…
indapamide... Thiazide like: inhibit Na/c…
furosemide (lasix)... 2nd aromatic ring i…
metolazone: quinazolinone... ketone inste…
chlorthalidone... phthalindone interconve…
26 terms
Medchem
Clark is best known for introduction o…
The property of a drug that describes…
The amplifier of the neuronal signal i…
Activation of Protein Kinase A (PKA) d…
occupation
affinity
second messenger
agonist, gPCR, Galphas
Clark is best known for introduction o…
occupation
The property of a drug that describes…
affinity
medchem
a compound that has at least one cente…
an equal mixture of a compounds two ro…
the two rotational antipodes of a chir…
The relationship between the possible…
Chiral
Racemic
Enantiomers
Diastereomers:
a compound that has at least one cente…
Chiral
an equal mixture of a compounds two ro…
Racemic
9 terms
medchem
Nitroglycerin or glyceryl trinitrate
amlodipine or norvasc
atorvastatin or lipitor
Cyclophoshamide
...
...
...
...
Nitroglycerin or glyceryl trinitrate
...
amlodipine or norvasc
...
22 terms
Medchem
C17 B ketol group
C 11 OH
R = OH
R- acetonide
Contributes most to potency (common group observed in corrico…
Involved in drug receptor interaction
May increase Na retention (MR activity)
(C16-C17) greatly increases potency and commonly observed in…
C17 B ketol group
Contributes most to potency (common group observed in corrico…
C 11 OH
Involved in drug receptor interaction
9 terms
Medchem
Sphingomylein
Galactocerebroside
HDL
LDL
Ceramide linked to phosphate ester bridge to choline phosphat…
ceramide + galactose ... found in brain... Krabbe's disease - def…
High Density Lipoprotein... high levels of cholesterol; low lev…
Low density lipoprotein ... responsible for transporting choles…
Sphingomylein
Ceramide linked to phosphate ester bridge to choline phosphat…
Galactocerebroside
ceramide + galactose ... found in brain... Krabbe's disease - def…
43 terms
Medchem
Procaine
Proparocaine
Tetracaine
Cyclomethylcaine
Novocaine
Alkaine, ophtheltic
Pontocaine
Surfacaine
Procaine
Novocaine
Proparocaine
Alkaine, ophtheltic
Medchem
Bioavailability
Cyclooxygenase
Prosteglandins
Synergistic
Ability to reach the largest part of the body
Enzyme aspirin binds to
Produced to cause pain fever and swelling
Two drugs working together
Bioavailability
Ability to reach the largest part of the body
Cyclooxygenase
Enzyme aspirin binds to
127 terms
medchem
estrogens synthesized from
aromatase
premenopause
postmeno
CHO
converts androstenedione into estrone... converts testosterone i…
estrogen made mainly in the ovaries
secretion of estradiol by the ovaries ceases and sex steroids…
estrogens synthesized from
CHO
aromatase
converts androstenedione into estrone... converts testosterone i…
24 terms
MEDCHEM
cortisol/hydrocortisone
1)prednisone 2)triamcinolone 3)dexamet…
beclomethasone/ budesonide
mifepristone / ketoconazole
glucocorticoids - natural agonists -replacement therapy -shor…
glucocorticoids - synthetic agonists - inflammation - organ t…
glucocorticoids - asthma - short hafl-lives - reduced toxicit…
glucocorticoids - glucocorticoid antagonists - competitive in…
cortisol/hydrocortisone
glucocorticoids - natural agonists -replacement therapy -shor…
1)prednisone 2)triamcinolone 3)dexamet…
glucocorticoids - synthetic agonists - inflammation - organ t…
Medchem
Molecular shape and location of functi…
central scaffold
common scaffolds include?
Aliphatic rings
flexibility of the scaffold and each appendage
relevant functional groups in 3D space
Flat Aryl- rings... Flat Heteroaryl- rings... both of which display…
semi-ridigity... limited spatial displays for adducts
Molecular shape and location of functi…
flexibility of the scaffold and each appendage
central scaffold
relevant functional groups in 3D space
23 terms
Medchem
Most support DA2 family
What DA receptor that is the major tar…
Where does D3 express
What receptors does Clozapine bind
D2
D2
limbic system
5HT2, D4 (10-15x higher) and D2
Most support DA2 family
D2
What DA receptor that is the major tar…
D2
Medchem
Prions are naturally occurring
(TSEs)
TSE are...
