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Study sets matching "medical biochemistry"

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Study sets matching "medical biochemistry"

45 terms
Medical Biochemistry
What is a protein
peptide bond
What group is the amino group
What group is the carboxyl group
Biomolecules comprised of amino acids linked together by pept…
NH2
COOH
What is a protein
Biomolecules comprised of amino acids linked together by pept…
peptide bond
177 terms
Medical Biochemistry
Hydrophobic
What is the difference between α-D-glu…
Which of the following is branched?... a.…
Sucrose can be hydrolyzed to which of…
Which of the following refers to a molecule which is insolubl…
They differ in the configuration of substituents C-2
Glycogen
Glucose and Fructose
Hydrophobic
Which of the following refers to a molecule which is insolubl…
What is the difference between α-D-glu…
They differ in the configuration of substituents C-2
34 terms
Medical Biochemistry
The primary electrolytes in blood are
the primary intracellular electrolytes…
the primary extracellular electrolytes…
Active transport
Sodium, Potassium, Chloride, and CO2
potassium, phosphate, and magnesium
Sodium, Chloride, and Bicarbonate
The movement of materials through a cell membrane using energ…
The primary electrolytes in blood are
Sodium, Potassium, Chloride, and CO2
the primary intracellular electrolytes…
potassium, phosphate, and magnesium
59 terms
Medical Biochemistry Lecture 20
4 Classes of Oxidoreductases
Oxidoreductases and generic rxn
Dehydrogenases and generic rxn
Hydroperoxidases
1) Oxidases... 2) Dehydrogenases... 3) Hydroperoxidases... 4) Oxygenases
Catalyze the removal of H or e⁻ from a substrate using O as a…
Transfer H from one substrate to another... AH (red) + B (ox) →…
Hydrolyze organic peroxides or Hydrogen peroxides... 1) Peroxid…
4 Classes of Oxidoreductases
1) Oxidases... 2) Dehydrogenases... 3) Hydroperoxidases... 4) Oxygenases
Oxidoreductases and generic rxn
Catalyze the removal of H or e⁻ from a substrate using O as a…
46 terms
Medical Biochemistry
Thiamine (V. B1)
Pyruvate dehydrogenase
a-ketoglutarate dehydrogenase
Transketolase
cofactor for 3 rxns of glucose metabolism:... 1. pyruvate dehydr…
converts pyruvate (the end-product of glycolysis) into acetyl…
enzyme of citric acid cycle
enzyme of the hexose monophosphate pathway. ... converts pentose…
Thiamine (V. B1)
cofactor for 3 rxns of glucose metabolism:... 1. pyruvate dehydr…
Pyruvate dehydrogenase
converts pyruvate (the end-product of glycolysis) into acetyl…
41 terms
Medical Biochemistry Lecture 10
Pyruvate Kinase (PK) Regulation
Glyceraldehyde-3-phophate dehydrogenase
1,3-BPG is what kind of molecule?
Two Glycolysis reactions resulting in…
+: F-1,6-bP... -: ATP
G-3-P +NAD+ ⇌ NADH + 1,3-BPG... Enzyme that converts G-3-P to 1…
A mixed anhydride
1) Phosphofructo kinase (PFK)... 2) Pyruvate Kinase (PK)
Pyruvate Kinase (PK) Regulation
+: F-1,6-bP... -: ATP
Glyceraldehyde-3-phophate dehydrogenase
G-3-P +NAD+ ⇌ NADH + 1,3-BPG... Enzyme that converts G-3-P to 1…
129 terms
Medical Biochemistry
Oncotic Pressure
Major metabolic source of acid
Buffer system in ECF
Buffer system in red blood cells
A form of osmotic pressure that only depends on plasma protei…
Carbon dioxide
Bicarbonate-carbonic acid
Hemoglobin
Oncotic Pressure
A form of osmotic pressure that only depends on plasma protei…
Major metabolic source of acid
Carbon dioxide
39 terms
Medical Biochemistry 19
ALS and Lou Genhrig's caused by
ALS symptoms
Are mutant mitochondria found in all t…
Asprin OD effect on mitochondria
Mutation in the gene encoding the cytosolic SOD (SOD1)
Attacking of motor neurons controlling voluntary muscles
No, they are sorted at random and may or may not end up in va…
Asprin can shuttle protons across the membrane dissipating pr…
ALS and Lou Genhrig's caused by
Mutation in the gene encoding the cytosolic SOD (SOD1)
ALS symptoms
Attacking of motor neurons controlling voluntary muscles
30 terms
Medical Biochemistry
Quinolone Drugs... Eg. Ciprofloxacin and…
Courmarins (including novobiocin)
Tenofovir
Azidothymidine
a. Inhibits DNA gyrase in prok in replication and transcripti…
a. inhibits bacterial DNA Gyrase topoisomease activity in bot…
a. anti-viral nucleotide... b. treats HIV/AIDS... c. inhibits rever…
a. an antiviral nucleoside... b. treats HIV/AIDS... c. inhibits rev…
Quinolone Drugs... Eg. Ciprofloxacin and…
a. Inhibits DNA gyrase in prok in replication and transcripti…
Courmarins (including novobiocin)
a. inhibits bacterial DNA Gyrase topoisomease activity in bot…
90 terms
Medical Biochemistry Exam 1
Cell theory
Properties of cells
Metabolism-- catabolism
Metabolism-- anabolism
1. Cell is basic unit of life... 2. All organisms are made of on…
Metabolism- sum total of all chemical reactions in an organis…
Break things down, exergonic
Build things up, endergonic
Cell theory
1. Cell is basic unit of life... 2. All organisms are made of on…
Properties of cells
Metabolism- sum total of all chemical reactions in an organis…
46 terms
Medical Biochemistry
Calories from alcohol
Maximum amount protein that can be deg…
Basal Metabolic Rate conditions
Basal Metabolic Rate estimate
7 kcal/gram
About 1/3
12h fast, awake, resiting
24 kcal/kg/day
Calories from alcohol
7 kcal/gram
Maximum amount protein that can be deg…
About 1/3
11 terms
Medical Biochemistry Chapter 2
Carbohydrate
All carbohydrates contain:
Monosaccharides
Disaccharides
-names end in "ose"... -have a formula of (CH2O)x where x is a n…
-a ketone or aldehyde group... -one or more hydroxyl groups... the…
-common single sugar groups ... -do not hydrolyze to simpler for…
-form when enzyme reactions occur at hydroxyl groups and new…
Carbohydrate
-names end in "ose"... -have a formula of (CH2O)x where x is a n…
All carbohydrates contain:
-a ketone or aldehyde group... -one or more hydroxyl groups... the…
20 terms
Medical Biochemistry Chapter 1
Amino acids are the building blocks of
Essential Amino Acids
Non-Essential Amino Acids
Amino acids are linked by
proteins
must be obtained directly from food
Human body is able to produce them on its own
peptide bonds
Amino acids are the building blocks of
proteins
Essential Amino Acids
must be obtained directly from food
78 terms
Medical Biochemistry Lecture 31
General Nucleotide Structure
Hypoxanthine
Xanthine
Dietary Nucleotide Catabolism
RNA base with a Inoside ribonucleoside
RNA base with a Xanthosine ribonucleoside
1) Pancreatic DNases and RNases hydrolyze to oligionucleotide…
General Nucleotide Structure
Hypoxanthine
RNA base with a Inoside ribonucleoside