How are TSE transmitted ?
CNS proteins
Transmissible spongiform encephalopathies
diseases caused by self-propagating misfolded prion proteins.
Tissue transplants (cornea) or eating of mammalian CNS tissues.
Prions are naturally occurring
CNS proteins
(TSEs)
Transmissible spongiform encephalopathies
8 terms
medchem
is mycobacteria fram pos or neg... how t…
how isoniazid work
what is side effects of using isoniazid
what should not be taken with isoniazi…
Mycobacteria are classified as Gram-positive ... BUT they have…
mycobacteria have to make fatty acid , and it need cofactor w…
Several enzyme will metabolise isoniazid and some of them can…
Absorption is decreased in the presence of Aluminum ion (espe…
is mycobacteria fram pos or neg... how t…
Mycobacteria are classified as Gram-positive ... BUT they have…
how isoniazid work
mycobacteria have to make fatty acid , and it need cofactor w…
69 terms
Medchem
What kind of agent is Amantadine HCl?
What is amantadine used for?
What is the MOA of amantadine?
What is amantadine also used to treat?
Prophylactic antiviral agent
Prophylaxis and early treatment of influenza caused by influe…
Inhibition of uncoating of the RNA virus, thereby blocking tr…
Parkinson's disease (promotes release of dopamine)
What kind of agent is Amantadine HCl?
Prophylactic antiviral agent
What is amantadine used for?
Prophylaxis and early treatment of influenza caused by influe…
medchem
what is treated with insulin
what is treated with insulin, insulin…
the cleaves preproinsulin
what happens between preproinsulin and…
type one diabetes
type two diabetes
endopeptidases
disulfide bridges form between the A and B chain
what is treated with insulin
type one diabetes
what is treated with insulin, insulin…
type two diabetes
50 terms
Medchem Final Exam Review
Stages of cancer
Binds to tubulin affect microtubule fo…
Interaction between Vincristine and Mi…
Binds to DNA and topoisomerase II
1. Initiation (Ethidium Bormide, UV radiation)... 2. Promotion (…
Vinka alkaloids
shortness of breath
Etoposide
Stages of cancer
1. Initiation (Ethidium Bormide, UV radiation)... 2. Promotion (…
Binds to tubulin affect microtubule fo…
Vinka alkaloids
89 terms
Medchem Drugs
Penicillin G... Penicillin
Penicillin VK... Penicillin
Cloxacillin... B-lactamase Resistant Peni…
Dicloxacillin... B-lactamase Resistant Pe…
Penicillin G... Penicillin
Penicillin VK... Penicillin
36 terms
Medchem-Fahmy
-Minoxidil... -vasodilator... -severe hypert…
-hydralazine... -vasodilator... -phthalazine…
-Diazoxide... -vasodilator... -rapid IV admi…
-sodium nitroprusside... -aterial and ven…
Minoxidil
hydralazine
diazoxide
sodium nitroprusside
-Minoxidil... -vasodilator... -severe hypert…
Minoxidil
-hydralazine... -vasodilator... -phthalazine…
hydralazine
86 terms
Medchem Drugs
estrogen
derivative, estrogen, esterification (…
derivative, estrogen, alkyl added (C-1…
metabolite, estrogen, oxidation (C17),…
this is derivative/metabolite of _____, what happened to it a…
this is derivative/metabolite of _____, what happened to it a…
this is derivative/metabolite of _____, what happened to it a…
estrogen
derivative, estrogen, esterification (…
this is derivative/metabolite of _____, what happened to it a…
Medchem Exam 3
Gemfibrozil (Lopid)
Nicotinic Acid (Niaspan) (Niacin)
Lovastatin (Mevacor)
Pravastatin (Pravachol)
Prevents biosynthesis of VLDL. Prevents esterfication of CE a…
Prevents biosynthesis of VLDL. Prevents esterfication of CE a…
HMG CoA Reductase Inhib. Napthalene derivative. QD.