50 terms
Medical Biochemistry Lecture 38
3 Types of cell surface receptors for…
Domains of nuclear hormone receptors
6 nuclear hormone receptors
GPCR TM domains have how many residues
1) GPCRs ... 2) Enzyme-linked (RTKs and Receptor Guanylyl cyclas…
N-term, activation, DNA binding, hormone binding domain... Acron…
PAT GEM... 1) Progesterone Receptor (PR)... 2) Androgen Receptor (A…
18-20
3 Types of cell surface receptors for…
1) GPCRs ... 2) Enzyme-linked (RTKs and Receptor Guanylyl cyclas…
Domains of nuclear hormone receptors
N-term, activation, DNA binding, hormone binding domain... Acron…
49 terms
Medical Biochemistry Lecture 32
UMP to UTP Process
CTP Synthetase Rxn
CPS-II regulation
CAD enzyme
This process will work for other NTPs as well!... 1) Nucleoside…
UTP + Gln + ATP → ADP + Pi + Glu + CTP
Downregulated by UTP and upregulated by PRPP
Giant peptide that performs the first 3 steps in pyrimidine s…
UMP to UTP Process
This process will work for other NTPs as well!... 1) Nucleoside…
CTP Synthetase Rxn
UTP + Gln + ATP → ADP + Pi + Glu + CTP
30 terms
Medical Biochemistry Lecture 50
β Thalassemia
α Thalassemia
Most common single gene disorder in hu…
Thalassemia geographical distribution
β Chain synthesis of Hb is diminished or absent. This results…
α-chain synthesis of Hb is dimished or absent. This results i…
Thalassemias
More common near the equator as they provide a degree of prot…
β Thalassemia
β Chain synthesis of Hb is diminished or absent. This results…
α Thalassemia
α-chain synthesis of Hb is dimished or absent. This results i…
55 terms
Medical Biochemistry Lecture 17
3 inhibitors of Complex I
Amytal
Antimycin A
Complex I cofactors
1) Amytal... 2) Rotenone... 3) MPP+
Barbituite (sleeping pill) that is a non-selective CNS depres…
Competitive inhibitor of Complex III that acts at the N-Site…
FMN, Fe-S
3 inhibitors of Complex I
1) Amytal... 2) Rotenone... 3) MPP+
Amytal
Barbituite (sleeping pill) that is a non-selective CNS depres…
54 terms
Medical Biochemistry Lecture 21
Simple Triacylglyerols
Mixed Triacylglyerols
Saturated fats
Unsaturated fats
Have the same FA at all 3 positions
Have different FA at all 3 positions
No double bonds, solid
1+ cis =, liquid at RT
Simple Triacylglyerols
Have the same FA at all 3 positions
Mixed Triacylglyerols
Have different FA at all 3 positions
164 terms
Medical Biochemistry Exam 2
What is Vitamin A? What are its functi…
What is Vitamin D? What are its functi…
What is Vitamin E? What are its functi…
What is Vitamin K? What are its functi…
Retinol, β-Carotene... Functions: Visual pigments in retina/gen…
Calciferol... Functions: Calcium regulation/absorption of intes…
Tocopherol... Functions: antioxidant (especially for cell membr…
Phylloquinone... Functions: Blood clotting... Deficiency: impaire…
What is Vitamin A? What are its functi…
Retinol, β-Carotene... Functions: Visual pigments in retina/gen…
What is Vitamin D? What are its functi…
Calciferol... Functions: Calcium regulation/absorption of intes…
44 terms
Medical Biochemistry Lecture 54
Fates of AA in the liver
Cori Cycle
Ketogenic AA are those that
Glucogenic AA are those that
1) Hepatocytic proteins/blood proteins... 2) Enter blood, enabli…
Can be converted to ketone bodies
Can be converted to metabolites that can be used to make Glc…
Fates of AA in the liver
1) Hepatocytic proteins/blood proteins... 2) Enter blood, enabli…
Cori Cycle
52 terms
Medical Biochemistry Lecture 12
FADH2 gives how many ATP
Mitochondrial NADH gives how much ATP?
TCA makes how many ATP PER TURN (NOT p…
Citrate Synthase Rxn
1.5
2.5
10... 9 Via NADH(7.5)/FADH2 (1.5) one via GDP -> GTP -> ATP
Acetyl-CoA + Oxaloacetate +H₂O → Citrate + CoA-SH
FADH2 gives how many ATP
1.5
Mitochondrial NADH gives how much ATP?
2.5
51 terms
Medical Biochemistry Lecture 23
FA Acyl CoA Synthetase (FA Thiokinase)…
FA Acyl CoA Synthetase operates where?