HMG CoA Reductase Inhib. Napthalene derivative. QD
Gemfibrozil (Lopid)
Prevents biosynthesis of VLDL. Prevents esterfication of CE a…
Nicotinic Acid (Niaspan) (Niacin)
Prevents biosynthesis of VLDL. Prevents esterfication of CE a…
121 terms
medchem exam 1
methacholine... for dx use inhalable... dire…
carbachol... glaucoma, AChE resistant... dir…
bethanechol... helps GI recover after ane…
pilocarpine... glaucoma... direct cholinergi…
methacholine... for dx use inhalable... dire…
carbachol... glaucoma, AChE resistant... dir…
141 terms
Medchem exam 2
digoxin... CHF, works at Na/K exchange... a.…
dobutamine... treat shock, IV... affects a1,…
dopamine... treat CHF with pulm edema... per…
milrinone... PDE 3 inhibitor for CHF... IV i…
digoxin... CHF, works at Na/K exchange... a.…
dobutamine... treat shock, IV... affects a1,…
457 terms
Medchem exam 2
what are drugs that can cause hypergly…
What are drugs that can cause hypoglyc…
B2 agonist does what to insulin?
Insulin promotes what?
-Glucocorticoids... -Nicotinic acid (Vit.B3)... -Thiazides... -thyroid…
-ACEI... -Ethanol
-B2 agonists enhance release of insulin
-glucose uptake into muscle/adipose tissue... -glycolysis... -glyco…
what are drugs that can cause hypergly…
-Glucocorticoids... -Nicotinic acid (Vit.B3)... -Thiazides... -thyroid…
What are drugs that can cause hypoglyc…
-ACEI... -Ethanol
1,103 terms
Medchem Exam 3
Both BDZ and BARB's enhance GABAergic…
BDZs should be prescribed for their
what are the key pharmacokinetic princ…
pharmacokinetics are primary determina…
GABA(a) receptor
pharmacokinetics
1.) rate of action (Lipid solubility)... 2.) DOA (redistribution…
hang-over or rebound effects
Both BDZ and BARB's enhance GABAergic…
GABA(a) receptor
BDZs should be prescribed for their
pharmacokinetics
445 terms
Medchem Exam 4
there is a strong relationship between…
most antidepressant drugs immediately…
for antidepressants, _______________ m…
many antidepressant drugs block ______…
serotonergic and non adrenergic
serotonergic and non adrenergic
increasing neural connections
-block monoamine reuptake... -some directly block monoamine rece…
there is a strong relationship between…
serotonergic and non adrenergic
most antidepressant drugs immediately…
serotonergic and non adrenergic
52 terms
Medchem exam 1
Red Flags (2)
ortho
meta
para
1. high protein binding with lipophilic drugs (hydrophobic)... C…
1,2 substitution
1, 3 substitution
1, 4 substitution
Red Flags (2)
1. high protein binding with lipophilic drugs (hydrophobic)... C…
ortho
1,2 substitution
36 terms
medchem exam 1 terms
ionic bonding
covalent bonding
davite bonding
sigma
occurs between two ions of opposite charge; water soluble
chemical bond that involves sharing of electrons
co-ordinate bond; covalent bond where one atom contributes bo…
head-on overlap; saturate bond;
ionic bonding
occurs between two ions of opposite charge; water soluble
covalent bonding
chemical bond that involves sharing of electrons
177 terms
MEDCHEM FINAL
What is intercellular signal transduct…
What is intracellular signal transduct…
What are the intercellular communicati…
What is endocrine signal transduction?
a signal passes from one cell to another
the receiving cell biochemically decodes signal
endocrine... paracrine... autocrine... juxtacrine... matricrine
specialized sender cells (glands) synthesize and secrete mole…
What is intercellular signal transduct…
a signal passes from one cell to another
What is intracellular signal transduct…
the receiving cell biochemically decodes signal
medchem- test 6
these are the DNA containing viruses
what are the adenovirus'
what are the Herpesv
what are the papovavirus'
...