How do fatty acids get into the inner…
Carnitine transport system
First step in the breakdown of FAs and TG synthesis. Function…
Outer mitochondrial membrane
First converted to fatty acyl CoA and then it depends on thei…
1) Fatty acyl CoA diffuses into intermembrane space of mitoch…
FA Acyl CoA Synthetase (FA Thiokinase)…
First step in the breakdown of FAs and TG synthesis. Function…
FA Acyl CoA Synthetase operates where?
Outer mitochondrial membrane
60 terms
Medical Biochemistry Lecture 22
Apo A-I functions
Apo B-100 functions
Apo B-48 functions
Apo C-II function
Activates LCAT and is a ligand for the HDL receptor
Ligand for the LDL receptor
Ligand for the chylomicron remnant receptor
Activates lipoprotein lipase
Apo A-I functions
Activates LCAT and is a ligand for the HDL receptor
Apo B-100 functions
Ligand for the LDL receptor
34 terms
Medical Biochemistry Lecture 13
NADPH function in the cell?
3 main functions of the Pentose Phosph…
Functional (not structural) difference…
Stages of Pentose Phosphate Pathway
1) Provide reducing power to biosynthetic rxns... 2) Serve as a…
1) Provide the cell with NADPH... 2) Convert Hexoses to Pentoses…
NADH is oxidized to make ATP (catabolic)... NADPH is used in bi…
Stage 1: Oxidative phase- provides NADPH and a hexose which i…
NADPH function in the cell?
1) Provide reducing power to biosynthetic rxns... 2) Serve as a…
3 main functions of the Pentose Phosph…
1) Provide the cell with NADPH... 2) Convert Hexoses to Pentoses…
36 terms
Medical Biochemistry Lecture 18
ATP synthase how many protons does it…
ATP-ADP Translocase
Atractyloside and Bongkrekic Acid
Atractyloside binds where?
3
Mitochondrial Inner membrane protein that is a ADP-ATP antipo…
Inhibitors of the ATP/ADP translocase
The cytosolic side of the ATP-ADP translocase
ATP synthase how many protons does it…
3
ATP-ADP Translocase
Mitochondrial Inner membrane protein that is a ADP-ATP antipo…
11 terms
Medical Biochemistry Final Review
G6P Activates what form of glycogen sy…
5-FU can have negative side effects if…
Enzymes and hormones affecting glycoge…
Diabetes affect on cholesterol
Pi'd form
Dihydropyrimidase
Lowers HDL raises LDL
G6P Activates what form of glycogen sy…
Pi'd form
5-FU can have negative side effects if…
Dihydropyrimidase
25 terms
Medical Biochemistry Lecture 39
PLC Mechanism of cell signalling
What is blocking PLC's active site?
Where does Phospholipase A1(PLA₁) clea…
Where does Phospholipase A2 (PLA₂) cle…
1) Ligand binds triggering receptor/G-prot interaction leadin…
X/Y linker
Acyl-chain 1 of PIP₂
Acyl-chain 2 of PIP₂
PLC Mechanism of cell signalling
1) Ligand binds triggering receptor/G-prot interaction leadin…
What is blocking PLC's active site?
X/Y linker
46 terms
Medical Biochemistry Lecture 10
What is SGLT-1? Where is it?
What is GLUT-2?
How is sodium important for things lik…
How is Calcium released once muscles r…
This is a sodium-dependent glucose transporter that gets gluc…
This is a glucose transporter that works with the Na/K ATPase…
In diarrhea, sodium is depleted from the intestinal lumen, wh…
Calcium is removed from the cell by the ATPase, which pumps i…
What is SGLT-1? Where is it?
This is a sodium-dependent glucose transporter that gets gluc…
What is GLUT-2?
This is a glucose transporter that works with the Na/K ATPase…
145 terms
The Big Picture: Medical Biochemistry
Formation of carbohydrate
Gluconeogenesis
Gluconeogenesis and Glycolysis picture
Degradation of Carbohydrate
Gluconeogenesis (Glyconeogenesis)
includes 11 enzymatic steps, which form one molecule of gluco…
Glycolysis
Formation of carbohydrate
Gluconeogenesis (Glyconeogenesis)
Gluconeogenesis
includes 11 enzymatic steps, which form one molecule of gluco…
45 terms
Medical Biochemistry Lecture 24
FA Biosynthesis occurs where
Acetyl-CoA Export from the mitochondri…
Where does the NADPH needed for FA syn…
Malic enzyme and Rxn
Cytosol
Citrate Carrier. ... 1) Citrate is exported by the citrate/malat…
~50% from Malic Enzyme the rest from pentose phosphate
Cytosolic enzyme that makes NADPH for FA synth.... Malate + NADP…
FA Biosynthesis occurs where
Cytosol
Acetyl-CoA Export from the mitochondri…
Citrate Carrier. ... 1) Citrate is exported by the citrate/malat…
23 terms
Medical Biochemistry Lecture 30
Tyrosine is involved in the creation o…
Why is there variation in outcomes bet…
Sapropterin
How is PKU-II differentiated from PKU-I
1) Proteins... 2) Melanin... 3) Catecholamines... 4) Fumarate and Acet…
Different mutations and *background variations that produce d…
Another name for Kuvan, the drug used to treat PKU-I
Pt doesn't show complete response to PKU-I treatments
Tyrosine is involved in the creation o…
1) Proteins... 2) Melanin... 3) Catecholamines... 4) Fumarate and Acet…
Why is there variation in outcomes bet…
Different mutations and *background variations that produce d…
50 terms
Medical Biochemistry Lecture 28
Urea Cycle
First Reaction in AA breakdown
Which AA don't undergo the initial Ami…
Alanine Aminotransferase (ALT)
AA specific Aminotransferase:... α-AA + α-KG ↔ α-ketoacid + Glu…
Thr and Lys
Ala + α-KG → Pyruvate + Glu
Urea Cycle
First Reaction in AA breakdown
AA specific Aminotransferase:... α-AA + α-KG ↔ α-ketoacid + Glu…
39 terms
Medical Biochemistry Lecture 36
Two ways to control enzymes
Feed forward activation
Allosteric inhibitors act competively…
Kinetic differences between isozymes
1) Amount of enzyme (synth or breakdown)... 2) Rate of enzyme
The first compound in a pathway activates a later step e.g. F…
can be both
Can have different kinetic parameters (Km, Vmax)
Two ways to control enzymes
1) Amount of enzyme (synth or breakdown)... 2) Rate of enzyme
Feed forward activation
The first compound in a pathway activates a later step e.g. F…
42 terms
Medical Biochemistry Lecture 29
AA give how many Cal/g
Glucogenic vs Ketogenic
Glucogenic AA are those that
Ketogenic AA are those that
4
AA classification system based on what was observed in diabet…
Can create Glc, can still make ketone bodies ofc
Cannot create Glc, can make ketone bodies
AA give how many Cal/g
4
Glucogenic vs Ketogenic
AA classification system based on what was observed in diabet…
43 terms
Medical Biochemistry Lecture 41
Insulin Receptor Structure
Cabohydrates and IR
Insulin Signalling Pathway to Akt/PKB
IRS-1 binding
Pre-formed dimer of 2 α and 2 β chains with 2 disulfides. Int…
Extracellular domain has carbs attached
1) Insulin binds... 2) Cross-Pi of intracellular domains... 3) Pi o…
Binds the Tyr of IR and also binds to membrane bound PIP₂
Insulin Receptor Structure
Pre-formed dimer of 2 α and 2 β chains with 2 disulfides. Int…
Cabohydrates and IR
Extracellular domain has carbs attached
30 terms
Medical Biochemistry Lecture 15
Glycogen Phosphorylase
Basic Glycogen Phosphorylase Regulation
Phosphorylation does what to the break…
2 Forms of Glycogen Phosphorylase B ac…
Enzyme that catalyzes the attack on glyocgen using an inorgan…
Has two forms a form (active, Pi'd) and b (inactive, not Pi'd…
Activates, both in glycogen and fat stores
1) Pi'd by Phosphorylase Kinase to form a... 2) Allosterically a…
Glycogen Phosphorylase
Enzyme that catalyzes the attack on glyocgen using an inorgan…
Basic Glycogen Phosphorylase Regulation
Has two forms a form (active, Pi'd) and b (inactive, not Pi'd…
27 terms
Medical Biochemistry Lecture 52
Glucokinase differs from hexokinase in…
5 Fates of G6P in liver
G6Phosphatase and location
Main energy source for the liver?