many types - resp tract and eye infections (keratitis)
1. herpes simplex virus 1 and 2... 2. varicella zoster - chicken…
1. human wart virus... 2. polyoma virus... 3. SV40
these are the DNA containing viruses
...
what are the adenovirus'
many types - resp tract and eye infections (keratitis)
medchem final
dopamine
chlorpromazine
haloperidol
droperidol
dopamine
chlorpromazine
76 terms
medchem Final
ibuprofen... SAR 4,6,7; NOT SAR 2... 60 % is…
Flurbiprofen
ketoprofen... inhibits leukotriene pathway
ketorolac... SAR 8... injection formulation…
ibuprofen... SAR 4,6,7; NOT SAR 2... 60 % is…
Flurbiprofen
22 terms
Medchem Final
Need to perfect Gs, Gi/o, Gq
Second messengers and their importance
Adrenergic effects
Alpha receptors
Heterotrimeric G-proteins; 3 major types involved in the tran…
cAMP, cGMP, CA2+,DAG
Adrenergic drugs, also called sympathomimetic drugs, stimulat…
Vasoconstriction off veins... Decrease motility of smooth muscle…
Need to perfect Gs, Gi/o, Gq
Heterotrimeric G-proteins; 3 major types involved in the tran…
Second messengers and their importance
cAMP, cGMP, CA2+,DAG
190 terms
MEDCHEM FINAL EXAM
In position 6, a -CL or -CF3 will prov…
which of the following groups is neede…
the thiazide-like diuretic, such as in…
identify the class of diuretics?
increase in lipophilicity and increase in DOA
A. -cooh... b. -NH3... c.-cooch3... d H2NO2S-
a-carboxy group... b-ketone... c-halogen... d-tertiary amine
In position 6, a -CL or -CF3 will prov…
increase in lipophilicity and increase in DOA
which of the following groups is neede…
A. -cooh... b. -NH3... c.-cooch3... d H2NO2S-
149 terms
Medchem 332 exam 1
enzyme
Importance of Enzyme to Pharmacy
substrate
catalytic power
a protein or RNA molecule that catalyzes a specific chemical…
Diagnostics, Drug targets
the particular compound acted upon by an enzyme
acceleration of the reaction rate over that of the noncatalyz…
enzyme
a protein or RNA molecule that catalyzes a specific chemical…
Importance of Enzyme to Pharmacy
Diagnostics, Drug targets
63 terms
medchem final
cocaine
benzocaine
procaine (novocaine)
proparocaine (Alcaine, optheltic)
cocaine
benzocaine
Medchem Exam 2
Levothyroxine Sodium (recognize struct…
Coumadin (recognize structure)
Rivaroxaban
Clopidogrel
Synthroid (Thyroid)
Warfarin (Anticoagulant)
Xarelto (Anticoagulant)
Plavix (Antiplatelet P2Y12 Inh)
Levothyroxine Sodium (recognize struct…
Synthroid (Thyroid)
Coumadin (recognize structure)
Warfarin (Anticoagulant)
121 terms
Medchem exam 1
norepinephrine... acts at a1, vasoconstri…
epinephrine... acts on b1, heart
dopamine... increases blood flow to kidneys
isoproterenol... affects B1 and B2 recept…
norepinephrine... acts at a1, vasoconstri…
epinephrine... acts on b1, heart
66 terms
medchem exam 2
Tyrosine... starting material for NE, L-D…
L-Dopa... Precurser for DA
Dopamine... Precurser for NE
Norepinephrine
Tyrosine... starting material for NE, L-D…
L-Dopa... Precurser for DA
692 terms
Medchem Module 1
Enzymes ... Antibodies... Cytokines... Growth F…
Antisense Oligonucleotides... Aptamers
Alirocumab (PRALUENT®)
PCSK9
Protein biologics (5)
Nucleic acid biologics (2)
The first-in-class cholesterol-lowering treatment that inhibi…
Alirocumab, a monoclonal antibody, scavenges ___________.
Enzymes ... Antibodies... Cytokines... Growth F…
Protein biologics (5)
Antisense Oligonucleotides... Aptamers
Nucleic acid biologics (2)
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