1) Liver localization... 2) High Km for Glc (none for other suga…
1) Converted to Glc and exported by G6-Phosphatase... 2) Convert…
Enzyme that removes the Pi from G6P. Predominately in liver b…
FA or α-keto acids
Glucokinase differs from hexokinase in…
1) Liver localization... 2) High Km for Glc (none for other suga…
5 Fates of G6P in liver
1) Converted to Glc and exported by G6-Phosphatase... 2) Convert…
32 terms
Medical Biochemistry Lecture 14
Glycerol enters Glycolysis where?
AAs enter glucose metabolism where?
When is lactose used as the gluconeoge…
Why does Lactate use a different proce…
Converted to DHAP
OAA and Pyruvate
After vigorous exercise
The conversion of Lactate → Pyruvate makes the NADH needed to…
Glycerol enters Glycolysis where?
Converted to DHAP
AAs enter glucose metabolism where?
OAA and Pyruvate
48 terms
Medical Biochemistry Lecture 34
ALA affect on neurons is due to what?
Reticuloendothelial system and relevan…
Hb is broken down to what?
Heme Oxygenase rxn, organ, and cofactor
It resembles GABA and can therefore affect neurons
Phagocytic cells in spleen, liver, and bone marrow. Collect a…
Heme + Globin. Globin is degraded by proteases to AAs, which…
Heme + O₂ + NADPH -> CO + Fe³⁺ + NADP⁺ + H₂O + Biliverdin... Or…
ALA affect on neurons is due to what?
It resembles GABA and can therefore affect neurons
Reticuloendothelial system and relevan…
Phagocytic cells in spleen, liver, and bone marrow. Collect a…
28 terms
Medical Biochemistry Lecture 56
What 3 Metabolic Pathways occur exclus…
What 4 Pathways occur in the mitochond…
What 2 metabolic pathways are partiall…
NADH gets into the mitochondria how?
Glycolysis, Pentose Phosphate, and FA Synthesis
TCA, Ox Phos, β-ox, Ketone body formation
Gluconeogenesis and Urea cycle
Glycerol phosphate shuttle or malate-asp shuttle
What 3 Metabolic Pathways occur exclus…
Glycolysis, Pentose Phosphate, and FA Synthesis
What 4 Pathways occur in the mitochond…
TCA, Ox Phos, β-ox, Ketone body formation
22 terms
Medical Biochemistry Lecture 57
Pyruvate-PEP Cycle
Ala promotes gluconeogenesis how?
How does FA oxidation promote gluconeo…
Phosphorylation of PK causes what (spe…
It inhibits both PK and provides additional Pyruvate for gluc…
Acetyl-CoA builds up turning off PDH, and on Pyruvate Carboxy…
Increases its Km. Forces Pyruvate -> PEP.
Pyruvate-PEP Cycle
Ala promotes gluconeogenesis how?
It inhibits both PK and provides additional Pyruvate for gluc…
18 terms
Medical Biochemistry Lecture 5
Examples of Irreversible Inhibitors
Timeline for reversible vs irreversibl…
Telling the difference between reversi…
How to get rid of a competitive inhibi…
1) Nerve gases and alkylphosphate pesticides... 2) Cyanide: reac…
Reversible inhibitors happen virtually instantaneously, irrev…
Reversible can be diluted out or seperated by chromatography…
Treat with excess substrate. Then substrate will out compete…
Examples of Irreversible Inhibitors
1) Nerve gases and alkylphosphate pesticides... 2) Cyanide: reac…
Timeline for reversible vs irreversibl…
Reversible inhibitors happen virtually instantaneously, irrev…
124 terms
Medical Biochemistry; Exam 3
Why do use urine for a drug screen?
What are the lab tests ordered for Dru…
What kind of tests do you order after…
What is hydrocodone and what is used f…
Because the drugs can be detected for a longer period of time
1. urine drug screen ... 2. Confirmatory tests
You would order a confirmatory test... because it is more spe…
Hydrocodone is a semi-synthetic opiate... - A treatment of chron…
Why do use urine for a drug screen?
Because the drugs can be detected for a longer period of time
What are the lab tests ordered for Dru…
1. urine drug screen ... 2. Confirmatory tests
26 terms
Medical Biochemistry Lecture 3
Catalytic Triad
Why is His often found in the active s…
Metal ion cofactors are often associat…
Holoenzyme
Ser-His-Asp
It has a dissociable H with a pKa close to physiological pH t…
Asp or Glu's (-) charge or coordinated to unshared pairs of e…
Enzyme with bound coenzyme
Catalytic Triad
Ser-His-Asp
Why is His often found in the active s…
It has a dissociable H with a pKa close to physiological pH t…
15 terms
Medical Biochemistry Lecture 4
Hyperuricemia is due to
CYP genes encode
Relevance of CYP SNPs
Grapefruit juice interactions
Also known as gout. Due to 3x increased activity of PRPP synt…
Encode the drug metabolizing enzymes in the cytochrome P450 p…
Variation in metabolization of drugs. Results in the having "…
Inhibitor of CYP3A4 which metabolizes >1/3rd of commonly pres…
Hyperuricemia is due to
Also known as gout. Due to 3x increased activity of PRPP synt…
CYP genes encode
Encode the drug metabolizing enzymes in the cytochrome P450 p…
22 terms
Medical Biochemistry Lecture 6
Most common irreversible protein modif…
Most common reversible protein modific…
Pi occurs on what AAs
Feedback inhibition usually takes plac…
Proteolytic cleavage to activate zymogens or proenzymes.
Phosphorylation or disulfide bond formation
Ser, Tyr, Thr
The first step. Prevent unneccessary build up of intermediates.
Most common irreversible protein modif…
Proteolytic cleavage to activate zymogens or proenzymes.
Most common reversible protein modific…
Phosphorylation or disulfide bond formation
34 terms
Medical Biochemistry - Eicosanoids
What are Eicosanoids?
What are the basic types of compounds…
Common features among the Eicosanoids…
What is the major source for Eicosanoi…
- Lipids... - Derived from 20 C fatty acids such as arachidonic…
- Prostoglandins... - Thromboxanes... - Leukotrienes
- Eicosanoids of one type or another are made in all tissue... -…
Glycerophospholipids in plasma membranes
What are Eicosanoids?
- Lipids... - Derived from 20 C fatty acids such as arachidonic…
What are the basic types of compounds…
- Prostoglandins... - Thromboxanes... - Leukotrienes
32 terms
Medical Biochemistry Chapter 7
Carbohydrates
functions of carbohydrates
aldose
ketose
hydrated carbons... produced via photosynthesis... can be as big as…
energy source... provide structural components for exoskeletons…
monosaccharide with an aldehyde funtionality
monosaccharide with a ketone functionality
Carbohydrates
hydrated carbons... produced via photosynthesis... can be as big as…
functions of carbohydrates
energy source... provide structural components for exoskeletons…
41 terms
Medical Biochemistry Lecture 10
Pyruvate Kinase (PK) Regulation
Glyceraldehyde-3-phophate dehydrogenase
1,3-BPG is what kind of molecule?
Two Glycolysis reactions resulting in…
+: F-1,6-bP... -: ATP
G-3-P +NAD+ ⇌ NADH + 1,3-BPG... Enzyme that converts G-3-P to 1…
A mixed anhydride
1) Phosphofructo kinase (PFK)... 2) Pyruvate Kinase (PK)
Pyruvate Kinase (PK) Regulation
+: F-1,6-bP... -: ATP
Glyceraldehyde-3-phophate dehydrogenase
G-3-P +NAD+ ⇌ NADH + 1,3-BPG... Enzyme that converts G-3-P to 1…
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